CN104338022A - Drug for treating rheumatism and rheumatoid - Google Patents

Drug for treating rheumatism and rheumatoid Download PDF

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CN104338022A
CN104338022A CN201410554101.3A CN201410554101A CN104338022A CN 104338022 A CN104338022 A CN 104338022A CN 201410554101 A CN201410554101 A CN 201410554101A CN 104338022 A CN104338022 A CN 104338022A
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radix
rhizoma
rheumatoid
radix aconiti
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CN104338022B (en
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宋怀
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/758—Zanthoxylum, e.g. pricklyash
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a drug for treating rheumatism and rheumatoid. The drug comprises the following raw materials: 5-15 parts of pseudo-ginseng, 5-15 parts of common monkshood mother root, 5-15 parts of radix aconiti agrestis, 1-3 parts of berba aristolochiae mollissimae, 2-4 parts of bee venom, 5-15 parts of camphor, 2-4 parts of borneol, 5-15 parts of Chinese prickly ash, 5-15 parts of semen brassicae, 5-15 parts of gastrodia elata, 10-18 parts of semen momordicae, 5-15 parts of notopterygium root and 150-250 parts of 95% ethyl alcohol. The recovery rate of the diseases is 100%; and the drug is free of recurrence, and free of toxic or side effect, is mainly used for treating rheumatism and rheumatoid, and can be used for treating traumatic injuries, slipped discs, cervical spondylosis, bony spur, various pains in waist and legs, eczema and the like.

Description

A kind of medicine for the treatment of rheumatic and rheumatoid
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of medicine for the treatment of rheumatic and rheumatoid.
Background technology
Rheumatic arthritis is a kind of common acute or chronic ICT.Can recurrent exerbation involve heart.Clinical with joint and muscle migrans miserable, heavily work, pain for feature, belong to allergic disease, be one of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.Typical performance is slight or moderate heating, migratory polyarthritis, affected joints mostly is the large joint such as knee joint, ankle, shoulder, elbow, wrist, is commonly transferred to another joint by a joint; pathological changes local presents red, swollen, scorching hot, severe pain, and some patients also has several joint to fall ill simultaneously.Atypical patient only has arthralgia and shows without other inflammation, and acute inflammation generally disappeared in 2 ~ 4 weeks, did not stay sequela, but normal recurrent exerbation.If active rheumatism affects heart, then can there is myocarditis, even leave over valve disorder.Rheumatoid arthritis is a kind of autoimmune disease, may with the difference of endocrine, metabolism, nutrition, geography, occupation, psychology and society environment, antibacterial and viral infection and heredity because there be relation the aspects such as rope, for main clinical manifestation, autoimmune inflammatory disease is belonged to pathological changes outside chronic, symmetry, many synovial jointss inflammation and joint.Suitable medicine is selected according to the feature of arthritic kind, symptom, the situation such as disease accompanied.Therapeutic Principle be early diagnosis and rationally as early as possible, drug combination.Conventional antirheumatic thing is as follows: (1) non-black body anti-inflammatory agent can suppress the synthesis of prostaglandin and produce rapidly anti-inflammatory analgesic effect, has better effects, but can not change the course of disease of disease to releasing pain.That commonly uses clinically has glucosamine hydrochloride granule, ibuprofen, penicillamine, diclofenac, aspirin, indomethacin etc.(2) slow effect antirheumatic is used for rheumatoid arthritis and seronegative spondyloanthropathy.Certain control action is had but onset is slower to the state of an illness.Conventional has golden mixture (intramuscular injection or oral), penicillamine, sulfasalazine, chloroquine etc.(3) cell toxicity medicament produces immunosuppressive action by different approaches.Conventional has cyclophosphamide, methotrexate, Jin Duchun etc.They are systemic lupus erythematosus (sle), rheumatoid arthritis and vasculitic Second line Drug often, though side effect is more and comparatively serious, has very large effect more afterwards to what improve these diseases.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, and provide a kind of medicine for the treatment of rheumatic and rheumatoid, its processing method is simple, and therapeutic effect is good, has no side effect.
Technical scheme of the present invention is as follows:
Treat a medicine for rheumatic and rheumatoid, adopt following formula, by weight, Radix Notoginseng 5 ~ 15, Radix Aconiti 5 ~ 15, Radix Aconiti Kusnezoffii 5 ~ 15, Herba Aristolochiae Mollissimae 1 ~ 3, Venenum apis 2 ~ 4, Camphora 5 ~ 15, Borneolum Syntheticum 2 ~ 4, Pericarpium Zanthoxyli 5 ~ 15, Semen Sinapis Albae 5 ~ 15, Rhizoma Gastrodiae 5 ~ 15, Semen Momordicae 10 ~ 18, Rhizoma Et Radix Notopterygii 5 ~ 15,95% ethanol 150 ~ 250; Prepare as follows: the stir-fry of Pericarpium Zanthoxyli slow fire is had fragrance to color burn by (A), Semen Sinapis Albae slow fire is fried to there being cracker to appear fragrant peppery gas its colour changed into yellow, Rhizoma Gastrodiae steams rear section, and Semen Momordicae Ex-all skin shells and gets core, and Rhizoma Et Radix Notopterygii clear water is cleaned to soak into and cut sheet, print; (B) Pericarpium Zanthoxyli step (A) processed, Semen Momordicae, Rhizoma Et Radix Notopterygii pulverization respectively, by Radix Notoginseng, Radix Aconiti, Radix Aconiti Kusnezoffii, Herba Aristolochiae Mollissimae pulverization respectively; (C) smalls in step (B) and Venenum apis, Camphora, Borneolum Syntheticum to be dropped into together in 95% ethanol brewed 40 days, by filtered through gauze, retain filtrate.
In the present invention, the Main Function of each medicine is as follows:
Pseudo-ginseng blood-circulation-invigovating, reducing swelling and alleviating pain; Notopterygium wind dispelling pain relieving; Venenum apis is dispeled the wind removing toxic substances pain relieving; Camphora has orifice opening, qi stagnation removing, wards off foul, killing parasites for relieving itching, reducing swelling and alleviating pain effect; Borneolum Syntheticum wind-expelling pain-stopping; Semen Momordicae dispelling wind for relieving itching; Radix Aconiti, Radix Aconiti Kusnezoffii wind-expelling pain-stopping; Pericarpium Zanthoxyli damp eliminating warming middle-JIAO is antipruritic; Rhizoma Gastrodiae expelling wind and removing dampness, Herba Aristolochiae Mollissimae, Semen Sinapis Albae dispel the wind sharp joint, wind-damp dispelling, thorn of boning; Alcohol detoxification.
The invention has the advantages that:
1, preparation method is simple, only need carry out parch, steams, grinds into powder, soaks, filter; 2, cure rate 100%, without recurrence; 3, have no side effect, although Radix Aconiti, Radix Aconiti Kusnezoffii are toxic, be through ethanol brewed after can remove toxicity; 4, the present invention cures mainly rheumatism and rheumatoid, also can treat traumatic injury, prolapse of lumbar intervertebral disc, cervical spondylosis, bony spur, various lumbago and skelalgia, eczema etc.
The invention will be further described below in conjunction with embodiment for detailed description of the invention.
Embodiment 1 one kinds treats the medicine of rheumatic and rheumatoid, adopts following formula, by weight, and Radix Notoginseng 5, Radix Aconiti 5, Radix Aconiti Kusnezoffii 5, Herba Aristolochiae Mollissimae 1, Venenum apis 4, Camphora 5, Borneolum Syntheticum 2, Pericarpium Zanthoxyli 5, Semen Sinapis Albae 5, Rhizoma Gastrodiae 5, Semen Momordicae 10, Rhizoma Et Radix Notopterygii 5,95% ethanol 150; Prepare as follows: the stir-fry of Pericarpium Zanthoxyli slow fire is had fragrance to color burn by (A), Semen Sinapis Albae slow fire is fried to there being cracker to appear fragrant peppery gas its colour changed into yellow, Rhizoma Gastrodiae steams rear section, and Semen Momordicae Ex-all skin shells and gets core, and Rhizoma Et Radix Notopterygii clear water is cleaned to soak into and cut sheet, print; (B) Pericarpium Zanthoxyli step (A) processed, Semen Momordicae, Rhizoma Et Radix Notopterygii pulverization respectively, by Radix Notoginseng, Radix Aconiti, Radix Aconiti Kusnezoffii, Herba Aristolochiae Mollissimae pulverization respectively; (C) smalls in step (B) and Venenum apis, Camphora, Borneolum Syntheticum to be dropped into together in 95% ethanol brewed 40 days, by filtered through gauze, retain filtrate.
Zhang, man, 42 years old, suffer from more than 10 years of rheumatic arthritis, various Drug therapy was invalid, and use the medicine of the present embodiment to alleviate pain at that time, every day is coated with affected part 4 times with cotton swab, and transference cure after month, follows up a case by regular visits to 3 years, without recurrence.
Embodiment 2 one kinds treats the medicine of rheumatic and rheumatoid, adopts following formula, by weight, and Radix Notoginseng 15, Radix Aconiti 15, Radix Aconiti Kusnezoffii 15, Herba Aristolochiae Mollissimae 3, Venenum apis 2, Camphora 15, Borneolum Syntheticum 4, Pericarpium Zanthoxyli 15, Semen Sinapis Albae 15, Rhizoma Gastrodiae 15, Semen Momordicae 18, Rhizoma Et Radix Notopterygii 15,95% ethanol 250; Prepare with embodiment 1 method.
King so-and-so, female, 58 years old, suffers from atrophic diseases for many years, morning stiff, joint nodosity, various Drug therapy is invalid, and use the medicine of the present embodiment to be coated with affected part 4 times with cotton swab every day, transference cure after ten days, follows up a case by regular visits to 3 years, without recurrence.
Embodiment 3 one kinds treats the medicine of rheumatic and rheumatoid, adopts following formula, by weight, and Radix Notoginseng 10, Radix Aconiti 10, Radix Aconiti Kusnezoffii 10, Herba Aristolochiae Mollissimae 2, Venenum apis 3, Camphora 10, Borneolum Syntheticum 3, Pericarpium Zanthoxyli 10, Semen Sinapis Albae 10, Rhizoma Gastrodiae 10, Semen Momordicae 14, Rhizoma Et Radix Notopterygii 10,95% ethanol 200; Prepare with embodiment 1 method.
Zhao so-and-so, female, 58 years old, suffer from rheumatism 8 years, skelalgia day by day increased the weight of, and make a definite diagnosis in certain hospital and suffer from rheumatic spur, various Drug therapy is invalid, and use the medicine of the present embodiment to be coated with affected part 5 times with cotton swab every day, after one month, bony spur disappears, and follows up a case by regular visits to 3 years, without recurrence.
Embodiment 4 one kinds treats the medicine of rheumatic and rheumatoid, adopts following formula, by weight, and Radix Notoginseng 8, Radix Aconiti 9, Radix Aconiti Kusnezoffii 10, Herba Aristolochiae Mollissimae 3, Venenum apis 4, Camphora 12, Borneolum Syntheticum 3, Pericarpium Zanthoxyli 10, Semen Sinapis Albae 10, Rhizoma Gastrodiae 10, Semen Momordicae 15, Rhizoma Et Radix Notopterygii 9,95% ethanol 220; Prepare with embodiment 1 method.
The Meng so-and-so, female, 55 years old, nineteen ninety starts lumbago and skelalgia, CT report display T5-S1 intervertebral disk hernia, and the hidden window in both sides is narrow, be in hospital with traction treatment treatment, remission, aggravation in 1992, lie in bed stiff, used the medicine of the present embodiment to be coated with affected part 5 times with cotton swab every day afterwards, and within three days, just can leave the bed and walk, fully recover after 20 days, follow up a case by regular visits to 3 years, without recurrence.
Embodiment 5 one kinds treats the medicine of rheumatic and rheumatoid, adopts following formula, by weight, and Radix Notoginseng 12, Radix Aconiti 7, Radix Aconiti Kusnezoffii 12, Herba Aristolochiae Mollissimae 3, Venenum apis 4, Camphora 12, Borneolum Syntheticum 3, Pericarpium Zanthoxyli 12, Semen Sinapis Albae 11, Rhizoma Gastrodiae 10, Semen Momordicae 16, Rhizoma Et Radix Notopterygii 12,95% ethanol 240; Prepare with embodiment 1 method.
Tang, man, 45 years old, nineteen ninety starts neck stiffness, aching of the shoulder and arm, arm ulnar side numbness, upper limb is praised difficulty and is developed into aching pain in waist and back gradually, can't take care of oneself, and uses the medicine of the present embodiment to be coated with affected part 5 times with cotton swab every day afterwards, all joints pain alleviates, transference cure after 15 days, X-ray film making display cervical vertebra is straight, and curvature is normal, follow up a case by regular visits to 5 years, without recurrence.

Claims (1)

1. treat a medicine for rheumatic and rheumatoid, it is characterized in that, adopt following formula: by weight, Radix Notoginseng 5 ~ 15, Radix Aconiti 5 ~ 15, Radix Aconiti Kusnezoffii 5 ~ 15, Herba Aristolochiae Mollissimae 1 ~ 3, Venenum apis 2 ~ 4, Camphora 5 ~ 15, Borneolum Syntheticum 2 ~ 4, Pericarpium Zanthoxyli 5 ~ 15, Semen Sinapis Albae 5 ~ 15, Rhizoma Gastrodiae 5 ~ 15, Semen Momordicae 10 ~ 18, Rhizoma Et Radix Notopterygii 5 ~ 15,95% ethanol 150 ~ 250; Prepare as follows: the stir-fry of Pericarpium Zanthoxyli slow fire is had fragrance to color burn by (A), Semen Sinapis Albae slow fire is fried to there being cracker to appear fragrant peppery gas its colour changed into yellow, Rhizoma Gastrodiae steams rear section, and Semen Momordicae Ex-all skin shells and gets core, and Rhizoma Et Radix Notopterygii clear water is cleaned to soak into and cut sheet, print; (B) Pericarpium Zanthoxyli step (A) processed, Semen Momordicae, Rhizoma Et Radix Notopterygii pulverization respectively, by Radix Notoginseng, Radix Aconiti, Radix Aconiti Kusnezoffii, Herba Aristolochiae Mollissimae pulverization respectively; (C) smalls in step (B) and Venenum apis, Camphora, Borneolum Syntheticum to be dropped into together in 95% ethanol brewed 40 days, by filtered through gauze, retain filtrate.
CN201410554101.3A 2014-10-20 2014-10-20 A kind of medicine for treating rheumatic and rheumatoid Active CN104338022B (en)

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Citations (4)

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CN1543991A (en) * 2003-11-25 2004-11-10 张华光 Cold dispelling and pain alleviating liquid and its preparation and operation guide
JP2009167160A (en) * 2007-12-17 2009-07-30 Kao Corp External preparation, hair restorer, nfat signal inhibitor and calcineurin inhibitor
CN101987189A (en) * 2010-11-16 2011-03-23 吴柱华 Detoxifying and channel dredging external application powder

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091296A (en) * 1993-02-15 1994-08-31 柳登顺 External-use analgesic and preparation method thereof
CN1543991A (en) * 2003-11-25 2004-11-10 张华光 Cold dispelling and pain alleviating liquid and its preparation and operation guide
JP2009167160A (en) * 2007-12-17 2009-07-30 Kao Corp External preparation, hair restorer, nfat signal inhibitor and calcineurin inhibitor
CN101987189A (en) * 2010-11-16 2011-03-23 吴柱华 Detoxifying and channel dredging external application powder

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Title
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苏涛等: ""马兜铃酸Ⅰ在大鼠体内的代谢特征研究"", 《中国中药杂志》 *

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