CN104338022B - A kind of medicine for treating rheumatic and rheumatoid - Google Patents
A kind of medicine for treating rheumatic and rheumatoid Download PDFInfo
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- CN104338022B CN104338022B CN201410554101.3A CN201410554101A CN104338022B CN 104338022 B CN104338022 B CN 104338022B CN 201410554101 A CN201410554101 A CN 201410554101A CN 104338022 B CN104338022 B CN 104338022B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses a kind of medicine for treating rheumatic and rheumatoid, using following formula, by weight, pseudo-ginseng 5 ~ 15, monkshood 5 ~ 15, radix aconiti agrestis 5 ~ 15, berba aristolochiae mollissimae 1 ~ 3, bee venom 2 ~ 4, camphor 5 ~ 15, borneol 2 ~ 4, Chinese prickly ash 5 ~ 15, semen brassicae 5 ~ 15, rhizoma Gastrodiae 5 ~ 15, semen momordicae 10 ~ 18, notopterygium root 5 ~ 15,95% alcohol 150 ~ 250;Cure rate 100% of the present invention, no recurrence has no toxic side effect, and cures mainly rheumatism and rheumatoid, can also treat traumatic injury, waist dish outstanding, cervical spondylopathy, spur, various waist-legs pain, eczema etc..
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of medicine for treating rheumatic and rheumatoid.
Background technology
Rheumatic arthritis is a kind of common acute or chronic connective tissue inflammation.Recurrent exerbation and heart can be involved.
Clinic is characterized with the migrans miserable, heavily write in joint and muscle, pain, is belonged to allergic disease, is the main table of rheumatic fever
It is one of existing, more with febris acuta and arthralgia onset.Typical performance is slight or moderate heating, migratory polyarthritis, by
Tired joint is generally the large joints such as knee, ankle, shoulder, elbow, wrist, common to be transferred to another joint by a joint, and lesion is locally presented
Red, swollen, scorching hot, severe pain, some patients also have several joints to fall ill simultaneously.Atypical patient only has arthralgia and without other
Inflammation is showed, and acute inflammation typically disappeared in 2~4 weeks, does not stay sequelae, but often recurrent exerbation.If active rheumatism influences heart,
Can then occur myocarditis, or even leave valve disorder.Rheumatoid arthritis is a kind of autoimmune disease, may with it is interior
In terms of secretion, metabolism, nutrition, geography, occupation, the difference of psychology and social environment, bacterium and virus infection and heredity are because of rope
There is relation, autoimmunity inflammatory, as main clinical manifestation, is belonged to using lesion outside chronic, symmetry, many synovial joints inflammation and joint
Disease.The characteristics of according to arthritic species, symptom, it is disease accompanied situations such as select suitable medicine.Principle of reatment is
Early diagnosis and as early as possible reasonable, drug combination.Conventional antirheumatic thing is as follows:(1)Non- black body anti-inflammatory agent can suppress prostatitis
The synthesis of parathyrine and produce anti-inflammatory analgesic effect rapidly, have better effects to releasing pain, but the course of disease of disease can not be changed.Face
That is commonly used on bed has aminoglucose hydrochloride particle, brufen, penicillamine, diclofenac, aspirin, Indomethacin etc..(2)
Slow effect antirheumatic drug is used for rheumatoid arthritis and seronegative spondyloanthropathy.There is certain control action to the state of an illness but rise
Effect is slower.Conventional has golden mixture(Intramuscular injection is oral), penicillamine, salicylazosulfapyridine, chloroquine etc..(3)Cell toxicity medicament leads to
Cross different approaches and produce immunosuppressive action.Conventional has endoxan, methotrexate (MTX), gold only spring etc..They are often system
The Second line Drug of property lupus erythematosus, rheumatoid arthritis and vasculitis, though side effect is more and more serious, to improving these diseases
Playing the role of more afterwards for disease is very big.
The content of the invention
It is an object of the invention to overcome the deficiencies in the prior art, and a kind of medicine for treating rheumatic and rheumatoid is provided, it
Processing method is simple, and therapeutic effect is good, has no side effect.
Technical scheme is as follows:
A kind of medicine for treating rheumatic and rheumatoid, using following formula, by weight, pseudo-ginseng 5 ~ 15, monkshood 5 ~ 15, grass
Crow 5 ~ 15, berba aristolochiae mollissimae 1 ~ 3, bee venom 2 ~ 4, camphor 5 ~ 15, borneol 2 ~ 4, Chinese prickly ash 5 ~ 15, semen brassicae 5 ~ 15, rhizoma Gastrodiae 5 ~ 15, semen momordicae
10 ~ 18, notopterygium root 5 ~ 15,95% alcohol 150 ~ 250;Prepare as follows:(A)Chinese prickly ash is fried to color burn with slow fire perfume (or spice)
Gas, semen brassicae is fried with slow fire to there is cracker to appear spicy gas its colour changed into yellow, and rhizoma Gastrodiae is cut into slices after steaming, and the cleared skin of semen momordicae shells
Benevolence is taken, notopterygium root clear water, which is cleaned to be impregnated with, cuts sheet, print;(B) by step(A)Treated Chinese prickly ash, semen momordicae, notopterygium root are ground into respectively
Smalls, pulverization is distinguished by pseudo-ginseng, monkshood, radix aconiti agrestis, berba aristolochiae mollissimae;(C) by step(B)In smalls and bee venom, camphor, borneol
Put into together in 95% alcohol brewed 40 days, with filtered through gauze, retain filtrate.
The main function of each medicine is as follows in the present invention:
Pseudo-ginseng blood-circulation-invigovating, swelling and pain relieving;Notopterygium wind dispelling is relieved pain;Bee venom wind-dispelling removing toxic substances analgesic;Camphor has orifice opening, profit stagnant
Gas, ward off that foul, desinsection is antipruritic, swelling and pain relieving effect;Borneol wind-expelling pain-stopping;Semen momordicae dispelling wind and arresting itching;Monkshood, radix aconiti agrestis wind-dispelling stop
Bitterly;Chinese prickly ash clearing damp middle benefit gas is antipruritic;Rhizoma Gastrodiae dispelling wind and eliminating dampness, berba aristolochiae mollissimae, semen brassicae wind-dispelling sharp joint, wind-damp dispelling, go spur;Alcohol solution
Poison.
The advantage of the invention is that:
1st, preparation method is simple and easy to apply, only need to carry out frying, steam, grinds, soaking, filtering;2nd, cure rate 100%,
Without recurrence;3rd, have no toxic side effect, although monkshood, radix aconiti agrestis are toxic, but toxicity can be released afterwards by alcohol is brewed;4th, originally
Invention cures mainly rheumatism and rheumatoid, can also treat traumatic injury, waist dish outstanding, cervical spondylopathy, spur, various waist-legs pain, eczema
Deng.
The invention will be further described with reference to embodiment for embodiment.
A kind of medicine for treating rheumatic and rheumatoid of embodiment 1, using following formula, by weight, and pseudo-ginseng 5, monkshood 5,
Radix aconiti agrestis 5, berba aristolochiae mollissimae 1, bee venom 4, camphor 5, borneol 2, Chinese prickly ash 5, semen brassicae 5, rhizoma Gastrodiae 5, semen momordicae 10, notopterygium root 5,95% alcohol
150;Prepare as follows:(A)Chinese prickly ash, which is fried with slow fire to color burn, fragrance, and semen brassicae is fried with slow fire to there is cracker
Spicy gas its colour changed into yellow is appeared, rhizoma Gastrodiae is cut into slices after steaming, and the cleared skin of semen momordicae, which shells, takes benevolence, notopterygium root clear water, which is cleaned to be impregnated with, cuts thickness
Piece, print;(B) by step(A)Treated Chinese prickly ash, semen momordicae, notopterygium root difference pulverization, by pseudo-ginseng, monkshood, radix aconiti agrestis, seek
Bone wind distinguishes pulverization;(C) by step(B)In smalls and bee venom, camphor, borneol put into together brewed 40 in 95% alcohol
My god, with filtered through gauze, retain filtrate.
Zhang, man, 42 years old, suffers from more than 10 years of rheumatic arthritis, various drug therapies are invalid, use the medicine of the present embodiment
Mitigate pain at that time, applying symptom behind affected part 4 times, one month with cotton swab daily disappears, follow-up 3 years, no recurrence.
A kind of medicine for treating rheumatic and rheumatoid of embodiment 2, using following formula, by weight, pseudo-ginseng 15, monkshood
15, radix aconiti agrestis 15, berba aristolochiae mollissimae 3, bee venom 2, camphor 15, borneol 4, Chinese prickly ash 15, semen brassicae 15, rhizoma Gastrodiae 15, semen momordicae 18, notopterygium root 15,
95% alcohol 250;It is prepared by the method for be the same as Example 1.
Mr. Wang, female 58 years old, suffers from atrophic diseases for many years, and morning stiffness, joint nodosity, various drug therapies are invalid, make
Symptom behind affected part 4 times, ten days is applied with the medicine of the present embodiment with cotton swab daily to disappear, follow-up 3 years, no recurrence.
A kind of medicine for treating rheumatic and rheumatoid of embodiment 3, using following formula, by weight, pseudo-ginseng 10, monkshood
10, radix aconiti agrestis 10, berba aristolochiae mollissimae 2, bee venom 3, camphor 10, borneol 3, Chinese prickly ash 10, semen brassicae 10, rhizoma Gastrodiae 10, semen momordicae 14, notopterygium root 10,
95% alcohol 200;It is prepared by the method for be the same as Example 1.
Zhao so-and-so, female 58 years old, suffers from rheumatic disease 8 years, skelagia is increasingly aggravated, made a definite diagnosis in certain hospital with rheumatic spur,
Various drug therapies are invalid, and applying spur behind affected part 5 times, one month with cotton swab daily using the medicine of the present embodiment disappears, follow-up
3 years, no recurrence.
A kind of medicine for treating rheumatic and rheumatoid of embodiment 4, using following formula, by weight, and pseudo-ginseng 8, monkshood 9,
Radix aconiti agrestis 10, berba aristolochiae mollissimae 3, bee venom 4, camphor 12, borneol 3, Chinese prickly ash 10, semen brassicae 10, rhizoma Gastrodiae 10, semen momordicae 15, notopterygium root 9,95%
Alcohol 220;It is prepared by the method for be the same as Example 1.
Meng so-and-so, female, 55 years old, nineteen ninety started pain in waist and lower extremities, and CT reports show T5-S1 disc herniations, and the hidden window in both sides is narrow
It is narrow, it is in hospital and is treated with traction treatment, remission, aggravation in 1992 is liied in bed stiff, later using the present embodiment
Medicine applies affected part 5 times with cotton swab daily, with regard to that can leave the bed on foot, is fully recovered after 20 days within three days, follow-up 3 years, no recurrence.
A kind of medicine for treating rheumatic and rheumatoid of embodiment 5, using following formula, by weight, pseudo-ginseng 12, monkshood
7, radix aconiti agrestis 12, berba aristolochiae mollissimae 3, bee venom 4, camphor 12, borneol 3, Chinese prickly ash 12, semen brassicae 11, rhizoma Gastrodiae 10, semen momordicae 16, notopterygium root 12,
95% alcohol 240;It is prepared by the method for be the same as Example 1.
Tang, man, 45 years old, it is numb that nineteen ninety starts neck stiffness, aching of shoulder and arm, arm ulnar side, upper limbs praise it is difficult by
Aching pain in waist and back is gradually developed into, be can't take care of oneself, affected part was applied 5 times with cotton swab daily using the medicine of the present embodiment later, Zhu Guan
Section pain mitigates, and symptom disappears after 15 days, and X-ray film making shows that cervical vertebra is straight, and curvature is normal, follow-up 5 years, no recurrence.
Claims (1)
1. a kind of medicine for treating rheumatic and rheumatoid, it is characterised in that use following formula:By weight, pseudo-ginseng 5 ~ 15,
Monkshood 5 ~ 15, radix aconiti agrestis 5 ~ 15, berba aristolochiae mollissimae 1 ~ 3, bee venom 2 ~ 4, camphor 5 ~ 15, borneol 2 ~ 4, Chinese prickly ash 5 ~ 15, semen brassicae 5 ~ 15, rhizoma Gastrodiae
5 ~ 15, semen momordicae 10 ~ 18, notopterygium root 5 ~ 15,95% alcohol 150 ~ 250;Prepare as follows:(A)By Chinese prickly ash fried with slow fire to
Color burn has fragrance, and semen brassicae is fried with slow fire to there is cracker to appear spicy gas its colour changed into yellow, and rhizoma Gastrodiae is cut into slices after steaming, Momordica cochinchiensis
The cleared skin of son, which shells, takes benevolence, and notopterygium root clear water, which is cleaned to be impregnated with, cuts sheet, print;(B) by step(A)Treated Chinese prickly ash, semen momordicae,
Notopterygium root distinguishes pulverization, and pseudo-ginseng, monkshood, radix aconiti agrestis, berba aristolochiae mollissimae are distinguished into pulverization;(C) by step(B)In smalls and honeybee
Poison, camphor, borneol are put into 95% alcohol brewed 40 days together, with filtered through gauze, retain filtrate.
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CN201410554101.3A CN104338022B (en) | 2014-10-20 | 2014-10-20 | A kind of medicine for treating rheumatic and rheumatoid |
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CN201410554101.3A CN104338022B (en) | 2014-10-20 | 2014-10-20 | A kind of medicine for treating rheumatic and rheumatoid |
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CN104338022B true CN104338022B (en) | 2017-07-14 |
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Citations (3)
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CN1091296A (en) * | 1993-02-15 | 1994-08-31 | 柳登顺 | External-use analgesic and preparation method thereof |
CN1543991A (en) * | 2003-11-25 | 2004-11-10 | 张华光 | Cold dispelling and pain alleviating liquid and its preparation and operation guide |
CN101987189A (en) * | 2010-11-16 | 2011-03-23 | 吴柱华 | Detoxifying and channel dredging external application powder |
Family Cites Families (1)
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JP5527951B2 (en) * | 2007-12-17 | 2014-06-25 | 花王株式会社 | External preparation, hair restorer, NFAT signal inhibitor and calcineurin inhibitor |
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2014
- 2014-10-20 CN CN201410554101.3A patent/CN104338022B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1091296A (en) * | 1993-02-15 | 1994-08-31 | 柳登顺 | External-use analgesic and preparation method thereof |
CN1543991A (en) * | 2003-11-25 | 2004-11-10 | 张华光 | Cold dispelling and pain alleviating liquid and its preparation and operation guide |
CN101987189A (en) * | 2010-11-16 | 2011-03-23 | 吴柱华 | Detoxifying and channel dredging external application powder |
Non-Patent Citations (3)
Title |
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"关于加强广防己等6种药材及其制剂监督管理的通知";国食药监注[2004]379号;《http://www.sfda.gov.cn/WS01/CL0844/10242.html》;20040805;第1-4页 * |
"国家食品药品监督管理局发布第6期药品不良反应信息通报";国家食品药品监督管理局;《药物警戒》;20040731;第1卷(第1期);第54-55页 * |
"马兜铃酸Ⅰ在大鼠体内的代谢特征研究";苏涛等;《中国中药杂志》;20040731;第29卷(第7期);第676-681页 * |
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