CN104324290A - 一种治疗玫瑰糠疹的中药组合物 - Google Patents

一种治疗玫瑰糠疹的中药组合物 Download PDF

Info

Publication number
CN104324290A
CN104324290A CN201410645957.1A CN201410645957A CN104324290A CN 104324290 A CN104324290 A CN 104324290A CN 201410645957 A CN201410645957 A CN 201410645957A CN 104324290 A CN104324290 A CN 104324290A
Authority
CN
China
Prior art keywords
parts
radix
chinese medicine
medicine composition
traditional chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410645957.1A
Other languages
English (en)
Inventor
韩如冰
Original Assignee
张鹏
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 张鹏 filed Critical 张鹏
Priority to CN201410645957.1A priority Critical patent/CN104324290A/zh
Publication of CN104324290A publication Critical patent/CN104324290A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Abstract

本发明公开了一种药物,特别公开了一种治疗玫瑰糠疹的中药组合物。该治疗玫瑰糠疹的中药组合物,其特殊之处在于:是由以下重量份数的组分制成:紫草10-20、防风10-15、荆芥10-15、黄芩10-15、石膏20-30、地黄20-30、赤芍10-15、牡丹皮10-15、鸡血藤15-20、土茯苓10-15、徐长卿10-15、板蓝根10-15、金银花10-15、菊花10-15、桑叶10-15、薄荷5-10。本发明通过凉血消风、清热解毒以达到治疗玫瑰糠疹的目的,其疗效显著,提高了患者的生活质量。本发明的中药,疗效好,见效快,无副作用,有效率达98.3%。

Description

一种治疗玫瑰糠疹的中药组合物
技术领域
[0001] 本发明主要涉及中药领域,尤其涉及一种治疗玫瑰糠疹的中药。
背景技术
[0002] 玫瑰糠疹是春秋季节容易发作的皮肤病,它好发于中青年之间,具有自限性。一般玫瑰糠疹好发于躯干和四肢近端处,在皮损处会出现数目不定的玫瑰色斑片,并且上面附有糠状鳞屑出现。虽然具有自限性,但是也会出现长期不愈的情况,临床上就发现很多玫瑰糠疹患者因为延误治疗时间而遗留下了难看的色素沉着现象。中医学认为,本病多因血热,复感风热邪毒,致使热客血分,风毒郁于肺脾二经,外发肌肤而成;外感风热之邪,闭塞于腠理,内有血热,耗伤津液,血热化燥,外泛于肌肤所致。
[0003]目前治疗玫瑰糠疹的药物,西医无特效药物,一般给予抗组胺药物、外用激素软膏等对症治疗,副作用大,效果不明显,只能缓解症状,治标不治本,容易反复,且缺乏专门针对玫瑰糠疹的中成药。
发明内容
[0004] 本发明目的就是为了弥补已有技术的缺陷,提供一种专门治疗玫瑰糠疹的中药组合物,它对于治疗玫瑰糠疹疗效明显,安全方便,副作用小。
[0005] 本发明是通过以下技术方案实现的:
一种治疗玫瑰糠疹的中药组合物,其特征在于:各原料的重量配比为:紫草10-20、防风10-15、荆芥10-15、黄芩10-15、石膏20-30、地黄20-30、赤芍10-15、牡丹皮10-15、鸡血藤15-20、土茯苓10-15、徐长卿10-15、板蓝根10-15、金银花10-15、菊花10-15、桑叶10-15、薄荷 5-10。
一种治疗玫瑰糠疹的中药组合物,其优选为:各原料的重量配比为:紫草15、防风12、荆芥12、黄芩12、石膏25、地黄25、赤芍12、牡丹皮12、鸡血藤18、土茯苓12、徐长卿12、板蓝根14、金银花12、菊花12、桑叶12、薄荷8。
本发明的配制方法如下:将上述中药用冷水浸泡I小时后煎煮,煎煮水份超过中药2-3公分,在水沸腾后用文火煎煮50分钟,过滤倒出药液即可。分早晚,一日两次。
[0006] 具体实施方式:
一种治疗玫瑰糠疹的中药组合物,其优选为:各原料的重量配比为:紫草15g、防风12g、荆芥12g、黄岑12g、石膏25g、地黄25g、赤苟12g、牡丹皮12g、鸡血藤18g、土获茶12g、徐长卿12g、板蓝根Hg、金银花12g、菊花12g、桑叶12g、薄荷8g。
称取以上对应组的原料组分,按照汤药的常规制法,加水煮成汤剂服用。每日I剂,早晚分服。
临床观察:
一般资料:
本发明人于2012年3月至2014年3月,对60例患者进行临床观察治疗。诊断标准为全国高等医药教材《皮肤性病学》有关玫瑰糠疹标准。其中男性28例,女性32例;年龄15-41岁,平均24.5岁,病程3-21天,平均5天。
[0007] (I)疗效评定标准:
治愈:皮损全部消退,留有色素减退斑,无瘙痒症状。
[0008] 显效:皮损消退彡70%,无(或)有轻度瘙痒。
[0009] 好转:皮损消退30%_70%,瘦库明显减轻。
[0010] 无效:皮损消退< 30%,瘙痒明显或体征无明显改变。
[0011] (2)治疗方法:
用本发明的药物用水煎煮取药液,每日I剂,早晚分服。每5天为I疗程,治疗3-6个疗程。
[0012] (3)治疗效果:
临床治愈49例,显效8例,好转2例,无效I例,所有病例均无不良反应。
[0013] (4)总结:有效率98.3%,治愈率81.7%。
[0014] 本发明通过凉血消风、清热解毒以达到治疗玫瑰糠疹的目的。本方中以紫草、地黄、牡丹皮、赤芍凉血分之热;黄芩、石膏、土茯苓清利湿热、泻火解毒;荆芥、防风、薄荷消肌肤之风热;佐鸡血藤养血活血,更兼金银花、板蓝根善解血中热毒;菊花、桑叶疏风清热;徐长卿以止痒。其疗效显著,大大减轻了患者痛苦,提高了患者的生活质量。本发明的中药,疗效好,见效快,无副作用,可明显缩短病程,提高治愈率,值得临床推广。
[0015] 为证明本发明具有很好的疗效,列举典型病例如下:
病例1.王某,女,24岁,2013年5月8日初诊。主诉:I周前因着凉感冒,头疼鼻塞,自服感冒药症状稍缓。不久发现胸背部红色斑片,瘙痒,表面轻度脱屑,继而双上肢、大腿亦发现红色皮疹,大小不等,经西医诊为“玫瑰糠疹”。予以扑尔敏、维生素C、葡萄糖酸钙等抗过敏治疗,效果欠佳。使用本发明中药,每日I剂,早晚分服,连服5剂,皮损明显好转,红色斑片渐消,痒感减轻。续服5剂病愈,皮损全部消失,临床治愈。
[0016]病例 2.赵某,女,28岁,2013年7月10日初诊。因玫瑰糠疹前来就诊,诊见躯干及四肢近端散布大小不等的椭圆形红斑,边缘有细碎糠状脱屑,胸背部皮损横向排列,呈向心性分布,长轴和皮肤纹理平行。舌质红,苔薄黄,脉浮滑数。属中医风热疮(玫瑰糠疹)。使用本发明中药,每日I剂,早晚分服,连服5剂,皮损明显好转,红色斑片渐消,痒感减轻。续服10剂病愈,皮损全部消失,临床治愈。

Claims (2)

1.一种治疗玫瑰糠疹的中药组合物,其特征在于:各原料的重量配比为:紫草10-20、防风10-15、荆芥10-15、黄芩10-15、石膏20-30、地黄20-30、赤芍10-15、牡丹皮10-15、鸡血藤15-20、土茯苓10-15、徐长卿10-15、板蓝根10-15、金银花10-15、菊花10-15、桑叶.10-15、薄荷 5-10。
2.如权利要求1所述的中药组合物,其特征在于:各原料的重量配比为:紫草15、防风.12、荆芥12、黄芩12、石膏25、地黄25、赤芍12、牡丹皮12、鸡血藤18、土茯苓12、徐长卿12、板蓝根14、金银花12、菊花12、桑叶12、薄荷8。
CN201410645957.1A 2014-11-15 2014-11-15 一种治疗玫瑰糠疹的中药组合物 Pending CN104324290A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410645957.1A CN104324290A (zh) 2014-11-15 2014-11-15 一种治疗玫瑰糠疹的中药组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410645957.1A CN104324290A (zh) 2014-11-15 2014-11-15 一种治疗玫瑰糠疹的中药组合物

Publications (1)

Publication Number Publication Date
CN104324290A true CN104324290A (zh) 2015-02-04

Family

ID=52399180

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410645957.1A Pending CN104324290A (zh) 2014-11-15 2014-11-15 一种治疗玫瑰糠疹的中药组合物

Country Status (1)

Country Link
CN (1) CN104324290A (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105770550A (zh) * 2016-04-13 2016-07-20 刘连强 一种治疗玫瑰糠疹的中药组合物
CN106075184A (zh) * 2016-06-28 2016-11-09 李霞 一种治疗玫瑰糠疹的口服液

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101757376A (zh) * 2008-10-22 2010-06-30 宋修芳 治疗玫瑰糠疹的中药
CN102293957A (zh) * 2010-06-22 2011-12-28 上海中医药大学附属岳阳中西医结合医院 治疗血热阳浮证相关皮肤病的中药颗粒剂及其制备

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101757376A (zh) * 2008-10-22 2010-06-30 宋修芳 治疗玫瑰糠疹的中药
CN102293957A (zh) * 2010-06-22 2011-12-28 上海中医药大学附属岳阳中西医结合医院 治疗血热阳浮证相关皮肤病的中药颗粒剂及其制备

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
俞友根等: "凉血消风、清热解毒法治疗玫瑰糠疹64例", 《四川中医》 *
雷鹏程: "《皮肤病性别中西医结合治疗学》", 31 January 2013, 北京大学医学出版社 *
高艳峰: "中西医结合治疗玫瑰糠疹疗效观察", 《内蒙古中医药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105770550A (zh) * 2016-04-13 2016-07-20 刘连强 一种治疗玫瑰糠疹的中药组合物
CN106075184A (zh) * 2016-06-28 2016-11-09 李霞 一种治疗玫瑰糠疹的口服液

Similar Documents

Publication Publication Date Title
CN102631593B (zh) 一种治疗水肿型红丝疔的中药洗剂制备方法
CN104042737A (zh) 一种治疗急性湿疹的外用药物组合物及其制备方法
CN104324290A (zh) 一种治疗玫瑰糠疹的中药组合物
CN101912567B (zh) 治疗慢性心肌炎的中药
CN104758726A (zh) 一种治疗尿路感染的中药组合物
CN103239503B (zh) 一种治疗骨痛病的中药制剂及其制备方法
CN104667026A (zh) 一种治疗胃肠积热型便秘的中药组合物
CN103099879B (zh) 治疗五更泄泻的中药制剂
CN102935214B (zh) 一种治疗尿毒症的中药组合物
CN104398740A (zh) 一种用于治疗小便不利的中药组合物
CN103933269A (zh) 一种治疗血崩病中药
CN103638159B (zh) 治疗急性乳腺炎的外用中药制剂
CN103721028B (zh) 一种治疗心绞痛的药物及制备方法
CN103191281B (zh) 生地黄口服液
CN103550363B (zh) 一种治疗耳聋耳鸣的中药组合物
CN106474316A (zh) 一种治疗原发性骨淋巴瘤的中药
CN103239655B (zh) 一种治疗银屑病的化斑汤
CN102380010A (zh) 一种治疗特发性水肿的中药配方
CN102836403B (zh) 一种利用刺梭罗治疗慢性肾炎的中药
CN102727675B (zh) 一种治疗鼻窦炎的中药胶囊
CN102846998A (zh) 一种治疗慢性肠炎(脾虚泻利)的中药方
CN102631633B (zh) 一种治疗便秘型红丝疔的中药洗剂制备方法
CN102805850B (zh) 一种治疗疲乏型急性肾小球肾炎的中药制备方法
CN104740423A (zh) 一种治疗风湿性关节炎的中药
CN102836404B (zh) 一种利用水丁香治疗慢性肾炎的中药

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150204