CN104352859A - Rhizoma panacis majoris-containing traditional Chinese medicine composition for lowering blood pressure - Google Patents
Rhizoma panacis majoris-containing traditional Chinese medicine composition for lowering blood pressure Download PDFInfo
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Abstract
The invention discloses a rhizoma panacis majoris-containing traditional Chinese medicine composition for lowering blood pressure and belongs to the technical field of medicines. The rhizoma panacis majoris-containing traditional Chinese medicine composition for lowering blood pressure, disclosed by the invention, is prepared from the following medicinal raw materials in parts by weight: 4-15 parts of peach kernel, 4-15 parts of safflower, 4-15 parts of hawthorn fruit, 4-15 parts of bamboo shavings, 2-7 parts of rhizoma panacis majoris, 1-5 parts of herba siegesbeckiae and 1-5 parts of uncaria rhynchophylla. According to the traditional Chinese medicine composition for lowering blood pressure, disclosed by the invention, after the 7 kinds of medicinal raw materials are combined according to a proportioning ratio, the traditional Chinese medicine composition has a synergistic function and is remarkable in treatment effect when the traditional Chinese medicine composition is used for treating hypertension, and obvious side effects and adverse reactions are not discovered.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of blood pressure lowering Chinese medicine composition containing Rhizoma Panacis Majoris, belong to medical art.
Background technology
Hypertension increases clinical syndrome for main manifestations with systemic arterial pressure, is modal cardiovascular disease.Hypertension can be divided into constitutional and the large class of Secondary cases two.In most patient, hypertensive etiology unknown, is referred to as essential hypertension, accounts for total hyperpietic's more than 95%; Less than in 5% patient, it is a kind of clinical manifestation of some disease that blood pressure raises, and itself has clearly and the independently cause of disease, is called secondary hypertension.Essential hypertension, also known as hypertension, usual onset is slow, often asymptomatic in early days, for many years conscious well even discovery blood pressure rising when physical examination, and small number of patients then just can be found after the complication such as the generation heart, brain, kidney.
Hypertension incidence is high, can bring out the generation of the disease such as coronary heart disease, cerebral hemorrhage, and great majority cause a series of damage of the vitals such as the heart, brain, kidney and serious pathological changes, or even nonfunction, and sugared, eagle matter metabolism disorder, very large threat is caused to the healthy of people.According to statistics, whole world Prevalence of Hypertension, up to 10%-20%, is suffered from hypertensive number and is reached 1,000,000,000, dies from per year over l200 ten thousand people the various diseases that hypertension causes.Population of China Prevalence of Hypertension is in rising trend, three national hypertension investigation displays.The sickness rate of l959 is 5.11%.L979-1980 annual morbidity is 7.73%, l990-1991 annual morbidity is 11.26%, and the existing hyperpietic of China has exceeded l.2 hundred million people, and annual still with the speed increase of more than 600 ten thousand people.According to World Health Organization's prediction, to the year two thousand twenty, noninfectious will account for 79% of China's cause of death.Wherein the cardiovascular disease such as hypertension will account for first place.Therefore, prevention and therapy hypertension has become the focus of society research; It is one of significant problem urgently to be resolved hurrily at present.
Hypertension is a kind of chronic disease needing long-term monitoring and treatment, needs to take medicine throughout one's life.Existing Altace Ramipril is generally Western medicine, and Long-term taking medicine can have larger side effect to the liver of human body, kidney etc., and easily causes the uncomfortable reaction such as cough, edema, dizziness.Therefore, be necessary to find a kind of little to health side effect, low-cost effective hypotensor.
Summary of the invention
To the object of the invention is to overcome in prior art existing above-mentioned deficiency, a kind of blood pressure lowering Chinese medicine composition is provided, this Chinese medicine composition low price, little to patient body side effect for blood pressure lowering good effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a blood pressure lowering Chinese medicine composition for Rhizoma Panacis Majoris, it is prepared from by the medicinal raw material of following weight proportion: 4 ~ 15 parts, Semen Persicae, 4 ~ 15 parts, Flos Carthami, Fructus Crataegi 4 ~ 15 parts, Caulis Bambusae In Taenia 4 ~ 15 parts, Rhizoma Panacis Majoris 2 ~ 7 Fen, Herba Siegesbeckiae 1 ~ 5 part, Ramulus Uncariae Cum Uncis 1 ~ 5 part.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Semen Persicae is 7 ~ 12 parts.Preferred, part by weight shared by Semen Persicae is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Flos Carthami is 7 ~ 12 parts.Preferred, part by weight shared by Flos Carthami is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Fructus Crataegi is 7 ~ 12 parts.Preferred, part by weight shared by Fructus Crataegi is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Caulis Bambusae In Taenia is 7 ~ 12 parts.Preferred, part by weight shared by Caulis Bambusae In Taenia is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Rhizoma Panacis Majoris is 4 ~ 6 parts.Preferred, part by weight shared by Rhizoma Panacis Majoris is 5 parts.
Preferably, shared by above-mentioned medicinal raw material proportioning Zhong ， Herba Siegesbeckiae, part by weight is 2 ~ 4 parts.Shared by preferred ， Herba Siegesbeckiae, part by weight is 3 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Ramulus Uncariae Cum Uncis is 2 ~ 4 parts.Preferred, part by weight shared by Ramulus Uncariae Cum Uncis is 3 parts.
The present invention is used for the Chinese medicine composition of blood pressure lowering, the active component of medicinal raw material can be extracted according to extracting method conventional on Chinese materia medica, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
The extracting method of Chinese medicine composition of the present invention can adopt but be not limited to following methods:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is condensed into extractum, dry, obtain the extract of medicinal raw material of the present invention.
(2) in above-mentioned extract, add pharmaceutic adjuvant and be mixed and made into acceptable various pharmaceutical dosage form on pharmaceutics.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Compared with prior art, beneficial effect of the present invention:
The present invention be used for blood pressure lowering Chinese medicine composition, be inventor based on motherland's medical science to hypertensive pathogenetic understanding, according to oneself clinical experience for many years, first determine a series of to the effective Chinese medicine of blood pressure lowering from numerous Chinese medicine, repeatedly verify through clinical again, screen.Wherein, Semen Persicae is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana; Bitter, sweet, flat; GUIXIN, liver, large intestine channel; There is blood circulation promoting and blood stasis dispelling, effect of loosening bowel to relieve constipation; For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, the diseases such as dryness of the intestine constipation.Flos Carthami, another name Flos Carthami; For the dried floral of feverfew Flos Carthami; Pungent, temperature; GUIXIN, Liver Channel; There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain; For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection such as to swell and ache the disease.Fructus Crataegi is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi; Sour, sweet, tepor; Return spleen, stomach, Liver Channel; There is promoting digestion and invigorating the stomach, effect of circulation of qi promoting dissipating blood stasis; For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle; Sweet, be slightly cold; Attach to the lung and stomach meridians; There is removing heat-phlegm, the effect relieved restlessness and prevented vomiting; For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, the diseases such as frequent fetal movement.Rhizoma Panacis Majoris is the dry rhizome of Araliaceae Rhizoma Panacis Majoris or Rhizoma Panacis bipinnatifidi (bamboo root Radix Notoginseng, turn round son seven, Rhizoma Coptidis Radix Notoginseng, floral leaf Radix Notoginseng); Bitter, sweet, be slightly cold; Return liver, lung, stomach warp; There is tonifying the lung, yin nourishing, active, effect of hemostasis; For deficiency of both QI and YIN, dysphoria with smothery sensation is thirsty, cough due to consumptive disease, injury from falling down, arthralgia, hemoptysis, spits blood, the diseases such as traumatic hemorrhage.Herba Siegesbeckiae, the wide Radix Saposhnikoviae of Chinese medicine name; Another name Herba Epimeredis Indicae, clothing of failing, air draft grass, Herba rabdosiae coetsae, Herba Siegesbeckiae [Fujian], Jia Herba Siegesbeckiae [Guangxi]; The wide Radix Saposhnikoviae of Labiatae Herba Epimeredis Indicae platymiscium, with all herbal medicine; Pungent, bitter, tepor; There is expelling pathogenic wind from the body surface, effect of regulating QI to relieve pain; For cold, fever, rheumatic arthritis, stomachache, gastroenteritis; Skin eczema is controlled in external, neurodermatitis, worm venom, the diseases such as carbuncle pyogenic infections from tumour or sore.Ramulus Uncariae Cum Uncis, calls Ramulus Uncariae macrophyllae, Wang Gambirplant Branchlet, hangs wind root, golden hook is careless, reversal of the natural order of things is stung; For the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, Ramulus Uncariae Cum Uncis, Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis; Sweet, cool; Return liver, pericardium channel; There is heat clearing away suppressing the hyperactive liver, effect of dispelling wind and relieving convulsion; Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; The diseases such as hypertension.Above-mentioned 7 taste Chinese herbal medicine, flavour of a drug are few but function is complete, 7 taste medicinal raw materials are by after described proportioning combination, for blood pressure lowering, there is Synergistic function, experimental study shows, Chinese medicine composition of the present invention is used for blood pressure lowering instant effect, good effect, and administration is after one week, can to take effect and evident in efficacy, and not occur obvious adverse reaction during patient consumes.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
In embodiments of the invention and comparative example, ethanol used is the aqueous solution of ethanol, and the percentage composition of ethanol, if no special instructions, is volumn concentration.
Embodiment 1
The present embodiment is used for the Chinese medicine composition of blood pressure lowering, is be prepared from by the medicinal raw material of following weight proportion: Semen Persicae 9g, Flos Carthami 9g, Fructus Crataegi 9g, Caulis Bambusae In Taenia 9g, Rhizoma Panacis Majoris 5g, Herba Siegesbeckiae 3g, Ramulus Uncariae Cum Uncis 3g.
The extracting method of above-mentioned medicinal raw material:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is condensed into extractum, dry, obtain the extract of the medicinal raw material of embodiment 1.
(2) in above-mentioned extract, add the soluble starch of extract weight 2 times of weight, granulate, dry, be distributed into bag, obtain granule.
Embodiment 2
The present embodiment is used for the Chinese medicine composition of blood pressure lowering, is be prepared from by the medicinal raw material of following weight proportion: Semen Persicae 15g, Flos Carthami 4g, Fructus Crataegi 15g, Caulis Bambusae In Taenia 4g, Rhizoma Panacis Majoris 7g, Herba Siegesbeckiae 5g, Ramulus Uncariae Cum Uncis 1g.
The above-mentioned medicinal raw material of the present embodiment for the preparation of the method for the Chinese medicine composition of blood pressure lowering with embodiment 1.
Embodiment 3
The present embodiment is used for the Chinese medicine composition of blood pressure lowering, is be prepared from by the medicinal raw material of following weight proportion: Semen Persicae 10g, Flos Carthami 8g, Fructus Crataegi 10g, Caulis Bambusae In Taenia 8g, Rhizoma Panacis Majoris 4g, Herba Siegesbeckiae 2g, Ramulus Uncariae Cum Uncis 4g.
The above-mentioned medicinal raw material of the present embodiment for the preparation of the method for the Chinese medicine composition of blood pressure lowering with embodiment 1.
Comparative example
This comparative example is used for the Chinese medicine composition of blood pressure lowering, is be prepared from by the medicinal raw material of following weight proportion: Semen Persicae 9g, Flos Carthami 9g, Fructus Crataegi 9g, Caulis Bambusae In Taenia 9g, Herba Siegesbeckiae 3g, Ramulus Uncariae Cum Uncis 3g.
The above-mentioned medicinal raw material of this comparative example for the preparation of the method for the Chinese medicine composition of blood pressure lowering with embodiment 1.
Pharmacodynamics and toxicity test:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test objective: the present invention is used for the Chinese medicine composition of blood pressure lowering to the hypotensive activity of original hypertensive rat.
2, test material
(1) medicine and reagent:
According to the Chinese medicine composition (making oral liquid) of embodiment 1 prepared by embodiment 1;
According to the Chinese medicine composition of comparative example prepared by comparative example, (making oral liquid);
Nifedipine Tablets: HARBIN PHARMACEUTICAL GROUP CO., LTD. General Pharm. Factory, (making oral liquid).
(2) animal: choose the original hypertensive rat 40 purchased from the laboratory animal department of the Chinese Academy of Sciences of Huaxi Medical Univ, body weight is 200 ~ 250g; Raise in positive pressure purification ventilation Animal House, room temperature 25 ± 2 DEG C, ad lib and drinking-water.
3, test method and result
Pretreatment before test: tested rat is put into measuring cell and carries out training 2 weeks, and blood pressure is measured second week rises the next day.The electrocaloric effect that before pressure measurement, animal puts into 37 ± 1 DEG C is heated, and measures rat systolic pressure after 15 minutes with RBP-1 type rat blood pressure instrument (Institute of Basic Medical Sciences of China-Japan Friendship Hospital, Beijing).
Process of the test: original hypertensive rat is divided into 4 groups at random, drug study group of the present invention, matched group 1, positive controls and model control group, often organize 10.The Chinese medicine composition oral liquid (7g raw medicinal herbs/kg, 1.5mL/50g) that the oral embodiment of the present invention of drug study group of the present invention 1 is obtained; The Chinese medicine composition oral liquid (7g raw medicinal herbs/kg, 1.5mL/50g) that the oral comparative example of the present invention of matched group 1 is obtained; Positive controls oral nifedipine sheet oral liquid (10mg/kg); The oral same volume distilled water of model control group, once a day, continuous 5 weeks.During administration and the ingesting of the mice respectively organized of fore-and-aft observing, movable and excretion situation situation all without exception occur.After administration the 1st, 2,3,4,5 weekends, measure the systolic pressure of rat, to measure 3 times at every turn, average.The blood pressure determination time after administration carries out after 2 hours in administration, and has measured in 4 hours upon administration.
Result of the test:
Adopt SPSS software to carry out statistical analysis, result of the test all represents with x ± s, and many group means compare employing ANOVA variance analysis, compare and check with q between group; There is significant P≤0.05 for difference.Result of the test is as shown in table 1, and table 1 was depicted as administration after 1 week, continuous 5 measurement statistical results to original hypertensive rat systolic pressure (unit: mmHg).
Table 1
Note: compare with model group:
*p<0.05; Compare with matched group 1:
▲ ▲p<0.05.
Experimental data in table 1 shows: the original hypertensive rat taking Chinese medicine composition oral liquid prepared by the embodiment of the present invention 1, administration is after 1 week, blood pressure starts to decline, continuously to the 4th weekend only, blood pressure is down to and is similar to normal value and substantially equal with the pressure value of positive controls; About 44mmHg is reduced relative to the rat blood pressure shrinkage value of model control group, and the Exemplary statistical data relative model matched group P<0.05 of medicine group of the present invention, there is significant difference.The present invention is used for the Chinese medicine composition of blood pressure lowering, for blood pressure lowering instant effect, good effect.
And matched group 1 shown in table 1 records rat blood pressure shrinkage value, after administration, blood pressure drops speed is slower.And administration is after 3 weeks, rat blood pressure shrinkage value still at about 120mmHg, and has no further decline.Chinese medicine composition for blood pressure lowering prepared by comparative example of the present invention, blood pressure lowering effect is poor; And the rat blood pressure shrinkage value statistical data of drug study group of the present invention is relative to the rat blood pressure shrinkage value statistical data P < 0.05 of matched group 1, has significant difference.Learn thus, the present invention is used for 7 kinds of medicinal raw materials of blood pressure lowering by after described weight proportion combination, and have Synergistic function, can significantly improve the curative effect of Chinese medicine composition, lack any component, the curative effect of Chinese medicine composition all significantly declines.
In sum, the present invention is containing the Chinese medicine composition for blood pressure lowering of Rhizoma Panacis Majoris, and for hyperpietic's blood pressure lowering short treating period, instant effect, administration can take effect and evident in efficacy for 1 week.7 kinds of medicinal raw materials, by after described weight proportion combination, have Synergistic function, can significantly improve the hypertensive curative effect of traditional Chinese medicine composition for treating; Lack any component, its curative effect all significantly declines, therapeutic effect as matched group 1 significantly reduces relative to the therapeutic effect of drug study group of the present invention, and blood pressure lowering traditional Chinese medicine composition for treating hypertension of the present invention is little to patient body side effect, is applicable to hyperpietic's long-term taking.
Claims (10)
1., containing a blood pressure lowering Chinese medicine composition for Rhizoma Panacis Majoris, it is characterized in that: it is prepared from by the medicinal raw material of following weight proportion: 4 ~ 15 parts, Semen Persicae, 4 ~ 15 parts, Flos Carthami, Fructus Crataegi 4 ~ 15 parts, Caulis Bambusae In Taenia 4 ~ 15 parts, Rhizoma Panacis Majoris 2 ~ 7 parts, Herba Siegesbeckiae 1 ~ 5 part, Ramulus Uncariae Cum Uncis 1 ~ 5 part.
2. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by Semen Persicae is 7 ~ 12 parts.
3. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by Flos Carthami is 7 ~ 12 parts.
4. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by Fructus Crataegi is 7 ~ 12 parts.
5. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by Caulis Bambusae In Taenia is 7 ~ 12 parts.
6. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by Rhizoma Panacis Majoris is 4 ~ 6 parts.
7. blood pressure lowering Chinese medicine composition according to claim 6, is characterized in that: part by weight shared by Rhizoma Panacis Majoris is 5 parts.
8. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that part by weight shared by: Herba Siegesbeckiae is 2 ~ 4 parts.
9. blood pressure lowering Chinese medicine composition according to claim 8, is characterized in that part by weight shared by: Herba Siegesbeckiae is 3 parts.
10. blood pressure lowering Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by Ramulus Uncariae Cum Uncis is 2 ~ 4 parts.
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Non-Patent Citations (3)
| Title |
|---|
| 中国民族药志编委会: "《中国民族药志 第4卷》", 31 December 2007, 四川民族出版社 * |
| 周宝宽: "心血管亚健康及正常高值血压的中药调治", 《辽宁中医杂志》 * |
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