CN104352524A - Cod Liver Oil Ointment for Hemorrhoids and Anal Fissures - Google Patents

Abstract

The present invention relates to the field of pharmaceutical technology, specifically a cod liver oil ointment for treating hemorrhoids and anal fissures; it is made of the following raw materials in parts by weight: 85-110 parts of seal liver oil, 20-40 parts of musk, 40-60 parts of zinc oxide, 15-37 parts of alum, 1-2 parts of borneol, 0.5-1.5 parts of azone, and 2-3 parts of vaseline; the ointment provided by the present invention is easy to apply to the affected area, protect the wound, promote wound healing, and relieve inflammation and itching. It has the effects of eliminating rot, promoting tissue regeneration, astringing, relieving inflammation, relieving itching, clearing away heat and relieving pain, and promoting wound healing. It has a significant therapeutic effect for treating skin and mucosal ulcers, perianal pain, itching, redness and swelling, and the effective rate can reach 100%, with little side effects. It has the advantages of definite efficacy, convenient use, rapid onset, safety and painlessness, good quality, etc., and is superior to the prior art.

Description

Cod Liver Oil Ointment for Hemorrhoids and Anal Fissures

technical field

The invention relates to the technical field of medicines, in particular to cod liver oil ointment for treating hemorrhoids and anal fissures.

Background technique

Anal fissure is a prismatic fissure or ulcer formed by the rupture of the anal canal skin below the dentate line. It is mostly caused by constipation, excessive defecation, and rupture of the anal skin. From the perspective of infection, it is mainly the anal crypt infection at the back of the anus, and the inflammation spreads to the subcutaneous part of the anal canal, resulting in the rupture of subcutaneous abscess and anal fissure. Anal fissure can cause perianal redness, perianal ulcer, perianal pain and other perianal diseases.

Hemorrhoids (haemorrhoids) are soft veins formed by the flexion and expansion of the hemorrhoidal venous plexus under the mucosa of the end of the rectum and the skin of the anal canal. It is a common disease and frequently-occurring disease that occurs inside and outside the anus. It can occur at any age, and it is more common in the age of 20 to 40. Most patients get worse with age. The pathogenesis of hemorrhoids is still inconclusive. Most scholars believe that it is a "vascular anal canal cushion", which is a part of normal anatomy. Only when symptoms such as bleeding, anal prolapse, and pain are combined, can it be called a disease.

Cod liver oil is mainly vitamin A and D. The main function of vitamin A is to maintain the normal growth, reproduction, vision, epithelial tissue integrity and anti-infection immune function of the body. Vitamin A deficiency can cause: children's bone development retardation; affect the development of tooth enamel cells, and the teeth are not perfect; the structure of the epithelial tissue is damaged; Various infections. The main function of vitamin D is to promote the absorption of calcium and phosphorus by the small intestinal mucosa; to promote the reabsorption of calcium and phosphorus by the renal tubules. Vitamin D deficiency can cause: reduced intestinal absorption of calcium and phosphorus, calcification of bone-like tissue disorders; rickets, manifested as easy to startle, sweating, irritability and bone changes.

At present, there are many medicines for treating hemorrhoids and anal fissure, but they have the disadvantages of slow effect, incompleteness, easy recurrence and complex prescriptions, and side effects on the body.

Contents of the invention

The object of the present invention is to address the above-mentioned problems and provide an ointment that uses seal cod liver oil as the main raw material and has significant curative effects on hemorrhoids and anal fissures.

In order to achieve the above object, the technical solution adopted in the present invention is: a cod liver oil ointment for treating hemorrhoids and anal fissure, made of the following raw materials in parts by weight: 85-110 parts of seal liver oil, 20-40 parts of musk, 40 parts of zinc oxide ～60 parts, 15～37 parts of alum, 1～2 parts of borneol, 0.5～1.5 parts of azone, 2～3 parts of petrolatum.

Further, it is made from the following raw materials in parts by weight: 90-100 parts of seal liver oil, 25-35 parts of musk, 45-55 parts of zinc oxide, 17-34 parts of alum, 1-2 parts of borneol, 0.5-1.3 parts of azone 2 to 3 parts of Vaseline.

Further, it is prepared from the following raw materials in parts by weight: 95 parts of seal liver oil, 25 parts of musk, 50 parts of zinc oxide, 30 parts of alum, 1.5 parts of borneol, 1.5 parts of azone, and 2.5 parts of petrolatum.

A preparation method of cod-liver oil ointment for treating hemorrhoids and anal fissures. The raw materials of musk, zinc oxide and alum are pulverized and sieved for later use; borneol, azone and melted vaseline are added to the pulverized fine powder and stirred. Add seal cod liver oil in the stirring process, and mix until semi-solidified.

Further, 20-40 parts of musk, 40-60 parts of zinc oxide and 15-37 parts of alum are crushed and sieved for later use; 1-2 parts of borneol, 0.5-1.5 parts of azone and 2-3 parts of melted vaseline Add to the crushed fine powder, stir, add 85 to 110 parts of seal cod liver oil during the stirring, and mix until semi-solidified.

The beneficial technical effect of the present invention is:

In the present invention, cod liver oil mainly contains vitamins A and D, and the main function of vitamin A is to maintain normal growth, reproduction, epithelial tissue integrity and anti-infection immune function of the body, can promote epithelial differentiation, and help maintain the health of skin and mucous membranes; zinc oxide It can promote the narrowing of tissue cell gaps in skin lesions, subside edema, reduce exudation, achieve dryness, anti-inflammation, and promote the recovery of skin lesions; absorb.

In the present invention, cod liver oil and zinc oxide are mixed according to appropriate proportions, and a synergistic effect is exerted, the effects of the respective components are mutually enhanced, and perianal diseases can be treated in a targeted manner, especially for perianal redness, perianal ulcer, and perianal pain Or perianal wound healing has a significant effect. Adding borneol can further enhance the analgesic and antiseptic effect.

In a word, the ointment provided by the present invention is easy to apply on the affected part, protects the wound, promotes wound healing, reduces inflammation and relieves itching. It has the effects of eliminating putrefaction and promoting muscle convergence, anti-inflammatory, antipruritic, heat-clearing and pain-relieving, and promoting wound healing. It has a remarkable curative effect on the treatment of skin and mucous membrane ulcers, itching, redness and swelling around the anus, the effective rate can reach 100%, and the side effects are small. The invention has the advantages of definite curative effect, convenient use, rapid onset of effect, safety and painlessness, good quality, etc., and is superior to the prior art.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1

Preparation method of seal liver oil

1) Storage of seal liver: the seal liver, a by-product of seal processing, is cleaned and stored in a freezer below -18～-22°C;

2) Pretreatment: Thaw the seal liver and chop it;

3) Enzymolysis: Add water to the hydrolysis pot to make the liquid-solid ratio (mL/g) 1:1-2:1, add hydrochloric acid to adjust the pH to 5.5-6.5, add 1.5-2.5% (mass) of seal liver Papain, sealed, placed in a constant temperature oscillator, enzymatically hydrolyzed at a speed of 100-150r/min and a temperature of 40-50°C for 3-4 hours;

4) Centrifugal separation after enzymatic treatment: after enzymatic hydrolysis, add hydrochloric acid to adjust the pH to 3-3.5 to denature and inactivate the complex protease, put it in a low-speed large-capacity centrifuge, and centrifuge while it is hot at a speed of 4000-5000r/min After 5-15 minutes, the upper layer of crude seal liver oil was separated; the middle lipoprotein emulsion produced by the first centrifugation was demulsified by freezing and thawing, that is, the enzymatic solution was frozen at -18-22°C for 10-14 hours, and then thawed at 38-42°C 1 to 2 hours for demulsification, and then centrifuged again;

5) Refining: Use 700-900g/L citric acid for degumming, the amount added is 0.5-1.5% (volume) of the oil; use 250-350g/L caustic soda-soda ash mixture (mass ratio 1.8-2.2:1) for degumming Acid, the amount added is 1.5-2.5% (volume) of the oil; decolorized with activated clay, the amount added is 8-11% (mass) of the oil; deodorized by vacuum distillation at 80-90°C for 5-15 minutes;

6) Low-temperature treatment: Slowly lower the refined seal liver oil to 3-8°C within 3-5 days, and then drop to -2°C--3°C for 10-20 hours, filter out the solid fat to obtain seal liver oil, and then Packed with vacuum pumped nitrogen.

Example 2

A cod liver oil ointment for treating hemorrhoids and anal fissure, which is made of the following raw materials in parts by weight: 85 parts of seal liver oil, 40 parts of musk, 40 parts of zinc oxide, 37 parts of alum, 1 part of borneol, 1.5 parts of azone, and 2 parts of vaseline share.

A preparation method of cod-liver oil ointment for treating hemorrhoids and anal fissures. The raw materials of 40 parts of musk, 40 parts of zinc oxide and 37 parts of alum are crushed and sieved for later use; 1 part of borneol, 1.5 parts of azone and 2 parts of melted vaseline are added Into the fine powder after the above pulverization, stir, add 85 parts of seal cod liver oil in the stirring process, mix until semi-solidified.

Example 3

A cod liver oil ointment for treating hemorrhoids and anal fissure, which is made of the following raw materials in parts by weight: 110 parts of seal liver oil, 20 parts of musk, 60 parts of zinc oxide, 15 parts of alum, 2 parts of borneol, 0.5 part of azone, and 3 parts of vaseline share.

A preparation method of cod-liver oil ointment for treating hemorrhoids and anal fissures. The raw materials of 20 parts of musk, 60 parts of zinc oxide and 15 parts of alum are pulverized and sieved for later use; 2 parts of borneol, 0.5 parts of azone and 3 parts of melted vaseline are added Add to the fine powder after pulverization, stir, add 110 parts of seal cod liver oil in the stirring process, and mix until semi-solidified.

Example 4

A cod liver oil ointment for treating hemorrhoids and anal fissures, which is made of the following raw materials in parts by weight: 95 parts of seal liver oil, 25 parts of musk, 50 parts of zinc oxide, 30 parts of alum, 1.5 parts of borneol, 1.5 parts of azone, and 2.5 parts of vaseline share.

A preparation method of cod-liver oil ointment for treating hemorrhoids and anal fissures. The raw materials of 25 parts of musk, 50 parts of zinc oxide and 30 parts of alum are pulverized and sieved for later use; 1.5 parts of borneol, 1.5 parts of azone and 2.5 parts of melted vaseline are added Into the above-mentioned pulverized fine powder, stir, add 95 parts of seal cod liver oil in the stirring process, and mix until semi-solidified.

Example 5

The products in the above-mentioned Examples 2, 3, and 4 are clinically verified.

150 patients with hemorrhoids, 74 males and 76 females, 45 cases of 1-2 internal hemorrhoids, 71 cases of 3rd stage mixed hemorrhoids, 54 cases of simple external hemorrhoids; 46 patients over 10 years old;

Medication method: the ointment of the present invention is applied around the anus, or the ointment is smeared with a cotton sliver and slowly inserted into the anus, once every 6-8 hours, one course of treatment a week.

Except 5 cases improved, the rest were cured, the cure rate was 100%.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of the present invention. within the scope of protection.

Claims (5)

1. a cod-liver oil ointment for the treatment of hemorrhoids and anal fissure, characterized in that it is made from the following raw materials in parts by weight: 85-110 parts of seal liver oil, 20-40 parts of musk, 40-60 parts of zinc oxide, 15-15 parts of alum 37 parts, 1-2 parts of borneol, 0.5-1.5 parts of azone, 2-3 parts of petrolatum. 2. The cod liver oil ointment for treating hemorrhoids and anal fissure according to claim 1 is characterized in that it is made of the following raw materials in parts by weight: 90 to 100 parts of seal liver oil, 25 to 35 parts of musk, and 45 to 55 parts of zinc oxide , 17-34 parts of alum, 1-2 parts of borneol, 0.5-1.3 parts of azone, and 2-3 parts of petrolatum. 3. the cod-liver oil ointment for the treatment of hemorrhoids and anal fissure according to claim 2 is characterized in that it is made from the raw materials of the following parts by weight: 95 parts of seal liver oil, 25 parts of musk, 50 parts of zinc oxide, 30 parts of alum, borneol 1.5 parts, Azone 1.5 parts, Vaseline 2.5 parts. 4. according to the preparation method of the cod-liver oil ointment for the treatment of hemorrhoids, anal fissure according to any one of claims 1 to 3, it is characterized in that, musk, zinc oxide and alum raw materials are pulverized and sieved for subsequent use; borneol, azone and melting Finally, Vaseline is added to the crushed fine powder, stirred, and seal cod liver oil is added in the stirring process, and mixed until semi-solidified. 5. according to claim 4, the preparation method of the cod liver oil ointment for the treatment of hemorrhoids and anal fissure is characterized in that 20 to 40 parts of musk, 40 to 60 parts of zinc oxide and 15 to 37 parts of alum are pulverized and sieved for subsequent use; Add 1 to 2 parts of borneol, 0.5 to 1.5 parts of azone and 2 to 3 parts of melted vaseline to the above pulverized fine powder, stir, add 85 to 110 parts of seal cod liver oil during the stirring process, and mix until half Freeze it.