CN104321072A - 神经调节蛋白在治疗外周神经损伤中的应用 - Google Patents

神经调节蛋白在治疗外周神经损伤中的应用 Download PDF

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Publication number
CN104321072A
CN104321072A CN201380026579.2A CN201380026579A CN104321072A CN 104321072 A CN104321072 A CN 104321072A CN 201380026579 A CN201380026579 A CN 201380026579A CN 104321072 A CN104321072 A CN 104321072A
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CN
China
Prior art keywords
body weight
neuregulin
weeks
compositions
effective dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380026579.2A
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English (en)
Chinese (zh)
Inventor
A·O·卡贾诺
A·J·贝拉
A·甘古利
J·亚奇
T·帕里
R·W·科尔伯恩
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Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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Filing date
Publication date
Application filed by Acorda Therapeutics Inc filed Critical Acorda Therapeutics Inc
Priority to CN201610027758.3A priority Critical patent/CN106511971A/zh
Publication of CN104321072A publication Critical patent/CN104321072A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201380026579.2A 2012-03-30 2013-03-29 神经调节蛋白在治疗外周神经损伤中的应用 Pending CN104321072A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610027758.3A CN106511971A (zh) 2012-03-30 2013-03-29 神经调节蛋白在治疗外周神经损伤中的应用

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261618381P 2012-03-30 2012-03-30
US61/618,381 2012-03-30
US201261674060P 2012-07-20 2012-07-20
US61/674,060 2012-07-20
US201261693585P 2012-08-27 2012-08-27
US201261693589P 2012-08-27 2012-08-27
US61/693,589 2012-08-27
US61/693,585 2012-08-27
US201361785419P 2013-03-14 2013-03-14
US61/785,419 2013-03-14
PCT/US2013/034634 WO2013149163A1 (en) 2012-03-30 2013-03-29 Use of neuregulin to treat peripheral nerve injury

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610027758.3A Division CN106511971A (zh) 2012-03-30 2013-03-29 神经调节蛋白在治疗外周神经损伤中的应用

Publications (1)

Publication Number Publication Date
CN104321072A true CN104321072A (zh) 2015-01-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380026579.2A Pending CN104321072A (zh) 2012-03-30 2013-03-29 神经调节蛋白在治疗外周神经损伤中的应用
CN201610027758.3A Pending CN106511971A (zh) 2012-03-30 2013-03-29 神经调节蛋白在治疗外周神经损伤中的应用

Family Applications After (1)

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CN201610027758.3A Pending CN106511971A (zh) 2012-03-30 2013-03-29 神经调节蛋白在治疗外周神经损伤中的应用

Country Status (15)

Country Link
US (3) US20150094263A1 (enExample)
EP (3) EP2830645B1 (enExample)
JP (4) JP6420233B2 (enExample)
CN (2) CN104321072A (enExample)
AU (4) AU2013237896B2 (enExample)
BR (1) BR112014024308B1 (enExample)
CA (1) CA2869070A1 (enExample)
DK (2) DK3278811T3 (enExample)
ES (2) ES2647917T3 (enExample)
IL (3) IL288785B2 (enExample)
MX (1) MX354598B (enExample)
NZ (1) NZ700546A (enExample)
PL (2) PL3278811T3 (enExample)
PT (2) PT2830645T (enExample)
WO (1) WO2013149163A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110946991A (zh) * 2018-09-27 2020-04-03 广州中医药大学(广州中医药研究院) 神经调节蛋白1的应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3338791T3 (da) 2008-07-17 2019-12-16 Acorda Therapeutics Inc Terapeutisk dosering af en neuregulin i behandling eller profylaxis af hjertesvigt
PL3235504T3 (pl) 2009-10-14 2020-03-31 Acorda Therapeutics, Inc. Zastosowanie neureguliny do leczenia uszkodzenia nerwu obwodowego
ITUB20155471A1 (it) * 2015-11-11 2017-05-11 Univ Degli Studi Di Torino Coniugato della neuregulina 1 per il trattamento delle lesioni dei nervi periferici
IL294038A (en) * 2015-12-04 2022-08-01 Univ Iowa Res Found Device, systems and methods for prediction, screening and monitoring of encephalopathy / delirium
CA3082878C (en) 2017-11-17 2024-02-20 The Research Foundation for State University of New York A method for treating damaged peripheral nerves using x-ray microbeam irradiation
CN114929099B (zh) * 2019-08-01 2025-08-15 马克·埃文斯 用于在分娩期间和分娩之前降低人类胎儿神经损伤风险及鉴定神经损伤存在的方法和设备
CN116116737B (zh) * 2023-04-14 2023-06-30 新华手术器械有限公司 止血钳毛坯自动上料装置及使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001089568A1 (en) * 2000-05-23 2001-11-29 Cenes Pharmaceuticals, Inc. Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
WO2009108390A2 (en) * 2008-02-29 2009-09-03 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels
WO2011047183A2 (en) * 2009-10-14 2011-04-21 Acorda Therapeutics, Inc. Use of a neuregulin to treat peripheral nerve injury
WO2012021818A2 (en) * 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use

Family Cites Families (10)

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US888A (en) 1838-08-20 perkins
US7037A (en) 1850-01-22 Grid-ikon slide-valve
US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US6087323A (en) * 1992-04-03 2000-07-11 Cambridge Neuroscience, Inc. Use of neuregulins as modulators of cellular communication
US7037888B1 (en) 1992-04-03 2006-05-02 Acorda Therapeutics, Inc. Methods for treating muscle diseases and disorders
EP1028735A4 (en) * 1997-10-14 2003-08-06 Cenes Pharmaceuticals Inc THERAPEUTIC METHOD COMPRISING THE USE OF NEUREGULIN
WO2009046453A2 (en) * 2007-10-05 2009-04-09 New England Medical Center (Nemc) Use of neuregulin-1 in reducing brain damage
DK3338791T3 (da) * 2008-07-17 2019-12-16 Acorda Therapeutics Inc Terapeutisk dosering af en neuregulin i behandling eller profylaxis af hjertesvigt
KR101237927B1 (ko) * 2009-05-07 2013-03-04 (주)문엔제이 신경손상 및 신경질환 예방 또는 치료용 약학조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001089568A1 (en) * 2000-05-23 2001-11-29 Cenes Pharmaceuticals, Inc. Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
WO2009108390A2 (en) * 2008-02-29 2009-09-03 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels
WO2011047183A2 (en) * 2009-10-14 2011-04-21 Acorda Therapeutics, Inc. Use of a neuregulin to treat peripheral nerve injury
WO2012021818A2 (en) * 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110946991A (zh) * 2018-09-27 2020-04-03 广州中医药大学(广州中医药研究院) 神经调节蛋白1的应用

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Publication number Publication date
JP7108724B2 (ja) 2022-07-28
PT3278811T (pt) 2021-03-03
EP3278811B1 (en) 2020-12-02
EP3842059A1 (en) 2021-06-30
EP2830645B1 (en) 2017-08-30
IL234882B (en) 2020-03-31
ES2647917T3 (es) 2017-12-27
HK1249038A1 (en) 2018-10-26
JP2021059605A (ja) 2021-04-15
DK3278811T3 (da) 2021-03-01
IL273186B (en) 2022-01-01
AU2018200592A1 (en) 2018-02-15
JP6420233B2 (ja) 2018-11-07
CA2869070A1 (en) 2013-10-03
MX354598B (es) 2018-03-12
HK1206632A1 (en) 2016-01-15
PL3278811T3 (pl) 2021-08-02
US20230117985A1 (en) 2023-04-20
IL273186A (en) 2020-04-30
PL2830645T3 (pl) 2018-01-31
BR112014024308A2 (pt) 2017-08-08
IL288785A (en) 2022-02-01
IL234882A0 (en) 2014-12-31
AU2013237896A1 (en) 2014-10-16
AU2019202401A1 (en) 2019-05-02
EP2830645A1 (en) 2015-02-04
JP2019131582A (ja) 2019-08-08
EP3278811A1 (en) 2018-02-07
JP2015514096A (ja) 2015-05-18
AU2019202401B2 (en) 2020-10-15
AU2013237896B2 (en) 2017-11-02
BR112014024308B1 (pt) 2021-11-30
DK2830645T3 (da) 2017-11-20
CN106511971A (zh) 2017-03-22
BR112014024308A8 (pt) 2018-01-23
US20160346353A1 (en) 2016-12-01
PT2830645T (pt) 2017-11-28
AU2020260539A1 (en) 2020-11-26
MX2014011838A (es) 2015-03-09
WO2013149163A1 (en) 2013-10-03
ES2857810T3 (es) 2021-09-29
US20150094263A1 (en) 2015-04-02
NZ700546A (en) 2017-05-26
JP2017149746A (ja) 2017-08-31
IL288785B (en) 2022-11-01
IL288785B2 (en) 2023-03-01

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Application publication date: 20150128