CN104321074B - 生长抑素类似物与11β‑羟化酶抑制剂的组合 - Google Patents

生长抑素类似物与11β‑羟化酶抑制剂的组合 Download PDF

Info

Publication number
CN104321074B
CN104321074B CN201380027076.7A CN201380027076A CN104321074B CN 104321074 B CN104321074 B CN 104321074B CN 201380027076 A CN201380027076 A CN 201380027076A CN 104321074 B CN104321074 B CN 104321074B
Authority
CN
China
Prior art keywords
combination
compound
cushing
syndrome
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380027076.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN104321074A (zh
Inventor
G·H·格里克
H·A·施密德
鲁托密斯基 M·R·马尔多纳多
L·李
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN104321074A publication Critical patent/CN104321074A/zh
Application granted granted Critical
Publication of CN104321074B publication Critical patent/CN104321074B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380027076.7A 2012-04-12 2013-04-10 生长抑素类似物与11β‑羟化酶抑制剂的组合 Active CN104321074B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261623117P 2012-04-12 2012-04-12
US61/623,117 2012-04-12
PCT/EP2013/057515 WO2013153129A1 (en) 2012-04-12 2013-04-10 Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors

Publications (2)

Publication Number Publication Date
CN104321074A CN104321074A (zh) 2015-01-28
CN104321074B true CN104321074B (zh) 2017-09-08

Family

ID=48289057

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380027076.7A Active CN104321074B (zh) 2012-04-12 2013-04-10 生长抑素类似物与11β‑羟化酶抑制剂的组合

Country Status (12)

Country Link
US (1) US9333234B2 (pt-PT)
EP (1) EP2836228B1 (pt-PT)
JP (1) JP6383352B2 (pt-PT)
KR (1) KR102136214B1 (pt-PT)
CN (1) CN104321074B (pt-PT)
AU (1) AU2013246908B2 (pt-PT)
BR (1) BR112014025058B1 (pt-PT)
CA (1) CA2869442C (pt-PT)
IN (1) IN2014DN09240A (pt-PT)
MX (1) MX362533B (pt-PT)
RU (1) RU2663455C2 (pt-PT)
WO (1) WO2013153129A1 (pt-PT)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ601077A (en) * 2010-01-14 2014-07-25 Novartis Ag Use of an adrenal hormone-modifying agent
WO2016005880A1 (en) * 2014-07-07 2016-01-14 Novartis Ag Pharmaceutical dosage forms
WO2016048984A1 (en) * 2014-09-25 2016-03-31 Cortendo Ab (Publ) Methods and compositions for the treatment of cushing's syndrome using 2s, 4r ketoconazole
CA3011728A1 (en) 2016-01-19 2017-07-27 Corcept Therapeutics, Inc. Differential diagnosis of ectopic cushing's syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1334742A (zh) * 1998-07-30 2002-02-06 研究及应用科学协会股份有限公司 促生长素抑制素类似物兰瑞肽的应用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03009048A (es) * 2001-04-09 2004-02-12 Univ Tulane Agonistas de la somatostatina.
GT200600381A (es) * 2005-08-25 2007-03-28 Compuestos organicos
ES2472446T3 (es) * 2009-11-30 2014-07-01 Novartis Ag Derivados de imidazol como inhibidores de aldosterona sintasa
NZ601077A (en) * 2010-01-14 2014-07-25 Novartis Ag Use of an adrenal hormone-modifying agent
WO2013131879A1 (en) * 2012-03-07 2013-09-12 Novartis Ag New application for pasireotide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1334742A (zh) * 1998-07-30 2002-02-06 研究及应用科学协会股份有限公司 促生长素抑制素类似物兰瑞肽的应用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Treatment of Pituitary-Dependent Cushing’s Disease with the Multireceptor Ligand Somatostatin Analog Pasireotide (SOM230): A Multicenter, Phase II Trial;M. Boscaro et al.;《J Clin Endocrinol Metab》;20090131;第94卷(第1期);摘要 *

Also Published As

Publication number Publication date
JP6383352B2 (ja) 2018-08-29
AU2013246908A1 (en) 2014-10-23
MX362533B (es) 2019-01-23
CN104321074A (zh) 2015-01-28
US20150087588A1 (en) 2015-03-26
JP2015512923A (ja) 2015-04-30
BR112014025058A2 (pt-PT) 2017-06-20
AU2013246908B2 (en) 2016-06-30
CA2869442A1 (en) 2013-10-17
KR102136214B1 (ko) 2020-07-22
WO2013153129A1 (en) 2013-10-17
EP2836228B1 (en) 2024-03-20
IN2014DN09240A (pt-PT) 2015-07-10
BR112014025058B1 (pt) 2022-07-12
EP2836228A1 (en) 2015-02-18
MX2014012321A (es) 2015-09-24
CA2869442C (en) 2020-09-08
US9333234B2 (en) 2016-05-10
KR20150004831A (ko) 2015-01-13
RU2663455C2 (ru) 2018-08-06
RU2014145351A (ru) 2016-06-10

Similar Documents

Publication Publication Date Title
JP7095028B2 (ja) 薬学的組成物及び方法
TWI621624B (zh) 合成的三萜系化合物及其使用於治療疾病之方法
Mikhail The metabolic syndrome: insulin resistance
CN104321074B (zh) 生长抑素类似物与11β‑羟化酶抑制剂的组合
JP2023507626A (ja) 駆出率が保たれた心不全を伴う肺高血圧症(PH-HF-pEF)を治療するためのレボシメンダン
JP2011503075A (ja) エポチロンまたはエポチロン誘導体誘発下痢を処置するためのコルチコステロイド
EP4009969A1 (en) Method of treating cancer
EP4342475A1 (en) Composition for treatment of covid-19 comprising taurodeoxycholic acid or pharmaceutically acceptable salt thereof as active ingredient
JP7444889B2 (ja) ソマトスタチン受容体陽性腫瘍のイメージング及び治療のための方法
US20050176829A1 (en) Methods for treating hypothyroidism
JP2006501154A (ja) 下垂体腫瘍およびクッシング症候群のような関連状態の処置としてのペルオキシソーム増殖因子活性化レセプター(PPAR)−γリガンドの使用
JP2020143037A (ja) 糖尿病合併心不全の治療用医薬組成物
Han et al. Evaluation of antihypertensive drugs in combination with enzyme replacement therapy in mice with Pompe disease
America et al. CLINICAL STUDY PROTOCOL Amendment# 4
JP2021528424A (ja) 対象における食後のグルコースレベルをコントロールする方法および使用
CA3232411A1 (en) Bioactive molecules for use in treating insulin resistance and/or restoring glucose homeostasis
US20070155770A1 (en) Treatment of anoragasmia or delayed orgasm
Zotarelli Filho State-of-the-Art Clinical Results of Growth Hormone Secretagogues, SARM and Antagonists
KR20230060465A (ko) 장내 glp-1 분비 촉진 및 염증 완화 효능을 가지는 아젤라산 조성물
IL311487A (en) Biologically active molecules for the treatment of diabetes
Valuev et al. Oral insulin preparation for regulation of the blood glucose level
Breining et al. Metformin Targets Brown Adipose Tissue in vivo and Reduces Oxygen Consumption in vitro RUNNING TITLE: Metformin Targets Brown Adipose Tissue
Mason 16th International Congress of Endocrinology/96th Annual Meeting and Exposition of the Endocrine Society (ICE/ENDO), Chicago, Illinois, USA-June 21-24, 2014
Lim Absence of Myostatin Improves Cardiac Function After Myocardial Infarction
JP2008239499A (ja) レプチン分泌促進剤

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant