CN104324080A - Injection for treating upper respiratory infection and preparation method of injection - Google Patents
Injection for treating upper respiratory infection and preparation method of injection Download PDFInfo
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Abstract
The invention discloses an injection for treating upper respiratory infection and a preparation method of the injection. The injection is prepared from the following major raw materials in parts by weight: 0.4-1.2 parts of fructus forsythiae, 0.8-1.6 parts of isatis root, 0.3-0.6 part of gypsum, 0.6-1.0 part of entireleaf neoalsomitra and 0.6-1.5 parts of eclipta alba. The injection for treating the upper respiratory infection is remarkable in curative effect and quick in effect taking, and does not cause drug resistance, and is clinically proved to have repeatability.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of injection for the treatment of upper respiratory tract infection and preparation method thereof.
Background technology
Upper respiratory tract infection refers to the acutely inflamed general name between nasal cavity to throat, is modal infectious disease.These disease four seasons, any age all can fall ill, and by containing the virulent spittle, droplet, or the apparatus through polluting is propagated.Normal when Abwehrkraft des Koepers reduces, as caught cold, tired, the situation such as to drench with rain, the former virus existed or invaded by the external world is or/and antibacterial, and ramp is bred, and causes infection.Chang Jifa bronchitis, pneumonia, nasal sinusitis, a few peoples can complicated with acute myocarditis, nephritis, rheumatic fever etc.Upper respiratory tract infection clinical manifestation can be divided into Types Below: one, common cold.For viral infection causes, be commonly called as " cold ".Onset is comparatively anxious, and main manifestations is sniffle, as sneeze, nasal obstruction, stream clear water sample nasal mucus, also can show as cough, dry pharynx, itching throat or burn feeling even Postnasal drip sense.Two, acute viral pharyngitis and laryngitis.Caused by rhinovirus, adenovirus, influenza virus, parainfluenza virus and enterovirus, respiratory syncytial virus etc.Clinical manifestation is itching throat and burning sensation, and pharyngalgia is not obvious.Cough rare.Acute laryngitis mostly is influenza virus, parainfluenza virus and adenovirus etc. and causes, and clinical manifestation is obvious hoarseness, difficulty speaking, can have heating, pharyngalgia or cough, has sore throat and increase the weight of during cough.Three, acute herpetic angina.How to be caused by CA, show as obvious pharyngalgia, heating.Be mainly in summer, be more common in child, occasionally in adult.Four, acute pharyngo conjunctivitis.Cause primarily of adenovirus, Coxsackie virus etc.Show as heating, pharyngalgia, photophobia, shed tears, swallow and conjunctiva obviously congested.Five, acute pharyngoamygdalitis.Pathogen mostly is Hemolytic streptococcus, is secondly hemophilus influenza, streptococcus pneumoniae, staphylococcus etc.Onset is anxious, and pharyngalgia is obvious, the heat that occurs together, fear of cold, and body temperature can reach more than 39 DEG C.Have a medical check-up and can find pharyngeal obvious hyperemia, antiadoncus, hyperemia, there is yellow purulent secretion on surface.Sometimes with neck submental lymph nodes enlargement, tenderness, and pulmonary haves a medical check-up absence of signs.Six, complication.Small number of patients can complicated with acute sinusitis, otitis media, tracheitis and bronchitis.Take pharyngitis as the upper respiratory tract infection of performance, some patients can secondary the Hemolytic streptococcus rheumatic fever, glomerulonephritis etc. that cause, and small number of patients can intercurrent disease viral myocarditis, should watch out for.Part youngster, owing to there occurs viral myocarditis, causes sudden death, significant.If upper susceptible people occurs that chest is stuffy and should pay close attention to, can not adopt a casual attitude.
The treatment of upper respiratory tract infection: 1. conventional symptomatic treatment medicine.(1) ipratropium bromide ipratropium bromide spray: placebo-controlled trial proves that to alleviation watery nasal discharge, sneeze effectively particularly the course of disease is brought into use for early stage 1st day.Main adverse reaction is be with the blood streak in 15% ~ 20% patient's mucus tears.(2) pseudoephedrine: act on respiratory mucosa alpha-adrenergic receptor, alleviates nasal mucosa congested, to heart and other peripheral blood vessel alpha-receptor effects very micro-.Alleviate nasal obstruction, can improving water flood.Unsuitable prolonged application, is limited for 3 ~ 5 days.(3) antihistaminic: first generation antihistamine drug as chlorphenamine maleate chlorphenamine to minimizing sneeze and rhinorrhea effective, old people has prostate hyperplasia, and person is cautious use of.The antihistaminic of non-sedating effect lacks anticholinergic effect, and effect is not affirmed.(4) antipyretic-antalgic agent: can select in heating and muscular soreness, headache.The most frequently used with acetaminophen acetaminophen.Should avoid that the neat husband with inverase is many fixed to be used simultaneously.Aspirin is applied repeatedly can increase virus output, and it is slight to improve symptom effect, will not recommend.(5) anti-tussive agents: for application is not generally advocated in protection coughre flex, but play is coughed when affecting rest and can be applied as one sees fit, more with dextromethorphan application.2. antiviral treatment: ribavirin virazole has certain inhibitory action to influenza and parainfluenza virus, respiratory syncytial virus, when clinical practice is only limitted to child's lower respiratory infection respiratory syncytial virus.Effective antiviral drugs be there is no at present to rhinovirus and other Respiroviruses.3. antibiotic application.Generally should, not need to apply antibiotic yet.The research of a placebo is presented at nose larynx flushing thing and cultivates the improvement that the subgroup having streptococcus pneumoniae, hemophilus influenza or moraxelle catarrhalis to grow accounts for 20% antibiotic therapy display symptom score.Therefore having bacteria planting, in respiratory secretions, granulocyte increases, and occurs the complication such as sinusitis, otitis media, and the patient that the underlying diseases such as chronic obstructive pulmonary disease COPD and the flu course of disease surpass 1 week suitably can apply antibiotic.4. treatment by Chinese herbs.Treatment by Chinese herbs common cold is effective.With clear temperature electuary.Often wrap 15 grams.Take after mixing it with water every day 4 key agents of each half bag have Folium Isatidis, Folium Mori, Rhizoma Phragmitis and Gypsum Fibrosum etc.
Publication number 1907306A(application number 200610111666.X) Chinese patent literature disclose a kind of injection for the treatment of upper respiratory tract infection and preparation method thereof.The preparation method of this injection is for extract Ramulus Et Folium Picrasmae medical material alcohol heating reflux, and merge extractive liquid, reclaims ethanol, be condensed into thick paste, then add ethanol and make dissolving, filters, merging filtrate, extracts feature alkali, and is condensed into thick paste, obtain preparation intermediate; Use this intermediate, routinely preparation process, customary adjuvant, makes required injection in addition.The Chinese patent literature of publication No. CN 102319295 A (application number 201110284877.4) discloses a kind of medicament for the treatment of upper respiratory tract infection, and it is made up by weight of following bulk drugs: Herba Inulae cappae, Herba Pteridis Multifidae, Fructus Forsythiae, Radix et Rhizoma Dysosmatis, Radix Glycyrrhizae, Radix Sophorae Tonkinensis and Radix Isatidis.Application publication number CN 103721090 A(application number 201210387474.7) Chinese patent literature disclose a kind of Chinese medicine composition being used for the treatment of upper respiratory tract infection, it is made up of the raw material of following parts by weight: Radix Bupleuri 30-35, Radix Puerariae 10-12, Gypsum Fibrosum 5-10, Radix Isatidis 20-25, Radix Scrophulariae 10-15, Rhizoma Osmundae 20-30, Stigma Maydis 20-35, Rhizoma Imperatae 30-45.
At present, doctor trained in Western medicine mainly adopts symptomatic treatment, there is no specific drug so far, and on the high side, and curative effect can not be entirely satisfactory.Life-time service antibiotic can reduce Abwehrkraft des Koepers, causes bacterial resistance, the normal flora of human body is lacked of proper care, can cause secondary infection on the contrary.Traditional herbal mixture compatibility is suitable, can reach the effect for the treatment of both the principal and secondary aspects of a disease.But people often only focus on the research of curative effect, again in addition with empirical be many, and the research of card effect and dose-effect relationship aspect is less, therefore repeatability is poor, and clinical expansion is restricted.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of injection for the treatment of upper respiratory tract infection and preparation method thereof.This injection is evident in efficacy, instant effect, can not produce drug resistance, through clinical verification, has repeatability.
Technical scheme of the present invention is:
The injection for the treatment of upper respiratory tract infection, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 0.4-1.2, Radix Isatidis 0.8-1.6, Gypsum Fibrosum 0.3-0.6, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.6-1.0, Herba Ecliptae 0.6-1.5.
The injection for the treatment of upper respiratory tract infection, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 0.6-1.0, Radix Isatidis 1.0-1.3, Gypsum Fibrosum 0.35-0.52, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.7-0.9, Herba Ecliptae 0.8-1.2.
The injection for the treatment of upper respiratory tract infection, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 0.8, Radix Isatidis 1.1, Gypsum Fibrosum 0.42, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.8, Herba Ecliptae 1.1.
The preparation method of the injection for the treatment of upper respiratory tract infection is:
(1) each crude drug is decocted with water three times, amount of water is 7.5-11 times of medical material gross weight, and first time decocts 35-70 minute, and second time decocts 25-60 minute, decocts 20-50 minute for the third time, merges three decocting liquids, filters, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 8-16 hour, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 65-85 DEG C of heated and stirred 25-55 minute, cold rear filter paper filtering, the pH 10%NaOH of gained medicinal liquid be adjusted to 6.5-8.0;
(4) step (3) gained medicinal liquid is added 6%-15% glucose solution, make, containing crude drug in whole 15%-25%, first to use filter paper filtering secondary, filter once with No. 4 sintered glass funnels again, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
Preferably be in step (1), amount of water is 8-10 times of medical material gross weight.
Preferably be in step (1), first time decocts 40-60 minute.
Preferably be in step (1), second time decocts 30-50 minute.
Preferably be in step (1), third time decocts 25-40 minute.
Preferably be in step (2), place 10-14 hour.
Preferably be in step (3), 0.5% medicinal charcoal is in 70-80 DEG C of heating.
Preferably be in step (3), heated and stirred 30-50 minute.
Preferably be, in step (3), the pH 10%NaOH of gained medicinal liquid to be adjusted to 6.8-7.5.
Preferably be, in step (4), to add 8%-12% glucose solution.
Preferably be in step (4), make containing crude drug in whole 18%-22%.
Be more preferably, in step (1), amount of water is 8.8 times of medical material gross weight.
Be more preferably, in step (1), first time decocts 50 minutes.
Be more preferably, in step (1), second time decocts 40 minutes.
Be more preferably, in step (1), third time decocts 30 minutes.
Be more preferably, place 12 hours in step (2).
Be more preferably, add 0.5% medicinal charcoal in step (3) in 75 DEG C of heating.
Be more preferably, heated and stirred 40 minutes in step (3).
Be more preferably, in step (3), the pH 10%NaOH of gained medicinal liquid be adjusted to 7.2.
Be more preferably, step adds 10% glucose solution in (4).
Be more preferably, make in step (4) containing crude drug in whole 20%.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Forsythiae: base is former: be the dry fruit of Oleaceae plants Fructus Forsythiae.The property of medicine: bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Radix Isatidis: base is former: be the dry root of cruciferae isatis.The property of medicine: bitter, cold.GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Gypsum Fibrosum: main component is hydrous calcium sulfate.In addition, the ferrum, magnesium etc. of a small amount of silicic acid, aluminium hydroxide, sulfide and trace is still had.The property of medicine: pungent, sweet, Great Cold.Attach to the lung and stomach meridians.Function cures mainly: clearing away heat-fire, and relieving restlessness is quenched the thirst, convergence granulation promoting.Cure mainly: apoplexy cold and heat, heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, three burnt large heat, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, pharynx heat of panting, also can do bath soup.
Neoalsomitra integrifoliola (Cogn.) Hucth.: base is former: be the tuber of cucurbitaceous plant rod hammer melon.The property of medicine: bitter, puckery, cold.Function cures mainly: heat-clearing and toxic substances removing, pain relieving.Main bacillary dysentery, enteritis, gastritis, pharyngolaryngitis, parotitis, periodontitis, epidemic hemorrhagic conjunctivitis, tonsillitis, high heat, urinary tract infection.
Herba Ecliptae: base is former: be the herb of dicotyledon medicine feverfew Eclipta prostrata.The property of medicine: sweet, sour, cool.Return kidney, Liver Channel.Function cures mainly: nourishing the liver and kidney, crow palpus teeth consolidating, cooling blood for hemostasis.Main deficiency of the liver and kindey, vertigo and tinnitus, blurring of vision, soreness of the waist and knees, turn white luxated tooth, stranguria caused by overstrain foul leukorrhea, spitting of blood, spits blood, epistaxis, hematuria, dysentery, metrorrhagia, traumatic hemorrhage.
The injection compatibility for the treatment of upper respiratory tract infection provided by the invention is scientific and reasonable.In addition, excellent results of the present invention also shows:
1, instant effect, evident in efficacy;
2, drug resistance can not be produced;
3, price is low, relieve patient ' s burden;
4, have no side effect, through clinical verification, there is repeatability.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the injection for the treatment of upper respiratory tract infection, the primary raw material medicine getting following weight is prepared from (getting 30g for every part): Fructus Forsythiae 0.4 part, Radix Isatidis 0.8 part, Gypsum Fibrosum 0.3 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.6 part, Herba Ecliptae 0.6 part.
The preparation method of the injection for the treatment of upper respiratory tract infection is:
(1) each crude drug is decocted with water three times, amount of water is 7.5 times of medical material gross weight, and first time decocts 35 minutes, and second time decocts 25 minutes, and third time decocts 20 minutes, merges three decocting liquids, filters, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 8 hours, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 65 DEG C of heated and stirred 25 minutes, cold rear filter paper filtering, is adjusted to 6.5 by the pH 10%NaOH of gained medicinal liquid;
(4) step (3) gained medicinal liquid is added 6% glucose solution, make, containing crude drug in whole 15%, first to use filter paper filtering secondary, then filter once with No. 4 sintered glass funnels, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
Consumption: maximum per kilogram of body weight is no more than 25 grams (crude drugs), minimum per kilogram of body weight is not less than 2 grams (crude drugs).Grasp according to the state of an illness, administering mode can use intravenous injection and intramuscular injection.
embodiment 2the injection for the treatment of upper respiratory tract infection, the primary raw material medicine getting following weight is prepared from (getting 20g for every part): Fructus Forsythiae 1.2 parts, Radix Isatidis 1.6 parts, Gypsum Fibrosum 0.6 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 1.0 parts, Herba Ecliptae 1.5 parts.
The preparation method of the injection for the treatment of upper respiratory tract infection is:
(1) each crude drug is decocted with water three times, amount of water is 11 times of medical material gross weight, and first time decocts 70 minutes, and second time decocts 60 minutes, and third time decocts 50 minutes, merges three decocting liquids, filters, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 16 hours, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 85 DEG C of heated and stirred 55 minutes, cold rear filter paper filtering, is adjusted to 8.0 by the pH 10%NaOH of gained medicinal liquid;
(4) step (3) gained medicinal liquid is added 15% glucose solution, make, containing crude drug in whole 25%, first to use filter paper filtering secondary, then filter once with No. 4 sintered glass funnels, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
model case one:yellow XX, man, 29 years old.Medical history: main cause is coughed and increased the weight of for 3 days to examine over one day.Have a medical check-up: body temperature is normal, swallow red tonsil little, heart rate 75 beats/min, two pulmonary respiration sound is not slightly heard and dry moist rale.Diagnosis: upper respiratory tract infection.Infuse 2 days without being clearly better.Use the injection of the present embodiment gained treatment upper respiratory tract infection, intravenous injection, per kilogram of body weight 15 grams (crude drug), every day 1 time.Use 1 time, cough symptom obviously alleviates.Use twice, all diseases disappear, without other untoward reaction in transfusion, and recovery from illness.
embodiment 3the injection for the treatment of upper respiratory tract infection, the primary raw material medicine getting following weight is prepared from (getting 40g for every part): Fructus Forsythiae 0.6 part, Radix Isatidis 1.0 parts, Gypsum Fibrosum 0.35 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.7 part, Herba Ecliptae 0.8 part.
The preparation method of the injection for the treatment of upper respiratory tract infection is:
(1) each crude drug is decocted with water three times, amount of water is 8 times of medical material gross weight, and first time decocts 40 minutes, and second time decocts 30 minutes, and third time decocts 25 minutes, merges three decocting liquids, filters, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 10 hours, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 70 DEG C of heated and stirred 30 minutes, cold rear filter paper filtering, is adjusted to 6.8 by the pH 10%NaOH of gained medicinal liquid;
(4) step (3) gained medicinal liquid is added 8% glucose solution, make, containing crude drug in whole 18%, first to use filter paper filtering secondary, then filter once with No. 4 sintered glass funnels, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
model case two:grandson XX, female, 32 years old.Medical history: occurred pharyngalgia before one week, generate heat subsequently, the highest 38.5 DEG C, bring down a fever after certainly taking the medicines such as GANMAO CHONGJI.Cough subsequently, few expectorant, pharyngeal discomfort.Take cefradine 5.Cough exacerbation of symptoms, impact sleep.Also cough incessantly daytime from today.After being ill, Stomach in Patients receive can, without Nausea and vomiting, without losing weight.Physical examination: T:37.5 DEG C, P:80 beat/min, R:20 beat/min, BP:125/75mmHg.Breathe smooth-going, superficial lymph knot does not touch enlargement, pharyngeal hyperemia, tonsil II ° enlargement.Two lungs kowtow that rhonchus is clear, respiratory murmur is slightly thick, do not hear and dry moist rale.Heart rate 80 beats/min, the rhythm of the heart is neat.Auxiliary examination: WBC:6.2; L:17%; N:78%; RBC:3.86; HB:129; PLT:204; Blood biochemistry and other no abnormality seen.Be diagnosed as upper respiratory tract infection.Use the injection of the present embodiment gained treatment upper respiratory tract infection, intravenous injection, per kilogram of body weight 10 grams (crude drug), every day 1 time.Use 1 time, cough symptom is obviously alleviated.Use 2 times, all diseases disappear, without other untoward reaction in transfusion, and recovery from illness.
embodiment 4the injection for the treatment of upper respiratory tract infection, the primary raw material medicine getting following weight is prepared from (getting 50g for every part): Fructus Forsythiae 1.0 parts, Radix Isatidis 1.3 parts, Gypsum Fibrosum 0.52 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.9 part, Herba Ecliptae 1.2 parts.
The preparation method of the injection for the treatment of upper respiratory tract infection is:
(1) each crude drug is decocted with water three times, amount of water is 10 times of medical material gross weight, and first time decocts 60 minutes, and second time decocts 50 minutes, and third time decocts 40 minutes, merges three decocting liquids, filters, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 14 hours, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 80 DEG C of heated and stirred 50 minutes, cold rear filter paper filtering, is adjusted to 7.5 by the pH 10%NaOH of gained medicinal liquid;
(4) step (3) gained medicinal liquid is added 12% glucose solution, make, containing crude drug in whole 22%, first to use filter paper filtering secondary, then filter once with No. 4 sintered glass funnels, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
model case three:king XX, female, 42 years old.Main suit: heating companioned with headache, watery nasal discharge 5 days.History of present illness: patient's private prosecution occurred fever without obvious inducement before 5 days, watery nasal discharge, with headache, town hospital transfusion 3 days without positive effect.There is pharyngalgia before telling one day, increase the weight of gradually, cough but no phlegm.Physical examination: health check-up: T:37.6 DEG C, P:86, R20/min, BP:120/80mmHg.Pharynx rear wall is obviously congested, visible lymph bubble, the congested II ° of enlargement of bilateral amygdala.Two pulmonary respiration sound is clear, does not hear and dry moist rale.Be diagnosed as acute upper respiratory tract infection.Use the injection of the present embodiment gained treatment upper respiratory tract infection, intravenous injection, per kilogram of body weight 15 grams (crude drug), every day 1 time.Use 1 time, all diseases disappear, and without other untoward reaction in transfusion, are totally lost, and recovery from illness, leaves.
embodiment 5the injection for the treatment of upper respiratory tract infection, the primary raw material medicine getting following weight is prepared from (getting 50g for every part): Fructus Forsythiae 0.8 part, Radix Isatidis 1.1 parts, Gypsum Fibrosum 0.42 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.8 part, Herba Ecliptae 1.1 parts.
The preparation method of the injection for the treatment of upper respiratory tract infection is:
(1) each crude drug is decocted with water three times, amount of water is 8.8 times of medical material gross weight, and first time decocts 50 minutes, and second time decocts 40 minutes, and third time decocts 30 minutes, merges three decocting liquids, filters, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 12 hours, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 75 DEG C of heated and stirred 40 minutes, cold rear filter paper filtering, is adjusted to 7.2 by the pH 10%NaOH of gained medicinal liquid;
(4) step (3) gained medicinal liquid is added 10% glucose solution, make, containing crude drug in whole 20%, first to use filter paper filtering secondary, then filter once with No. 4 sintered glass funnels, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
test example 1the clinical practice of the injection of embodiment 5 gained treatment upper respiratory tract infection: in May ,-2013 in November, 2011,272 routine upper respiratory tract infection patients are screened in 6 hospitals, women 150 example, wherein male 122 example, oldest 65 years old, minimum 3 years old of age, 35.5 years old mean age, course of disease 2-8 days, average course of disease 2.5 days.Be divided into two groups at random, experimental group and matched group.Experimental group women 77 example, male 59 example, age 3-65 year, 35.5 years old mean age, course of disease course of disease 2-8 days, average course of disease 2.5 days.Matched group women 73 example, male 63 example, age 3-65 year, 35.5 years old mean age, course of disease course of disease 2-8 days, average course of disease 2.5 days.Between two groups of patients, the aspect such as sex, age, course of disease compares, and no significant difference (P > 0.05), has comparability.Experimental group uses embodiment 5 products obtained therefrom, and consumption: maximum per kilogram of body weight is no more than 25 grams (crude drugs), minimum per kilogram of body weight is not less than 2 grams (crude drugs).Grasp according to the state of an illness, administering mode can use intravenous injection and intramuscular injection.Matched group uses the medicine (as ribavirin granule, SHUANGHUANGLIAN KOUFUYE, amoxicillin etc.) of conventional therapy treatment upper respiratory tract infection.Curative effect judging standard: cure: body temperature is normal, total white blood cells disappears at normal range, Clinical symptom and sign; Effective: body temperature is normal, total white blood cells is obviously alleviated close to normal range, Clinical symptom and sign; Take a turn for the better: body temperature takes a turn for the better close to normal range, Clinical symptom and sign close to normal, total white blood cells; Invalid: body temperature do not fall or raise, total white blood cells is higher than 10 × 10
9/ L, Clinical symptom and sign are without improvement or increase the weight of.Total effective rate is the percentage ratio that healing adds that effective number of cases accounts for all number of cases of this group.Treat result after 2 days as shown in table 1.
Table 1: use embodiment 5 product upper respiratory tract infection patient treatment outcome
As can be seen from Table 1, experimental group cures 102 examples, effective 34 examples, total effective rate 100%; Matched group cures 68 examples, effective 30 examples, and take a turn for the better 24 examples, invalid 14 examples, total effective rate 72.06%.Test shows, experimental group and matched group difference have significance, and the successful of experimental group is better than matched group.
The present invention selects Fructus Forsythiae, Radix Isatidis, Gypsum Fibrosum, Neoalsomitra integrifoliola (Cogn.) Hucth. and Herba Ecliptae to carry out compatibility, makes the injection for the treatment of upper respiratory tract infection.Fructus Forsythiae heat-clearing and toxic substances removing in side, dispersing swelling and dissipating binds.Radix Isatidis heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Gypsum Fibrosum clearing away heat-fire, relieving restlessness is quenched the thirst, convergence granulation promoting.Neoalsomitra integrifoliola (Cogn.) Hucth. heat-clearing and toxic substances removing, pain relieving.Herba Ecliptae nourishing the liver and kidney, crow palpus teeth consolidating, cooling blood for hemostasis.All medicines share, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, pain relieving, reach the object for the treatment of upper respiratory tract infection.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the injection of upper respiratory tract infection, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Forsythiae 0.4-1.2, Radix Isatidis 0.8-1.6, Gypsum Fibrosum 0.3-0.6, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.6-1.0, Herba Ecliptae 0.6-1.5.
2. the injection for the treatment of upper respiratory tract infection according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 0.6-1.0, Radix Isatidis 1.0-1.3, Gypsum Fibrosum 0.35-0.52, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.7-0.9, Herba Ecliptae 0.8-1.2.
3. the injection for the treatment of upper respiratory tract infection according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 0.8, Radix Isatidis 1.1, Gypsum Fibrosum 0.42, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.8, Herba Ecliptae 1.1.
4., according to the preparation method of the injection of the arbitrary described treatment upper respiratory tract infection of claim 1-3, it is characterized in that, step is as follows:
(1) each crude drug is decocted with water three times, amount of water is 7.5-11 times of medical material gross weight, and first time decocts 35-70 minute (preferably, first time decoction 40-60 minute; Be more preferably, first time decocts 50 minutes), second time decocts 25-60 minute, and (preferred, second time decocts 30-50 minute; Be more preferably, second time decocts 40 minutes), third time decocts 20-50 minute, and (preferred, third time decocts 25-40 minute; Be more preferably, third time decocts 30 minutes), merge three decocting liquids, filter, water-bath is concentrated into 1:1 concentration;
(2) add 95% ethanol and become medicinal liquid containing 82% ethanol, fully stir, place 8-16 hour, filter, filtrate recycling ethanol, is dissolved in water into 1:5 concentration, then adds 95% ethanol and become medicinal liquid containing 85% ethanol, place, filter, filtrate normal pressure reclaims ethanol extremely without ethanol taste;
(3) by step (2) gained medicine adding distil water to 1:1 concentration, add 0.5% medicinal charcoal in 65-85 DEG C of heated and stirred 25-55 minute, cold rear filter paper filtering, the pH 10%NaOH of gained medicinal liquid be adjusted to 6.5-8.0;
(4) step (3) gained medicinal liquid is added 6%-15% glucose solution and (preferably, add 8%-12% glucose solution; Be more preferably, add 10% glucose solution), make, containing crude drug in whole 15%-25%, first to use filter paper filtering secondary, then filter once with No. 4 sintered glass funnels, in embedding 500 mL of saline bottle, high steam (105 DEG C) sterilizing 1.2 hours, to obtain final product.
5. the preparation method of the injection for the treatment of upper respiratory tract infection according to claim 4, is characterized in that, in step (1), amount of water is 8-10 times (preferred amount of water is 8.8 times of medical material gross weight) of medical material gross weight.
6. the preparation method of the injection for the treatment of upper respiratory tract infection according to claim 4, is characterized in that, places 10-14 hour (preferably placing 12 hours) in step (2).
7. the preparation method of the injection for the treatment of upper respiratory tract infection according to claim 4, is characterized in that, adds 0.5% medicinal charcoal in 70-80 DEG C of heating (preferably adding 0.5% medicinal charcoal in 75 DEG C of heating) in step (3).
8. the preparation method of the injection for the treatment of upper respiratory tract infection according to claim 4, is characterized in that, in step (3) heated and stirred 30-50 minute (preferred heated and stirred 40 minutes).
9. the preparation method of the injection for the treatment of upper respiratory tract infection according to claim 4, is characterized in that, in step (3), the pH 10%NaOH of gained medicinal liquid is adjusted to 6.8-7.5(and preferably the pH 10%NaOH of gained medicinal liquid is adjusted to 7.2).
10. the preparation method of the injection for the treatment of upper respiratory tract infection according to claim 4, is characterized in that, makes preferably to make containing crude drug in whole 20% containing crude drug in whole 18%-22%(in step (4)).
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410653616.9A CN104324080B (en) | 2014-11-18 | 2014-11-18 | The injection for the treatment of upper respiratory tract infection and preparation method |
| CN201610197588.3A CN105853510A (en) | 2014-11-18 | 2014-11-18 | Injection for treating upper respiratory infection |
| CN201610197587.9A CN105687335A (en) | 2014-11-18 | 2014-11-18 | Injection for treating upper respiratory tract infection |
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| CN201410653616.9A CN104324080B (en) | 2014-11-18 | 2014-11-18 | The injection for the treatment of upper respiratory tract infection and preparation method |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610197588.3A Division CN105853510A (en) | 2014-11-18 | 2014-11-18 | Injection for treating upper respiratory infection |
| CN201610197591.5A Division CN105663258A (en) | 2014-11-18 | 2014-11-18 | Preparation method of injection for treating upper respiratory infection |
| CN201610197589.8A Division CN105770012A (en) | 2014-11-18 | 2014-11-18 | Preparation method of injection liquid for treating upper respiratory infection |
| CN201610197587.9A Division CN105687335A (en) | 2014-11-18 | 2014-11-18 | Injection for treating upper respiratory tract infection |
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| CN201610197588.3A Withdrawn CN105853510A (en) | 2014-11-18 | 2014-11-18 | Injection for treating upper respiratory infection |
| CN201610197587.9A Withdrawn CN105687335A (en) | 2014-11-18 | 2014-11-18 | Injection for treating upper respiratory tract infection |
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| CN103768308B (en) * | 2014-02-25 | 2016-05-04 | 王晖 | A kind of pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract and preparation method thereof |
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2014
- 2014-11-18 CN CN201410653616.9A patent/CN104324080B/en not_active Expired - Fee Related
- 2014-11-18 CN CN201610197588.3A patent/CN105853510A/en not_active Withdrawn
- 2014-11-18 CN CN201610197587.9A patent/CN105687335A/en not_active Withdrawn
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| CN104324080B (en) | 2016-11-23 |
| CN105687335A (en) | 2016-06-22 |
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