CN104322555A - Preservative used for liquid washing product and preparation method thereof - Google Patents
Preservative used for liquid washing product and preparation method thereof Download PDFInfo
- Publication number
- CN104322555A CN104322555A CN201410508354.7A CN201410508354A CN104322555A CN 104322555 A CN104322555 A CN 104322555A CN 201410508354 A CN201410508354 A CN 201410508354A CN 104322555 A CN104322555 A CN 104322555A
- Authority
- CN
- China
- Prior art keywords
- preservative
- washing
- isothiazolinone
- articles
- bronopol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a preservative used for a liquid washing product. The preservative is characterized by including following components, by mass, 1-3.5% of sodium nitrate, 1-3.5% of isothiazolinone, 5-15% of bronopol, 5-10% of sodium dehydroacetate and the balance water, wherein a mass percentage sum of various components is 100%. The invention also provides a preparation method of the preservative used for the liquid washing product. In the invention, a plurality of active components having different antibacterial performances are compounded together to form a novel preservative of which an antibacterial scope is broadened and an antibacterial activity is improved and meanwhile a preservative cost is reduced. In the invention, a plurality of preservatives are compounded within a permitted amount and a safety of a product is ensured on the basis of achieving a preventing and treating object.
Description
Technical field
The present invention relates to household chemicals field, refer to a kind of preservative for liquid articles for washing and preparation method thereof particularly.
Background technology
Along with the arrival in global low-carbon (LC) epoch, the articles for washing industry of China also starts to enter and turns to main development trend with liquid.Articles for washing needs long storage periods more, for ensureing that it is not subject to microbial destruction within the shelf-life, must add appropriate preservative.Complexity due to cleaning product formula is microbial growth, breeding provides enough nutrients, the usual practice of a kind of preservative of permanent single use makes the pesticide resistance of microorganism to preservative constantly upgrade, the pesticide resistance of microorganism to preservative refers to a certain preservative and uses continuously for a long time, cause flora to reduce the sensitivity of this preservative, thus cause the bactericidal effect of this preservative to decline.For ensureing that its bactericidal effect then needs constantly to increase preservative dosage, long-term high dose adds preservative then can cause medicament residual contamination environment, the research topic that thus exploitation has safety, Compositional antiseptic agent that is efficient, wide spectrum has become washing industry important.
Summary of the invention
Object of the present invention is exactly the deficiency that will solve above-mentioned background technology, provides a kind of and reduces microbial resistance, broad-spectrum antibacterial property is good, consumption is few, the preservative for liquid articles for washing of use safety and preparation method thereof.
Technical scheme of the present invention is: a kind of articles for washing preservative, is characterized in that, the mass percent of each composition is: sodium nitrate 1%-3.5%; Isothiazolinone 1%-3.5%; Bronopol 5%-15%; Dehydro sodium acetate 5%-10%; Surplus is water; Each constituent mass percentage sum is 100%.Bronopol chemical name is the bromo-2-nitro of 2--1.3-propane diols.
Preferably, described isothiazolinone is the mixture aqueous solution of 2-methyl isophthalic acid-isothiazoline-3-ketone (MI) and 5-chloro-2-methyl-1-isothiazoline-3-ketone (CMI), and the percentage that wherein 2-methyl isophthalic acid-isothiazoline-3-ketone (MI) accounts for isothiazolinone quality with the gross mass of 5-chloro-2-methyl-1-isothiazoline-3-ketone (CMI) is 1.5%-1.6%.
Preferably, the liquid articles for washing pH scope that described preservative is suitable for is 4-9.
Preferably, described preservative service property (quality) is the 0.01%-1% of articles for washing gross mass.
The present invention also provides a kind of preparation method of the preservative for liquid articles for washing, comprises following processing step:
A. each component is taken in proportion: sodium nitrate 1%-3.5%; Isothiazolinone 1%-3.5%; Bronopol 5%-15%; Dehydro sodium acetate 5%-10%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Often kind of preservative has oneself specific sterilization object, and single preservative can only resist specific bacteria, preservatives different for several sterilization object is carried out with the use of, improve while drug effect and also can reduce addition.And a kind of preservative high dose uses, and not only can cause safety problem, also can develop immunity to drugs, and the probability that microorganism develops immunity to drugs to two or more preservative be extremely low, particularly the different mechanism of action preservative with the use of time.
Remarkable advantage of the present invention is:
(1) form new food preservative by composite for the active component of different for several tool anti-microbial property together, widened its antibacterial range, added antibacterial activity, reduced anticorrosion cost simultaneously.
(2) the present invention is by composite under allowance of Determination of Preservatives, prevents and treats on object basis reaching, ensure that the safety of product.
(3) Compositional antiseptic agent of the present invention effectively prevents the generation of microbial resistance.
Embodiment
The present invention is described in further detail for specific embodiment below.
Embodiment 1
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 1%; Isothiazolinone 3.5% (mass concentration is 1.5%); Bronopol 5%; Dehydro sodium acetate 5%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.01% of liquid articles for washing quality.
Embodiment 2
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 2%; Isothiazolinone 2.5% (mass concentration is 1.6%); Bronopol 10%; Dehydro sodium acetate 8%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.2% of liquid articles for washing quality.
Embodiment 3
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 3.5%; Isothiazolinone 1% (mass concentration is 1.5%); Bronopol 15%; Dehydro sodium acetate 10%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.15% of liquid articles for washing quality.
Embodiment 4
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 1.5%; Isothiazolinone 2% (mass concentration is 1.6%); Bronopol 8%; Dehydro sodium acetate 6%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.5% of liquid articles for washing quality.
Embodiment 5
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 1.8%; Isothiazolinone 3% (mass concentration is 1.5%); Bronopol 12%; Dehydro sodium acetate 7%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.79% of liquid articles for washing quality.
Embodiment 6
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 2.1%; Isothiazolinone 1.5% (mass concentration is 1.55%); Bronopol 13%; Dehydro sodium acetate 8%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.8% of liquid articles for washing quality.
Embodiment 7
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 2.5%; Isothiazolinone 3% (mass concentration is 1.5%); Bronopol 15%; Dehydro sodium acetate 5%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 0.65% of liquid articles for washing quality.
Embodiment 8
For a preparation method for the preservative of liquid articles for washing, it is characterized in that comprising the following steps:
A. each component is taken by mass fraction: sodium nitrate 3%; Isothiazolinone 2% (mass concentration is 1.5%); Bronopol 6%; Dehydro sodium acetate 10%; Surplus is water; Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Obtained preservative is evenly placed in liquid articles for washing, and preservative quality is 1% of liquid articles for washing quality.
Performance test
By blank liquid detergent 0 (not adding preservative), liquid detergent 1 (adds the preservative that mass fraction is 0.1% in blank liquid detergent, this preservative is the composition of isothiazolinone, Bronopol and dehydro sodium acetate three kinds of preservatives), liquid detergent 2 (adding embodiment 2 obtain preservative that mass fraction is 0.1% in blank liquid detergent)
Adopt the antiseptic power of four inoculation method working samples: bacterial classification is included in home washings and produces and 12 bacterioids common in use, saccharomycete and mould.Connecing bacteria concentration is: bacterium 10
6~ 10
7clump count/gram; Mould is 10
4~ 10
5clump count/gram.Respectively at the 0th day, the 2nd day, the 7th day, when the 14th day, inoculate bacterial classification amount as above in the sample to which, and the residual bacterium amount in different time inside counting sample.When the bacterium amount in sample is in continuing, obviously reducing trend, simultaneously the residual bacterium amount of the 27th day lower than 100 clump counts, it has been generally acknowledged that this sample has excellent antiseptic effect.
Count of bacteria: by the dilution of sample be applicable to bacterial growth medium---TSA carries out plate count, put into constant incubator 30 DEG C cultivate two days, observe bacterium growing state and count.
Yeast and mold count: by the dilution of sample be applicable to yeast and fungus growth medium---PDA carries out plate count, put into constant incubator 25 DEG C and cultivate five days, observe yeast and fungus growth situation and count.
Content of microorganisms horizontal mipmap is as shown in table 1 below: at the end of it has been generally acknowledged that test, and during content of microorganisms < 100 in every gram of sample, the 0-1 that namely marks divides.
Table 1 content of microorganisms horizontal mipmap
| Opinion rating | Clump count/gram sample |
| 0 | ＜10 |
| 1 | 10～99 |
| 2 | 10 2～999 |
| 3 | 10 3～3×10 3 |
| 4 | ＞3×10 3 |
Test result
1. initial bacterium inspection result is as shown in table 2
Table 2 initial bacterium inspection result
As can be seen from the above table, blank liquid detergent sample is contaminated, and bacterial content exceeds standard.Liquid detergent 1 is not contaminated with liquid detergent 2.
2. antibacterium pollution capacity is as shown in table 3
Table 3 antibacterium pollution capacity result
| Sample | Day 0 | Day 3 | Day 7/8 | Day 14 | Day 20 | Day 27 |
| Liquid detergent 1 | 4 | 0 | 0 | 0 | 0 | 0 |
| Liquid detergent 2 | 3 | 0 | 0 | 0 | 0 | 0 |
As can be seen from the above table, liquid detergent 1 and liquid detergent 2 can effective kill bacteria fast, maintain long-acting control effects (in test period asepsis growth), and the initial antibacterium pollution capacity of liquid detergent 2 is better than liquid detergent 1 simultaneously, shows that sample has excellent antiseptic effect.
3. antimycotic pollution capacity is as shown in table 4
The antimycotic pollution capacity result of table 4
| Sample | Day 0 | Day 3 | Day 7/8 | Day 14 | Day 20 | Day 27 |
| Liquid detergent 1 | 4 | 3 | 0 | 0 | 0 | 0 |
| Liquid detergent 2 | 4 | 2 | 0 | 0 | 0 | 0 |
As can be seen from the above table, liquid detergent 1 and liquid detergent 2 can effective killing fungus fast, maintain long-acting control effects (in test period asepsis growth) simultaneously, and liquid detergent 2 is better than liquid detergent 1 at the antimycotic pollution capacity of the 3rd day, show that sample has excellent antiseptic effect.
Claims (5)
1. for a preservative for liquid articles for washing, it is characterized in that, the mass percent of each component is:
Sodium nitrate 1%-3.5%;
Isothiazolinone 1%-3.5%;
Bronopol 5%-15%;
Dehydro sodium acetate 5%-10%;
Surplus is water;
Each constituent mass percentage sum is 100%.
2. as claimed in claim 1 for the preservative of liquid articles for washing, it is characterized in that, described isothiazolinone is the mixture aqueous solution of 2-methyl isophthalic acid-isothiazoline-3-ketone and 5-chloro-2-methyl-1-isothiazoline-3-ketone, and wherein the gross mass of MIT and CMIT accounts for the percentage of isothiazolinone quality is 1.5%-1.6%.
3. as claimed in claim 1 for the preservative of liquid articles for washing, it is characterized in that, the liquid articles for washing pH scope that described preservative is suitable for is 4-9.
4., as claimed in claim 1 for the preservative of liquid articles for washing, it is characterized in that, described preservative service property (quality) is the 0.01%-1% of liquid articles for washing gross mass.
5. the preparation method of a kind of preservative for liquid articles for washing as claimed in claim 1, is characterized in that comprising the following steps:
A. each component is taken in proportion: sodium nitrate 1%-3.5%;
Isothiazolinone 1%-3.5%;
Bronopol 5%-15%;
Dehydro sodium acetate 5%-10%;
Surplus is water;
Each constituent mass percentage sum is 100%.
B. successively sodium nitrate, Bronopol and dehydro sodium acetate are added in isothiazolinone, then add part water in step a and stir under 40 DEG C of conditions.
C. step b gained mixed liquor is added water remaining in step a to stir, namely obtain articles for washing preservative finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410508354.7A CN104322555A (en) | 2014-09-26 | 2014-09-26 | Preservative used for liquid washing product and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410508354.7A CN104322555A (en) | 2014-09-26 | 2014-09-26 | Preservative used for liquid washing product and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104322555A true CN104322555A (en) | 2015-02-04 |
Family
ID=52397488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410508354.7A Pending CN104322555A (en) | 2014-09-26 | 2014-09-26 | Preservative used for liquid washing product and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104322555A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109418262A (en) * | 2017-08-29 | 2019-03-05 | 三博生化科技（上海）有限公司 | A kind of preservative and preparation method thereof |
| CN116240079A (en) * | 2023-03-07 | 2023-06-09 | 陕西华润实业公司 | Compound preservative for washing and preparation method and application thereof |
-
2014
- 2014-09-26 CN CN201410508354.7A patent/CN104322555A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 顾学斌，王磊，马振瀛: "《抗菌防霉技术手册》", 31 July 2011, article "第二章 防霉抗菌剂品种" * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109418262A (en) * | 2017-08-29 | 2019-03-05 | 三博生化科技（上海）有限公司 | A kind of preservative and preparation method thereof |
| CN116240079A (en) * | 2023-03-07 | 2023-06-09 | 陕西华润实业公司 | Compound preservative for washing and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105997545B (en) | Compositional antiseptic agent containing glycerol caprylate and decoyl hydroximic acid and preparation method thereof | |
| CN105399219A (en) | Water quality regulation and control compound microbial preparation and production method thereof | |
| CN110679594A (en) | Compound acidifier and preparation method and application thereof | |
| CN105283535A (en) | Antimicrobial wash | |
| CN103549622A (en) | Natural bacteriostat composition applied to synergistic inhibition to common microbes | |
| CN107164454A (en) | Benza microbial limit tests | |
| CN107333977A (en) | A kind of bacteria inhibiting composition and its applied in acidulant is prepared | |
| CN107669543A (en) | A kind of preservative and preparation method thereof | |
| CN101984834B (en) | Fruit disease antiseptic preservative agent | |
| CN104322555A (en) | Preservative used for liquid washing product and preparation method thereof | |
| CN101578997B (en) | Compound disinfectant for circulating water systems | |
| CN104800134A (en) | Preservative for skin care product | |
| CN104207956A (en) | Compound antiseptic containing natamycin and application of compound antiseptic | |
| CN104521762A (en) | Method for reducing microbiological contamination rate by encapsulating explant by virtue of coating film containing fungicide in plant tissue culture | |
| CN104496893B (en) | Preservative Gemini Geminis quaternary ammonium salt and preservative | |
| CN109924201B (en) | Compound bactericide of perylenequinone compound | |
| CN104705324B (en) | A kind of bactericidal composition containing Zhongshengmycin and chitosan oligosaccharide | |
| CN108913627B (en) | A kind of leavening of aflatoxin degradation, preparation method and application | |
| CN114698634B (en) | Application of isomeric tridecanol polyoxyethylene ether in iodine disinfectant and application method thereof | |
| CN102640781A (en) | Fresh meat composite biological preservative and preparation method of fresh meat composite biological preservative | |
| CN102939966B (en) | A kind of compound disinfectant, its preparation method and application | |
| CN109769837A (en) | A kind of pesticide synergistic combination preventing and treating fruits and vegetables gray mold | |
| CN110199994A (en) | A kind of disinfectant and preparation method thereof, application, feed addictive | |
| CN106879602A (en) | It is a kind of to cooperate with the composition for pressing down bacterium and antibacterium biofilm formation | |
| CN104523748A (en) | Compound iodine disinfectant and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150204 |
|
| RJ01 | Rejection of invention patent application after publication |