CN104368265A - Standardized modular modularized pharmacy production device and production method - Google Patents
Standardized modular modularized pharmacy production device and production method Download PDFInfo
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- CN104368265A CN104368265A CN201410443357.7A CN201410443357A CN104368265A CN 104368265 A CN104368265 A CN 104368265A CN 201410443357 A CN201410443357 A CN 201410443357A CN 104368265 A CN104368265 A CN 104368265A
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Abstract
The invention relates to the technical field of pharmaceutical equipment, and particularly relates to a standardized modular modularized pharmacy production device and production method applicable to a pharmaceutical liquid dispensing system, the standardized modular modularized pharmacy production device includes a tank module, a heat exchanger module, a PH regulator module, a feed liquid pump transfer module, a compressed air / nitrogen intake module, a cleaning module, a filtering module and an electrical control cabinet module, according to the composition and function, the device is divided into function modules with independent functions; according to the different functions, the way, specification and composition of the function modules are divided into various standardized components, the function modules and the components commonly form an enterprise module library, through the dynamic combination of the function modules and the components, a variety of technological requirements of users can be met, so that non-standard products are converted into standardized production, the device quality, stability and production efficiency are greatly improved, and the device ensures the stability of the production process, and makes the operation maintenance simpler.
Description
[technical field]
The present invention relates to pharmaceutical equipment and preparation method's technical field, pharmaceutical device and production method are produced in a kind of standardization, modularization, modularization being applicable to pharmacy liquid mixing system and on-line cleaning system specifically.
[background technology]
At present, pharmacy liquid mixing system, on-line cleaning system equipment manufacturing process be by various valve, pipe fitting and electric controling element according to
figurepaper is making and installation one by one.Due to the different reason such as production technology, use habit, process layout that each medicine is looked forward to, very large difference is there is in each medicine enterprise to the demand of pharmacy liquid mixing system, on-line cleaning system equipment, make medicine look forward to all needing to list " user's request specification " according to the production technology of oneself to manufacturer when purchasing pharmacy liquid mixing system, on-line cleaning system equipment and carry out custom-made, manufacturer then needs to design pharmacy liquid mixing system, on-line cleaning system equipment according to " user's request specification ", has designed rear basis
figurevalve, pipe fitting are connected manufacture with electric controling element by paper one by one.
The otherness of pharmacy liquid mixing system, on-line cleaning system equipment not only gives manufacturer also to making medication look forward to bringing very large puzzlement and burden, needs to drop into a large amount of human and material resources.The otherness of these pharmacy liquid mixing systems, on-line cleaning system equipment demand and nonstandardized technique, have any different between the product that same manufacturer is produced, also there is a great difference in the product that different manufacturer produces, increase product design and production difficulty, cause quality in the production process of product low, repair rate is high, and the production cycle is long, reduce production efficiency, also increase on-the-spot installation difficulty.Pharmacy corporation also needs for each liquid mixing system formulates standard separately at setting and acceptance of equipment, checking, staffs training, routine use with when safeguarding simultaneously.
[summary of the invention]
The object of the invention is to overcome above-mentioned pharmacy liquid mixing system, the otherness of on-line cleaning system equipment causes quality in the production process of product low, repair rate is high, production cycle is long, reduce production efficiency, also the technical problems such as on-the-spot installation difficulty are increased, under a kind of prerequisite meeting the regulations such as cGMP is provided, reduce the design of manufacturer, production and field erected difficulty, improve the production efficiency of manufacturer, the module of normalise simultaneously also facilitates the examination to equipment of pharmacy corporation, device authentication, staffs training, routine use and maintenance
pharmaceutical device and production method are produced in a kind of standardization, modularization, modularization.
For realizing above object, a kind of modular assembly process units being provided, comprising: tank module, heat exchanger module, PH adjustment module, feed pump shift module, compressed air/nitrogen air inlet module, cleaning module, filtering module, electrical control cabinet module:
Described tank module enters Control Component, the heating of unadjustable formula tank chuck cooling package, tank bottoms material assembly, magnetic agitation assembly, sampling assemble, Weighing module by canister assembly, tank deck assembly, breather component, tank fluid, canister assembly storage tank forms, tank deck assembly is connected to form by tube for entering can road, froth breaking mouth pipeline, is provided with by-pass valve control and pressure instrumentation above tube for entering can road, breather component is by respirator, logical atmosphere controlling valve, empty intake valve, online sterilizing pipeline and control valve thereof, online sterilising temp detecting instrument, gas tank overhead-valve, the pipeline that connects tank is pressed to form, wherein respirator snap ring suitable for reading connects logical atmosphere controlling valve, presses empty intake valve, arrange mouth snap ring under respirator and connect online sterile tube road and control valve, online sterilising temp detecting instrument, respirator end opening snap ring connects gas tank overhead-valve, connects the pipeline of tank, tank fluid enters Control Component by on-line cleaning inlet channel and control valve thereof, dosing cooling water for injection inlet channel and control valve thereof, water for injection temperature detection sensor, online sterilizing pure steam inlet pipeline and control valve thereof, drip washing discharge tube and control valve thereof, tank body connecting line and control valve composition thereof, wherein dosing cools the upper left side that water for injection inlet channel and control valve and water for injection temperature detection sensor thereof are welded in assembly, online sterilizing pure steam inlet pipeline and control valve thereof are welded in immediately below water for injection temperature detection sensor, drip washing discharge tube and control are welded in the right side of water for injection temperature detection sensor, tank body connecting line and control valve thereof are welded in the rightmost side of assembly, end is connected with tank snap ring, unadjustable formula tank chuck heating cooling package is by refrigerant inlet channel and control valve, refrigerant outlet conduit and control valve thereof, and refrigerant discharge pipe road and control valve thereof connect and compose, tank bottoms material assembly is made up of material pipeline and control valve, discharge pipe and control valve thereof, is provided with online sterilizing instrumentation above material pipeline, magnetic agitation assembly is magnetic stirring apparatus, sampling assemble is made up of sterile sampling valve, sterilizing pure steam inlet pipeline and control valve thereof,
Described heat exchanger module comprises the adjustable assembly of chuck heating cooldown rate, the unadjustable formula assembly of chuck heating cooldown rate, heat exchanger, valve pipe assembly composition, described chuck heating cooldown rate adjustable heat exchanger chuck assembly goes out assembly and refrigerant by refrigerant and enters assembly and form, refrigerant goes out assembly and regulates angle pedestal valve and pipe fitting to form by DN40, controls the opening and closing that refrigerant goes out heat exchanger jacket passageway; Refrigerant enters assembly DN40 angle pedestal valve, y-type filter, DN 20 angle pedestal valve, buffer-type Pressure gauge, y-type filter filters and enters refrigerant, Pressure gauge detects and enters refrigerant pressure, DN40 angle pedestal valve control refrigerant enters the logical of heat exchanger chuck and closes, and DN20 angle pedestal valve controls logical the closing purging chuck compressed air channel; Described chuck heating cooldown rate non-adjustable type heat exchanger chuck assembly goes out assembly and refrigerant by refrigerant and enters assembly and form, and refrigerant goes out assembly and is made up of DN40 angle pedestal valve and pipe fitting, controls the opening and closing that refrigerant goes out heat exchanger jacket passageway; Refrigerant enters assembly DN40 angle pedestal valve, y-type filter, DN 20 angle pedestal valve, buffer-type Pressure gauge, y-type filter filters and enters refrigerant, Pressure gauge detects and enters refrigerant pressure, DN40 angle pedestal valve control refrigerant enters the logical of heat exchanger chuck and closes, and DN20 angle pedestal valve controls logical the closing purging chuck compressed air channel;
Described feed pump shift module is made up of feed liquid shifting pump and pipe fitting;
Described compressed air/nitrogen air inlet module be divided into band filter pressure sky/nitrogen air intake assembly and be not with filter type press sky/nitrogen air intake assembly, not with filter type press sky/nitrogen air inlet module by with the breather component common gas filter in tank module;
Described on-line cleaning module on-line cleaning module is made up of for water assembly scavenging pump, on-line cleaning backwater assembly, on-line cleaning, on-line cleaning backwater assembly is made up of water return pipeline and control valve, the pressure of return water instrumentation be arranged on water return pipeline, rinse water discharge tube and control valve thereof, and on-line cleaning is upper installation supply water temperature instrumentation, pressure of supply water instrumentation, water supply flow detecting instrument, the water supply Conductivity detection instrument at water supply line for water assembly;
Described filtering module can be divided into de-carbon filter assemblies, 0.45 μm of level prefilter assembly and 0.22 μm of sterilizing filter assembly, de-carbon filter assemblies is divided into online disinfection type de-carbon filter assemblies and off-line disinfection type de-carbon filter assemblies, 0.45 μm of level prefilter assembly is divided into online disinfection type 0.45 μm of level prefilter assembly and off-line disinfection type 0.45 μm of level prefilter assembly, and 0.22 μm of sterilizing filter assembly is divided into online disinfection type 0.22 μm of sterilizing filter assembly and off-line disinfection type 0.22 μm of sterilizing filter assembly;
Described electrical control cabinet module is made up of PLC, frequency converter, touch-screen, relay.
Described PH is adjusted to manual adjustments.
Each described functional module and constituent components together constitute the module storehouse of enterprise, modules or assembly meet the repertoire of setting by dynamic group synthesis pharmaceutical liquid mixing system and on-line cleaning equipment, module or assembly can be added, the extension of practical function and expansion.
A kind of production method adopting above-mentioned modular assembly process units:
Step 1: according to the various functions of pharmacy liquid mixing system, on-line cleaning system equipment, classification of equipment is become each functional module, each functional module is divided into each standardized constituent components according to the different implementations of function, specification and constituted mode;
Step 1.1: pharmacy liquid mixing system can be divided into tank module, heat exchanger module, PH adjustment module, feed pump shift module, compressed air/nitrogen air inlet module, on-line cleaning module, filtering module, electrical control cabinet module according to various function;
Step 1.2: various functional module is divided into each standardized constituent components according to different implementations, specification and constituted mode;
Step 1.2.1: tank Module Division becomes tank chuck to cool the adjustable assembly of heating, the unadjustable formula assembly of the cooling rate of heat addition, breather component, sampling assemble, tank deck assembly, leve detecting assembly, mixing component, tank bed material liquid assembly, drain assembly formation; Breather component is divided into can disinfection type breather component and off-line disinfection type breather component online; Sterile sampling assembly and disposable sterilized sampling pocket type sampling assemble when sampling assemble is divided into sterile sampling valve type sampling assemble, acupuncture; Leve detecting assembly is divided into Weighing module formula leve detecting assembly and liquid level gauge formula leve detecting assembly; Mixing component is divided into magnetic stirring assembly and mechanical agitation type assembly;
Step 1.2.2: heat exchanger module is divided into heat exchanger chuck to heat the adjustable assembly of cooldown rate, the unadjustable formula assembly of chuck heating cooldown rate, heat exchanger assembly, valve pipe assembly;
Step 1.2.3: compressed air/nitrogen air inlet module be divided into band filter pressure sky/nitrogen air intake assembly and be not with filter type press sky/nitrogen air intake assembly, not with filter type press sky/nitrogen air inlet module by with the breather component common gas filter in tank module;
Step 1.2.4: on-line cleaning module is divided into self-priming pump type on-line cleaning assembly, centrifugal pump type on-line cleaning assembly, on-line cleaning input duct assembly, on-line cleaning fluid conduit assembly;
Step 1.2.5: filtering module can be divided into de-carbon filter assemblies, 0.45 μm of level prefilter assembly and 0.22 μm of sterilizing filter assembly; De-carbon filter assemblies is divided into online disinfection type de-carbon filter assemblies and off-line disinfection type de-carbon filter assemblies; 0.45 μm of level prefilter assembly is divided into online disinfection type 0.45 μm of level prefilter assembly and off-line disinfection type 0.45 μm of level prefilter assembly; 0.22 μm of sterilizing filter assembly is divided into online disinfection type 0.22 μm of sterilizing filter assembly and off-line disinfection type 0.22 μm of sterilizing filter assembly;
Step 1.2.6: electric control module, puts together parts electric control systems of electrical control that needs all in equipment;
Step 2: by step one divide the standardized modular assembly obtained and set up Component Gallery according to the difference of specification;
Step 3: for each module is write
independentdebugging routine, can debug separately each module;
Step 4: select various functional module group part to combine from module storehouse, forms an equipment of meeting customer need;
Step 5: produce various module, each module is debugged separately, various module is carried out combination assembling, overall debugging.
Advantage of the present invention is: by by rational for liquid mixing system modularization, modularization, set up systematization, standardized module storehouse, equipment will no longer manufacture and design by single valve, pipe fitting and electrical equipment, only need directly various systematization, standardized module to be carried out dynamic combined, obtain the equipment meeting customer demand, not only achieve facility compact, easy for installation, also improve quality and the stability of equipment; Each module can manufacture in factory simultaneously, debugging and functional test separately, the production cycle of a large amount of equipment that shortens, field installation time, debugging cycle, shorten project duration, standardized module provides convenience also to the device authentication of pharmaceutical industry, staffs training, routine use and maintenance, also reduces the technical requirement to production operation employee; Modules or assembly can meet the repertoire of setting by dynamic group synthesis pharmaceutical liquid mixing system and on-line cleaning equipment, again can by adding module, the extension of practical function and expansion, facilitate the equipment extension function increase in user's future, safeguard, upgrade and transformation.
[accompanying drawing explanation]
figure1 is pharmacy liquid mixing system of the present invention and the on-line cleaning system equipment technological process of production
figure;
figure2 is tank module production and assembly signal in the present invention
figure;
figure3 is heat exchanger module production and assembly signal in the present invention
figure;
figure4 is on-line cleaning module production and assembly signal in the present invention
figure;
figure5 is filtering module production and assembly signal in the present invention
figure;
figurein: 1. canister assembly 2. tank deck assembly 3. breather component 4. tank fluid enters non-adjustable type heat exchanger chuck assembly 13. scavenging pump assembly 14. on-line cleaning backwater assembly 15. on-line cleaning of Control Component 5. unadjustable formula tank chuck heating cooling package 6. tank bottoms material assembly 7. magnetic agitation assembly 8. sampling assemble 9. Weighing module 10. heat exchanger assembly 11. water for injection assembly 12. for water assembly 16. filtering module;
Specify
figure1 is attached as summary of the present invention
figure.
[detailed description of the invention]
In order to the standardization of pharmacy liquid mixing system in the present invention, on-line cleaning system equipment, modularization and Componentized are described more clearly
novelmanufacturing process, below in conjunction with attached
figurethe invention will be further described, and the structure of this device and principle are very clearly concerning the people of this specialty.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1
Modularization, modularization production and assembly new paragon consider that pharmacy liquid mixing system, on-line cleaning system equipment need the various composition functions possessed, and becomes each to have mutually classification of equipment according to each composition function
independentthe functional module of function; Modules is divided into each standardized constituent components according to the different implementations of function, specification and formation, each functional module and constituent components together constitute the module storehouse of enterprise, by the dynamic combined of each functional module and constituent components, the various process requirements of user can be met; Make nonstandard product be converted into standardized production, greatly improve device fabrication efficiency, ensure that stable processing technique, make Operation and Maintenance simpler.See
figure1, concrete steps are as follows:
According to the various functions of pharmacy liquid mixing system, on-line cleaning system equipment, classification of equipment is become each functional module, each functional module is divided into each standardized constituent components according to the different implementations of function, specification and constituted mode;
Following various functional parameter is understood from a client " user's request handbook ":
1. this liquid needs low temperature to configure, and Agitation Tank requires to have refrigerating function, does not need to regulate, tank volume 300L;
2. dosing water for injection need first be cooled to less than 25 DEG C, then regulates with Agitation Tank;
3. dosing needs stirring, on-line period;
4. need in dosing process accurately to control dosing amount;
5. dosing equipment need with respirator, ensures the pressure balance in Agitation Tank if desired;
6. dosing equipment adopts the empty material transfer mode of pressure to carry out material transfer;
7. dosing adopts an aseptic filtration, the cleaning of filter off-line, online sterilizing;
8. liquid mixing system need possess function of on-line cleaning, online sterilizing function, and can ensure final effect;
From module storehouse, select suitable module, be combined into the liquid mixing system equipment meeting client, according to
figurepaper connects into each module, selects
figurethe various modules of 2-5, the liquid mixing system equipment of composition can meet " the user's request handbook " that client provides.
Pharmacy liquid mixing system can be divided into tank module, heat exchanger module, PH adjustment module, feed pump shift module, compressed air/nitrogen air inlet module, on-line cleaning module, filtering module, electrical control cabinet module according to various function, and various functional module is divided into each standardized constituent components according to different implementations, specification and constituted mode;
figurethe 2 tank module signals that are liquid mixing system equipment in the present invention
figuretank module enters Control Component 4, the heating of 38mm caliber unadjustable formula tank chuck cooling package 5,25mm caliber tank bottoms material assembly 6, magnetic agitation assembly 8,12.7mm caliber sampling assemble 7, sampling module 8, Weighing module 9 assembly by 300L canister assembly 1,25mm caliber tank deck assembly 2,5 inches of breather components 3,25mm caliber tank fluid, pH is adjusted to manual adjustments, therefore without pH module; Canister assembly 1 is made up of 300L storage tank; Tank deck assembly 2 is made up of tube for entering can road and valve, froth breaking mouth pipeline and by-pass valve control, pressure instrumentation; 5 inches of breather components 3, by respirator, logical atmosphere controlling valve, press empty intake valve, online sterilizing pipeline and control valve thereof, online sterilising temp detecting instrument composition; Tank fluid enters Control Component 4 by on-line cleaning inlet channel and control valve, dosing cooling water for injection inlet channel and control valve thereof, water for injection temperature detection sensor, the online pure steam inlet pipeline of sterilizing and control valve, drip washing discharge tube and control valve thereof, tank body connecting line and control valve composition thereof; 38mm caliber unadjustable formula tank chuck heating cooling package 5 is by refrigerant inlet channel and control valve, refrigerant outlet conduit and control valve thereof, and refrigerant discharge pipe road and control valve thereof are formed; 25mm caliber tank bottoms material assembly 6 is made up of material pipeline and control valve, discharge pipe and control valve thereof, online sterilizing instrumentation; Magnetic agitation assembly 7 is made up of magnetic agitation, 12.7mm caliber sampling assemble 8 assembly is made up of sterile sampling valve, sterilizing pure steam inlet pipeline and control valve thereof.
figurethe 3 heat exchanger module signals that are liquid mixing system equipment in the present invention
figure, heat exchanger module is by heat exchanger assembly 10,25mm caliber water for injection assembly 11,38mm caliber non-adjustable type heat exchanger chuck assembly 12; Heat exchanger assembly 10 is made up of a heat exchanger; 25mm caliber water for injection assembly 11 by DN25 diaphragm valve 2, U-shaped curved 1,1, elbow, 25mm pipe fitting form; 38mm caliber non-adjustable type heat exchanger chuck assembly 12 goes out assembly and refrigerant by refrigerant and enters assembly and form, and refrigerant goes out assembly and is made up of DN40 angle pedestal valve and 38mm pipe fitting, controls the opening and closing that refrigerant goes out heat exchanger jacket passageway; Refrigerant enters assembly and is made up of DN40 angle pedestal valve, DN40 y-type filter, buffer-type Pressure gauge, DN20 angle pedestal valve, y-type filter filters and enters refrigerant, Pressure gauge detects and enters refrigerant pressure, DN40 angle pedestal valve control refrigerant enters the logical of heat exchanger chuck and closes, and DN20 angle pedestal valve controls logical the closing purging chuck compressed air channel.
figure4 is liquid mixing system equipment on-line cleaning module signal in the present invention
figure, on-line cleaning module is made up of for water assembly 15 scavenging pump assembly 13, on-line cleaning backwater assembly 14, on-line cleaning; Scavenging pump assembly 13 is made up of scavenging pump; On-line cleaning backwater assembly 14 is made up of water return pipeline and control valve, pressure of return water instrumentation, rinse water discharge tube and control valve thereof; On-line cleaning is made up of water supply line, supply water temperature instrumentation, pressure of supply water instrumentation, water supply flow detecting instrument, water supply Conductivity detection instrument for water assembly 15.
figure5 is liquid mixing system equipment filtering module signal in the present invention
figure, filter assemblies is made up of a sterilizing filter, filtration input duct and control valve, filter pressure instrumentation, fluid pipeline and control valve thereof, sterilizing pipeline and control valve, sterilizing condensate water steam trap and drain water piping.
Modules assembly is pressed
figureafter paper has connected, tank module 25mm caliber product water assembly is connected with heat exchanger module 25mm caliber water for injection assembly, tank module 25mm caliber product water assembly is connected for water assembly with on-line cleaning module on-line cleaning, tank module 25mm caliber tank bottoms material assembly is connected with filter module, by filtering module and on-line cleaning module and on-line cleaning backwater assembly, obtain required liquid mixing system.
Machine debugging, mails to client and carries out site installation test after completing, debug, trained rear payment user, project terminates.
Claims (4)
1. a modular assembly process units, comprising: tank module, heat exchanger module, PH adjustment module, feed pump shift module, compressed air/nitrogen air inlet module, cleaning module, filtering module, electrical control cabinet module, is characterized in that:
Described tank module enters Control Component, the heating of unadjustable formula tank chuck cooling package, tank bottoms material assembly, magnetic agitation assembly, sampling assemble, Weighing module by canister assembly, tank deck assembly, breather component, tank fluid, canister assembly storage tank forms, tank deck assembly is connected to form by tube for entering can road, froth breaking mouth pipeline, is provided with by-pass valve control and pressure instrumentation above tube for entering can road, breather component is by respirator, logical atmosphere controlling valve, empty intake valve, online sterilizing pipeline and control valve thereof, online sterilising temp detecting instrument, gas tank overhead-valve, the pipeline that connects tank is pressed to form, wherein respirator snap ring suitable for reading connects logical atmosphere controlling valve, presses empty intake valve, arrange mouth snap ring under respirator and connect online sterile tube road and control valve, online sterilising temp detecting instrument, respirator end opening snap ring connects gas tank overhead-valve, connects the pipeline of tank, tank fluid enters Control Component by on-line cleaning inlet channel and control valve thereof, dosing cooling water for injection inlet channel and control valve thereof, water for injection temperature detection sensor, online sterilizing pure steam inlet pipeline and control valve thereof, drip washing discharge tube and control valve thereof, tank body connecting line and control valve composition thereof, wherein dosing cools the upper left side that water for injection inlet channel and control valve and water for injection temperature detection sensor thereof are welded in assembly, online sterilizing pure steam inlet pipeline and control valve thereof are welded in immediately below water for injection temperature detection sensor, drip washing discharge tube and control are welded in the right side of water for injection temperature detection sensor, tank body connecting line and control valve thereof are welded in the rightmost side of assembly, end is connected with tank snap ring, unadjustable formula tank chuck heating cooling package is by refrigerant inlet channel and control valve, refrigerant outlet conduit and control valve thereof, and refrigerant discharge pipe road and control valve thereof connect and compose, tank bottoms material assembly is made up of material pipeline and control valve, discharge pipe and control valve thereof, is provided with online sterilizing instrumentation above material pipeline, magnetic agitation assembly is magnetic stirring apparatus, sampling assemble is made up of sterile sampling valve, sterilizing pure steam inlet pipeline and control valve thereof,
Described heat exchanger module comprises the adjustable assembly of chuck heating cooldown rate, the unadjustable formula assembly of chuck heating cooldown rate, heat exchanger, valve pipe assembly composition, described chuck heating cooldown rate adjustable heat exchanger chuck assembly goes out assembly and refrigerant by refrigerant and enters assembly and form, refrigerant goes out assembly and regulates angle pedestal valve and pipe fitting to form by DN40, controls the opening and closing that refrigerant goes out heat exchanger jacket passageway; Refrigerant enters assembly DN40 angle pedestal valve, y-type filter, DN 20 angle pedestal valve, buffer-type Pressure gauge, y-type filter filters and enters refrigerant, Pressure gauge detects and enters refrigerant pressure, DN40 angle pedestal valve control refrigerant enters the logical of heat exchanger chuck and closes, and DN20 angle pedestal valve controls logical the closing purging chuck compressed air channel; Described chuck heating cooldown rate non-adjustable type heat exchanger chuck assembly goes out assembly and refrigerant by refrigerant and enters assembly and form, and refrigerant goes out assembly and is made up of DN40 angle pedestal valve and pipe fitting, controls the opening and closing that refrigerant goes out heat exchanger jacket passageway; Refrigerant enters assembly DN40 angle pedestal valve, y-type filter, DN 20 angle pedestal valve, buffer-type Pressure gauge, y-type filter filters and enters refrigerant, Pressure gauge detects and enters refrigerant pressure, DN40 angle pedestal valve control refrigerant enters the logical of heat exchanger chuck and closes, and DN20 angle pedestal valve controls logical the closing purging chuck compressed air channel;
Described feed pump shift module is made up of feed liquid shifting pump and pipe fitting;
Described compressed air/nitrogen air inlet module be divided into band filter pressure sky/nitrogen air intake assembly and be not with filter type press sky/nitrogen air intake assembly, not with filter type press sky/nitrogen air inlet module by with the breather component common gas filter in tank module;
Described on-line cleaning module on-line cleaning module is made up of for water assembly scavenging pump, on-line cleaning backwater assembly, on-line cleaning, on-line cleaning backwater assembly is made up of water return pipeline and control valve, the pressure of return water instrumentation be arranged on water return pipeline, rinse water discharge tube and control valve thereof, and on-line cleaning is upper installation supply water temperature instrumentation, pressure of supply water instrumentation, water supply flow detecting instrument, the water supply Conductivity detection instrument at water supply line for water assembly;
Described filtering module can be divided into de-carbon filter assemblies, 0.45 μm of level prefilter assembly and 0.22 μm of sterilizing filter assembly, de-carbon filter assemblies is divided into online disinfection type de-carbon filter assemblies and off-line disinfection type de-carbon filter assemblies, 0.45 μm of level prefilter assembly is divided into online disinfection type 0.45 μm of level prefilter assembly and off-line disinfection type 0.45 μm of level prefilter assembly, and 0.22 μm of sterilizing filter assembly is divided into online disinfection type 0.22 μm of sterilizing filter assembly and off-line disinfection type 0.22 μm of sterilizing filter assembly;
Described electrical control cabinet module is made up of PLC, frequency converter, touch-screen, relay.
2. a kind of modular assembly process units as claimed in claim 1, is characterized in that described PH is adjusted to manual adjustments.
3. a kind of modular assembly process units as claimed in claim 1, it is characterized in that each described functional module and constituent components together constitute the module storehouse of enterprise, modules or assembly meet the repertoire of setting by dynamic group synthesis pharmaceutical liquid mixing system and on-line cleaning equipment, module or assembly can be added, the extension of practical function and expansion.
4. adopt a production method for modular assembly process units according to claim 1, it is characterized in that:
Step 1: according to the various functions of pharmacy liquid mixing system, on-line cleaning system equipment, classification of equipment is become each functional module, each functional module is divided into each standardized constituent components according to the different implementations of function, specification and constituted mode;
Step 1.1: pharmacy liquid mixing system can be divided into tank module, heat exchanger module, PH adjustment module, feed pump shift module, compressed air/nitrogen air inlet module, on-line cleaning module, filtering module, electrical control cabinet module according to various function;
Step 1.2: various functional module is divided into each standardized constituent components according to different implementations, specification and constituted mode;
Step 1.2.1: tank Module Division becomes tank chuck to cool the adjustable assembly of heating, the unadjustable formula assembly of the cooling rate of heat addition, breather component, sampling assemble, tank deck assembly, leve detecting assembly, mixing component, tank bed material liquid assembly, drain assembly formation; Breather component is divided into can disinfection type breather component and off-line disinfection type breather component online; Sterile sampling assembly and disposable sterilized sampling pocket type sampling assemble when sampling assemble is divided into sterile sampling valve type sampling assemble, acupuncture; Leve detecting assembly is divided into Weighing module formula leve detecting assembly and liquid level gauge formula leve detecting assembly; Mixing component is divided into magnetic stirring assembly and mechanical agitation type assembly;
Step 1.2.2: heat exchanger module is divided into heat exchanger chuck to heat the adjustable assembly of cooldown rate, the unadjustable formula assembly of chuck heating cooldown rate, heat exchanger assembly, valve pipe assembly;
Step 1.2.3: compressed air/nitrogen air inlet module be divided into band filter pressure sky/nitrogen air intake assembly and be not with filter type press sky/nitrogen air intake assembly, not with filter type press sky/nitrogen air inlet module by with the breather component common gas filter in tank module;
Step 1.2.4: on-line cleaning module is divided into self-priming pump type on-line cleaning assembly, centrifugal pump type on-line cleaning assembly, on-line cleaning input duct assembly, on-line cleaning fluid conduit assembly;
Step 1.2.5: filtering module can be divided into de-carbon filter assemblies, 0.45 μm of level prefilter assembly and 0.22 μm of sterilizing filter assembly; De-carbon filter assemblies is divided into online disinfection type de-carbon filter assemblies and off-line disinfection type de-carbon filter assemblies; 0.45 μm of level prefilter assembly is divided into online disinfection type 0.45 μm of level prefilter assembly and off-line disinfection type 0.45 μm of level prefilter assembly; 0.22 μm of sterilizing filter assembly is divided into online disinfection type 0.22 μm of sterilizing filter assembly and off-line disinfection type 0.22 μm of sterilizing filter assembly;
Step 1.2.6: electric control module, puts together parts electric control systems of electrical control that needs all in equipment;
Step 2: by step one divide the standardized modular assembly obtained and set up Component Gallery according to the difference of specification;
Step 3: for each module writes independently debugging routine, can debug separately each module;
Step 4: select various functional module group part to combine from module storehouse, forms an equipment of meeting customer need;
Step 5: produce various module, each module is debugged separately, various module is carried out combination assembling, overall debugging.
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| CN105413552A (en) * | 2015-11-19 | 2016-03-23 | 无锡意凯自动化技术有限公司 | Sterile vacuum emulsification system |
| CN109304128A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | If the liquid medicine dosing system and its cleaning method of T-type liquid filter |
| CN111931316A (en) * | 2020-05-26 | 2020-11-13 | 中建八局天津建设工程有限公司 | Modular assembly type machine room equipment and pipeline construction method |
| CN113262202A (en) * | 2021-06-30 | 2021-08-17 | 江西益佰年药业股份有限公司 | Preparation process method of calcium zinc gluconate oral liquid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105413552A (en) * | 2015-11-19 | 2016-03-23 | 无锡意凯自动化技术有限公司 | Sterile vacuum emulsification system |
| CN109304128A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | If the liquid medicine dosing system and its cleaning method of T-type liquid filter |
| CN109304128B (en) * | 2017-07-26 | 2024-01-23 | 上海至纯洁净系统科技股份有限公司 | Liquid medicine preparation system with T-shaped liquid filter and cleaning method thereof |
| CN111931316A (en) * | 2020-05-26 | 2020-11-13 | 中建八局天津建设工程有限公司 | Modular assembly type machine room equipment and pipeline construction method |
| CN113262202A (en) * | 2021-06-30 | 2021-08-17 | 江西益佰年药业股份有限公司 | Preparation process method of calcium zinc gluconate oral liquid |
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