CN104304624A - Compound radix salviae miltiorrhizae sugar for patient with hypertension - Google Patents
Compound radix salviae miltiorrhizae sugar for patient with hypertension Download PDFInfo
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Abstract
The invention discloses compound radix salviae miltiorrhizae sugar for treating hypertension, and belongs to the technical field of traditional Chinese medicine healthcare. The compound radix salviae miltiorrhizae sugar is prepared from the following ingredients in parts by weight: 1000-1200 parts of white granulated sugar, 200-220 parts of sorghum starch, 25-35 parts of a radix salviae miltiorrhizae extract, 1-3 parts of a ginseng extract, and 1-3 parts of redroot gromwell root extract, wherein each of the extracts of the ingredients is extracted with water, which is ten times heavier than the extract. The compound radix salviae miltiorrhizae sugar disclosed by the invention is based on the rules of treatment of invigorating the blood circulation to remove stasis, nourishing the blood and tranquilization, reasonable in formula, simple in preparation technology, and wide in application range. The compound radix salviae miltiorrhizae sugar is prepared from purely traditional Chinese herbal materials, wide in source, low in cost, high in cure rate, and free of residue of the medicine, has no toxic or side effects, and the remarkable effects of comprehensively adjusting microcirculation and functions of the body, can effectively relieve the symptom of hypertension, has no toxic or side effects, and can be taken for a long time to stably control the blood pressure.
Description
Technical field
The invention belongs to field of health care food, relate to the compound Danshen Root sugar that a kind of hypertensive patient takes particularly.
Background technology
The blood pressure of normal person fluctuates within the specific limits with internal and external environment change.Overall crowd, blood pressure level raised gradually with the age, more obvious with systolic pressure, but after 50 years old, diastolic pressure presents downward trend, and pulse pressure also strengthens thereupon.In recent years; the understanding of people to the effect of cardiovascular disease multiple risk factors and the heart, brain, kidney target-organ protection deepens continuously; hypertensive diagnostic criteria is also in continuous adjustment; think that the danger difference of cardiovascular disease occurs the patient of same blood pressure level at present; therefore the concept of blood pressure layering has been had; namely the different patient of cardiovascular disease risk factor occurs, and suitable blood pressure level should have difference.Doctor on the basis of normative reference, judges the most suitable blood pressure range of this patient according to its concrete condition, adopts remedy measures targetedly when patient.
Hypertension incidence reason: be 1. accustomed to factor heredity, about half hyperpietic has family history.2. environmental factor.3. the age.The incidence of disease the trend increased with age growth, and within more than 40 years old, person's incidence of disease is high.4. other overweight people's incidences of disease are high; Contraceptive; Sleep Apnea-hypopnea Syndrome.
Hypertension can be divided into two classes clinically:
1. essential hypertension.Be a kind of with blood pressure rising for main clinical manifestation and the not yet clear and definite independent disease of the cause of disease.
2. secondary hypertension.Be also called symptomatic hypertension, in this kind of disease, the cause of disease is clear and definite, and hypertension is only one of clinical manifestation of this kind of disease, and blood pressure can temporary or persistence rising.
Hypertensive symptom varies with each individual.Early stage possibility is asymptomatic or symptom is not obvious, only after tired, stress, anxious state of mind, blood pressure can occur and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom gradually.Now be called as benign hypertension.Benign hypertension common clinical symptoms have headache, dizziness, absent minded, failure of memory, extremity numbness, enuresis nocturna increase, palpitaition, uncomfortable in chest, weak etc.Even there will be severe headache, vomiting, palpitaition, the symptom such as dizzy when blood pressure is elevated to a certain degree suddenly, time serious, obnubilation, tic can occur.This just belongs to accelerated hypertension and hypertension critical illness, and how infringement and the pathology of the organs such as the serious heart, brain, kidney can occur in a short time, as apoplexy, heart stalk, renal failure etc.Symptom there is no consistent relation with the level that blood pressure raises.
1. therapeutic purposes and principle
The final purpose of Treatment of Hypertension reduces hyperpietic's heart, the incidence of cerebrovascular disease and the death rate.Treatment of Hypertension should establish controlling of blood pressure desired value.On the other hand, hypertension usually merges with the hazards of other hearts, cerebrovascular disease and exists, such as hypercholesterolemia, obesity, diabetes etc., collaboratively increases the weight of cardiovascular disease risk, and remedy measures should be comprehensive.
(1) 1. behavior of making the life better loses weight.2. reduce sodium salt to take in.3. calcium and sylvite is supplemented.4. fat intake is reduced.5. motion is increased.6. give up smoking, limit and drink.
(2) controlling of blood pressure standard individuation is due to cause of disease difference, and hypertension incidence mechanism is not quite similar, and clinical application is treated respectively, selects most suitable medicine and dosage, to obtain optimum curative effect.
(3) although controlling of blood pressure is in normal range (NR) after multiple cardiovascular risk factors Collaborative Control Treatment of Hypertension, the Other Risk Factors beyond blood pressure raises still produces material impact to prognosis.
2. antihypertensive drug therapy
(1) antihypertensive drugs kind 1. diuretics.2. beta-blocker.3. calcium channel blocker.4. angiotensin converting enzyme inhibitor.5. angiotensin-ii receptor retarding agent.
(2) therapeutic scheme is most of can separately or conbined usage thiazide diuretic, beta-blocker etc. without complication or complication patient.Treatment should from low dose, progressively ascending-dose.When clinical practice uses, patient's cardiovascular risk factors situation, target organ damage, Complication, efficacy of antihypertensive treatment, bad reaction etc., all can affect the selection of depressor.2 grades of hyperpietics just can adopt two kinds of antihypertensive drugs therapeutic alliances when starting.
Following different bad reaction may be there is in each hypotensor conventional at present.
Diuretics is applicable to the early stage or Mild Hypertension people of hypertension.As Hydrochioro (Aquarium), chlorthalidone, FRUSEMIDE (furosemide) etc., main adverse reaction has hypopotassaemia, hypercalcinemia, hyperglycaemia and hyperlipidemia etc.In addition, also there is adverse effect to the patient of renal hypofunction, increasing of blood urea nitrogen and creatinine can be caused.Therefore person is cautious use of renal insufficiency.Have a kind of diuretic antihypertensive medicine in addition indopamide, long-term taking can cause hypopotassaemia, occasionally can cause hyperuricemia, on blood calcium, blood sugar and blood fat then without impact.
It is fast that beta-receptor blocking agent is applicable to heart rate, and heart function well accompanies the light medium-sized hypertensive patient of coronary disease and angina pectoris.As Propranolol (inderal), metoprolol (Betaloc), atenolol (atenolol) and bisoprolol (rich Soviet Union, health can) etc., can bradycardia be caused, bring out bronchial astehma, hyperglycaemia, hyperlipidemia etc.And hypoglycemic clinical sign can be covered.Also acute heart failure can be brought out as heavy dose uses.So, to merge simultaneously atrioventricular block, hyperlipidemia, hyperuricemia, diabetes or asthma patient should not use.
Alpha-receptor blocking agent is applicable to the bad hypertensive patient of obesity, hyperlipidemia and renal function.Conventional has prazosin (Prazosin), Terazosin (hytrin) and Doxazosin (Quinazosin) etc.It is rear that both are also used for the treatment of hyperplasia of prostate.Common adverse reactions is postural hypotension, and especially first dose easily occurs when taking medicine, and should reduce by half and take, and note avoiding get up night as far as possible when therefore taking medicine first at dose just before going to bed.
Calcium antagonist is applicable to the hypertensive patient merging renal insufficiency or diabetes.Change after nifedipine sheet (nifedipine), felodipine (Plendil) and Amlodipine (Amlodipine Besylate Tablet) etc. as conventional in Dihydropyridine calcium antagonist all can produce the side effects such as flush, headache, palpitating speed, ankle oedema.Wherein nifedipine (nifepine) is even the effect causing hyperglycaemia, therefore, be combined glycosuria patient as far as possible need not, as must, then general opinions low dose, and answer periodic review blood sugar.Verapamil (verapamil) in non-Dihydropyridine calcium antagonist and ground that sulphur (diltiazem hydrochloride), owing to having inhibitory action to sinus node function and Atrioventricular Conduction, easily cause sinus bradycardia and atrioventricular block.Therefore, should not use the patient of bradycardia and atrioventricular block.But without the side effect of ankle oedema both rear.In addition, diltiazem hydrochloride occasionally can teratogenesis tire or stillborn foetus, therefore contraindication in pregnancy.
Angiotensin converting enzyme inhibitor is applicable to complication with diabetes or slight renal hypofunction patient, as captopril (Captopril), enalapril (Enalapril), Benazepril (Lotensin), Cilazapril (a flat Soviet Union), Perindopril (Acertil) and fosinopril (illiteracy promise) etc.The most common bad reaction is cough in various degree, itches, dry cough to swallow, and incidence is 10% ~ 20%.Other rare bad reactions have angioneurotic edema, potassemia, Neuroleptic Leukocytopenia, hypoglycemia etc.Severe renal hypofunction patient to be cautious use of or need not.
Angiotensin I I receptor antagonist is applicable to the not tolerant hypertensive patient of angiotensin converting enzyme inhibitor.As Losartan (Cozaar), Valsartan (Valsartan) etc.Not yet find that there is obvious bad reaction at present, slight dizziness can be had, feel sick, occasionally can cause potassemia.
Central depressor is applicable to renal hypofunction, renal hypertension or gestation hypertension patient, as ethyldopa, clonidine etc. all cause dizzy, postural hypotension and hypogona dism etc.
Composite antihypertensive preparation is as conventional Compound Reserpine (falling sheet again), Hypotensor No 0, and interior Esidri can cause the bad reactions such as drowsiness, weak, nasal obstruction, gastrorrhagia, sex dysfunction, and canker patient be cautious use of.In addition, Hypotensive tablels and Zhenju Jiangya Tablet long-term taking, occasionally can cause sex dysfunction, therefore a middle-aged person will be cautious use of.FUFANG LUOBUMA PIAN is containing guanethidine, and occasionally can orthostatic hypotension occur and fall down, therefore the elderly will be cautious use of.Captopril Compound includes captopril and Hydrochioro, easily causes excitant dry cough and diuresis.Chronic bronchitis and pharyngitis person is had to be cautious use of.
Be used alone western medicine at present, long-term taking, body easily forms tolerance, and dosage can constantly increase, and side effect is comparatively large, long-term to patient body.
Summary of the invention
The technical problem that will solve of the present invention is to provide the compound Danshen Root sugar that a kind of hypertensive patient takes, and the present invention can recover rapidly blood pressure, taking convenience by each medicine components compatibility, have no side effect and safe and effective.
The present invention is achieved through the following technical solutions:
The compound Danshen Root sugar that a kind of hypertensive patient takes, it is made up of by weight following component: white granulated sugar 1000-1200 part, sorghum starch 200-220 part, Salvia root P.E 25-35 part, ginseng extract 1-3 part, Radix Arnebiae extract 1-3 part, the extract of above-mentioned each composition is the concentrated spray powder of water extract, and every gram of extract is equivalent to crude drug 10 grams.
Described various raw material optimum ratio amount is: white granulated sugar 1100 parts, sorghum starch 210 parts, Salvia root P.E 30 parts, ginseng extract 2 parts, Radix Arnebiae extract 2 parts.
Described white granulated sugar, sorghum starch, Salvia root P.E, ginseng extract, Radix Arnebiae extract granularity are 20-200 order.
The processing method of described red sage root sugar:
1. starch and a part of white granulated sugar are added a small amount of water to dissolve in advance and be heated to 60 DEG C (container is heated in a water bath).
2. Salvia root P.E, ginseng extract (10 times of extractions), Radix Arnebiae extract (10 times of extractions) are dissolved in boiling water simultaneously, slowly pour in the syrup that starch and granulated sugar dissolves again, constantly stir, be washed into the starch paste of thickness, then add remaining white granulated sugar, constantly carry out stirring and making it flash melt, put into aluminum pot and heat infusion, and constantly stir with slice, avoid being burned.Infusion makes moisture evaporate in 30 ~ 40 minutes, until till steam of constantly emerging in pot.
3. then close fire cooling, to be poured in the wooden frame spilling starch or shaping on chopping board, wooden frame is high 1.5 centimetres.
4. be cut into main piece of the length of long 3 centimetres after cooling by knife, be compound Danshen Root sugar finished product.
The mode of taking of described compound Danshen Root sugar is chewing, everyone each chewing 1 piece, every day 3 times, can long-term taking.
The characteristic of medicine is as follows:
White granulated sugar: white granulated sugar is put down, and taste is sweet, moistening lung is promoted the production of body fluid, tonifying middle-Jiao and Qi, heat-clearing and damp-drying drug, preventing phlegm from forming and stopping coughing, removing toxic substances sobers up, falls and turbidly to soothe the spirit; To can be used in treatment empty gastral cavity pain, splenasthenic diarrhea, xeropulmonary cough, dry mouth yearningly and the illness such as beriberi, scabies, bittern intoxication, eczema of scrotum.
Sorghum starch: taste is sweet, warm in nature, puckery, enters spleen, stomach warp; So it has the effect with stomach, disappear long-pending, Wen Zhong, puckery stomach, only cholera; Function cures mainly water retention due to hypofunction of the spleen, indigestion and the disease such as damp-heat diarrhea, difficult urination.
Salvia root P.E (10 times of extractions): red sage root bitter, micro-pungent, cold nature; The medicine of the heart, spleen, liver, kidney blood system; There is promoting blood circulation, nourishing blood and tranquilization, effect of cool blood detumescence.Cure mainly hemostasis head, chest, the side of body, abdomen pain, gather, irregular menstruation, dysmenorrhoea is through closing, and the stagnant stomachache of the stasis of blood in postpartum, joint pain, fall dozen stasis of blood and swell, warm disease is vexed, palpitation due to deficiency of blood, sore swollen toxin, red rash mange.Modern study shows strengthen myocardial contractive power, improve cardiac function, does not increase MCO; Energy coronary artery dilating, increases MBF; Expansion peripheral vascular, blood flow increases; Cerebral blood flow (CBF) declines; Can antithrombus formation.
Ginseng extract (10 times of extractions): sweet, the micro-hardship of taste is warm in nature, flat.Return spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, Gu de-, promote the production of body fluid, calms the nerves, intelligence development.Effect: reinforce vital energy, multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid to quench thirst, intelligence development of calming the nerves.
Cure mainly: internal lesion caused by overexertion is deficient, food less, burnout, gastric disorder causing nausea tells food, stool lingering diarrhea, void cough that syndrome characterized by dyspnea, spontaneous perspiration are cruelly de-, palpitation with fear, forgetful, dizziness and headache, impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's slowly frightened and for a long time void not again, the disease of all qi-blood-body fluid deficiencies.
Radix Arnebiae extract (10 times of extractions): Asian puccoon is sweet, flat, enter percardium, Liver Channel.Control warm macula, jaundice with damp-heat pathogen, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, large carbuncle.Modern study shows there is obvious hypotensive effect.
The combination principle of red sage root sugar is that mouthfeel is applicable to, convenient making.Above-mentioned compatibility, white granulated sugar, sorghum starch and middle invigorating the spleen, Salvia root P.E (10 times of extractions) and Radix Arnebiae extract (10 times of extractions) promoting blood circulation, nourishing blood and tranquilization, ginseng extract reinforces vital energy, full side is treated both principal and secondary aspect of disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation microcirculation.
Red sage root sugar, reaches the effect of promoting blood circulation, nourishing blood and tranquilization, and QI-blood circulation in adjustment body, obviously reduces hypertension, can the symptom such as fast pain relief, recovers appetite and digestive function.
The present invention's beneficial effect compared with prior art:
The present invention is with promoting blood circulation, nourishing blood and tranquilization for the rules for the treatment of, and reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, and wide material sources, cost are low, and cure rate is high, medicine noresidue, have no side effect, there is the effect of significant across-the-board regulation microcirculation and adjustment body function, effectively alleviate hypertension symptom, long-term taking, has no side effect, and controlling of blood pressure is stablized.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
Various raw materials in prescription are taken white granulated sugar 1100g, sorghum starch 210g, Salvia root P.E (10 times of extractions) 35g, ginseng extract (10 times of extractions) 2g, Radix Arnebiae extract (10 times of extractions) 2g.Make by previous process.
The extracting method of described Salvia root P.E is: get raw medicinal herbs 100g, and add water 1000ml, leaches liquid after boiling, the dregs of a decoction 500ml that adds water boils again, be merged into previous extraction liquid after leaching liquid, be concentrated into 200ml, be spray dried to solubility powdered extract.
The extracting method of described ginseng extract is: get raw medicinal herbs 100g, and add water 1000ml, leaches liquid after boiling, the dregs of a decoction 500ml that adds water boils again, be merged into previous extraction liquid after leaching liquid, be concentrated into 200ml, be spray dried to solubility powdered extract.
The extracting method of described Radix Arnebiae extract is: get raw medicinal herbs 100g, and add water 1000ml, leaches liquid after boiling, the dregs of a decoction 500ml that adds water boils again, be merged into previous extraction liquid after leaching liquid, be concentrated into 200ml, be spray dried to solubility powdered extract.
Embodiment 2
Various raw materials in prescription are taken white granulated sugar 1200g, sorghum starch 200g, Salvia root P.E (10 times of extractions) 30g, ginseng extract (10 times of extractions) 2g, Radix Arnebiae extract (10 times of extractions) 3g, make by previous process.
Embodiment 3
Various raw materials in prescription are taken white granulated sugar 1100g, sorghum starch 220g, Salvia root P.E (10 times of extractions) 25g, ginseng extract (10 times of extractions) 2g, Radix Arnebiae extract (10 times of extractions) 2g, make by previous process.
Embodiment 4
Various raw materials in prescription are taken white granulated sugar 1000g, sorghum starch 220g, Salvia root P.E (10 times of extractions) 35g, ginseng extract (10 times of extractions) 1g, Radix Arnebiae extract (10 times of extractions) 1g, make by previous process.
Embodiment 5
Various raw materials in prescription are taken white granulated sugar 1200g, sorghum starch 200g, Salvia root P.E (10 times of extractions) 30g, ginseng extract (10 times of extractions) 1g, Radix Arnebiae extract (10 times of extractions) 2g, make by previous process.
Clinical testing:
Application example 1:
Lai Shan town, Laishan District, Yantai hospital
This hospital successively has 15 patients to use the present invention, 57 years old mean age, and they start only after tired, stress, anxious state of mind, blood pressure to occur and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom gradually.Common clinical symptoms have headache, dizziness, absent minded, failure of memory, extremity numbness, enuresis nocturna increase, palpitaition, uncomfortable in chest, weak etc.The health products made of formula of the application embodiment of the present invention 1 are by everyone each serving with 1 piece, and every day 3 times, after being used in conjunction 6 days, transference cure, adheres to taking for a long time, and hypertension symptom is without recurrence, and 14 people all effective 4, and 1 people is invalid, and efficient is 93%.
Application example 2:
Haiyang, Yantai two Shili shop hospital
This hospital successively has 30 patients to use the present invention, 59 years old mean age, and their blood pressure is higher for a long time, even there will be severe headache, vomiting, palpitaition, the symptom such as dizzy, time serious, obnubilation, tic can occur when blood pressure is elevated to a certain degree suddenly.The health products made of formula of the application embodiment of the present invention 1 are by everyone each serving with 1 piece, and every day 3 times, after being used in conjunction 6 days, transference cure, adheres to taking for a long time, and hypertension symptom is without recurrence, and 27 people are effective, and 3 people are invalid, and efficient is 90%.
Application Example 3
The Contrast on effect of the present embodiment application compound Danshen Root of the present invention sugar and single red sage root sugar, the red sage root and Asian puccoon or the red sage root and ginseng composite sugar health products, the composition of each group, in table 1, is made by previous process.
The composition of each group of table 1 and content
The health products that each component of table 1 is made, have no side effect.Single or the compound Danshen Root made of each component of table 1 is sugared to be taken to 45 hyperpietics, 58 years old mean age of patient, their blood pressure is higher for a long time, even there will be severe headache, vomiting, palpitaition, the symptom such as dizzy when blood pressure is elevated to a certain degree suddenly, time serious, obnubilation, tic can occur.By everyone each serving with 1 piece, every day 3 times, be used in conjunction 6 days, recover normal and long-term taking does not recur for effective standard with blood pressure, clinical trial result is in table 2.
Table 2 each compound Danshen Root sugar effect
| ? | The present invention program | Control group 1 | Control group 2 | Control group 3 |
| Effectively | 41 | 28 | 29 | 25 |
| Invalid | 4 | 17 | 16 | 20 |
| Efficient | 91％ | 62％ | 64％ | 56％ |
Above effect proves, technical solution of the present invention reasonable recipe, and Synergistic between each component.Above-mentioned detailed description of the red sage root sugar that hypertensive patient takes being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. the compound Danshen Root sugar of a Hypertension, it is characterized in that it is made up of by weight following component: white granulated sugar 1000-1200 part, sorghum starch 200-220 part, Salvia root P.E 25-35 part, ginseng extract 1-3 part, Radix Arnebiae extract 1-3 part, the extract of above-mentioned each composition is the concentrated spray powder of water extract, and every gram of extract is equivalent to crude drug 10 grams.
2. the compound Danshen Root sugar of a kind of Hypertension according to claim 1, is characterized in that described various material proportional quantity is white granulated sugar 1100 parts, sorghum starch 210 parts, Salvia root P.E 30 parts, ginseng extract 2 parts, Radix Arnebiae extract 2 parts.
3. the compound Danshen Root sugar of a kind of Hypertension according to claim 1, is characterized in that described white granulated sugar, sorghum starch, Salvia root P.E, ginseng extract, Radix Arnebiae extract granularity are 20-200 order.
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Application publication date: 20150128 |