CN104324140A - 一种治疗家畜咳嗽气喘的喷雾剂 - Google Patents

一种治疗家畜咳嗽气喘的喷雾剂 Download PDF

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CN104324140A
CN104324140A CN201410606511.8A CN201410606511A CN104324140A CN 104324140 A CN104324140 A CN 104324140A CN 201410606511 A CN201410606511 A CN 201410606511A CN 104324140 A CN104324140 A CN 104324140A
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唐建华
龚聪
袁启峰
毕海林
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CHONGQING FANGTONG ANIMAL PHARMACEUTICAL Co Ltd
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Abstract

本发明公开了一种治疗家畜咳嗽气喘的喷雾剂，由如下重量份的组分配制而成：洋金花20-30份，牛黄10-15份，薄荷10-15份，穿心莲10-15份，黄芪5-10份，桂枝5-10份，白芍5-10份，白芍5-10份、防己5-10份、麻黄1-5份，苦杏仁1-5份。本发明的喷雾剂使用方便，增强了家畜用药的顺应性，无任何毒副作用，见效快，治疗效果好，成本低廉，适合工业应用。

Description

一种治疗家畜咳嗽气喘的喷雾剂
技术领域
本发明涉及兽药领域，尤其涉及一种治疗家畜呼吸道感染，具有平喘、止咳功能的喷雾剂。
背景技术
近年来呼吸道疾病已成为家畜养殖场最常见、危害最严重的疾病之一。这些疾病主要有：猪喘气病、传染性胸膜肺炎、猪副嗜血杆菌病、萎缩性鼻炎、猪肺疫、呼吸道综合症、链球菌病、大肠杆菌感染。家畜呼吸道感染常常是由病毒性、细菌性或真菌性病因引起的，常见的支原体和大肠杆菌混合感染、大肠杆+菌和巴氏杆菌或传染性支气管炎或传染性囊病病毒混合感染。这种混合感染的有害影响常较单一感染更严重，在家畜饲养过程中，管理因素：例如，通风、湿度、尘埃、或氨气浓度过高，均对呼吸道疾病的发生具有重大影响。目前治疗家畜咳嗽气喘病的药物主要是化学合成药品，但这类药物的长期、普遍使用，机体易产生耐药性而使疗效降低，并且存在化学药物的致残致畸缺陷。所以广大养殖户不得不把目光转向中草药，以求得疗效好、见效快的中药组方。目前我国的中兽药还处于药物配伍缺少系统研究、产品剂型粗糙、有效成分不明确、产品质量不稳定的低水平状态。应用于家畜平喘、止咳用的金花平喘散为由原料药洋金花、麻黄、苦杏仁、石膏、明矾粗粉碎后制成的散剂，存在剂量大、剂型粗、外观差，有效成分不能充分释放，生物利用率低等不足，严重影响了中药质量和治疗效果。为了克服这些不足，发展绿色家畜养殖业，不仅是提高家畜养殖产品市场竞争力的迫切需要，而且也是新世纪家畜养殖业的发展方向。
发明内容
为了克服上述技术问题，本发明的目的在于提供一种治疗家畜咳嗽气喘的喷雾剂，由如下重量份的组分配制而成：洋金花20-30份，牛黄10-15份，薄荷10-15份，穿心莲10-15份，黄芪5-10份，桂枝5-10份，白芍5-10份，白芍5-10份、防己5-10份、麻黄1-5份，苦杏仁1-5份。
作为优选，本发明的喷雾剂由如下重量份的组分配制而成：洋金花20份，牛黄10份，薄荷10份，穿心莲10份，黄芪8份，桂枝6份，白芍6份、防己8份、麻黄4份，苦杏仁4份。
作为优选方案，本发明的喷雾剂还可以包括药学可接受的载体和/或助剂。
本发明还提供一种治疗家畜咳嗽气喘的喷雾剂的制备方法，包括如下步骤：1)将洋金花，穿心莲，黄芪，白芍，防己于水中浸泡过夜；煎煮2小时，浓缩得浸膏；2)将薄荷，桂枝，麻黄，苦杏仁粉碎，加入70％的乙醇溶液，超声10分钟；转移至提取器中加热回流2小时，提取液浓缩的浸膏；3)合并步骤1)，2)所得浸膏，加入牛黄粉末混合均匀；4)加入15％的乙醇溶液，搅拌2h，离心，过滤，滤液灌装制成喷雾剂。
具体实施方式
为了进一步理解本发明，下面结合实施例对本发明优选实施方案进行描述，但是应当理解，这些描述只是为进一步说明本发明的特征和优点，而不是对本发明权利要求的限制。
实施例1
将洋金花200g，穿心莲100g，黄芪80g，白芍60g，防己80g于2000ml水中浸泡过夜；煎煮2小时，减压浓缩得浸膏；将薄荷100g，桂枝60g，麻黄40g，苦杏仁40g粉碎，加入70％的乙醇溶液，超声10分钟；转移至提取器中加热回流2小时，提取液浓缩的浸膏；合并所得浸膏，加入牛黄粉末100g混合均匀；4加入15％的乙醇溶液，搅拌2h，离心，过滤，滤液灌装制成喷雾剂。
实施例2
将洋金花250g，穿心莲120g，黄芪50g，白芍60g，防己80g于2000m l水中浸泡过夜；煎煮2小时，减压浓缩得浸膏；将薄荷100g，桂枝60g，麻黄40g，苦杏仁40g粉碎，加入70％的乙醇溶液，超声10分钟；转移至提取器中加热回流2小时，提取液浓缩的浸膏；合并所得浸膏，加入牛黄粉末100g混合均匀；4加入15％的乙醇溶液，搅拌2h，离心，过滤，滤液灌装制成喷雾剂。
治疗试验
个体养殖户自然发病的荣昌仔猪285头，症状表现为精神沉郁、头下垂,站立一隅或犬状坐式呼吸，气喘、咳嗽，呼吸次数剧增,主要为呈腹式呼吸，严重时出现痉挛性咳嗽甚至呕吐。病猪精神沉郁，不愿走动，食欲减少，身体消瘦，皮毛粗乱，喜卧怕冷，体温及食欲变化不大而生长发育迟缓。剖检可见肺有不同程度的水肿和气肿，两肺的尖叶和心叶呈对称性、融合性支气管肺炎病变。在病猪肺部的尖叶、心叶、中间叶和膈叶的前缘呈肉样或虾肉样实变。肺门和纵膈淋巴结明显肿大、质硬、灰白色、切面多汁，其他内脏一般无明显变化。通过临床症状、血清学诊断、剖检症状、X光透视片检等诊断方法确诊为猪气喘病阳性。每日向猪圈喷药水10次，每次10分钟。
使用效果：病猪咳嗽、呼吸困难的症状逐渐减轻，精神好转，采食、采水也逐渐恢复正常，食欲明显增加，用药5d后，除病重死亡的12头外，其余患病猪只基本治愈，治愈率达95.8％，体重增长率也逐渐回升。
上述实施例仅例示性说明本发明的原理及其功效，而非用于限制本发明。任何熟悉此技术的人士皆可在不违背本发明的精神及范畴下，对上述实施例进行修饰或改变。因此，举凡所属技术领域中具有通常知识者在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变，仍应由本发明的权利要求所涵盖。

Claims (4)

1.一种治疗家畜咳嗽气喘的喷雾剂，其特征在于：由如下重量份的组分配制而成：洋金花20-30份，牛黄10-15份，薄荷10-15份，穿心莲10-15份，黄芪5-10份，桂枝5-10份，白芍5-10份，白芍5-10份、防己5-10份、麻黄1-5份，苦杏仁1-5份。
2.如权利要求1所述治疗家畜咳嗽气喘的喷雾剂，其特征在于：由如下重量份的组分配制而成：洋金花20份，牛黄10份，薄荷10份，穿心莲10份，黄芪8份，桂枝6份，白芍6份、防己8份、麻黄4份，苦杏仁4份。
3.如权利要求1或2所述治疗家畜咳嗽气喘的喷雾剂，其特征在于：还可以包括药学可接受的载体和/或助剂。
4.如权利要求1所述治疗家畜咳嗽气喘的喷雾剂的制备方法，包括如下步骤：1)将洋金花，穿心莲，黄芪，白芍，防己于水中浸泡过夜；煎煮2小时，浓缩得浸膏；2)将薄荷，桂枝，麻黄，苦杏仁粉碎，加入70％的乙醇溶液，超声10分钟；转移至提取器中加热回流2小时，提取液浓缩的浸膏；3)合并步骤1)，2)所得浸膏，加入牛黄粉末混合均匀；4)加入15％的乙醇溶液，搅拌2h，离心，过滤，滤液灌装制成喷雾剂。
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN106729546A (zh) * 2016-12-26 2017-05-31 中悦民安（北京）科技发展有限公司 一种防治畜禽咳喘的药物组合物及其制备工艺
CN106729545A (zh) * 2016-12-26 2017-05-31 中悦民安（北京）科技发展有限公司 一种用于治疗动物咳嗽的中药组合物及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729546A (zh) * 2016-12-26 2017-05-31 中悦民安（北京）科技发展有限公司 一种防治畜禽咳喘的药物组合物及其制备工艺
CN106729545A (zh) * 2016-12-26 2017-05-31 中悦民安（北京）科技发展有限公司 一种用于治疗动物咳嗽的中药组合物及其制备方法

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