CN104363775B - Waterborne liquid beverage - Google Patents

Waterborne liquid beverage Download PDF

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Publication number
CN104363775B
CN104363775B CN201380018383.9A CN201380018383A CN104363775B CN 104363775 B CN104363775 B CN 104363775B CN 201380018383 A CN201380018383 A CN 201380018383A CN 104363775 B CN104363775 B CN 104363775B
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CN
China
Prior art keywords
liquid beverage
waterborne liquid
pectin
polyoxyethylene
nonionic surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380018383.9A
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Chinese (zh)
Other versions
CN104363775A (en
Inventor
堂本隆史
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of CN104363775A publication Critical patent/CN104363775A/en
Application granted granted Critical
Publication of CN104363775B publication Critical patent/CN104363775B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/732Pectin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/231Pectin; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients

Abstract

The present invention provides waterborne liquid beverage, it is characterised in that be combined with LM pectin and polyoxyethylene system nonionic surfactant.

Description

Waterborne liquid beverage
Technical field
The present invention relates to the liquid beverage of aqueous, it may use the fields such as medicine, quasi drug and food.
Background technology
Obesity is to cause the serious social problem of metabolism syndrome.As the effective means for pre-preventing obesity, can list and limit going on a diet of food intake, but practical situation is consequent empty stomach sense can cause going on a diet and cannot continue for a long time.Thus, it is provided with to eliminate sense on an empty stomach using spice or flavor compounds as the empty stomach sense demulcent (with reference to patent documentation 1) of main component, cereals (with reference to patent documentation 2), edibility phosphoprotein and the carbonate (with reference to patent documentation 3) etc. of metal.
As for one of method improving this empty stomach sense, report has use agar, makes the method (with reference to patent documentation 4) that the gel strength of the agar after impregnating certain time in gastric juice improves.But, owing to needing to chew hard gel and swallowed, therefore, it is difficult to say that its practicality is high.It addition, be also reported the method (with reference to patent documentation 5) using stomach valve (gastricraft) compositions containing gel, but gel strength is low, does not reaches long-time suppression sense on an empty stomach.
Prior art literature
Patent documentation
Patent documentation 1: Japanese Patent Laid-Open 2008-7427 publication
Patent documentation 2: Japanese Patent Laid-Open 2007-53929 publication
Patent documentation 3: Japanese Patent Laid-Open 2010-94085 publication
Patent documentation 4: Japanese Patent Laid-Open 2008-110923 publication
Patent documentation 5: Japan Patent spy's table 2009-530254 publication.
Summary of the invention
The problem that invention is to be solved
It is an object of the invention to provide waterborne liquid beverage, although it has is common waterborne liquid beverage before consumption, but understands after drinking and react with gastric acid under one's belt and gelation, delay make the character that satiety is good under one's belt.
Means for solving the above
The present inventor conducts in-depth research to solve the problems referred to above, found that: be combined with LM pectin, the waterborne liquid beverage of polyoxyethylene system nonionic surfactant reacts and gelation with simulated gastric fluid (Japanese Pharmacopoeia the 1st liquid), it is possible to obtain the gel of high intensity.
By the way of the present invention obtained by above-mentioned opinion as follows.
(1) waterborne liquid beverage, it is characterised in that be combined with LM pectin and polyoxyethylene system nonionic surfactant.
(2) waterborne liquid beverage aforementioned (1), wherein, the use level of polyoxyethylene system nonionic surfactant is more than 0.005 mass parts relative to 1 mass parts LM pectin.
(3) aforementioned (1) or the waterborne liquid beverage of (2), wherein, polyoxyethylene system nonionic surfactant is polyoxyethylene hydrogenated Oleum Ricini.
(4) the waterborne liquid beverage any one of aforementioned (1) ~ (3), wherein, pH is 3.5 ~ 7.0.
Invention effect
Pass through the present invention, it is possible to provide waterborne liquid beverage, it is believed that it reacts with gastric acid and gelation, its gel strength height, therefore, it is possible to long-time maintenance feels the state being eliminated on an empty stomach.
Detailed description of the invention
" pectin " refers to the water-soluble polysaccharides using the polygalacturonic acid of α-Isosorbide-5-Nitrae-bonding as main component, and it extracts from Fructus Mali pumilae, citrus.The pectin of the present invention can be derived from Fructus Mali pumilae, be derived from citrus any one, but must be the ratio of the composition as methyl ester of the galacturonic acid presented in free acid or methyl ester constituting sugar as pectin " the LM pectin " less than 50%.It addition, the pectin that the ratio of methyl ester is more than 50% is referred to as HM pectin, its in acidic region soluble solid constituents if not more than 55% then will not gelation, be therefore unsuitable for the present invention.
The use level of LM pectin is 0.01 ~ 10 mass % in waterborne liquid beverage, from taking and the aspect of gel strength under one's belt, more preferably 0.1 ~ 3.5 mass %.
As " polyoxyethylene system nonionic surfactant ", polyoxyethylene hydrogenated Oleum Ricini, polyoxyethylene sorbitan fatty acid ester, cithrol, polyoxyethylene glycerol fatty acid esters can be listed.
The use level of polyoxyethylene system nonionic surfactant is 0.005 ~ 50 mass parts relative to 1 mass parts LM pectin, preferably 0.01 ~ 50 mass parts.Under this mixing ratio, it is possible to provide reacting with gastric acid and gelation, its gel strength height, therefore president's time maintains the waterborne liquid beverage feeling the state being eliminated on an empty stomach.
About the pH of the waterborne liquid beverage of the present invention, due to LM pectin when pH is less than 3.5 can gelation, the most preferably 3.5 ~ 7.0, from the aspect of the ease of manufacturing of waterborne liquid beverage, more preferably 4.0 ~ 7.0.
In order to the pH of the waterborne liquid beverage of the present invention is maintained at above-mentioned scope, the pH adjusting agents such as organic acid can be coordinated as required.
It addition, as other composition, can suitably coordinate vitamins, minerals, aminoacid and its esters, crude drug, extracts from crude drugs, caffeine, Lac regis apis, dextrin etc. in the range of effect of the present invention not damaging.And then, do not damaging in the range of effect of the present invention, can the most suitably coordinate the additives such as antioxidant, coloring agent, spice, correctives, preservative agent, sweetening material.
The waterborne liquid beverage of the present invention can be prepared by conventional method, and its method is not particularly limited.Such as after can be by weighing each composition and being dissolved in appropriate pure water, regulate pH, and then interpolation pure water adjusts capacity, implements filtration as required, sterilization processing is prepared.
The waterborne liquid beverage of the present invention can provide as the various beverages in the field of food such as medicine and quasi drug, tea beverage, sports drink such as refreshment drink water, functional drinks and health beverage (De リ Application Network), syrup.
Embodiment
Embodiment described below, comparative example and test example, illustrate the present invention in further detail.
[embodiment and comparative example]
Citric acid hydrate and sodium benzoate is added in pure water, and then add the polyoxyethylene hydrogenated Oleum Ricini (embodiment 1 ~ 6) as polyoxyethylene system nonionic surfactant, the SY-Glyster MO 750 (comparative example 2) as polyglyceryl fatty acid ester or as the Refined Soybean lecithin (comparative example 3) of lecithin and make it dissolve, with hydrochloric acid sodium hydroxide pH adjusted to 3.5(final pH be the situation of 4.0), 4.5(final pH be 4.5,7.0 situation).This solution being heated to 80 DEG C, makes LM pectolysis, adding pure water in this solution and making total amount is 100mL, adjusts pH to 4.0,4.5 or 7.0 with sodium hydroxide.Each experimental liquid is filled and sterilizes to vial, obtain the embodiment 1 ~ 6 shown in table 1 ~ 3 and the beverage of comparative example 1 ~ 5.
[table 1]
[table 2]
[table 3]
The mensuration of [test example 1] gel strength
Gel strength (fracture strength) measures by following method.
In 50mL beaker, put into the sample of the beverage of preparation in the embodiment 1 ~ 6 of 12.5mL and comparative example 1 ~ 5, drip Japanese Pharmacopoeia the 1st liquid (Japanese Pharmacopoeia slaking test method the 1st liquid) of 12.5mL along wall quietly.It addition, Japanese Pharmacopoeia the 1st liquid is comparable to the acid solution (pH is 1.2) of gastric juice.After at room temperature placing 1 hour, with rheometer measurement gel strength (fracture strength).
Use instrument: FUDOH flow graph (レ オ テ ッ Network company model: RT-2100NJ-CW)
Use adapter: viscoelasticity thick pole φ 20mm
Test model: destructive test
Measurement range: 20N
Log speed: 1cm/min
The meansigma methods of 3 measurement results is shown in table 4 ~ 6.
[table 4]
[table 5]
[table 6]
By coordinating polyoxyethylene system nonionic surfactant (polyoxyethylene hydrogenated Oleum Ricini) as in Example 1, gel strength (fracture strength) dramatically increases compared with comparative example 1.The lecithin (Refined Soybean lecithin) added in the polyglyceryl fatty acid ester (SY-Glyster MO 750) added in comparative example 2 or comparative example 3, compared with the comparative example 1 being not added with them, does not observes the rising of gel strength.
By coordinating polyoxyethylene system nonionic surfactant as embodiment 2 and 3, and to make pH be 4.0 ~ 7.0, and gel strength (fracture strength) dramatically increases compared with comparative example 4 and 5.
By coordinating the polyoxyethylene system nonionic surfactant of more than 0.005 mass parts as embodiment 4 ~ 6 relative to 1 mass parts LM pectin, gel strength (fracture strength) dramatically increases compared with comparative example 1.
Industrial applicability
Passing through the present invention, it is possible to provide waterborne liquid beverage, it reacts with gastric acid and gelation, its gel strength height, therefore, it is possible to long-time maintenance feels the state being eliminated on an empty stomach.Thus, by the present invention being provided as the go on a diet medicine as target, quasi drug and food with pre-preventing obesity, the development of these industries can be expected.

Claims (3)

1. waterborne liquid beverage, it is to cooperate with LM pectin and the waterborne liquid beverage of polyoxyethylene system nonionic surfactant, it is characterised in that described polyoxyethylene system nonionic surfactant is polyoxyethylene hydrogenated Oleum Ricini.
2. the waterborne liquid beverage described in claim 1, wherein, the use level of polyoxyethylene system nonionic surfactant is more than 0.005 mass parts relative to 1 mass parts LM pectin.
3. the waterborne liquid beverage described in claim 1 or 2, wherein, pH is 3.5 ~ 7.0.
CN201380018383.9A 2012-04-04 2013-04-03 Waterborne liquid beverage Expired - Fee Related CN104363775B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012085091 2012-04-04
JP2012-085091 2012-04-04
PCT/JP2013/060170 WO2013151082A1 (en) 2012-04-04 2013-04-03 Aqueous liquid beverage

Publications (2)

Publication Number Publication Date
CN104363775A CN104363775A (en) 2015-02-18
CN104363775B true CN104363775B (en) 2016-08-03

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JP (1) JP6183355B2 (en)
CN (1) CN104363775B (en)
HK (1) HK1203321A1 (en)
PH (1) PH12014502222A1 (en)
SG (1) SG11201406307RA (en)
TW (1) TW201402135A (en)
WO (1) WO2013151082A1 (en)

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JPWO2016104334A1 (en) * 2014-12-25 2017-10-05 大正製薬株式会社 Aqueous liquid beverage

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Publication number Publication date
JPWO2013151082A1 (en) 2015-12-17
WO2013151082A1 (en) 2013-10-10
SG11201406307RA (en) 2014-11-27
TW201402135A (en) 2014-01-16
JP6183355B2 (en) 2017-08-23
CN104363775A (en) 2015-02-18
PH12014502222A1 (en) 2015-01-12
HK1203321A1 (en) 2015-10-30

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