CN104337860A - Medicinal composition for treating chronic superficial gastritis and preparation method thereof - Google Patents
Medicinal composition for treating chronic superficial gastritis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to a medicinal composition for treating chronic superficial gastritis. In particular, the medicinal composition is prepared from the raw materials of radish seed and liquoric root. The two medicinal materials are used together, and perform synergistic interaction, so that the functions of smoothening qi, dissipating stasis, eliminating expansion, removing mite, harmonizing stomach, relieving pain, invigorating spleen, replenishing qi, clearing heat and detoxifying are achieved. As proved by animal test, the composition has a remarkable treatment effect on chronic superficial gastritis, and is convenient to carry and use.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of pharmaceutical composition for the treatment of chronic superficial gastritis, particularly, is the pharmaceutical composition be prepared from for raw material with Semen Raphani, Radix Glycyrrhizae.
Background technology
What chronic gastritis (chronic gastritis) referred to that gastric epithelial suffers various virulence factor often attacks the specificity chronic inflammation pathological changes that occurs repeatedly, a kind of common with the chronic inflammatory disease of epigastric discomfort or the pain gastric mucosa that is cardinal symptom or atrophic lesion, belong to the category such as the traditional Chinese medical science " gastric abscess ", " abdominal distention ", " noisy ", " feeling of fullness ", " syndrome of feeling fullness and distension in the upper abdomen ", a kind of commonly encountered diseases, frequently-occurring disease, its sickness rate occupies first of gastropathy, account for the 80%-90% that outpatient service accepts gastroscopy patient, and male is more than women.China in 1982 chronic gastritis academic conference is divided into chronic superficial gastritis and chronic atrophic gastritis two class, and wherein chronic superficial gastritis is very common clinically.
Chronic superficial gastritis affected males is more than women, in the majority with person between twenty and fifty.Its clinical manifestation is: epigastrium pain, or distending pain, or twinge, or dull pain, or causalgia, and how on the feed rear pain increases the weight of, and anti-feel is comfortable on an empty stomach.Often there is sensation of fullness in gastral cavilty portion, even can prolong and two sides of body, belch, pantothenic acid, Nausea and vomiting, loss of appetite, notably anorexia, lose heart, weak, loose stool etc., bring larger misery to patient, thus affect quality of life and work, study, life.
Semen Raphani: pungent, sweet, flat.Return lung, spleen, stomach warp.Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.Modern study shows: Semen Raphani is extensive in clinical practice, is mainly used in the disease for the treatment of digestive system, as diseases such as constipation, postoperative abdominal distention, intestinal obstruction, gastritis, all achieves comparatively satisfied curative effect.In addition, Semen Raphani is also usually used in the treatment of respiratory system, cardiovascular system, skin and pediatric disease.Modern clinic also treats hypertension, pancreatitis, gastritis, urinary dysfunction, chloasma, metrorrhagia etc. with it.Especially more suitable with hyperpietic to digestive system, respiratory system.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, alleviates Chinese materia medica tocixity, strong.
Glycyrrhizae Decoction for Purging Stomach-Fire is the ancient prescription on treatise on Febrile Diseases, there is pungent drugs can disperse and bitter drugs can descend, mildly regulating cold and heat, effect of the painful abdominal mass that disappears relieving accumulation of pathogens, can disappear " painful abdominal mass " by tonify deficiency, is the good recipe for the treatment of insufficiency of stomach painful abdominal mass knot, in side, emphasis dosage uses Radix Glycyrrhizae Preparata, regulate the patient of the retardance of weakness of the spleen and stomach, mechanism of qi, lifting imbalance with its stronger invigorating middle warmer stomach function regulating effect, thus reach treatment gastric abscess, belch, retch, vexed uneasiness, indigested food of receiving, the diseases such as lower profit.
Qing Dynasty's doctor Xu Ling tire is said: " total person of disease is sick for it, and a disease always has number card ".That is, disease can summarize card.Therefore, samely dialectically relate to different diseases, comprise the reason of disease, position, character.Disclose only its function, simply can not know that it is effective to clinical concrete disease by inference.There is no the relevant report separately Semen Raphani, Radix Glycyrrhizae compatibility being used for the treatment of chronic superficial gastritis at present.
Summary of the invention
An object of the present invention is to provide a kind of pharmaceutical composition for the treatment of chronic superficial gastritis.
In order to achieve the above object, the present invention adopts following technical method: a kind of pharmaceutical composition for the treatment of chronic superficial gastritis, is made up of the raw material of Chinese medicine of following weight portion: Semen Raphani 2-5 part, Radix Glycyrrhizae 3-6 part.
Wherein, the preferred Semen Raphani (parched) of Semen Raphani described above, because of Semen Raphani tool " raw ripe different control ", " raw rise ripe falling " property feature, inventor selects Semen Raphani (parched), gets its property and falls, for the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.
Preferably, the pharmaceutical composition for the treatment of chronic superficial gastritis described above, is made up of the raw material of Chinese medicine of following weight portion: Semen Raphani 3 parts, 5 parts, Radix Glycyrrhizae.
Pharmaceutical composition of the present invention is active component by the water of Semen Raphani, Radix Glycyrrhizae or extractive with organic solvent, adds the preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, described preparation is: one or more in capsule, tablet, pill, granule.
Preferably, preparation described above is capsule.
Present invention also offers a kind of method preparing this pharmaceutical composition, it comprises the steps:
A. the Semen Raphani of recipe quantity described above is got, offer medicine when cooking bottom temperature reaches 180-230 DEG C, Quick uniform stir-fries to quality and heaves, easy decortication, when having cracker and peculiar fragrance, take out, dry in the air cool, pulverize, be fed into grease press force feed, be depressed into oil yield when reaching 60% ± 10% of fatty oil content in raw material, stop force feed, fatty oil is separately deposited, Semen Raphani (parched) medicine cake after physics defat is broken into coarse powder, soak 0.5 h, heating and refluxing extraction three times, amount of water is 3-5 times of spice, extraction time is 0.5-1.5h, filter, merging filtrate, be evaporated to 1.01-1.10 g/ml, add 95% ethanol, limit edged rapid stirring, concentration of alcohol is made to be 80%, leave standstill 24 h, filter, filtrate reduced in volume reclaims ethanol extremely without alcohol taste, continue to be concentrated into dry, obtain Semen Raphani extract,
B. get the Radix Glycyrrhizae of recipe quantity described above, pulverize, with the soak by water twice of 4-6 times of weight portion, each 1-2 hour, merge decoction liquor, being concentrated into relative density is 1.06-1.15(60 DEG C), vacuum drying, obtains Radix Glycyrrhizae extract;
C. the extract of above-mentioned gained is mixed, be ground into 100-200 object fine powder, add pharmaceutically acceptable adjuvant or complementary composition and be prepared into pharmaceutically conventional dosage form.
Medicine of the present invention is made up of Semen Raphani and Radix Glycyrrhizae, and two medicine compatibilities use, and plays synergistic function, there is regulating QI to remove the stagnation, relieving distension except full and stomach and alleviating pain, invigorating the spleen and replenishing QI, the function of heat-clearing and toxic substances removing, treatment chronic superficial gastritis Be very effective, and carry, easy to use; Every day, dosage was little, and crude drug source is extensive.
Detailed description of the invention
The preparation of embodiment 1 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 300g, Radix Glycyrrhizae 500g.
Preparation method: the Semen Raphani of getting recipe quantity described above, offer medicine when cooking bottom temperature reaches 180-230 DEG C, Quick uniform stir-fries to quality and heaves, easy decortication, when having cracker and peculiar fragrance, take out, dry in the air cool, pulverize, be fed into grease press force feed, be depressed into oil yield when reaching 60% ± 10% of fatty oil content in raw material, stop force feed, fatty oil is separately deposited, Semen Raphani (parched) medicine cake after physics defat is broken into coarse powder, soak 0.5 h, heating and refluxing extraction three times, amount of water is 3-5 times of spice, extraction time is 0.5-1.5h, filter, merging filtrate, be evaporated to 1.01-1.10 g/ml, add 95% ethanol, limit edged rapid stirring, concentration of alcohol is made to be 80%, leave standstill 24 h, filter, filtrate reduced in volume reclaims ethanol extremely without alcohol taste, continue to be concentrated into dry, obtain Semen Raphani extract.Get the Radix Glycyrrhizae of recipe quantity described above, pulverize, with the soak by water twice of 4-6 times of weight portion, each 1-2 hour, merge decoction liquor, being concentrated into relative density is 1.06-1.15(60 DEG C), vacuum drying, obtains Radix Glycyrrhizae extract.Mixed by the extract of above-mentioned gained, be ground into 100-200 object fine powder, add pharmaceutically acceptable adjuvant or complementary composition is prepared into capsule 1000, every intragranular is tolerant is 0.34g, and every is equivalent to crude drug 0.8g.
The preparation of embodiment 2 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 300g, Radix Glycyrrhizae 400g.
Preparation method: with reference to embodiment 1.
The preparation of embodiment 3 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 300g, Radix Glycyrrhizae 600g.
Preparation method: with reference to embodiment 1.
The preparation of embodiment 4 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 500g, Radix Glycyrrhizae 600g.
Preparation method: with reference to embodiment 1.
The preparation of embodiment 5 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 500g, Radix Glycyrrhizae 300g.
Preparation method: with reference to embodiment 1.
The preparation of embodiment 6 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 300g, Radix Glycyrrhizae 300g.
Preparation method: with reference to embodiment 1.
The preparation of embodiment 7 medicament composition capsule agent of the present invention
Prescription: Semen Raphani 200g, Radix Glycyrrhizae 300g.
Preparation method: with reference to embodiment 1.
The preparation of embodiment 8 medicinal composition tablets of the present invention
Preparation method: the Semen Raphani of getting recipe quantity described above, offer medicine when cooking bottom temperature reaches 180-230 DEG C, Quick uniform stir-fries to quality and heaves, easy decortication, when having cracker and peculiar fragrance, take out, dry in the air cool, pulverize, be fed into grease press force feed, be depressed into oil yield when reaching 60% ± 10% of fatty oil content in raw material, stop force feed, fatty oil is separately deposited, Semen Raphani (parched) medicine cake after physics defat is broken into coarse powder, soak 0.5 h, heating and refluxing extraction three times, amount of water is 3-5 times of spice, extraction time is 0.5-1.5h, filter, merging filtrate, be evaporated to 1.01-1.10 g/ml, add 95% ethanol, limit edged rapid stirring, concentration of alcohol is made to be 80%, leave standstill 24 h, filter, filtrate reduced in volume reclaims ethanol extremely without alcohol taste, continue to be concentrated into dry, obtain Semen Raphani extract.Get the Radix Glycyrrhizae of recipe quantity described above, pulverize, with the soak by water twice of 4-6 times of weight portion, each 1-2 hour, merge decoction liquor, being concentrated into relative density is 1.06-1.15(60 DEG C), vacuum drying, obtains Radix Glycyrrhizae extract.The extract of above-mentioned gained is mixed, is ground into 100-200 object fine powder, add pharmaceutically acceptable adjuvant or complementary composition is prepared into 1000, tablet.
Beneficial effect of the present invention is proved below by way of pharmacodynamics test.
The protective effect that embodiment 9 pharmaceutical composition of the present invention damages chronic superficial gastritis gastric mucosa
1. laboratory animal: SD rat 70, male and female half and half, body weight (160 ± 20) g, is provided by Shandong Traditional Chinese Medicine University's Experimental Animal Center.
2. trial drug: medicament composition capsule prepared by the embodiment of the present invention 1; Bismuth aluminate compound (Hayao Group Sanjing Pharmaceutical 4th Factory Co., Ltd. produces, the accurate word H23021337 of traditional Chinese medicines)
3. the preparation of model, grouping and administration: adopt 0.02% ammonia to drink and coordinate irregular diet to stimulate, continued stimulus 90 d brings out rat chronic superficial gastritis model, check Confirming model to copy successfully through gastric tissue pathological examination (HE dyeing).By model copy group rat random packet: the high, medium and low dosage group of pharmaceutical composition of the present invention, bismuth aluminate compound matched group and model control group, 10/group, male and female half and half, and together enter experiment with Normal group.Animal continuous gavage 30 d, wherein pharmaceutical composition of the present invention high, medium and low dosage group dosage is 1.36,0.68,0.34 g/kg, bismuth aluminate compound matched group is 0.9 g/kg, Normal group and model control group gavage consubstantiality hydrops.
4. evaluation index and method
4.1 stomach lining inflammation degree evaluations: next day after last administration, successively by only sacrificed by decapitation rat after fasting about 12 hours, cut open the belly immediately, ligation cardia pylorus, the full stomach of clip, gastral cavity is cut open along lesser gastric curvature, full stomach after embathing is fixed by 10% formalin, get the holostrome coat of the stomach of a wide about 0.5cm from glandular stomach to pylorus along every rat greater gastric curvature, conventional dehydration, specimens paraffin embedding slices, HE dyes, with chronic inflammatory disease degree, activity level, distortion and interstitial congestion and edema degree three are as Score index, every is divided into normal (-), slightly (+), moderate (++), severe (+++) (corresponding 0, 1, 2, 3 points, there are all the other inflammatories to show and add 1 point), finally with pyloric part and body of stomach score with for inflammatory appraisal result: 0-0 divides: normal, 1-4 divides: slight, 5-8 divides: moderate, more than 9 points: severe.
The positive layer thickness of 4.2 Gastric Mucosa B/PAS: above-mentioned gastric tissue does AB/PAS dyeing simultaneously, measures the positive layer thickness (μm) of AB/PAS with micrometer, calculates mean and the standard deviation of each group, check the significance of more each group difference with t.
4.3 statistic analysis result with
represent, data acquisition SPSS 13.0 software is analyzed.
5. result
Observe visible: chronic superficial gastritis rat main manifestations is gastric mucosa congestion edema, color is light in pale red, red and white, be dispersed in point-like, speckle or strip hemorrhage and rotten to the corn, visible remote hemorrhage and fresh hemorrhage, mucosa injury rate is high, local, individual animal gastric antrum portion duplicature thickens, the yellow exudate of accidental mucus, mucous epithelium AB/PAS is positive, and layer thickness reduces, and barrier system suffers damage.
From table 1,2, the continuous gastric infusion of medicament composition capsule of the present invention 30 days, obviously can alleviate the degree of inflammation of chronic superficial gastritis Antrum and gastric body mucosa, simultaneously administration group Antrum, the positive layer thickness of body of stomach Gastric Mucosa B/PAS also comparatively model group obviously increase, show that medicament composition capsule of the present invention has obvious inhibitory action to the stomach lining inflammation of chronic superficial gastritis rat and gastric mucosa atrophy pathological changes.
Table 1 medicament capsule of the present invention on the impact of chronic superficial gastritis gastric mucosa of rat degree of inflammation (
)
Note: compare with model control group, * represents that P < 0.05, * * represents P < 0.01.
Table 2 medicament capsule of the present invention on the impact of the positive layer thickness of chronic superficial gastritis gastric mucosa of rat AB/PAS (
)
Note: compare with model control group, * represents that P < 0.05, * * represents P < 0.01.
Claims (6)
1. treat a pharmaceutical composition for chronic superficial gastritis, it is characterized in that being made up of the raw material of Chinese medicine of following weight portion: Semen Raphani 2-5 part, Radix Glycyrrhizae 3-6 part.
2. the pharmaceutical composition for the treatment of chronic superficial gastritis as claimed in claim 1, is characterized in that being made up of the raw material of Chinese medicine of following weight portion: Semen Raphani 3 parts, 5 parts, Radix Glycyrrhizae.
3. prepare a method for the pharmaceutical composition for the treatment of chronic superficial gastritis as claimed in claim 1 or 2, it is characterized in that comprising the following steps:
A, get the Semen Raphani of recipe quantity described above, offer medicine when cooking bottom temperature reaches 180-230 DEG C, Quick uniform stir-fries to quality and heaves, easy decortication, when having cracker and peculiar fragrance, take out, dry in the air cool, pulverize, be fed into grease press force feed, be depressed into oil yield when reaching 60% ± 10% of fatty oil content in raw material, stop force feed, fatty oil is separately deposited, Semen Raphani (parched) medicine cake after physics defat is broken into coarse powder, soak 0.5 h, heating and refluxing extraction three times, amount of water is 3-5 times of spice, extraction time is 0.5-1.5h, filter, merging filtrate, be evaporated to 1.01-1.10 g/ml, add 95% ethanol, limit edged rapid stirring, concentration of alcohol is made to be 80%, leave standstill 24 h, filter, filtrate reduced in volume reclaims ethanol extremely without alcohol taste, continue to be concentrated into dry, obtain Semen Raphani extract,
B. get the Radix Glycyrrhizae of recipe quantity described above, pulverize, with the soak by water twice of 4-6 times of weight portion, each 1-2 hour, merge decoction liquor, at being concentrated into 60 DEG C, relative density is 1.06-1.15, and vacuum drying, obtains Radix Glycyrrhizae extract;
C. the extract of above-mentioned gained is mixed, be ground into 100-200 object fine powder, add pharmaceutically acceptable adjuvant or complementary composition and be prepared into pharmaceutically conventional dosage form.
4. the pharmaceutical composition for the treatment of chronic superficial gastritis as claimed in claim 1 or 2, is characterized in that: described pharmaceutical composition is in capsule, tablet, pill or granule.
5. the pharmaceutical composition for the treatment of chronic superficial gastritis as claimed in claim 4, is characterized in that: described pharmaceutical composition is capsule.
6. the pharmaceutical composition for the treatment of chronic superficial gastritis as claimed in claim 1 or 2, is characterized in that: described Semen Raphani is Semen Raphani (parched).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233069A (en) * | 2015-11-18 | 2016-01-13 | 吴斌 | Medicine for treating chronic atrophic gastritis |
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Non-Patent Citations (1)
| Title |
|---|
| 俞丽霞，等: "《中药药理学》", 31 December 2012, 浙江大学出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233069A (en) * | 2015-11-18 | 2016-01-13 | 吴斌 | Medicine for treating chronic atrophic gastritis |
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