JPWO2013151082A1 - Aqueous liquid beverage - Google Patents
Aqueous liquid beverage Download PDFInfo
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- JPWO2013151082A1 JPWO2013151082A1 JP2014509181A JP2014509181A JPWO2013151082A1 JP WO2013151082 A1 JPWO2013151082 A1 JP WO2013151082A1 JP 2014509181 A JP2014509181 A JP 2014509181A JP 2014509181 A JP2014509181 A JP 2014509181A JP WO2013151082 A1 JPWO2013151082 A1 JP WO2013151082A1
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- aqueous liquid
- pectin
- liquid beverage
- polyoxyethylene
- nonionic surfactant
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- 239000007788 liquid Substances 0.000 title claims abstract description 26
- 235000013361 beverage Nutrition 0.000 title claims abstract description 17
- -1 polyoxyethylene Polymers 0.000 claims abstract description 25
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 19
- 239000001814 pectin Substances 0.000 claims abstract description 17
- 235000010987 pectin Nutrition 0.000 claims abstract description 17
- 229920001277 pectin Polymers 0.000 claims abstract description 17
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 14
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- 238000002156 mixing Methods 0.000 abstract description 4
- 239000000499 gel Substances 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 12
- 235000003642 hunger Nutrition 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 4
- 210000004211 gastric acid Anatomy 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000008589 Obesity Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 244000141359 Malus pumila Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000021016 apples Nutrition 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/231—Pectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
Abstract
本発明は、ＬＭペクチン及びポリオキシエチレン系非イオン性界面活性剤を配合したことを特徴とする水性液体飲料を提供する。The present invention provides an aqueous liquid beverage characterized by blending LM pectin and a polyoxyethylene nonionic surfactant.
Description
本発明は、水性の液体飲料に関し、医薬品、医薬部外品及び食品等の分野において利用されうる。 The present invention relates to an aqueous liquid beverage and can be used in the fields of pharmaceuticals, quasi drugs, foods and the like.
肥満はメタボリックシンドロームに至る深刻な社会問題である。肥満を予防するための有効な手段としては、食事摂取量を制限してのダイエットが挙げられるが、これによって生じる空腹感のため、長続きしないというのが実状であった。そこで、空腹感を解消するために、香料又は香料化合物を主成分とする空腹感緩和剤（特許文献１参照）、シリアル食品（特許文献２参照）、可食性リンタンパクと金属の炭酸塩（特許文献３参照）などが提供されている。 Obesity is a serious social problem that leads to metabolic syndrome. An effective means for preventing obesity is a diet with a limited dietary intake, but the actual situation is that it does not last long because of the feeling of hunger. Therefore, in order to eliminate the feeling of hunger, the hunger sensation relieving agent (see Patent Document 1), a cereal food (see Patent Document 2), an edible phosphoprotein, and a metal carbonate (Patent) Reference 3) is provided.
そうした空腹感を改善するための方法の1つとして、寒天を用い、胃液に一定時間浸された後の寒天のゲル強度を向上させる方法（特許文献４参照）が報告されている。しかしながら、固いゲルを咀嚼して飲みこむ必要があるため、実用性が高いとは言いがたい。また、ゲル化剤を含む胃内ラフト組成物を用いる方法（特許文献５参照）も報告されているが、ゲルの強度が低く、空腹感を長時間抑制するには至っていない。 As one method for improving such a feeling of hunger, a method has been reported in which agar is used to improve the gel strength of agar after being immersed in gastric juice for a certain period of time (see Patent Document 4). However, since it is necessary to chew and swallow a hard gel, it is difficult to say that it is highly practical. Moreover, although the method (refer patent document 5) using the gastric raft composition containing a gelatinizer is also reported, the intensity | strength of a gel is low and it has not led to suppressing a feeling of hunger for a long time.
本発明の目的は、飲む前は普通の水性液体飲料であるが、飲んだ後に胃の中で胃酸と反応してゲル化し、胃の中に滞留して腹持ちがよいという性質を有する水性液体飲料を提供することである。 The object of the present invention is an ordinary aqueous liquid drink before drinking, but after drinking, it reacts with gastric acid in the stomach and gels, and it stays in the stomach and has the property of having a good stomach. Is to provide.
本発明者は、上記課題を解決するために鋭意検討した結果、ＬＭペクチン、ポリオキシエチレン系非イオン性界面活性剤を配合した水性液体飲料は、人工胃液（日局第１液）と反応してゲル化し、高強度のゲルが得られることを見いだした。 As a result of intensive studies to solve the above problems, the inventor of the present invention reacts with an artificial gastric juice (JP 1st liquid) in an aqueous liquid drink containing LM pectin and a polyoxyethylene nonionic surfactant. And found that a high-strength gel was obtained.
かかる知見により得られた本発明の態様は次のとおりである。
（１）ＬＭペクチン及びポリオキシエチレン系非イオン性界面活性剤を配合したことを特徴とする水性液体飲料。
（２）ポリオキシエチレン系非イオン性界面活性剤の配合量がＬＭペクチンの１質量部に対して０．００５質量部以上である前記（１）の水性液体飲料。
（３）ポリオキシエチレン系非イオン性界面活性剤がポリオキシエチレン硬化ヒマシ油である前記（１）又は（２）の水性液体飲料。
（４）ｐＨが３．５〜７．０である前記（１）〜（３）の何れかの水性液体飲料。The embodiments of the present invention obtained from such findings are as follows.
(1) An aqueous liquid beverage comprising LM pectin and a polyoxyethylene nonionic surfactant.
(2) The aqueous liquid beverage according to (1), wherein the amount of the polyoxyethylene-based nonionic surfactant is 0.005 parts by mass or more with respect to 1 part by mass of LM pectin.
(3) The aqueous liquid beverage according to (1) or (2) above, wherein the polyoxyethylene nonionic surfactant is polyoxyethylene hydrogenated castor oil.
(4) The aqueous liquid beverage according to any one of (1) to (3), wherein the pH is 3.5 to 7.0.
本発明により、胃酸と反応してゲル化し、そのゲル強度が高いため、空腹感を解消した状態を長時間維持させることができると考えられる水性液体飲料を提供することが可能となった。 According to the present invention, it is possible to provide an aqueous liquid drink that is considered to be able to maintain a state in which a feeling of hunger is eliminated for a long time because it gels by reacting with gastric acid and has a high gel strength.
「ペクチン」とは、α−１，４−結合したポリガラクツロン酸が主成分の水溶性多糖類であり、リンゴや柑橘類から抽出される。本発明のペクチンは、リンゴ由来、柑橘類由来の何れのものであってもよいが、ペクチンの構成糖であってフリーの酸若しくはメチルエステルとして存在するガラクツロン酸がメチルエステルであるものの比率が５０％未満の「ＬＭペクチン」であることが必要である。因みに、メチルエステルの比率が５０％以上のペクチンをＨＭペクチンというが、酸性域では可溶性固形分が５５％以上でないとゲル化しないため、本発明には適さない。 “Pectin” is a water-soluble polysaccharide composed mainly of α-1,4-linked polygalacturonic acid, and is extracted from apples and citrus fruits. The pectin of the present invention may be derived from apples or citrus fruits, but the proportion of pectin constituting galacturonic acid present as free acid or methyl ester is 50%. Less than “LM pectin”. Incidentally, pectin having a methyl ester ratio of 50% or more is referred to as HM pectin. However, in the acidic region, it does not gel unless the soluble solid content is 55% or more, and is not suitable for the present invention.
ＬＭペクチンの配合量は、水性液体飲料中０．０１〜１０質量％であり、服用性及び胃中でのゲルの強度という点から、０．１〜３．５質量％がより好ましい。 The compounding quantity of LM pectin is 0.01-10 mass% in an aqueous liquid drink, and 0.1-3.5 mass% is more preferable from the point of taking property and the intensity | strength of the gel in a stomach.
「ポリオキシエチレン系非イオン性界面活性剤」としては、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステルが挙げられる。 Examples of the “polyoxyethylene nonionic surfactant” include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, and polyoxyethylene glycerin fatty acid ester.
ポリオキシエチレン系非イオン性界面活性剤の配合量は、ＬＭペクチン１質量部に対して０.００５〜５０質量部であり、０．０１〜５０質量部が好ましい。この配合割合において、胃酸と反応してゲル化し、そのゲル強度が高いため空腹感を解消した状態が長時間持続する水性液体飲料を提供することができる。 The compounding quantity of a polyoxyethylene type nonionic surfactant is 0.0050-50 mass parts with respect to 1 mass part of LM pectin, and 0.01-50 mass parts is preferable. In this blending ratio, it reacts with gastric acid to gel, and since the gel strength is high, it is possible to provide an aqueous liquid beverage in which a state in which the feeling of hunger is eliminated continues for a long time.
本発明の水性液体飲料のｐＨは、ＬＭペクチンがｐＨ３．５未満でゲル化することから３．５〜７．０が好ましく、水性液体飲料の製造のし易さという点から、４．０〜７．０がより好ましい。 The pH of the aqueous liquid beverage of the present invention is preferably 3.5 to 7.0 because LM pectin gels at a pH of less than 3.5, and 4.0 to 4.0 from the viewpoint of ease of production of the aqueous liquid beverage. 7.0 is more preferable.
本発明の水性液体飲料のｐＨを上記範囲に保つために、必要に応じて有機酸等のｐＨ調整剤を配合することができる。 In order to keep the pH of the aqueous liquid beverage of the present invention in the above range, a pH adjuster such as an organic acid can be blended as necessary.
また、その他の成分として、ビタミン類、ミネラル類、アミノ酸及びその塩類、生薬、生薬抽出物、カフェイン、ローヤルゼリー、デキストリン等を本発明の効果を損なわない範囲で適宜に配合することができる。更に必要に応じて、抗酸化剤、着色剤、香料、矯味剤、保存剤、甘味料等の添加物を本発明の効果を損なわない範囲で適宜に配合することができる。 As other components, vitamins, minerals, amino acids and salts thereof, herbal medicines, herbal extracts, caffeine, royal jelly, dextrin, and the like can be appropriately blended within a range not impairing the effects of the present invention. Furthermore, additives such as antioxidants, colorants, fragrances, flavoring agents, preservatives, sweeteners and the like can be appropriately blended as necessary so long as the effects of the present invention are not impaired.
本発明の水性液体飲料は、常法により調製することができ、その方法は特に限定されるものではない。例えば、各成分を秤量し適量の精製水に溶解した後、ｐＨを調整し、更に精製水を加えて容量調整し、必要に応じてろ過、殺菌処理を施すことにより調製することができる。 The aqueous liquid beverage of the present invention can be prepared by a conventional method, and the method is not particularly limited. For example, after each component is weighed and dissolved in an appropriate amount of purified water, the pH is adjusted, the volume is further adjusted by adding purified water, and filtration and sterilization are performed as necessary.
本発明の水性液体飲料は、清涼飲料水、機能性飲料の他、ドリンク剤、シロップ等の医薬品及び医薬部外品、茶飲料、スポーツドリンク等の食品領域における各種飲料として提供することができる。 The aqueous liquid drink of the present invention can be provided as various drinks in food areas such as soft drinks, functional drinks, pharmaceuticals such as drinks and syrups, quasi drugs, tea drinks, and sports drinks.
以下に実施例、比較例及び試験例を示し、本発明をより詳細に説明する。 Hereinafter, the present invention will be described in more detail with reference to Examples, Comparative Examples and Test Examples.
[実施例及び比較例]
精製水にクエン酸水和物及び安息香酸ナトリウムを添加し、更に、ポリオキシエチレン系非イオン性界面活性剤としてポリオキシエチレン硬化ヒマシ油（実施例１〜６）、ポリグリセリン脂肪酸エステルとしてデカグリセリンモノオレイン酸エステル（比較例２）、又はレシチンとして精製大豆レシチン（比較例３）を添加し溶解させて、塩酸・水酸化ナトリウムでｐＨを３．５（最終ｐＨ４．０の場合）、４．５（最終ｐＨ４．５、７．０の場合）に調整した。該溶液を８０℃に加温し、ＬＭペクチンを溶解させ、該溶液に精製水を加えて全量１００ｍＬとし、水酸化ナトリウムでｐＨを４．０、４．５または７．０に調整した。各試験液をガラスビンに充填後殺菌し、表１〜３に示す実施例１〜６及び比較例１〜５の飲料を得た。[Examples and Comparative Examples]
Citric acid hydrate and sodium benzoate are added to purified water, polyoxyethylene hydrogenated castor oil (Examples 1 to 6) as a polyoxyethylene nonionic surfactant, and decaglycerin as a polyglycerin fatty acid ester. 3. Monooleic acid ester (Comparative Example 2) or purified soybean lecithin (Comparative Example 3) as lecithin is added and dissolved, and the pH is 3.5 (when the final pH is 4.0) with hydrochloric acid / sodium hydroxide. 5 (in the case of final pH 4.5, 7.0). The solution was heated to 80 ° C. to dissolve LM pectin, and purified water was added to the solution to make a total volume of 100 mL, and the pH was adjusted to 4.0, 4.5, or 7.0 with sodium hydroxide. Each test solution was filled in a glass bottle and sterilized to obtain beverages of Examples 1 to 6 and Comparative Examples 1 to 5 shown in Tables 1 to 3.
[試験例１] ゲル強度の測定
ゲル強度（破断強度）は下記の方法で測定した。[Test Example 1] Measurement of gel strength Gel strength (breaking strength) was measured by the following method.
５０ｍＬビーカーに１２．５ｍＬの実施例１〜６及び比較例１〜５で調製した飲料のサンプルを入れ、１２．５ｍＬの日局１液（日本薬局方崩壊試験法第１液）を壁面に沿って静かに滴下した。なお、日局１液は、胃液に相当する酸性溶液（ｐＨは１．２）である。室温で１時間放置後、レオメーターにてゲル強度（破断強度）を測定した。 Put 12.5 mL of the beverage samples prepared in Examples 1 to 6 and Comparative Examples 1 to 5 in a 50 mL beaker, and add 12.5 mL of JP 1 liquid (Japanese Pharmacopoeia Disintegration Test Method 1st liquid) along the wall surface. And dripped gently. In addition, JP 1 liquid is an acidic solution (pH is 1.2) corresponding to gastric juice. After standing at room temperature for 1 hour, the gel strength (breaking strength) was measured with a rheometer.
使用機器：ＦＵＤＯＨ
レオメーター（レオテック製 型式：ＲＴ−２１００ＮＪ−ＣＷ)
使用アダプタ：粘弾性太丸棒φ２０ｍｍ
試験モード：破断試験
測定レンジ：２０Ｎ
テーブル速度：１ｃｍ／ｍｉｎ
３回の測定結果の平均値を表４〜６に示す。Equipment used: FUDOH
Rheometer (Rheotech model: RT-2100NJ-CW)
Adapter used: Viscoelastic thick round bar φ20mm
Test mode: Break test Measurement range: 20N
Table speed: 1 cm / min
Tables 4 to 6 show the average values of the three measurement results.
実施例１のようにポリオキシエチレン系非イオン性界面活性剤（ポリオキシエチレン硬化ヒマシ油）を配合することで比較例１に比し、ゲル強度（破断強度）が顕著に増加した。比較例２において添加したポリグリセリン脂肪酸エステル（デカグリセリンモノオレイン酸エステル）又は比較例３において添加したレシチン（精製大豆レシチン）では、これらが無添加の比較例１に比し、ゲル強度の上昇が認められなかった。 Compared to Comparative Example 1, the gel strength (breaking strength) was remarkably increased by blending a polyoxyethylene nonionic surfactant (polyoxyethylene hydrogenated castor oil) as in Example 1. In the polyglycerin fatty acid ester (decaglycerin monooleate) added in Comparative Example 2 or the lecithin (purified soybean lecithin) added in Comparative Example 3, the gel strength was increased compared to Comparative Example 1 in which these were not added. I was not able to admit.
実施例２及び３のようにポリオキシエチレン系非イオン性界面活性剤を配合しｐＨ４．０〜７．０とすることで比較例４及び５に比し、ゲル強度（破断強度）が顕著に増加した。 Compared with Comparative Examples 4 and 5, the gel strength (breaking strength) is remarkable by blending a polyoxyethylene nonionic surfactant as in Examples 2 and 3 and adjusting the pH to 4.0 to 7.0. Increased.
実施例４〜６のようにＬＭペクチン１質量部に対して、ポリオキシエチレン系非イオン性界面活性剤を０．００５質量部以上配合することで比較例１に比し、ゲル強度（破断強度）が顕著に増加した。 Compared to Comparative Example 1 by adding 0.005 parts by mass or more of polyoxyethylene nonionic surfactant to 1 part by mass of LM pectin as in Examples 4 to 6, the gel strength (breaking strength) ) Increased significantly.
本発明により、胃酸と反応してゲル化し、そのゲル強度が高いため空腹感を解消した状態を長時間維持させることができる水性液体飲料を提供することが可能となった。よって、本発明を肥満予防のためのダイエットを志向した医薬品、医薬部外品及び食品として提供することにより、これらの産業の発達が期待される。 According to the present invention, it is possible to provide an aqueous liquid drink that can be gelled by reacting with gastric acid and maintain a state in which the feeling of hunger is eliminated for a long time because of its high gel strength. Therefore, the development of these industries is expected by providing the present invention as a pharmaceutical, quasi-drug and food aimed at preventing obesity.
Claims (4)
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| JP2012085091 | 2012-04-04 | ||
| PCT/JP2013/060170 WO2013151082A1 (en) | 2012-04-04 | 2013-04-03 | Aqueous liquid beverage |
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| HK (1) | HK1203321A1 (en) |
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| JPWO2016104334A1 (en) * | 2014-12-25 | 2017-10-05 | 大正製薬株式会社 | Aqueous liquid beverage |
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| SG11201406307RA (en) | 2014-11-27 |
| HK1203321A1 (en) | 2015-10-30 |
| CN104363775B (en) | 2016-08-03 |
| TW201402135A (en) | 2014-01-16 |
| WO2013151082A1 (en) | 2013-10-10 |
| PH12014502222A1 (en) | 2015-01-12 |
| JP6183355B2 (en) | 2017-08-23 |
| CN104363775A (en) | 2015-02-18 |
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