CN104352524A - Cod liver oil ointment for treating hemorrhoids and anal fissure - Google Patents
Cod liver oil ointment for treating hemorrhoids and anal fissure Download PDFInfo
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- CN104352524A CN104352524A CN201410554116.XA CN201410554116A CN104352524A CN 104352524 A CN104352524 A CN 104352524A CN 201410554116 A CN201410554116 A CN 201410554116A CN 104352524 A CN104352524 A CN 104352524A
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- liver oil
- cod
- cod liver
- anal fissure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
- A61K35/06—Mineral oils, e.g. paraffinic oils or aromatic oils based on aromatic hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention relates to the technical field of drugs, in particular to a cod liver oil ointment for treating hemorrhoids and anal fissure. The cod liver oil ointment is prepared from the following raw materials in parts by weight: 85 to 100 parts of seal liver oil, 20 to 40 parts of musk, 40 to 60 parts of zinc oxide, 15 to 37 parts of alum, 1 to 2 parts of borneol, 0.5 to 1.5 parts of azone, and 2 to 3 parts of Vaseline. The cod liver oil ointment provided by the invention is easily applied to infected parts, protects wounds, promotes wound healing, diminishes inflammation and alleviates itching, has the efficacy of removing slough, promoting tissue regeneration, realizing astringency, diminishing inflammation, relieving itching, clearing away heat and alleviating pain, and promoting wound healing, has obvious curative effects on treating mucocutaneous ulcer and perianal ache, itchiness and red and swollen, has small side effects, has the advantages of exact curative effect, good convenience in use, rapidness in taking effect, high safety, painless, good quality and the like, and is superior to the prior art and the effective rate can reach 100 percent.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, specifically a kind of cod liver oil ointment being used for the treatment of hemorrhoid, anal fissure.
Background technology
Anal fissure is that the following anal canal skin of pectinate line is broken and formed prismatic breach or ulcer, and be a kind of common anal canal disease, be apt to occur in person between twenty and fifty, child also can occur, and old people is less.Mostly be constipation, defecation is too exerted oneself, and skin of anus is broken cause.Learn angle from infection, mainly the anus crypts at anus rear portion infects, and inflammation spreads to anal canal subcutaneous part, causes subcutaneous abscess ulceration to form anal fissure.Purple grass oil can be caused, Perianal ulceration, the perianals such as crissum pain after anal fissure.
Hemorrhoid (haemorrhoids) are hemorrhoidal plexus flexing and expansion and the soft vein groups formed under rectum end mucosa, anal canal skin.The commonly encountered diseases occurred in outside anal, frequently-occurring disease.Any age all can fall ill, common with 20 ~ 40 years old, and most patient increases with the age and increases the weight of.About the pathogenesis of hemorrhoid there is no final conclusion at present, most scholar thinks " vascular anal canal pad ", is a part for normal anatomy, when only having the symptoms such as merging is hemorrhage, anus prolapsus, pain, just can be called disease.
Mainly vitamin A and D in cod-liver oil.The major function of vitamin A maintains the sound and anti-infectious immunity function of body normal growth, reproduction, vision, epithelial tissue.Can cause during vitamin A deficiency: children's's skeletal development retardation; Affect tooth enamel cell development, tooth is unsound; Structural damage knitted by epithelium group dcxc.xyygf.com capsule of Chinese caterpillar fungus; Immunologic hypofunction easily causes the various infection of respiratory tract, digestive tract and urinary tract.The major function of vitamin D promotes that small intestinal mucosa is to the absorption of calcium, phosphorus; Promote that renal tubules is to the heavily absorption of calcium phosphorus.Can cause during vitamin D deficiency: calcium phosphorus reduces through intestinal absorption, osteoid tissue calcification obstacle; Rickets, shows as easily frightened, hyperhidrosis, agitation and skeleton change.
The medicine of current treatment hemorrhoid, anal fissure is many, but existence takes effect slowly, thoroughly, easily recurrence prescription is not complicated, health is had to the shortcoming of side effect.
Summary of the invention
The object of the invention is for above-mentioned Problems existing, provide one to utilize sea dog cod-liver oil for primary raw material, hemorrhoid, anal fissure are had to the ointment of significant curative effect.
For achieving the above object, the technical solution used in the present invention is: a kind of cod liver oil ointment for the treatment of hemorrhoid, anal fissure, is made up of the raw material of following parts by weight: sea dog liver oil 85 ~ 110 parts, 20 ~ 40 parts, Moschus, zinc oxide 40 ~ 60 parts, Alumen 15 ~ 37 parts, Borneolum Syntheticum 1 ~ 2 part, azone 0.5 ~ 1.5 part, 2 ~ 3 parts, vaseline.
Further, be made up of the raw material of following parts by weight: sea dog liver oil 90 ~ 100 parts, 25 ~ 35 parts, Moschus, zinc oxide 45 ~ 55 parts, Alumen 17 ~ 34 parts, Borneolum Syntheticum 1 ~ 2 part, azone 0.5 ~ 1.3 part, 2 ~ 3 parts, vaseline.
Further, be made up of the raw material of following parts by weight: sea dog liver oil 95 parts, 25 parts, Moschus, zinc oxide 50 parts, Alumen 30 parts, Borneolum Syntheticum 1.5 parts, azone 1.5 parts, 2.5 parts, vaseline.
Treat the preparation method of cod liver oil ointment for hemorrhoid, anal fissure, by sieving for standby after Moschus, zinc oxide and Alumen raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by vaseline after Borneolum Syntheticum, azone and fusing, stir, add sea dog cod-liver oil in whipping process, mixing is to partly solidifying and get final product.
Further, by sieving for standby after 20 ~ 40 parts, Moschus, zinc oxide 40 ~ 60 parts and Alumen 15 ~ 37 parts of raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by 2 ~ 3 parts, vaseline after Borneolum Syntheticum 1 ~ 2 part, azone 0.5 ~ 1.5 part and fusing, stir, add sea dog cod-liver oil 85 ~ 110 parts in whipping process, mixing is to partly solidifying and get final product.
Advantageous Effects of the present invention is:
In the present invention, mainly vitamin A and D in cod-liver oil, the major function of vitamin A maintains the sound and anti-infectious immunity function of body normal growth, reproduction, epithelial tissue, can promote epithelial differentiation, help the health safeguarding skin and mucosa; Zinc oxide can impel cutaneous lesion histiocyte gap shrinks, and edema extinction, oozes out minimizing, reaches dry, antiinflammatory, promotes the effects such as skin lesion recovery; Borneolum Syntheticum has the effect of pain relieving antiseptical, can be used for neuralgia and antiinflammatory, and mucosa, subcutaneous tissue all easily absorb.
The present invention is by cod-liver oil, zinc oxide presses the mixing of suitable proportion composition, and played cooperative effect, the effect of respective component strengthens all each other, perianal can be treated targetedly, especially have remarkable result to purple grass oil, Perianal ulceration, crissum pain or crissum wound healing.Add Borneolum Syntheticum, the effect of pain relieving antiseptical can be strengthened further.
In a word, ointment provided by the present invention, is easy to be applied in affected part, and protection wound, promotes wound healing, antiinflammatory, antipruritic.There is effect of the necrotic tissue and promoting muscle growing convergence that disappears, antiinflammatory, antipruritic, clearing away heat to alleviate pain, promotion wound healing.Have significant curative effect for treatment skin mucosa ulcer, crissum sufferings redness, effective percentage can reach 100%, and side effect is little.There is the advantages such as determined curative effect, easy to use, onset rapid, safety is painless, quality is good, be better than prior art.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
The preparation method of sea dog liver oil
1) storage of sea dog liver: by sea dog processing byproduct sea dog liver, after cleaning, less than-18 ~-22 DEG C chilled storages;
2) pretreatment: sea dog liver is thawed, chopping;
3) enzymolysis: add water in hydrolyzer, liquid-solid ratio (mL/g) is made to be 1:1 ~ 2:1, salt adding acid for adjusting pH is 5.5 ~ 6.5, add sea dog liver 1.5 ~ 2.5%(quality) papain, sealing, being placed in constant temperature oscillator, is 100 ~ 150r/min at rotating speed, enzymolysis 3 ~ 4h at temperature 40 ~ 50 DEG C;
4) centrifugalize after enzyme denaturing process: enzymolysis terminates, salt adding acid for adjusting pH to 3 ~ 3.5, make compound protease deactivation, are placed in low speed large capacity centrifuge, at rotating speed 4000 ~ 5000r/min centrifugal 5 ~ 15min while hot, be separated to obtain the thick sea dog liver oil in upper strata; The middle level lipoprotein emulsion of first time centrifugal generation adopts freeze and unfreeze breaking method, and namely enzymolysis solution freezes 10 ~ 14h at-18 ~-22 DEG C, and 38 ~ 42 DEG C of 1 ~ 2h that thaw carry out breakdown of emulsion, and then centrifugalize;
5) refine: come unstuck with the citric acid of 700 ~ 900g/L, addition is 0.5 ~ 1.5%(volume of oil mass); With Caustic soda-soda mixture (mass ratio 1.8 ~ 2.2:1) deacidification of 250 ~ 350g/L, addition is oil mass 1.5 ~ 2.5%(volume); With activated decoloration, addition is 8 ~ 11%(quality of oil mass); At 80 ~ 90 DEG C, distilling under reduced pressure 5 ~ 15min carries out deodorize;
6) K cryogenic treatment: refining sea dog liver oil is slowly dropped to 3 ~ 8 DEG C within the time of 3 ~ 5d, then drops to-2 DEG C ~-3 DEG C, needs 10 ~ 20h, and the solid fat of elimination obtains sea dog liver edible vegetable oil, then adopts evacuation to rush nitrogen packaging.
Embodiment 2
Treat a cod liver oil ointment for hemorrhoid, anal fissure, be made up of the raw material of following parts by weight: sea dog liver oil 85 parts, 40 parts, Moschus, zinc oxide 40 parts, Alumen 37 parts, Borneolum Syntheticum 1 part, azone 1.5 parts, 2 parts, vaseline.
Treat the preparation method of cod liver oil ointment for hemorrhoid, anal fissure, by sieving for standby after 40 parts, Moschus, zinc oxide 40 parts and Alumen 37 parts of raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by 2 parts, vaseline after Borneolum Syntheticum 1 part, azone 1.5 parts and fusing, stir, add sea dog cod-liver oil 85 parts in whipping process, mixing is to partly solidifying and get final product.
Embodiment 3
Treat a cod liver oil ointment for hemorrhoid, anal fissure, be made up of the raw material of following parts by weight: sea dog liver oil 110 parts, 20 parts, Moschus, zinc oxide 60 parts, Alumen 15 parts, Borneolum Syntheticum 2 parts, azone 0.5 part, 3 parts, vaseline.
Treat the preparation method of cod liver oil ointment for hemorrhoid, anal fissure, by sieving for standby after 20 parts, Moschus, zinc oxide 60 parts and Alumen 15 parts of raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by 3 parts, vaseline after Borneolum Syntheticum 2 parts, azone 0.5 part and fusing, stir, add sea dog cod-liver oil 110 parts in whipping process, mixing is to partly solidifying and get final product.
Embodiment 4
Treat a cod liver oil ointment for hemorrhoid, anal fissure, be made up of the raw material of following parts by weight: sea dog liver oil 95 parts, 25 parts, Moschus, zinc oxide 50 parts, Alumen 30 parts, Borneolum Syntheticum 1.5 parts, azone 1.5 parts, 2.5 parts, vaseline.
Treat the preparation method of cod liver oil ointment for hemorrhoid, anal fissure, by sieving for standby after 25 parts, Moschus, zinc oxide 50 parts and Alumen 30 parts of raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by 2.5 parts, vaseline after Borneolum Syntheticum 1.5 parts, azone 1.5 parts and fusing, stir, add sea dog cod-liver oil 95 parts in whipping process, mixing is to partly solidifying and get final product.
Embodiment 5
Product in above-described embodiment 2,3,4 is carried out clinical verification.
150 routine hemorrhoid patients, man 74 example, female 76 example, 1-2 phase internal hemorrhoid 45 example, 3 phase mixed hemorrhoid 71 examples, pure external hemorrhoid 54 example; 13 examples of the course of disease more than 20 years, more than 10 years patient 44 examples, more than 5 years patient 46 examples;
Administrated method: ointment of the present invention is applied in perianal, or with cotton sliver smear the ointment longevity slowly insert as anal, medication in 6-8 hour once, a course for the treatment of Monday.
Except 5 examples take a turn for the better, all the other are all cured, cure rate 100%.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. treat the cod liver oil ointment of hemorrhoid, anal fissure for one kind, it is characterized in that, be made up of the raw material of following parts by weight: sea dog liver oil 85 ~ 110 parts, 20 ~ 40 parts, Moschus, zinc oxide 40 ~ 60 parts, Alumen 15 ~ 37 parts, Borneolum Syntheticum 1 ~ 2 part, azone 0.5 ~ 1.5 part, 2 ~ 3 parts, vaseline.
2. treat the cod liver oil ointment of hemorrhoid, anal fissure according to claim 1, it is characterized in that, be made up of the raw material of following parts by weight: sea dog liver oil 90 ~ 100 parts, 25 ~ 35 parts, Moschus, zinc oxide 45 ~ 55 parts, Alumen 17 ~ 34 parts, Borneolum Syntheticum 1 ~ 2 part, azone 0.5 ~ 1.3 part, 2 ~ 3 parts, vaseline.
3. treat the cod liver oil ointment of hemorrhoid, anal fissure according to claim 2, it is characterized in that, be made up of the raw material of following parts by weight: sea dog liver oil 95 parts, 25 parts, Moschus, zinc oxide 50 parts, Alumen 30 parts, Borneolum Syntheticum 1.5 parts, azone 1.5 parts, 2.5 parts, vaseline.
4. according to any one of claims 1 to 3, treat the preparation method of cod liver oil ointment of hemorrhoid, anal fissure, it is characterized in that, by sieving for standby after Moschus, zinc oxide and Alumen raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by vaseline after Borneolum Syntheticum, azone and fusing, stir, add sea dog cod-liver oil in whipping process, mixing is to partly solidifying and get final product.
5. treat the preparation method of cod liver oil ointment of hemorrhoid, anal fissure according to claim 4, it is characterized in that, by sieving for standby after 20 ~ 40 parts, Moschus, zinc oxide 40 ~ 60 parts and Alumen 15 ~ 37 parts of raw material pulverizing; Be added in the fine powder after above-mentioned pulverizing by 2 ~ 3 parts, vaseline after Borneolum Syntheticum 1 ~ 2 part, azone 0.5 ~ 1.5 part and fusing, stir, add sea dog cod-liver oil 85 ~ 110 parts in whipping process, mixing is to partly solidifying and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410554116.XA CN104352524A (en) | 2014-10-20 | 2014-10-20 | Cod liver oil ointment for treating hemorrhoids and anal fissure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410554116.XA CN104352524A (en) | 2014-10-20 | 2014-10-20 | Cod liver oil ointment for treating hemorrhoids and anal fissure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104352524A true CN104352524A (en) | 2015-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410554116.XA Pending CN104352524A (en) | 2014-10-20 | 2014-10-20 | Cod liver oil ointment for treating hemorrhoids and anal fissure |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181551A (en) * | 2007-12-05 | 2008-05-21 | 陶登保 | Externally used unction for curing hemorrhoid |
| CN102579500A (en) * | 2012-02-24 | 2012-07-18 | 北京市肛肠医院 | Compound cod-liver oil ointment as well as preparation method and application thereof |
-
2014
- 2014-10-20 CN CN201410554116.XA patent/CN104352524A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181551A (en) * | 2007-12-05 | 2008-05-21 | 陶登保 | Externally used unction for curing hemorrhoid |
| CN102579500A (en) * | 2012-02-24 | 2012-07-18 | 北京市肛肠医院 | Compound cod-liver oil ointment as well as preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 吴杲等主编: "《科学合理用药》", 31 January 2013 * |
| 宋修俭等: "鲨鱼油口服乳的制备", 《沈阳药学院学报》 * |
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Application publication date: 20150218 |
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