CN102579500A - Compound cod-liver oil ointment as well as preparation method and application thereof - Google Patents
Compound cod-liver oil ointment as well as preparation method and application thereof Download PDFInfo
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- CN102579500A CN102579500A CN2012100463606A CN201210046360A CN102579500A CN 102579500 A CN102579500 A CN 102579500A CN 2012100463606 A CN2012100463606 A CN 2012100463606A CN 201210046360 A CN201210046360 A CN 201210046360A CN 102579500 A CN102579500 A CN 102579500A
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Abstract
The invention relates to a compound cod-liver oil ointment as well as a preparation method and application thereof. The compound cod-liver oil ointment comprises the following raw materials in parts by weight: 80-120 parts of cod-liver oil, 35-65 parts of zinc oxide and 3.5-6.5 parts of ethacridine lactate. The compound cod-liver oil ointment has the effects of removing necrotic tissue, promoting granulation, converging, diminishing inflammation, reliving itching, clearing heat and reliving pain and promoting wound healing and has obvious curative effects of treating skin mucosa ulcer and sufferings and red swollen crissum. As a whole, the compound cod-liver oil ointment has the advantages that the curative effect is definite, use is convenient, acting is quick and the like, and is safe; no pain is generated; and the effective rate of the compound cod-liver oil ointment reaches 100%.
Description
Technical field
The present invention relates to a kind of compound ointment, especially relate to a kind of compound cod-liver oil ointment, and its method for preparing and application.
Background technology
Anal fissure is that the following anal canal skin of pectinate line is broken and formed prismatic breach or ulcer, is a kind of common anal canal disease, good sending out in person between twenty and fifty, and the child also can be taken place, and the old people is less.Mostly be constipation, defecation is too exerted oneself, and skin of anus is broken cause.Learning angle from infecting, mainly is that the anus crypts at anus rear portion infects, and inflammation spreads to the anal canal subcutaneous part, causes the subcutaneous abscess ulceration to form anal fissure.Can cause after the anal fissure that crissum is red and swollen, crissum ulcer, perianals such as crissum pain.
At present domestic about treating above-mentioned perianal, comprise that the ointment of crissum wound healing is of common occurrence, Chinese prescription is arranged, the Western medicine prescription is also arranged, but because its complicated process of preparation, curative effect is slow, shortcomings such as specific aim difference can not let patient's relieving the pain caused by diseases timely.And a kind of compound cod-liver oil zinc ointment of selling on the market, the composition that comprises has: cod-liver oil, zinc oxide, nitrofural, anhydrous lanolin, vaseline, Pulvis Talci.Be mainly used in acute and chronic dermatitis, eczema, chilblain, minor burn, scald etc.Since its main a large amount of compositions be zinc oxide (contain zinc oxide (ZnO) for labelled amount 90.0%～110.0%), zinc oxide has certain convergence, protection and desiccation, so this ointment just makes the affected part dry mainly as a kind of weak convergence agent, convergence.
But the crissum that causes owing to anal fissure is red and swollen, crissum ulcer, and crissum pain comprises crissum wound healing etc., and skin produces rhegma, and it is not smooth that the evil poison of repeated infection causes local anal canal QI-blood circulation, and wound loses nutrition and causes ulcer.For this symptom, existing medicament can not be alleviated the paroxysmal pain of laceration of skin targetedly for the patient, nourishes wound, reaches the effect of healing.
Summary of the invention
The objective of the invention is to, to the problems referred to above, a kind of compound cod-liver oil ointment is provided, this ointment can be treated perianal targetedly.
Another object of the present invention is to, a kind of method for preparing of said compound cod-liver oil ointment is provided.
Another purpose of the present invention is, the application of said compound cod-liver oil ointment in preparation treatment perianal medicine is provided.
To achieve these goals, compound cod-liver oil ointment provided by the invention comprises the raw material of following weight portion: cod-liver oil 80-120 part, zinc oxide 35-65 part and ethacridine lactate 3.5-6.5 part.
Compound cod-liver oil ointment provided by the invention preferably, comprises the raw material of following weight portion: cod-liver oil 90-110 part, zinc oxide 45-55 part and ethacridine lactate 4.5-5.5 part.By the ointment best results that this weight portion scope obtains, the upper limit that surpasses this scope then has side effect after the administration, if be lower than this scope lower limit, then drug effect is relatively poor.
Compound cod-liver oil ointment provided by the invention more preferably, comprises the raw material of following weight portion: 100 parts of cod-liver oil, 5.0 parts of 50 parts of zinc oxide and ethacridine lactate.
Compound cod-liver oil ointment of the present invention also comprises Borneolum Syntheticum.
Wherein, the consumption of said Borneolum Syntheticum is 0.6-1.2 part, preferred 0.8-1.0 part, more preferably 0.9 part.
Compound cod-liver oil ointment of the present invention also comprises pharmaceutically acceptable carrier.
Wherein, said pharmaceutically acceptable carrier is a greasing base.Be easy to smear absorption and wound is had protective effect.
Wherein, said greasing base is vaseline, lanoline, lanonol or silicone oil.Preferred vaseline.
Wherein, said vaseline can be Yellow Vaselin or white vaseline etc.
The method of the above-mentioned compound cod-liver oil ointment of preparation provided by the invention comprises: with the coarse powder raw material sieving for standby of zinc oxide, ethacridine lactate; Pharmaceutically acceptable carrier is joined in the fine powder after the above-mentioned pulverizing, stir, in whipping process, add cod-liver oil, mixing promptly gets to partly solidifying.
In the above-mentioned method for preparing:
Operable raw material Borneolum Syntheticum adds in whipping process equally in the said compound cod-liver oil ointment, earlier it is dissolved in suitable solvent before adding and dissolves, and Borneolum Syntheticum solution is joined in the raw material.
Wherein, the solvent of dissolving Borneolum Syntheticum can be ethanol, acetone, isopropyl alcohol or ethyl acetate, preferred alcohol.
Said pharmaceutically acceptable carrier is if solid needs earlier it to be melted, and the temperature of fusing is 40-70 ℃, preferred 50-60 ℃.
Said stirring utilizes blender to carry out, and blender is modulated the 130-220 rotating speed, preferred 150-200 rotating speed.
The application of above-mentioned compound cod-liver oil ointment provided by the invention in preparation treatment perianal medicine.
Especially the application in preparation treatment crissum redness, crissum ulcer, crissum pain or crissum wound healing medicine.
Compound cod-liver oil ointment of the present invention, beneficial effect is following:
1) in the cod-liver oil mainly be vitamin A and D, the major function of vitamin A is to keep body normal growth, reproduction, the sound anti-infectious immunity function that reaches of epithelial tissue, can promote the epithelium differentiation, helps to safeguard the health of skin and mucosa;
2) zinc oxide can impel histiocyte gap, skin lesion position to dwindle, and edema extinction is oozed out minimizing, reaches dry, and antiinflammatory promotes effects such as skin lesion recovery;
3) ethacridine lactate has the effect of disinfection;
4) Borneolum Syntheticum has the effect of pain relieving antiseptical, can be used for neuralgia and antiinflammatory, and mucosa, subcutaneous tissue all are prone to absorb.
The present invention is with cod-liver oil; Zinc oxide and ethacridine lactate are pressed suitable proportion and are formed mixing; Brought into play cooperative effect; The effect of component all strengthens each other separately, can treat perianal targetedly, especially crissum redness, crissum ulcer, crissum pain or crissum wound healing is had remarkable result.Add Borneolum Syntheticum, can strengthen the effect of pain relieving antiseptical further.
Preparation technology is simple, and the ointment quality of processing is even, fine and smooth, no harsh feeling; Viscosity is suitable, is easy to coating, does not melt loss; Stable in properties, do not have the denaturalization phenomenon that becomes sour, can keep the intrinsic curative effect of medicine; Do not have bad zest, meet hygienic requirement.
In a word, compound cod-liver oil ointment provided by the present invention is easy to be applied in the affected part, and the protection wound promotes wound healing, antiinflammatory, antipruritic.Effect with the necrotic tissue and promoting muscle growing convergence that disappears, antiinflammatory, antipruritic, clearing away heat to alleviate pain, promotion wound healing.For treatment skin mucosa ulcer, crissum sufferings redness significant curative effect is arranged, effective percentage can reach 100%, and side effect is little.Have determined curative effect, easy to use, onset rapidly, advantage such as safety is painless, quality is good, be superior to prior art.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1
1, prescription: cod-liver oil 100g, zinc oxide 50g, ethacridine lactate 5.0g, Yellow Vaselin adds to 1000g, configuration 1000g ointment.
2, method for preparing: with zinc oxide, ethacridine lactate coarse powder raw material is pulverized sieving for standby according to the present embodiment weighing; Yellow Vaselin is melted under 50 ℃ of temperature in the mixing fine powders that joins in proportion after zinc oxide and ethacridine lactate are pulverized; Under molten condition, blender being transferred to rotating speed is 180 at the uniform velocity to stir; Add cod-liver oil in the whipping process, mixing promptly gets to partly solidifying.
Embodiment 2
1, prescription: cod-liver oil 100g, zinc oxide 50g, ethacridine lactate 5.0g, Borneolum Syntheticum 0.9g, white vaseline adds to 1000g, configuration 1000g ointment.
2, method for preparing: with zinc oxide, ethacridine lactate coarse powder raw material is pulverized sieving for standby according to the present embodiment weighing; White vaseline is melted under 55 ℃ of temperature in the mixing fine powders that joins in proportion after zinc oxide and ethacridine lactate are pulverized; Under molten condition, blender being transferred to rotating speed is 180 at the uniform velocity to stir; Add cod-liver oil in the whipping process and be dissolved in alcoholic acid Borneolum Syntheticum solution; Mixing promptly gets to partly solidifying.The ointment best results that makes by present embodiment.
Embodiment 3
1, prescription: cod-liver oil 120g, zinc oxide 35g, ethacridine lactate 6.5g, Borneolum Syntheticum 0.6g, Yellow Vaselin adds to 1000g, configuration 1000g ointment.
2, method for preparing: with zinc oxide, ethacridine lactate coarse powder raw material is pulverized sieving for standby according to the present embodiment weighing; Yellow Vaselin is melted under 60 ℃ of temperature in the mixing fine powders that joins in proportion after zinc oxide and ethacridine lactate are pulverized; Under molten condition, blender being transferred to rotating speed is 200 at the uniform velocity to stir; Add cod-liver oil and the Borneolum Syntheticum solution that is dissolved in acetone in the whipping process; Mixing promptly gets to partly solidifying.
Embodiment 4
1, prescription: cod-liver oil 80g, zinc oxide 65g, ethacridine lactate 3.5g, Borneolum Syntheticum 1.2g, white vaseline adds to 1000g, configuration 1000g ointment.
2, method for preparing: with zinc oxide, ethacridine lactate coarse powder raw material is pulverized sieving for standby according to the present embodiment weighing; White vaseline is melted under 50 ℃ of temperature in the mixing fine powders that joins in proportion after zinc oxide and ethacridine lactate are pulverized; Under molten condition, blender being transferred to rotating speed is 150 at the uniform velocity to stir; Add cod-liver oil and the Borneolum Syntheticum solution that is dissolved in ethyl acetate in the whipping process; Mixing promptly gets to partly solidifying.
Embodiment 5
1, prescription: cod-liver oil 90g, zinc oxide 55g, ethacridine lactate 4.5g, Borneolum Syntheticum 0.8g, white vaseline adds to 1000g, configuration 1000g ointment.
2, method for preparing: with zinc oxide, ethacridine lactate coarse powder raw material is pulverized sieving for standby according to the present embodiment weighing; White vaseline is melted under 55 ℃ of temperature in the mixing fine powders that joins in proportion after zinc oxide and ethacridine lactate are pulverized; Under molten condition, blender being transferred to rotating speed is 190 at the uniform velocity to stir; Add cod-liver oil in the whipping process and be dissolved in alcoholic acid Borneolum Syntheticum solution; Mixing promptly gets to partly solidifying.
Embodiment 6
1, prescription: cod-liver oil 110g, zinc oxide 45g, ethacridine lactate 5.5g, Borneolum Syntheticum 1.0g, white vaseline adds to 1000g, configuration 1000g ointment.
2, method for preparing: with zinc oxide, ethacridine lactate coarse powder raw material is pulverized sieving for standby according to the present embodiment weighing; White vaseline is melted under 60 ℃ of temperature in the mixing fine powders that joins in proportion after zinc oxide and ethacridine lactate are pulverized; Under molten condition, blender being transferred to rotating speed is 160 at the uniform velocity to stir; Add cod-liver oil and the Borneolum Syntheticum solution that is dissolved in isopropyl alcohol in the whipping process; Mixing promptly gets to partly solidifying.
Comparative Examples
1, prescription: cod-liver oil 100g, Borneolum Syntheticum 0.9g, white vaseline adds to 1000g, preparation 1000g ointment.
2, method for preparing: white vaseline in 55 ℃ of fusings, under molten condition, is modulated 180 rotating speeds with blender and at the uniform velocity stirred, in whipping process, add cod-liver oil and be dissolved in alcoholic acid Borneolum Syntheticum solution, mixing promptly gets to partly solidifying.
Test Example
The ointment treatment skin mucosa ulcer, the red and swollen clinical observation of crissum sufferings that utilize the present invention to prepare:
Clinical data: 180 examples, be divided into two groups at random, 105 examples are organized in treatment, matched group 75 examples.
(1) include the case standard in:
A. realize clear, the patient that can clearly express operating position;
B. the age is at 18-65 between year;
C. the patient knows the inside story and agrees.
(2) get rid of the case standard:
A. the enteropathy patient who merges malignant tumor;
B. suffers from serious skin disease patient;
C. can't take care of oneself, the slurred speech patient.
(3) therapeutic evaluation standard:
(version in 2006) efficacy evaluation is as the criterion execution by " up-to-date hospital clinical medical diagnosis on disease foundation and healing improvement manual of standards ".Produce effects: gargalesthesia disappears around patient's anus, the red and swollen disappearance of crissum, ulcer surface healing.Effectively: gargalesthesia alleviates around patient's anus, and the crissum redness alleviates, the most healings of ulcer surface.Invalid: treatment back above-mentioned symptom does not have improvement.
(4) clinical observation:
The treatment group: according to the ointment that embodiment 2 prepares, be applied in the affected part every day in right amount, 1-2 time on the one, logotype 7-14 days.
Matched group: according to the ointment that Comparative Examples prepares, be applied in the affected part every day in right amount, 1-2 time on the one, logotype 7-14 days.
(5) result of the test: said treatment group and matched group Comparison of therapeutic are seen table 1, table 2, table 3.
Table 1 treatment group experimental result
Table 2 matched group experimental result
Table 3 liang group curative effect comparative result
| Group | Effectively (n) | Invalid (n) | Total effective rate (%) | Amount to (n) |
| The treatment group | 105 | 0 | 100％ | 105 |
| Matched group | 46 | ------ | 61.3％ | 75 |
Conclusion: like table 1,2, shown in 3, treatment group and matched group have notable difference on total effective rate, and from clinical observation, the treatment group all obviously is superior to matched group in pain relieving, short wound healing, aspect antipruritic.
Though, the present invention has been done detailed description in the preceding text with general explanation and specific embodiments, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (10)
1. a compound cod-liver oil ointment is characterized in that, comprises the raw material of following weight portion: cod-liver oil 80-120 part, zinc oxide 35-65 part and ethacridine lactate 3.5-6.5 part.
2. compound cod-liver oil ointment according to claim 1 is characterized in that, comprises the raw material of following weight portion: cod-liver oil 90-110 part, zinc oxide 45-55 part and ethacridine lactate 4.5-5.5 part.
3. compound cod-liver oil ointment according to claim 1 and 2 is characterized in that, comprises the raw material of following weight portion: 100 parts of cod-liver oil, 5.0 parts of 50 parts of zinc oxide and ethacridine lactate.
4. according to any described compound cod-liver oil ointment of claim 1-3, it is characterized in that said ointment also comprises Borneolum Syntheticum.
5. compound cod-liver oil ointment according to claim 4 is characterized in that, the consumption of said Borneolum Syntheticum is 0.6-1.2 part, preferred 0.8-1.0 part, more preferably 0.9 part.
6. according to any described compound cod-liver oil ointment of claim 1-5, it is characterized in that said ointment also comprises pharmaceutically acceptable carrier.
7. compound cod-liver oil ointment according to claim 6 is characterized in that, said pharmaceutically acceptable carrier is a greasing base.
8. compound cod-liver oil ointment according to claim 7 is characterized in that, said greasing base is a vaseline, lanoline, lanonol or silicone oil; Preferred vaseline.
9. the method for preparing of any described compound cod-liver oil ointment of claim 6-8 comprises: with the coarse powder raw material sieving for standby of zinc oxide, ethacridine lactate; Pharmaceutically acceptable carrier is joined in the fine powder after the above-mentioned pulverizing, stir, in whipping process, add cod-liver oil, mixing promptly gets to partly solidifying.
10. the application of any described compound cod-liver oil ointment of claim 1-8 in preparation treatment perianal medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104352524A (en) * | 2014-10-20 | 2015-02-18 | 中山百鸥医药科技有限公司 | Cod liver oil ointment for treating hemorrhoids and anal fissure |
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| CN101066340A (en) * | 2007-05-16 | 2007-11-07 | 苏振芳 | Compound externally applied tetrodotoxin ointment and its prepn |
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- 2012-02-24 CN CN201210046360.6A patent/CN102579500B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101066340A (en) * | 2007-05-16 | 2007-11-07 | 苏振芳 | Compound externally applied tetrodotoxin ointment and its prepn |
| CN101062054A (en) * | 2007-06-08 | 2007-10-31 | 郑淑芬 | Medicine for curing wound |
Non-Patent Citations (1)
| Title |
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| 王敏 等: "冰片乳膏治疗痔疮切割术后疼痛的护理体会", 《实用护理杂志》, vol. 11, no. 02, 31 December 1995 (1995-12-31), pages 33 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352524A (en) * | 2014-10-20 | 2015-02-18 | 中山百鸥医药科技有限公司 | Cod liver oil ointment for treating hemorrhoids and anal fissure |
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