CN104435225A - Traditional Chinese medicine for treating hypertension and preparation method of capsule thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation and particularly relates to a traditional Chinese medicine for treating hypertension and a preparation method of a capsule thereof. The traditional Chinese medicine preparation is prepared from the following raw traditional Chinese medicinal materials in parts by weight: 10-15 parts of gynostemma pentaphylla, 15-20 parts of rhizoma alismatis, 8-10 parts of poria cocos, 15-20 parts of roots of kudzu vines, 8-10 parts of ligusticum wallichii, 5-8 parts of bighead atractylodes rhizome, 10-15 parts of mother chrysanthemum, 3-5 parts of oriental wormwood, 5-8 parts of hawthorn, 15-20 parts of selfheal, 3-5 parts of fresh gingers, 5-8 parts of purple perilla, 10-15 parts of eucommia ulmoides, 5-8 parts of semen cassia, 5-8 parts of lucid ganoderma and 5-8 parts of scutellaria baicalensis. The preparation method of the capsule comprises the following steps: weighing the raw medicinal materials in parts by weight, and adding water and decocting twice, wherein the amount of water added each time is 4 times of the raw medicinal materials, and decocting is performed for 2 hours for the first time and 1 hour for the second time; combining the filtrates, filtering, and drying to obtain fine powder; adding glucosum anhydricum powder into the fine powder and uniformly mixing; and putting the mixed powder into a capsule filler to fill to obtain the capsule which is 0.4-0.6g. The traditional Chinese medicine provided by the invention has the advantages of dredging blood and achieving a relaxation effect on symptoms such as headache and dizziness caused by hypertension.

Description

A kind of preparation method for the treatment of hypertensive Chinese medicine and capsule thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of preparation method for the treatment of hypertensive Chinese medicine and granule thereof.

Background technology

Hypertension is one of commonly encountered diseases of internal department, is based on the clinical syndrome of arteriotony rising.Along with the change of human life style and living environment, the ratio that hypertension accounts in total population is more and more higher, and Chinese Hypertensive Population is more than 1.6 hundred million.Authority's statistics hyperpietic over half dies from renal failure, heart failure, counts for much with western medicine of depressurization.Western medicine can make patient produce strong drug dependence.Blood pressure lowering on the surface, wrecks the heart, brain, kidney actually, but also dizziness can be brought, feel sick, nervous, the side effect such as asthma and edema, brings huge misery to patient.Just substantially death penalty has been sentenced once take depressor for those sleeps, the false hypertension caused of feeling bad.Depressor impels the health blood pressure regulating mechanisms of patient to tell degeneration, hypertension wants to request medicine will recover the function of human blood-pressure regulating system, blood pressure lowering can not be carried out by use Western medicine blindly, because allow you forever be unable to do without it once take, therefore, it is possible to develop, there is treatment high blood pressure disease, reduce incidence rate and mortality rate beyond cardiovascular and cerebrovascular vessel to greatest extent, and the Chinese medicine extending patient vitals is just significant.

Summary of the invention

According to above the deficiencies in the prior art, the invention provides a kind of preparation method for the treatment of hypertensive Chinese medicine and granule thereof, can vessel softening, dredging blood circulation and blood pressure lowering.

One of the present invention treats hypertensive Chinese medicine preparation, according to weight parts, is prepared by following raw material of Chinese medicine: Herba Taxilli 10-15 part, Radix Puerariae 15-20 part, Rhizoma Chuanxiong 8-10 part, Flos Chrysanthemi Indici 10-15 part, Fructus Crataegi 5-8 part, Spica Prunellae 15-20 part, Folium Perillae 5-8 part, Ramulus Uncariae Cum Uncis 10-15 part, Cortex Eucommiae 10-15 part, Semen Cassiae 5-8 part, Ganoderma 5-8 part, Radix Scutellariae 5-8 part, Herb Gynostemmae Pentaphylli 10-15 part.

One treats hypertensive Chinese medicine preparation, according to weight parts, preferably formulated by following raw material of Chinese medicine: Herba Taxilli 12 parts, Radix Puerariae 17 parts, Rhizoma Chuanxiong 9 parts, Flos Chrysanthemi Indici 12 parts, Fructus Crataegi 7 parts, Spica Prunellae 17 parts, Folium Perillae 6 parts, Ramulus Uncariae Cum Uncis 12 parts, the Cortex Eucommiae 12 parts, Semen Cassiae 7 parts, Ganoderma 7 parts, Radix Scutellariae 7 parts, Herb Gynostemmae Pentaphylli 12 parts.

Treat a preparation method for hypertensive Chinese medicinal capsule, comprise the following steps:

1) decoct with water twice by above-mentioned weight ratio weighting raw materials, add 4 times of water gagings at every turn, first time decocts 2 hours, and second time decocts 1 hour, and merging filtrate, after filtration, is dried to fine powder;

2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;

3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, namely obtain the capsule of every 0.4-0.6 gram.

Pharmacology analysis:

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature.Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.

Rhizoma Alismatis: diuretic, eliminating dampness by diuresis, expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.

Poria: there is antioxidation, anti-aging, increase immunity, improve the effect of brain cell activity.Poria has stronger diuresis, can treat nephritis, heart failure edema.Also have sedation in addition, effective to neurasthenia.Lightly seasoned property is put down, kind benefiting QI and nourishing blood, and mind tranquilizing and the heart calming, relieves internal heat anticancer; Mild in medicine property and, dampness removing and do not hinder healthy energy, contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.; Can be relaxed gastrointestinal smooth muscle, the effects such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial;

Radix Puerariae: Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Induce sweat and bring down a fever, promote the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, to have loose bowels.

Rhizoma Chuanxiong: property and flavor of peppery and warm, can expelling wind and activating blood circulation pain relieving, is mainly applicable to the diseases such as the dysmenorrhea of head-body-pain and stagnation of QI and blood, amenorrhea and postpartum stagnation stomachache, and this is one of common Chinese hypotensor material.

The Rhizoma Atractylodis Macrocephalae: sweetness and bitterness is warm in nature, main returns taste warp, and with spleen invigorating, dampness for Main Function, what praised by forefathers is " spleen air making-up and spleen enlivening first key medicine ".The spleen has the function to transport and transform nutrients because of deficiency of spleen-QI, and transporting is lost strong, often water wet in raw, cause lack of appetite, loose stool or have loose bowels, all cards of phlegm retention, edema, leukorrhagia.

Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent, heat-clearing and toxic substances removing, the effect of reducing blood pressure, Hypertension, can single decoction, also can with Spica Prunellae, the same use of Semen Cassiae, function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.

Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly the pharmaceutical researches such as jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis and have function of gallbladder promoting, the effects such as liver function protecting is antipyretic, antiinflammatory, blood fat reducing, coronary dilating.

Fructus Crataegi: be longer than dissipating fluid-retention food, strengthening the spleen and stomach, row stagnation of QI, repercussive blood.Dredging, vessel softening, reduce blood pressure and cholesterol, increase coronary flow, improve the effects such as heart vigor, heart tonifying; Effectively can prevent and treat atherosclerosis, angiocardiopathy preventing.

Spica Prunellae: cold in nature, sweet in the mouth, pungent, micro-hardship, have the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, clearing away liver-fire, Disperse hepatic depression, be usually used in Hypertension and have the liver-heat patients such as headache, dizzy, tinnitus, dysphoria with smothery sensation, insomnia, Spica Prunellae has the effect reduced blood pressure, and energy blood vessel dilating, contained by it, rutin has antiinflammatory action, and can reduce vascular permeability, reduces fragility, reduce liver fat, Spica Prunellae also has the effect of resisting cancerous cell.

Rhizoma Zingiberis Recens: pungent, tepor, returns lung taste through relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, separates poison of drug.

Folium Perillae: pungent, temperature.Return lung, spleen channel.Relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.

The Cortex Eucommiae: pungent, flat, nontoxic, regulate the flow of vital energy and enrich blood.Blood pressure lowering, invigorating the liver and kidney, bone and muscle strengthening, antiabortive gas.Be applicable to: caused by liver and kidney deficiency: card is shown in that dizzy, soreness of waist and knee joint, muscles and bones flaccidity are weak etc.Be more common in hypertension, vertigo, apoplexy sequela, chronic renal disease, poliomyelitis etc.Instability of kidney QI: card is shown in frequent micturition or dripping urination, uncontrolled urination is itched, sexual impotence, anemia of pregnant woman are weak, frequent fetal movement or waist pendant pain etc.Be more common in chronic prostatosis, sexual dysfunction, infertility, threatened abortion or habitual abortion etc.; Caused by liver and kidney deficiency sign person is there is for diseases such as chronic joint diseases, bone tuberculosis, dysmenorrhea, dysfunctional uterine bleeding, chronic pelvic inflammatory diseases.

Semen Cassiae: help irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple control headache, paste again the brain heart and stop epistaxis; Make pillow victory Semen sojae atricolor, control wind syndrome of head, improving eyesight, reducing blood pressure and blood fat, reduce cholesterol, liver heat removing and eyesight improving, diuretic relieving constipation, except effects such as constipation.Through medical research display, there is good curative effect to treatment hypertension, coronary heart disease, and can also the liver protecting, improve the immunity of human body.

Ganoderma: GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.As the Chinese tradition valuable ingredient of Chinese medicine having thousands of years medicinal histories, possesses very high medical value, modern pharmacology research through scientific research institution's many decades confirms, Ganoderma is for enhancing body immunity, regulate blood glucose, control blood pressure, adjuvant therapy chemicotherapy, hepatoprotective, the aspects such as hypnotic all have significant curative effect.

Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Wherein, function of the present invention is following 3 points:

1, blood pressure lowering, blood fat reducing, complication prevention: hypertension, hyperlipidemia all belong to metabolism syndrome.Hypertension shows human vas, and hyperlipidemia shows systemic blood.The two does not fall for a long time, all can impel into atherosclerotic formation, causes complication.Blood pressure, blood fat are steady, could prevent " two is high " complication.

2, steady blood pressure lowering: hypertension is embodied in that blood vessel die back, blood vessel are stiff, blood vessel blockage, and arteriole pressure enhancing etc. causes blood pressure to raise.The draft Chinese medicine such as Rhizoma Chuanxiong, Flos Chrysanthemi Indici, Fructus Crataegi, can have an impact to blood vessel, and prevent blood vessel die back, softening, dredging vascellum, reduce small artery resistance, prevention of arterial is atherosis, and long-term drink can realize steady blood pressure lowering.

3, safe blood fat reducing: abnormalities of sugar/lipid metabolism, causes human body lipid to exceed normal value.Main manifestations is that triglyceride and serum cholesterol are higher, the lipidosis in blood, and hyperlipidemia, easily forms atherosclerosis, causes complication.Fructus Crataegi in the present invention can absorb cholesterol, and Flos Chrysanthemi Indici can promote lipid metabolism, dissolving, can increase glomerular filtration, and promote sugar metabolism in body, Semen Cassiae can reduce cholesterol and blood pressure, and Folium Pini can be invigorated blood circulation, and improves hyperlipidemia.Long-term drink medicinal liquid of the present invention, can purify the blood, and recovers the oxygen supply of the organs such as heart and brain kidney, blood supply, recovers Human Lipid Metabolism, is controlled within normal value by blood fat.

4, adjust internal organs, urge metabolism, giving consideration to both the incidental and fundamental gets rid of illness root: the traditional Chinese medical science thinks that hypertension, hyperlipidemia are not only sick at blood vessel, blood, also impaired in close relations with the internal organs of human body.Hypertension, hyperlipidemia, to the injury of internal organs, can cause that Liver and kidney two is empty, phlegm-damp is obstructed, taste are impaired, blood stasis due to qi deficiency etc.And impaired blood pressure, the blood fat of can causing of internal organs raises.As the synthesis of body's cholesterol, 70% by liver synthesis, conversion, decomposition, metabolism, and liver damage can cause body's cholesterol higher, easily forms hyperlipidemia.

To sum up: long-term drink medicament of the present invention, while reducing blood pressure and blood fat, can the vital organs of the human body be nursed one's health, recover lipid metabolism, steady blood fat.Flos Chrysanthemi Indici can nurse one's health liver, has the effect of liver heat removing and eyesight improving, the liver benefiting nourishing YIN; Radix Puerariae can strengthening spleen, tonifying kidney, boosting qi and nourishing yin; Folium Stevlae Rebaudianae clearing away lung-heat, strengthening the spleen and stomach; Fructus Crataegi energy blood circulation promoting and blood stasis dispelling, treatment abdominal pain diarrhea etc.Medicament of the present invention is nursed one's health comprehensively, recovers body fat metabolism and Liver and kidney metabolism, steady blood pressure blood fat, eliminates future trouble and to get rid of illness root.

The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable, by vessel softening, dredging blood circulates and blood pressure lowering, has good remission effect to the symptom such as headache, dizziness, cerebral infarction, limbs fatigue that hypertension causes simultaneously.

Efficacy evaluation:

Cure: systolic pressure≤18.7kPa (140mmHg) and diastolic pressure≤12.0kPa (90mmHg).

Effective: systolic pressure >=18.7kPa (140mmHg) and (or) diastolic pressure >=12.0kPa (90mmHg), but blood pressure decreases.

Invalid: blood pressure is unchanged, other severity of symptoms.

Below enumerate several model case:

Case 1:

Huang, female, 64 years old, suffers from hypertension and sciatica, repeatedly fails to respond to any medical treatment through hospital, takes the present invention and cures for 45 days, hypertension and sciatica symptom completely without, within 2 years, have no recurrence.

Case 2:

High so-and-so, man, 45 years old, suffer from hypertension and scapulohumeral periarthritis 3 years, repeatedly fail to respond to any medical treatment through hospital, the medicinal liquid taking embodiment 2 was cured for 60 days, hypertension and symptoms of shoulder periarthritis completely without, within 2 years, have no recurrence.。

Case 3:

Wang, man, 50 years old, suffers from hypertension and scapulohumeral periarthritis 3 years, repeatedly fails to respond to any medical treatment through hospital, and the medicinal liquid taking embodiment 3 is cured for 50 days, hypertension and symptoms of shoulder periarthritis completely without, within 3 years, have no recurrence.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described, but the present invention is not limited to specific embodiment.

Embodiment 1:

One treats hypertensive Chinese medicine preparation, according to weight parts, is prepared by following raw material of Chinese medicine: Herb Gynostemmae Pentaphylli 10 parts, Rhizoma Alismatis 20 parts, 8 parts, Poria, Radix Puerariae 20 parts, Rhizoma Chuanxiong 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Flos Chrysanthemi Indici 10 parts, Herba Artemisiae Scopariae 5 parts, Fructus Crataegi 5 parts, Spica Prunellae 20 parts, 3 parts, Rhizoma Zingiberis Recens, Folium Perillae 5 parts, the Cortex Eucommiae 10 parts, Semen Cassiae 8 parts, Ganoderma 5 parts, Radix Scutellariae 8 parts.

Embodiment 2:

One treats hypertensive Chinese medicine preparation, according to weight parts, is prepared by following raw material of Chinese medicine: Herb Gynostemmae Pentaphylli 15 parts, Rhizoma Alismatis 15 parts, 10 parts, Poria, Radix Puerariae 15 parts, Rhizoma Chuanxiong 10 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Flos Chrysanthemi Indici 15 parts, Herba Artemisiae Scopariae 3 parts, Fructus Crataegi 8 parts, Spica Prunellae 15 parts, 5 parts, Rhizoma Zingiberis Recens, Folium Perillae 5 parts, the Cortex Eucommiae 15 parts, Semen Cassiae 5 parts, Ganoderma 8 parts, Radix Scutellariae 5 parts.

Embodiment 3:

One treats hypertensive Chinese medicine preparation, according to weight parts, is prepared by following raw material of Chinese medicine: Herb Gynostemmae Pentaphylli 12 parts, Rhizoma Alismatis 17 parts, 9 parts, Poria, Radix Puerariae 17 parts, Rhizoma Chuanxiong 9 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Flos Chrysanthemi Indici 12 parts, Herba Artemisiae Scopariae 4 parts, Fructus Crataegi 7 parts, Spica Prunellae 17 parts, Semen Plantaginis 7 parts, Folium Perillae 7 parts, Ramulus Uncariae Cum Uncis 13 parts, the Cortex Eucommiae 12 parts, Semen Cassiae 7 parts, Ganoderma 7 parts, Radix Scutellariae 7 parts, 7 parts, Rhizoma Zingiberis Recens.

Embodiment 4:

Treat a preparation method for hypertensive Chinese medicinal capsule, comprise the following steps:

1) decoct with water twice by the weight ratio weighting raw materials of embodiment 1, add 4 times of water gagings at every turn, first time decocts 2 hours, and second time decocts 1 hour, and merging filtrate, after filtration, is dried to fine powder;

2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;

3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, namely obtain the capsule of 0.4 gram every.

Embodiment 5:

Treat a preparation method for hypertensive Chinese medicinal capsule, comprise the following steps:

1) decoct with water twice by the weight ratio weighting raw materials of embodiment 2, add 4 times of water gagings at every turn, first time decocts 2 hours, and second time decocts 1 hour, and merging filtrate, after filtration, is dried to fine powder;

2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;

3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, namely obtain the capsule of 0.6 gram every.

Embodiment 6:

Treat a preparation method for hypertensive Chinese medicinal capsule, comprise the following steps:

1) decoct with water twice by the weight ratio weighting raw materials of embodiment 3, add 4 times of water gagings at every turn, first time decocts 2 hours, and second time decocts 1 hour, and merging filtrate, after filtration, is dried to fine powder;

2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;

3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, namely obtain the capsule of 0.5 gram every.

To sum up:

Collect 120 routine outpatient service hyperpietics, man 60 example, female 60 example; Age 40-70 year, average 56 years old; The course of disease is the longest 2 years, the shortest 3 weeks, on average about 5 months.Be divided into embodiment 1, embodiment 2, embodiment 3 at random, Western medicine (captopril) group, often organize 30 examples; Each group of patient age symptom is formed without significant difference; The preparation that treatment group patient takes in embodiment 1 in the present invention, embodiment 2 and embodiment 3 is treated respectively, 2 times on the one, serve on 2 months.

Statistical result is as follows:

Result: effectively in 90 routine patients in the treatment group medicament group of embodiment 1,2,3 (adopt) account for 61 examples, accounts for 68%; Take a turn for the better 28 example, account for 31%, totally effective with transfer 99% to well.

As can be seen from the above table, pharmaceutical composition of the present invention can be used for effectively treating hypertension, and rebound rate is low.

Claims (3)

1. treat a hypertensive Chinese medicine preparation, it is characterized in that: according to weight parts, prepared by following raw material of Chinese medicine: Herb Gynostemmae Pentaphylli 10-15 part, Rhizoma Alismatis 15-20 part, Poria 8-10 part, Radix Puerariae 15-20 part, Rhizoma Chuanxiong 8-10 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Flos Chrysanthemi Indici 10-15 part, Herba Artemisiae Scopariae 3-5 part, Fructus Crataegi 5-8 part, Spica Prunellae 15-20 part, Rhizoma Zingiberis Recens 3-5 part, Folium Perillae 5-8 part, Cortex Eucommiae 10-15 part, Semen Cassiae 5-8 part, Ganoderma 5-8 part, Radix Scutellariae 5-8 part.

2. one according to claim 1 treats hypertensive Chinese medicine preparation, it is characterized in that: according to weight parts, formulated by following raw material of Chinese medicine: Herb Gynostemmae Pentaphylli 12 parts, Rhizoma Alismatis 17 parts, 9 parts, Poria, Radix Puerariae 17 parts, Rhizoma Chuanxiong 9 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Flos Chrysanthemi Indici 12 parts, Herba Artemisiae Scopariae 4 parts, Fructus Crataegi 7 parts, Spica Prunellae 17 parts, Semen Plantaginis 7 parts, Folium Perillae 7 parts, Ramulus Uncariae Cum Uncis 13 parts, the Cortex Eucommiae 12 parts, Semen Cassiae 7 parts, Ganoderma 7 parts, Radix Scutellariae 7 parts, 7 parts, Rhizoma Zingiberis Recens.

3. a preparation method for the hypertensive Chinese medicinal capsule for the treatment of according to claim 1, is characterized in that comprising the following steps:

1) decoct with water twice by above-mentioned weight ratio weighting raw materials, add 4 times of water gagings at every turn, first time decocts 2 hours, and second time decocts 1 hour, and merging filtrate, after filtration, is dried to fine powder;

2) by step 1) in fine powder add anhydrous grape Icing Sugar mix homogeneously;

3) above-mentioned mixed-powder is put into capsule filling machine and carry out filling, namely obtain the capsule of every 0.4-0.6 gram.