CN104324246A - Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof - Google Patents

Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof Download PDF

Info

Publication number
CN104324246A
CN104324246A CN201410514789.2A CN201410514789A CN104324246A CN 104324246 A CN104324246 A CN 104324246A CN 201410514789 A CN201410514789 A CN 201410514789A CN 104324246 A CN104324246 A CN 104324246A
Authority
CN
China
Prior art keywords
parts
chinese medicine
granule
traditional chinese
clear paste
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410514789.2A
Other languages
Chinese (zh)
Inventor
李中昕
王方铎
刘青青
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410514789.2A priority Critical patent/CN104324246A/en
Publication of CN104324246A publication Critical patent/CN104324246A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a traditional Chinese medicine granule and particularly relates to preparation methods of a traditional Chinese medicine for treating hypertension and a granule thereof. The traditional Chinese medicine granule is prepared from following traditional Chinese medicine raw materials, by weight, 10-15 parts of taxillus sutchuenensis, 15-20 parts of kudzu roots, 8-10 parts of rhizoma chuanxiong, 10-15 parts of chrysanthemum indicum, 5-8 parts of hawthorns, 15-20 parts of prunella vulgaris, 4-8 parts of dogbane leaves, 10-15 parts of uncaria, 10-15 parts of gastrodia elata, 5-8 parts of semen cassia, 5-8 parts of ganoderma lucidum, 5-8 parts of radix scutellariae and 2-5 parts of clerodendrum trichotomum. The granule is prepared through following steps: selecting the traditional Chinese medicine raw materials according to the proportions, grinding the traditional Chinese medicine raw materials into fine powders and mixing the fine powders uniformly to obtain a mixture; adding the mixture to eight times of ethanol with a concentration being 65% for heating reflux extraction for 45 min to obtain an extract and adding the rest part to six times of ethanol with the concentration being 65% for heating reflux extraction for 30 min to obtain an extract; mixing the two extracts with filtration; concentrating the extracts to a clear paste with a density being 1.50 for later use; and adding dextrin and sugar to the clear paste, manufacturing the clear paste into granules and packaging the granules. The traditional Chinese medicine granule has effects of softening blood vessels and dredging blood circulation for reducing blood pressure, and meanwhile has alleviate effects on headache, dizziness and the like symptoms caused by hypertension.

Description

A kind of preparation method for the treatment of hypertensive Chinese medicine and granule thereof
Technical field
The present invention relates to a kind of Chinese medicinal granule, be specifically related to a kind of preparation method for the treatment of hypertensive Chinese medicine and granule thereof.
Background technology
Hypertension is one of commonly encountered diseases of internal department, is based on the clinical syndrome of arteriotony rising.Along with the change of human life style and living environment, the ratio that hypertension accounts in total population is more and more higher, and Chinese Hypertensive Population is more than 1.6 hundred million.Authority's statistics hyperpietic over half dies from renal failure, heart failure, counts for much with western medicine of depressurization.Western medicine can make patient produce strong drug dependence.Blood pressure lowering on the surface, wrecks the heart, brain, kidney actually, but also dizziness can be brought, feel sick, nervous, the side effect such as asthma and edema, brings huge misery to patient.Just substantially death penalty has been sentenced once take depressor for those sleeps, the false hypertension caused of feeling bad.Depressor impels the health blood pressure regulating mechanisms of patient to tell degeneration, hypertension wants to request medicine will recover the function of human blood-pressure regulating system, blood pressure lowering can not be carried out by use Western medicine blindly, because allow you forever be unable to do without it once take, therefore, it is possible to develop, there is treatment high blood pressure disease, reduce incidence rate and mortality rate beyond cardiovascular and cerebrovascular vessel to greatest extent, and the Chinese medicine extending patient vitals is just significant.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides a kind of preparation method for the treatment of hypertensive Chinese medicine and granule thereof, can vessel softening, dredging blood circulation and blood pressure lowering.
One of the present invention treats hypertensive Chinese medicinal granule, according to weight parts, is prepared by following raw material of Chinese medicine: Herba Taxilli 10-15 part, Radix Puerariae 15-20 part, Rhizoma Chuanxiong 8-10 part, Flos Chrysanthemi Indici 10-15 part, Fructus Crataegi 5-8 part, Spica Prunellae 15-20 part, Folium Apocyni Veneti 4-8 part, Ramulus Uncariae Cum Uncis 10-15 part, Rhizoma Gastrodiae 10-15 part, Semen Cassiae 5-8 part, Ganoderma 5-8 part, Radix Scutellariae 5-8 part, flower bulb paulownia 2-5 part.
One treats hypertensive Chinese medicinal granule, according to weight parts, preferably formulated by following raw material of Chinese medicine: Herba Taxilli 12 parts, Radix Puerariae 17 parts, Rhizoma Chuanxiong 9 parts, Flos Chrysanthemi Indici 12 parts, Fructus Crataegi 7 parts, Spica Prunellae 17 parts, Folium Apocyni Veneti 6 parts, Ramulus Uncariae Cum Uncis 12 parts, 12 parts, Rhizoma Gastrodiae, Semen Cassiae 7 parts, Ganoderma 7 parts, Radix Scutellariae 7 parts, flower bulb paulownia 4 parts.
A kind of preparation method for the treatment of hypertensive Chinese medicinal granule, step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, and alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, filters after extracted twice liquid merges, be concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Pharmacology analysis:
Herba Taxilli: slightly warm in nature, bitter but sweet flavor.Invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Cure mainly soreness of waist and knee joint; Muscles and bones flaccidity is weak; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Rheumatic arthralgia, hypertension.
Radix Puerariae: cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Induce sweat and bring down a fever, promote the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, to have loose bowels.
Rhizoma Chuanxiong: property and flavor of peppery and warm, can expelling wind and activating blood circulation pain relieving, is mainly applicable to the diseases such as the dysmenorrhea of head-body-pain and stagnation of QI and blood, amenorrhea and postpartum stagnation stomachache, and this is one of common Chinese hypotensor material.Clinical report is used for the treatment of hypertension and reserpine share, and has good synergism.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent, heat-clearing and toxic substances removing, the effect of reducing blood pressure, Hypertension, can single decoction, also can with Spica Prunellae, the same use of Semen Cassiae, function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.
Fructus Crataegi: be longer than dissipating fluid-retention food, strengthening the spleen and stomach, row stagnation of QI, repercussive blood.Dredging, vessel softening, reduce blood pressure and cholesterol, increase coronary flow, improve the effects such as heart vigor, heart tonifying; Effectively can prevent and treat atherosclerosis, angiocardiopathy preventing.
Summer is withered: cold in nature, and sweet in the mouth, pungent, micro-hardship, have the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, clearing away liver-fire, Disperse hepatic depression, be usually used in Hypertension and have the liver-heat patients such as headache, dizzy, tinnitus, dysphoria with smothery sensation, insomnia, Spica Prunellae has the effect reduced blood pressure, and energy blood vessel dilating, contained by it, rutin has antiinflammatory action, and can reduce vascular permeability, reduces fragility, reduce liver fat, Spica Prunellae also has the effect of resisting cancerous cell.
Folium Apocyni Veneti: cool in nature, sweet in the mouth, hardship.Suppressing the hyperactive liver to relieve the wind syndrome heat clearing away, has good action to symptoms such as elimination headache and dizzy, feeling of fullness in the head, insomnias.Headache for liver fire exuberance is dizzy, convulsion with spasms.This product has the effect reduced blood pressure.
Ramulus Uncariae Cum Uncis: suppressing the hyperactive liver to relieve the wind syndrome heat clearing away, can be used for the diseases such as dizzy, the headache caused by excessive rising of liver-YANG, conjunctival congestion.
Rhizoma Gastrodiae: suppressing the hyperactive liver to relieve the wind syndrome, is applicable to the headache caused by excessive rising of liver-YANG, the disease such as dizzy.If hygrophlegmatic vertigo can the spleen strengthening and damp drying medicine such as the adapted Rhizoma Pinelliae, the Rhizoma Atractylodis Macrocephalae, Poria, as banxia baizhu tianma decoction.
Semen Cassiae: help irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple control headache, paste again the brain heart and stop epistaxis; Make pillow victory Semen sojae atricolor, control wind syndrome of head, improving eyesight, reducing blood pressure and blood fat, reduce cholesterol, liver heat removing and eyesight improving, diuretic relieving constipation, except effects such as constipation.Through medical research display, there is good curative effect to treatment hypertension, coronary heart disease, and can also the liver protecting, improve the immunity of human body.
Ganoderma: GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.As the Chinese tradition valuable ingredient of Chinese medicine having thousands of years medicinal histories, possesses very high medical value, modern pharmacology research through scientific research institution's many decades confirms, Ganoderma is for enhancing body immunity, regulate blood glucose, control blood pressure, adjuvant therapy chemicotherapy, hepatoprotective, the aspects such as hypnotic all have significant curative effect.
Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Flower bulb paulownia: nature and flavor: pungent, bitter, sweet, cool.Gui Jing: enter Liver Channel, gallbladder meridian, spleen channel.Cure mainly: dispelling the wind and dampness pathogens arthralgia pain, hemiplegia, hypertension, migraine; Malaria, dysentery, hemorrhoid, carbuncle skin ulcer scabies.
Wherein, function of the present invention is following 3 points:
1, blood pressure lowering, blood fat reducing, complication prevention: hypertension, hyperlipidemia all belong to metabolism syndrome.Hypertension shows human vas, and hyperlipidemia shows systemic blood.The two does not fall for a long time, all can impel into atherosclerotic formation, causes complication.Blood pressure, blood fat are steady, could prevent " two is high " complication.
2, steady blood pressure lowering: hypertension is embodied in that blood vessel die back, blood vessel are stiff, blood vessel blockage, and arteriole pressure enhancing etc. causes blood pressure to raise.The draft Chinese medicine such as Rhizoma Chuanxiong, Flos Chrysanthemi Indici, Fructus Crataegi, can have an impact to blood vessel, and prevent blood vessel die back, softening, dredging vascellum, reduce small artery resistance, prevention of arterial is atherosis, and long-term drink can realize steady blood pressure lowering.
3, safe blood fat reducing: abnormalities of sugar/lipid metabolism, causes human body lipid to exceed normal value.Main manifestations is that triglyceride and serum cholesterol are higher, the lipidosis in blood, and hyperlipidemia, easily forms atherosclerosis, causes complication.Fructus Crataegi in the present invention can absorb cholesterol, and Flos Chrysanthemi Indici can promote lipid metabolism, dissolving, can increase glomerular filtration, and promote sugar metabolism in body, Semen Cassiae can reduce cholesterol and blood pressure, and Folium Pini can be invigorated blood circulation, and improves hyperlipidemia.Long-term drink medicinal liquid of the present invention, can purify the blood, and recovers the oxygen supply of the organs such as heart and brain kidney, blood supply, recovers Human Lipid Metabolism, is controlled within normal value by blood fat.
4, adjust internal organs, short metabolism giving consideration to both the incidental and fundamental gets rid of illness root: the traditional Chinese medical science thinks that hypertension, hyperlipidemia are not only sick at blood vessel, blood, also impaired in close relations with the internal organs of human body.Hypertension, hyperlipidemia, to the injury of internal organs, can cause that Liver and kidney two is empty, phlegm-damp is obstructed, taste are impaired, blood stasis due to qi deficiency etc.And impaired blood pressure, the blood fat of can causing of internal organs raises.As the synthesis of body's cholesterol, 70% by liver synthesis, conversion, decomposition, metabolism, and liver damage can cause body's cholesterol higher, easily forms hyperlipidemia.
To sum up: long-term drink medicament of the present invention, while reducing blood pressure and blood fat, can the vital organs of the human body be nursed one's health, recover lipid metabolism, steady blood fat.Flos Chrysanthemi Indici can nurse one's health liver, has the effect of liver heat removing and eyesight improving, the liver benefiting nourishing YIN; Radix Puerariae can strengthening spleen, tonifying kidney, boosting qi and nourishing yin; Folium Stevlae Rebaudianae clearing away lung-heat, strengthening the spleen and stomach; Fructus Crataegi energy blood circulation promoting and blood stasis dispelling, treatment abdominal pain diarrhea etc.Medicament of the present invention is nursed one's health comprehensively, recovers body fat metabolism and Liver and kidney metabolism, steady blood pressure blood fat, eliminates future trouble and to get rid of illness root.
The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable, by vessel softening, dredging blood circulates and blood pressure lowering, has good remission effect to the symptom such as headache, dizziness, cerebral infarction, limbs fatigue that hypertension causes simultaneously.
Efficacy evaluation:
Cure: systolic pressure≤18.7kPa (140mmHg) and diastolic pressure≤12.0kPa (90mmHg).
Effective: systolic pressure >=18.7kPa (140mmHg) and (or) diastolic pressure >=12.0kPa (90mmHg), but blood pressure decreases.
Invalid: blood pressure is unchanged, other severity of symptoms.
Below enumerate several model case:
Case 1:
Huang, female, 64 years old, suffers from hypertension and sciatica, repeatedly fails to respond to any medical treatment through hospital, takes the present invention and cures for 45 days, hypertension and sciatica symptom completely without, within 2 years, have no recurrence.
Case 2:
Liu so-and-so, man, 45 years old, suffer from hypertension, ischium god pain simultaneously and suffer from scapulohumeral periarthritis, through hospital, multi-treatment was invalid, takes liquid medicine applying of the present invention 35 days continuously and cures, each disease symptoms completely without, within 2 years, have no recurrence.
Case 3:
Huang, man, 53 years old, suffers from hypertension and scapulohumeral periarthritis 3 years, repeatedly fails to respond to any medical treatment through hospital, takes medicinal liquid of the present invention and cures for 50 days, hypertension and symptoms of shoulder periarthritis completely without, within 3 years, have no recurrence.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, but the present invention is not limited to specific embodiment.
Embodiment 1:
One treats hypertensive Chinese medicinal granule, according to weight parts, is prepared by following raw material of Chinese medicine: Herba Taxilli 10 parts, Radix Puerariae 15 parts, Rhizoma Chuanxiong 8 parts, Flos Chrysanthemi Indici 10 parts, Fructus Crataegi 5 parts, Spica Prunellae 15 parts, Folium Apocyni Veneti 4 parts, Ramulus Uncariae Cum Uncis 10 parts, 10 parts, Rhizoma Gastrodiae, Semen Cassiae 5 parts, Ganoderma 5 parts, Radix Scutellariae 5 parts, flower bulb paulownia 2 parts.
Embodiment 2:
One treats hypertensive Chinese medicinal granule, according to weight parts, is prepared by following raw material of Chinese medicine: Herba Taxilli 15 parts, Radix Puerariae 20 parts, Rhizoma Chuanxiong 10 parts, Flos Chrysanthemi Indici 15 parts, Fructus Crataegi 8 parts, Spica Prunellae 20 parts, Folium Apocyni Veneti 8 parts, Ramulus Uncariae Cum Uncis 15 parts, 15 parts, Rhizoma Gastrodiae, Semen Cassiae 8 parts, Ganoderma 8 parts, Radix Scutellariae 8 parts, flower bulb paulownia 5 parts.
Embodiment 3:
One treats hypertensive Chinese medicinal granule, according to weight parts, is prepared by following raw material of Chinese medicine: Herba Taxilli 12 parts, Radix Puerariae 17 parts, Rhizoma Chuanxiong 9 parts, Flos Chrysanthemi Indici 12 parts, Fructus Crataegi 7 parts, Spica Prunellae 17 parts, Folium Apocyni Veneti 6 parts, Ramulus Uncariae Cum Uncis 12 parts, 12 parts, Rhizoma Gastrodiae, Semen Cassiae 7 parts, Ganoderma 7 parts, Radix Scutellariae 7 parts, flower bulb paulownia 4 parts.
Embodiment 4:
A kind of preparation method for the treatment of hypertensive Chinese medicinal granule, step is as follows: choose each component of medicine in the ratio of embodiment 1, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, and alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, filters after extracted twice liquid merges, be concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Embodiment 5:
A kind of preparation method for the treatment of hypertensive Chinese medicinal granule, step is as follows: choose each component of medicine in the ratio of embodiment 2, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, and alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, filters after extracted twice liquid merges, be concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Embodiment 6:
A kind of preparation method for the treatment of hypertensive Chinese medicinal granule, step is as follows: choose each component of medicine in the ratio of embodiment 3, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, and alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, filters after extracted twice liquid merges, be concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
To sum up:
Collect 150 routine outpatient service hyperpietics, man 75 example, female 75 example; Age 40-70 year, average 56 years old; The course of disease is the longest 2 years, the shortest 3 weeks, on average about 5 months.Be divided into matched group (unreal treat treatment), embodiment 1, embodiment 2, embodiment 3 at random, Western medicine (captopril) group, often organize 30 examples; Each group of patient age symptom is formed without significant difference; The granule that treatment group patient takes in embodiment 1 in the present invention, embodiment 2 and embodiment 3 is treated respectively, 2 times on the one, serve on 2 months.
Statistical result is as follows:
Result: effectively in 90 routine patients in the treatment group medicament group of embodiment 1,2,3 (adopt) account for 60 examples, accounts for 67%; Take a turn for the better 29 example, account for 32%, totally effective with transfer 98% to well.
As can be seen from the above table, pharmaceutical composition of the present invention can be used for effectively treating hypertension, and rebound rate is low.

Claims (3)

1. treat a hypertensive Chinese medicinal granule, it is characterized in that: according to weight parts, prepared by following raw material of Chinese medicine: Herba Taxilli 10-15 part, Radix Puerariae 15-20 part, Rhizoma Chuanxiong 8-10 part, Flos Chrysanthemi Indici 10-15 part, Fructus Crataegi 5-8 part, Spica Prunellae 15-20 part, Folium Apocyni Veneti 4-8 part, Ramulus Uncariae Cum Uncis 10-15 part, Rhizoma Gastrodiae 10-15 part, Semen Cassiae 5-8 part, Ganoderma 5-8 part, Radix Scutellariae 5-8 part, flower bulb paulownia 2-5 part.
2. one according to claim 1 treats hypertensive Chinese medicinal granule, it is characterized in that: according to weight parts, formulated by following raw material of Chinese medicine: Herba Taxilli 12 parts, Radix Puerariae 17 parts, Rhizoma Chuanxiong 9 parts, Flos Chrysanthemi Indici 12 parts, Fructus Crataegi 7 parts, Spica Prunellae 17 parts, Folium Apocyni Veneti 6 parts, Ramulus Uncariae Cum Uncis 12 parts, 12 parts, Rhizoma Gastrodiae, Semen Cassiae 7 parts, Ganoderma 7 parts, Radix Scutellariae 7 parts, flower bulb paulownia 4 parts.
3. the preparation method of the hypertensive Chinese medicinal granule for the treatment of according to claim 1, it is characterized in that step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, and alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, filters after extracted twice liquid merges, be concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
CN201410514789.2A 2014-09-29 2014-09-29 Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof Pending CN104324246A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410514789.2A CN104324246A (en) 2014-09-29 2014-09-29 Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410514789.2A CN104324246A (en) 2014-09-29 2014-09-29 Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof

Publications (1)

Publication Number Publication Date
CN104324246A true CN104324246A (en) 2015-02-04

Family

ID=52399136

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410514789.2A Pending CN104324246A (en) 2014-09-29 2014-09-29 Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof

Country Status (1)

Country Link
CN (1) CN104324246A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104840606A (en) * 2015-05-27 2015-08-19 大连大学 Antihypertensive traditional Chinese medicine composition and preparation method thereof
CN104998087A (en) * 2015-08-25 2015-10-28 崔新明 Traditional Chinese medicine composition for treating primary hypertension and preparing method of traditional Chinese medicine composition
CN105030968A (en) * 2015-07-05 2015-11-11 吴优 Liver-kidney yin deficiency hypertension treatment medicine and preparation method thereof
CN105124317A (en) * 2015-09-29 2015-12-09 峨眉山市全林农业科技有限公司 Mixed feed for preventing and curing laying hen contagious viral diseases
CN105169002A (en) * 2015-08-28 2015-12-23 覃伟 Traditional Chinese medicine formula for lowering blood pressure and preparation method of traditional Chinese medicine formula
CN105285479A (en) * 2015-12-03 2016-02-03 四川农业大学 Special feed formula for free-ranging chickens
CN105560911A (en) * 2016-01-04 2016-05-11 李林卿 Traditional Chinese medicine for treating hypertension and preparation method thereof
CN105613885A (en) * 2016-02-12 2016-06-01 王莹 Compound antihypertensive healthy tea containing Inonotuso bliquus (Fr ) Pilat and preparation method of compound antihypertensive healthy tea containing Inonotuso bliquus (Fr ) Pilat
CN106214985A (en) * 2016-08-16 2016-12-14 蒋安为 Traditional Chinese medicine for treating hypertension
CN106606614A (en) * 2017-01-17 2017-05-03 杨明祥 Traditional Chinese medicine oil for massage
CN107568605A (en) * 2017-10-30 2018-01-12 重庆井谷元食品科技有限公司 A kind of natto powder with treatment hypertension effect and preparation method thereof
CN107714954A (en) * 2017-11-03 2018-02-23 贺云清 A kind of Chinese medicine for treating hypertension
CN107714953A (en) * 2017-10-10 2018-02-23 季艮 A kind of Chinese medicine composition for reducing hypertension and preparation method thereof, application method
CN113209227A (en) * 2021-05-25 2021-08-06 高州市鑫达食品销售有限公司 Blood pressure reducing composition, tea bag and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102293947A (en) * 2011-09-28 2011-12-28 曹文真 Traditional Chinese medicine for treating hypertension
CN103316244A (en) * 2013-06-27 2013-09-25 罗寿山 Traditional Chinese medicine for treating hypertension

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102293947A (en) * 2011-09-28 2011-12-28 曹文真 Traditional Chinese medicine for treating hypertension
CN103316244A (en) * 2013-06-27 2013-09-25 罗寿山 Traditional Chinese medicine for treating hypertension

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104840606A (en) * 2015-05-27 2015-08-19 大连大学 Antihypertensive traditional Chinese medicine composition and preparation method thereof
CN105030968A (en) * 2015-07-05 2015-11-11 吴优 Liver-kidney yin deficiency hypertension treatment medicine and preparation method thereof
CN104998087A (en) * 2015-08-25 2015-10-28 崔新明 Traditional Chinese medicine composition for treating primary hypertension and preparing method of traditional Chinese medicine composition
CN105169002A (en) * 2015-08-28 2015-12-23 覃伟 Traditional Chinese medicine formula for lowering blood pressure and preparation method of traditional Chinese medicine formula
CN105124317A (en) * 2015-09-29 2015-12-09 峨眉山市全林农业科技有限公司 Mixed feed for preventing and curing laying hen contagious viral diseases
CN105285479A (en) * 2015-12-03 2016-02-03 四川农业大学 Special feed formula for free-ranging chickens
CN105560911A (en) * 2016-01-04 2016-05-11 李林卿 Traditional Chinese medicine for treating hypertension and preparation method thereof
CN105560911B (en) * 2016-01-04 2019-07-19 李丽娟 A kind of Chinese medicine and preparation method thereof for treating hypertension
CN105613885A (en) * 2016-02-12 2016-06-01 王莹 Compound antihypertensive healthy tea containing Inonotuso bliquus (Fr ) Pilat and preparation method of compound antihypertensive healthy tea containing Inonotuso bliquus (Fr ) Pilat
CN106214985A (en) * 2016-08-16 2016-12-14 蒋安为 Traditional Chinese medicine for treating hypertension
CN106606614A (en) * 2017-01-17 2017-05-03 杨明祥 Traditional Chinese medicine oil for massage
CN107714953A (en) * 2017-10-10 2018-02-23 季艮 A kind of Chinese medicine composition for reducing hypertension and preparation method thereof, application method
CN107568605A (en) * 2017-10-30 2018-01-12 重庆井谷元食品科技有限公司 A kind of natto powder with treatment hypertension effect and preparation method thereof
CN107714954A (en) * 2017-11-03 2018-02-23 贺云清 A kind of Chinese medicine for treating hypertension
CN113209227A (en) * 2021-05-25 2021-08-06 高州市鑫达食品销售有限公司 Blood pressure reducing composition, tea bag and preparation method thereof

Similar Documents

Publication Publication Date Title
CN104324246A (en) Preparation methods of traditional Chinese medicine for treating hypertension and granule thereof
CN101708315B (en) Chinese medicinal preparation for treating headache and preparation method thereof
CN104491579A (en) Traditional Chinese medicine with weight loss function
CN103623280B (en) A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease
CN104435225A (en) Traditional Chinese medicine for treating hypertension and preparation method of capsule thereof
CN103520670A (en) Traditional Chinese medicine composition for treating neonatal jaundice
CN106109521A (en) A kind of Radix Notoginseng oral liquid
CN101904939A (en) Chinese herb medicine for treating senile metrorrhagia
CN104288413A (en) Traditional Chinese medicine composition for treating infantile dysentery as well as preparation method and application thereof, and preparation comprising composition
CN103860773A (en) Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof
CN103479971A (en) Chinese medicine preparation for curing hyperactivity of liver-yang
CN104623615A (en) Medicine for treating asthma
CN104888093A (en) Infantile diarrhea treatment umbilical paste
CN104623410A (en) Traditional Chinese medicine for treating radiation pneumonitis
CN103520625A (en) Traditional Chinese medicine for treating liver-kidney disharmony type stuffiness and fullness
CN102670897A (en) Chinese herba preparation for treating bacterial dysentery
CN105998268A (en) Traditional Chinese medicine composition for relieving asthenopia and preparation method of traditional Chinese medicine composition
CN101496885B (en) Chinese herbal medicine preparation for treating tumor
CN105412830A (en) Medicine for treating acute icteric hepatitis and preparation method thereof
CN105853882A (en) Medicine for treating stomach illness and preparation method
CN105687779A (en) Cough and asthma relieving particle and preparation method thereof
CN103721154A (en) Traditional Chinese medicinal preparation for treating gastrointestinal diseases and preparation method of traditional Chinese medicinal preparation
CN105343785A (en) Traditional Chinese medicine pills for treating vertebrobasilar insufficiency (VBI) and preparation method thereof
CN104707003B (en) The Chinese medicinal capsule for the treatment of hypertension, hyperlipidemia
CN105055976A (en) Beverage for treating neuropathic headache

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150204