CN1043188C - Oral liquid containing calcium and proteins and its preparation - Google Patents
Oral liquid containing calcium and proteins and its preparation Download PDFInfo
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- CN1043188C CN1043188C CN93111488A CN93111488A CN1043188C CN 1043188 C CN1043188 C CN 1043188C CN 93111488 A CN93111488 A CN 93111488A CN 93111488 A CN93111488 A CN 93111488A CN 1043188 C CN1043188 C CN 1043188C
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Abstract
The present invention relates to oral medicinal solution containing calcium protein for new lives and a preparation process thereof. The oral medicinal solution is composed of bone paste extracting solution, many kinds of medicine extracting solution and corrigent refined honey solution. The preparation process comprises the following steps: respectively preparing bone paste extracting solution, many kinds of medicine extracting solution and corrigent refined honey solution; then proportionally mixing the three kinds of solution; after high-temperature disinfection and sterilization, cooling the mixture of the three kinds of solution to the room temperature, and filtering the mixture to obtain filtrate for preparing the oral medicinal solution. The oral medicinal solution has the efficiency of nourishing the marrow, strengthening bones, supplying qi and producing blood, mainly treats symptoms of calcium deficiency and anemia during gestational periods and lactation of women and for kids, students and old people, and has a health care function.
Description
The present invention relates to a kind of edible animal bone paste, medicine and refined honey method redistilled calcium protein oral liquor and manufacturing process thereof.
At present, it is various in style that the various nutrition oral administrations that decline are prolonged in nourishing healthy, the Fructus Alpiniae Oxyphyllae of taking for child, student, old man on the market, but the primary raw material of most nutrition oral administrations is botanicals or has that edible plant, mineral material are refining to form concurrently, though there are certain curative effect and health-care effect in system of trace such as rich in proteins, aminoacid, vitamin and germanium, zinc, iodine unit to the many patients of child, student and the old and the weak.But that extracts from the edible animal bone that active ingredients such as calcic, ferrum, zinc, protein, aminoacid make specializes in anemia of pregnant woman, wet nurse, children's, student, the Nutrious health-care oral tonic of old people to replenish the calcium, both at home and abroad report as yet.Existing calcium-supplementing preparation mostly is based on vegetalitas or mineral calcium on the market, does not contain the animality free calcium, and this calcium preparation only is that simple calcium is formed, and composition is single, and dissolubility is also poor, and human body is difficult to absorb.
It is main the object of the present invention is to provide a kind of animal bone that is rich in active animal calcium, ferrum, aminoacid and other trace element to stick with paste extracting solution, be aided with benefiting QI and nourishing blood, the herbal extract of enriching blood and refined honey liquid, adopt refining calcium protein oral liquid and the manufacturing process thereof that forms of scientific method.This kind calcium protein oral liquid has the effect of beneficial marrow bone strengthening, qi-supplementing, blood-engendering, is applicable to the disease and the health-care effect of woman gestationperiod, age of sucking, children's, student and old people's calcium deficiency, anemia.
The object of the present invention is achieved like this: utilize bone is stuck with paste through soaking, decoct, separate, adjust PH, digesting, boil, filter operation and make bone paste extracting solution, with medicines such as Ganoderma, Radix Codonopsis, the Radix Astragali, Auricularia, Fructus Jujubae through soak, decoct, concentrate, precipitate with ethanol, filtration treatment make drug extract, be equipped with refined honey liquid again, then above three kinds of extracting solution allocated in proportion, sterilization, water-cooled, filtration treatment, be refined into calcium egg oral liquid.
Prescription of the present invention and manufacturing process are as follows:
One, prescription
Calcium protein oral liquid of the present invention contains (weight %): bone is stuck with paste extracting solution 50-70, drug extract 20-40, correctives (refined honey liquid) 10-20, described medicine is Radix Codonopsis, the Radix Astragali, Ganoderma, Auricularia, Fructus Jujubae etc., 1000 kilograms of calcium protein oral liquids of every preparation use raw material to be: bone is stuck with paste 80-100 kilogram, Radix Codonopsis 5-10 kilogram, Radix Astragali 5-10 kilogram, Ganoderma 5-10 kilogram, Auricularia 5-10 kilogram, Fructus Jujubae 5-10 kilogram, Mel 10-20 kilogram.
Two, manufacturing process
The present invention prepares bone at first respectively and sticks with paste extracting solution, drug extract and correctives refined honey liquid, then above-mentioned three kinds of solution are prepared burden in proportion, through the high-temperature sterilization sterilization, be cooled to that room temperature is filtered, detection is product after qualified, concrete steps are as follows:
1, bone is stuck with paste the extracting solution preparation method:
Comprise bone paste immersion, decoction, centrifugalize, adjustment PH, digest, boil, filter operation.
Bone is stuck with paste and is adopted number of patent application 92106938.3 product that obtains, the bone (meeting food sanitation standard) that promptly adopts chicken, pig, cattle fooder animal slaughtering to split through veterinary inspector, through being crushed to 0.1-1 centimetre, add material bone and stick with paste the 30-40% bating liquor of weight, bating liquor concentration is 1.0-1.5N, the softening time is 30-40 hour, and environmental testing control temperature is 10-30 ℃.Bating liquor is by proteolytic enzyme 0.01%, food grade concentrated hydrochloric acid 1-3%, and lactic acid 1-3%, citric acid 1-2% and water are formed (weight).Pass through the ultra micro granulated processed again, make granularity more than 200 orders, the PH that final bone is stuck with paste is 3-5, and moisture is 68-72%, and calcium content is more than 2%.
Bone is stuck with paste and soaked: soak is 0.6-1 a times of bone paste amount, the composition of soak is: the food grade concentrated hydrochloric acid is 0.5-1%, lactic acid is 0.5-1%, citric acid is 0.2-0.3%, proteolytic enzyme is 0.01-0.02%, and adding distil water to 100% (weight) is adjusted PH3.5-4.5, temperature is controlled at 30-40 ℃, and soak time is 2-4 hour.
Decoct and centrifugal treating: bone is stuck with paste soak in steam-jacked kettle, and the control temperature is 100-120 ℃, and pressure is the 0.05-0.1 MPa, decocts 30-60 minute.Pour link-suspended basket centrifuge (pad is put 103 industrial filter cloths in the rotary drum) then into, rotating speed is controlled at 1500-3000 rev/min, and be 5-15 minute the duration of runs.Get the sodium hydroxide solution adjustment PH to 5-6 that centrifugal filtrate adds 1-2%.
Digest, boil and filtration treatment: centrifugal filtrate is added proteolytic enzyme 0.01-0.02%, temperature 30-40 ℃ of digestion 4-8 hour, remove the floating thing in upper strata, boiled then 5-10 minute, with 1.2 micron pore size membrane filtrations, the above-mentioned bone produced is stuck with paste extracting solution exist under the 1-5 ℃ of low temperature cold preservation standby.
2, the manufacturing process of drug extract:
Comprise the raw material arrangement, distilled water immersion of multiple medicine, decoction filtering repeatedly: decoction filtering for the first time, decoction filtering for the second time, decoction filtering merges three filtrates and concentrates for the third time, ethanol quiet heavy, reclaim operation composition such as ethanol.
Medicine material should not have mould, no worm, does not have rotten material, meets national medical material standard.All medicines chop up into the 1-2 centimeter length with cutter, clean with clear water.Ganoderma, Radix Codonopsis, the Radix Astragali, Fructus Jujubae etc. are with 5 times of amount distilled water immersions 30 minutes, and Auricularia is used the distilled water immersion 30 minutes of 6 times of amounts separately.Ganoderma, Radix Codonopsis, the Radix Astragali, Fructus Jujubae grade in an imperial examination are once put into multi-function extractor and were decocted 30-50 minute, add then to decoct 30-50 minute after Auricularia soaks water, cross leaching liquid; Be incorporated as 4 times of amount distilled water of filtering residue when decocting for the second time and decocted 30-40 minute, cross leaching liquid, be incorporated as 4 times of amount distilled water of filtering residue when decocting for the third time and decocted 30 minutes.Be placed in the jacketed pan or boil in the multi-function extractor and be concentrated into living medication amount decocting filtrates for above-mentioned three times, be cooled to room temperature then, add the ethanol 45-55% of purity 95%, quiet heavy 24-36 hour.Boiling ethanol evaporation to medicinal liquid again in multi-function extractor does not have till the alcohol flavor.
3, refined honey liquid technology:
Is 5: 1 with Mel with the distilled water ratio, is put in and boils 20-40 minute in the jacketed pan, and temperature is 100-110 ℃ and removes floating thing then, gets refined honey liquid with husky plug filtered while hot.
4, calcium protein oral liquid compounding:
In 100,000 grades clean working area, the ratio of extracting solution 50-70, drug extract 20-40 and refined honey liquid 10-20 (weight %) that bone is stuck with paste is put into proportion container, under high temperature 100-120 ℃, sterilized 40-60 minute, water-cooled is to room temperature then, select the membrane filtration of 0.8 micron pore size for use, get filtrate and detect to pour in the ampere bottle after qualified and get final product.The ampere bottle is washed repeatedly with tap water in advance and is got rid of, the reuse distilled water cleans clean, at pressure is 0.15 MPa, sterilized 30-40 minute down for high temperature 120-140 ℃, in temperature 80-100 ℃ drying, the above-mentioned oral liquid of fill cleans ampere bottle appearance residual liquor oven dry (80-100 ℃) more then, check with light whether transparency has foreign body, and passed examination is promptly packed and dispatched from the factory.
The calcium protein oral liquid that the present invention makes is through Hunan Medical University, Hunan health and epidemic prevention station, the Hunan Province college of traditional Chinese medicine and Hunan Province's drug abuse test institute verification test, and its performance indications, drug effect and toxicity test result meet state-set standard.
One, performance indications:
1. sense organ indication:
Color and luster be pale brown color as the refined honey color, fragrant and sweet slightly tart flavour of mouthfeel and bitter taste, refrigerant good to eat, do not have other abnormal flavour, 1.5 years shelf-lifves.
2. sanitary index:
Meet national GB2759-81 standard.
3. nutritive index:
Per 10 milliliters of content in the product of the present invention
| Project | Calcium mg | Ferrum mg | Zinc mg | Protein g | VitBlmg | VitAmg | Folic acid μ g |
| Desired value | ≥70±2 | ≥7.5 | ≥2.0 | ≥0.2 | ≥0.1 | ≥1 | ≥5 |
4, cure mainly function
Have beneficial marrow bone strengthening, qi-supplementing, blood-engendering effect, cure mainly anemia, the calcium deficiency in puerperal before children's, student, old man and the women's tire.
Two, calcium protein oral liquid drug effect, toxicity test result
The drug effect part:
(1) anti-stress experiment: with hungry 48 hours survey mice serum Ca
++Prerun is found: between normal blank and model blank significant difference P＜0.01 is arranged, prove hunger Ca in the mice serum after 48 hours
++Content obviously descends, and carries out following experiment with this method modeling.
1, resisting fatigue experiment: carry out simultaneously by last method modeling and administration, as a result oral liquid little, in, the swimming continuance time of heavy dose of group is longer than obviously all that model is blank to be organized, P＜0.05 proves that this product has antifatigue effect.
2, anoxia enduring experiment: after last method modeling and administration; As a result oral liquid little, in, the death time significant prolongation of heavy dose of group, with the blank group of model relatively, be respectively P＜0.01, P＜0.05, P＜0.01 proves that this product has prolongation mice survival ability in anaerobic environment.
3, cold-resistant experiment: method is the same, in-10 ℃ of ice, experimentize, as a result oral liquid little, in, heavy dose of and the blank life span that more all can obviously prolong mice of organizing of model, be respectively P＜0.01, prove that this product has the survival ability of prolongation mice in cold environment.
(2) experiment of enriching blood: experimentize with the modeling of docking depletion method, as a result distilled water group oral liquid little, in, the hemoglobin (Hb) of heavy dose of group with after the modeling with get rid of medicine after difference % lead relatively, significant difference is all arranged, respectively with P＜0.05 and P＜0.01, proof oral liquid heavy dose has the effect that increases mice hemoglobin (Hb), with erythrocyte (RBC) is index, wherein after the modeling with take medicine after difference % lead relatively, between heavy dose of group of oral liquid and distilled water group significant difference P＜0.05 is arranged.With before the modeling with take medicine after difference % lead relatively, wherein oral liquid little, in, there were significant differences between heavy dose of group and distilled water group, P is respectively P＜0.05 and P＜0.01.In sum, experimental result proves: in the oral liquid, heavy dose of group has the mice blood hemoglobin of increasing and erythrocytic effect.
(3) immunization experiment
1. hemolysin experiment experimentizes with the erythrocyte method, as a result oral liquid little, in to the formation and the distilled water comparison there was no significant difference of hemolysin in the normal mice serum, P＞0.05; But the heavy dose of group of oral liquid relatively has significant difference with distilled water, proves the be formed with facilitation of oral liquid heavy dose to hemolysin in the normal mice serum, thereby has the effect that strengthens the normal mouse specific immune function.
2. carbon clearance experiment: measure phagocytic activity with the carbon clearance method, as a result in the oral liquid dosage 15 ' time and distilled water relatively its phagocytic index (K2) have significant difference, P＜0.05, and phagocytic index of other each group even there was no significant difference P＞0.05 5 ' and 15 ' time, with the activate the phagocytic capacity is index, wherein the oral liquid heavy dose is at 5 ', 15 ' (a
1a
2) and oral liquid in dosage (a 15 ' time
2) significant difference is all arranged, P＜0.05, the phagocytic function that prove in the oral liquid, heavy dose has increase normal mouse reticuloendothelial cell system, the effect of enhancing non-specific immunity function.Experimental result shows: the calcium protein oral liquid has the effect that increases immune function of mice.
(4) to the influence of pregnant mouse-anti fatigue capability:
Get 50 of pregnant 7-10 days pregnant Mus, be divided into 4 groups, be distilled water, oral liquid little, in, heavy dose, swimming test is carried out in administration after 8 days, as a result oral liquid little, in, big and the comparison of distilled water group, significant difference is all arranged, and all P＜0.05 proves that this product has the effect of enhancing body endurance to pregnant Mus.
(5) take medicine front and back to Ca in the rat blood serum
++The influence of concentration
Get 40 of Wistar rat, be divided into distilled water, oral liquid is little, heavy dose of 3 groups, and heart extracting blood is measured the Ca in the serum that takes medicine before and after three days
++Concentration, the result shows: own control all had the equal P of significant difference＜0.01 before and after little, the heavy dose of group of oral liquid was taken medicine, and distilled water group there was no significant difference P＞0.05 is with Ca in the serum
++Concentration and distilled water relatively, oral liquid is little, heavy dose of group all has significant difference P＜0.01, and with the difference before and after taking medicine and distilled water relatively, oral liquid small dose group there was no significant difference P＞0.05 wherein, the heavy dose of group has significant difference P＜0.01.Proof calcium protein oral liquid can obviously increase Ca in the rat blood serum
++Concentration.
The toxicity test part:
(1) acute toxicity is with 432% concentration, after pressing 0.4ml/10 gram ig and giving HiN mice calcium protein oral liquid 2 times, observes continuously seven days, none animal dead, there is no other untoward reaction, its consumption has reached 533.3 times of 50kg body weight adult, proves this product safety non-toxic.
(2) long poison experiment: get 60 of 85.60 ± 5.32wistar rat and experimentize: be divided into dosage in distilled water, the oral liquid (90%), (270%) three group of oral liquid heavy dose, the ig administration is 30 days continuously, the result:
(1) body weight: between three groups at 15 days, 30 days equal no significant differences, P＞0.05.
(2) hemogram: hemoglobin, erythrocyte, leukocyte, the equal no significant difference of N (nitrogen), I (iodine) between three groups, P＞0.05, but in the Pt oral liquid, heavy dose of group all is starkly lower than the distilled water group, is respectively P＜0.05 and P＜0.01, and with the increase of dosage, Pt reduces.
(3) liver function is a no significant difference between index, three groups with ALT, BUN, P＞0.05.
(4) serum Ca
++Concentration; No significant difference between three groups, P＞0.05, but in the oral liquid, heavy dose of mean is than distilled water group height.
(5) pathological section, dosage group, heavy dose of group in the oral liquid, the heart of blank treated animal, fallopian tube, ovary, uterus and testis are all normal, the liver of each treated animal and kidney are has the visible parenchyma group of minority swollen, but middle dosage group, heavy dose of group compare with the blank group, statistically nonsignificance.
Conclusion: the calcium protein oral liquid is to nontoxic after rat ig30 days.
The present invention sticks with paste extracting solution based on bone, and the effect of kidney tonifying marrow facilitating is arranged greatly, makes then hard smart Sheng of bone of marrow foot, the smart Sheng then can be converted into blood, and bone sticks with paste nutritions such as being rich in calcium, thereby to children's, student, old man and women's pregnancy period, breast phase calcium deficiency, anemia person, both but tonifying for deficiency syndrome can be prevented its loss again.The gas that is aided with Radix Codonopsis, the Radix Astragali, tonifying the spleen and stomach, then QI and blood can be spontaneous, overcomes spiritual deficient, fatigue and weak, and benefit can promote the recovery of the disease of anemia.And Radix Codonopsis, the Radix Astragali and bone paste extracting solution match, and taste two are mended, and make the machine that mutual conversion generation is arranged between bone marrow and the QI and blood.Can mend nutrient blood greatly with Ganoderma, Fructus Jujubae, Auricularia, Mel etc. among QI invigorating again, itself and Radix Codonopsis, the Radix Astragali are harmonious, and the wonderful of qi and blood tonifying then arranged.Each medicine of full side is assisted mutually, nature and flavor are gentle, mend and not dry, play the merit of beneficial marrow bone strengthening, qi-supplementing, blood-engendering altogether.So for treatment calcium deficiency, anemia marrow lose the good medicine of weak bone, insufficiency of vital energy and blood disease, through the magical effect that prevention is also arranged of informal dress.
Claims (8)
1, a kind of calcium protein oral liquid is characterized in that it is made up of following composition:
Bone is stuck with paste extracting solution 50-70%, drug extract 20-40%, and correctives (refined honey liquid) 10-20%, described medicine material is Radix Codonopsis, the Radix Astragali, Ganoderma, Auricularia, Fructus Jujubae; It uses the raw material weight proportioning to be: bone is stuck with paste 80-100, Radix Codonopsis 5-10, Radix Astragali 5-10, Ganoderma 5-10, Auricularia 5-10, Fructus Jujubae 5-10, Mel 10-20.
2, a kind of manufacturing process of calcium protein oral liquid, it is characterized in that it is to select raw material and proportioning earlier, prepare bone more respectively and stick with paste extracting solution, multiple drug extract and correctives refined honey liquid, then above-mentioned three kinds of solution are prepared burden in proportion, sterilize through high-temperature sterilization, be cooled to room temperature, filter institute's obtain filtrate and make, concrete steps are as follows:
(1) select the raw material weight proportioning to be: bone is stuck with paste 80-100, Radix Codonopsis 5-10, Radix Astragali 5-10, Ganoderma 5-10, Auricularia 5-10, Fructus Jujubae 5-10, Mel 10-20;
(2) bone is stuck with paste extracting solution preparation technology, comprise that the bone paste soaks, decoct, centrifugalize, transfer PH, digestion, boil, filter operation, the composition of soak is: the food grade concentrated hydrochloric acid is 0.5-1%, and lactic acid is 0.5-1%, and citric acid is 0.2-0.3%, proteolytic enzyme is 0.01-0.02%, adding distil water to 100% is adjusted PH3.5-4.5, and temperature is controlled at 30-40 ℃, soak time is 2-4 hour, bone is stuck with paste soak in steam-jacked kettle, and the control temperature is 100-120 ℃, and pressure is the 0.05-0.1 MPa, decocted 30-60 minute, centrifugalize then, centrifugal filtrate add aqueous slkali and adjust PH to 5-6, add proteolytic enzyme 0.01-0.02%, temperature 30-40 ℃ of digestion 4-8 hour, remove the floating thing in upper strata, boiled then 5-10 minute, filter, make bone and stick with paste extracting solution, exist under the low temperature cold preservation standby;
(3) preparation technology of multiple drug extract, comprise multiple medicine material Radix Codonopsis, the Radix Astragali, Ganoderma, Auricularia, Fructus Jujubae through cleaning, put in order, chopping up, decoction filtering repeatedly, all filtrate boiling are concentrated into living medication amount, be cooled to room temperature, quiet heavy with ethanol, boil ethanol evaporation to medicinal liquid again and do not have till the alcohol flavor;
(4) preparation technology of correctives refined honey liquid comprises and uses distilled water diluting Mel, boils filtration;
(5) calcium protein oral liquid compounding is stuck with paste extracting solution 50-70%, drug extract 20-40% with bone and refined honey liquid 10-20% puts into mixing container, high temperature 100-120 ℃ of sterilization 40-60 minute, cools off, filters, uses conventional method test package finished product.
3, manufacturing process according to claim 2 is characterized in that soak is 0.6-1 a times that bone is stuck with paste weight.
4, manufacturing process according to claim 2 is characterized in that described aqueous slkali is the sodium hydroxide solution of 1-2%.
5, manufacturing process according to claim 2 is characterized in that Ganoderma, Radix Codonopsis, the Radix Astragali, Fructus Jujubae in this medicine with the distilled water immersion of 5 times of weight 30 minutes, and Auricularia is used the distilled water immersion 30 minutes of 6 times of weight separately.
6, manufacturing process according to claim 5 is characterized in that this medicine divides three decoctions, and decocting time is 30-50 minute at every turn.
7, manufacturing process according to claim 2, it is characterized in that this ethanol quiet heavy in the make a living 45-55% of drug weight of used ethanol, the quiet heavy time is 24-36 hour.
8, manufacturing process according to claim 2 is characterized in that the Mel and the ratio of distilled water are 5: 1, boils 20-40 minute, and temperature is 100-110 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111488A CN1043188C (en) | 1993-07-10 | 1993-07-10 | Oral liquid containing calcium and proteins and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111488A CN1043188C (en) | 1993-07-10 | 1993-07-10 | Oral liquid containing calcium and proteins and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1097317A CN1097317A (en) | 1995-01-18 |
| CN1043188C true CN1043188C (en) | 1999-05-05 |
Family
ID=4989266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111488A Expired - Lifetime CN1043188C (en) | 1993-07-10 | 1993-07-10 | Oral liquid containing calcium and proteins and its preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN1043188C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103202858A (en) * | 2012-01-16 | 2013-07-17 | 湖南天劲制药有限责任公司 | Pig bone nutrient and bone-strengthening and blood-generating oral liquid prepared by same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079120A (en) * | 1992-05-26 | 1993-12-08 | 湖南天心饲料开发总公司长禽类加工厂 | The food method of animal bone |
-
1993
- 1993-07-10 CN CN93111488A patent/CN1043188C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079120A (en) * | 1992-05-26 | 1993-12-08 | 湖南天心饲料开发总公司长禽类加工厂 | The food method of animal bone |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103202858A (en) * | 2012-01-16 | 2013-07-17 | 湖南天劲制药有限责任公司 | Pig bone nutrient and bone-strengthening and blood-generating oral liquid prepared by same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1097317A (en) | 1995-01-18 |
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