CN104297471A - Detecting system for test paper - Google Patents
Detecting system for test paper Download PDFInfo
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- CN104297471A CN104297471A CN201410624869.3A CN201410624869A CN104297471A CN 104297471 A CN104297471 A CN 104297471A CN 201410624869 A CN201410624869 A CN 201410624869A CN 104297471 A CN104297471 A CN 104297471A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
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Abstract
The embodiment of the invention discloses a detecting system for test paper. The system comprises a detecting unit used for information collection, and a colorimetric photosensitive device used for information processing and analysis, wherein the detecting unit is a black detecting card; the colorimetric photosensitive device comprises a light-emitting unit, an optical imaging unit and a photoelectric processing unit. The detecting system has more accurate analytical sensitivity, and through the adoption of the detecting system, the lower limit of the detection of products can be effectively improved, and the range of clinical detection can be enlarged.
Description
Technical field
The present invention relates to medical detection technology, particularly relate to a kind of detection paper system.
Background technology
Immuno-gold labeling technology mainly make use of the characteristic that gold grain has high electron density, at gold mark protein combination place, visible pitchy particle under the microscope, when these labels are assembled in a large number at corresponding part place, naked eyes red color visible or pink spot, thus in qualitative or quantitative tachysynthesis detection method.For quantitative test, usually send illumination by automatic light source to test card with detector, receive the light be reflected back and be converted to electric signal, then by carrying out to the analysis of electric signal the color that quantitative comparison test strips occurs at reflection ray place.
Based on the universal architecture that reflected light Cleaning Principle and gold mark test card get stuck, when the illumination that light source is launched is at reading window, some radiance is beaten on the slope of window edge, except small part light is absorbed, the reflection that most of light gets stuck through white, be received by the receiver together with the light that reflected light can reflect with test strips, it is irregular for propagating at the object glazed thread of surface imperfection due to reflected light, the size that affects for each test result is uncertain, and this series products all cannot address this problem at present.
Summary of the invention
Embodiments provide a kind of detection paper system, it is characterized in that, comprise the detecting unit for information acquisition and the colorimetric photosensitive device for information process analysis; Described detecting unit is a black test card; Described colorimetric photosensitive device comprises, luminescence unit, optical image unit, photoelectric processing unit.
Preferably, described luminescence unit comprises more than one illuminator; Described optical image unit comprises light hole, imaging subelement; Described photoelectric processing unit comprises receiver, photoelectric processing circuit board; Described illuminator is evenly installed around light hole, described light source circuit board is placed on the front end of described imaging hole, described light hole is facing to described imaging subelement, and described photoelectric processing unit is positioned over the rear end of imaging subelement and described receiver faces toward described imaging subelement.
Preferably, described imaging subelement is an imaging aperture, and its diameter is between 0.1mm to 2.00mm.
Preferably, described imaging subelement is an imaging aperture, and its diameter is between 1mm to 1.20mm.
Preferably, described imaging subelement comprises two convex lens.
Preferably, described illuminator is LED.
Preferably, described receiver is photoelectric cell.
Further, the acceptable effective lambda1-wavelength of described photoelectric cell is 200nm to 800nm.
Preferably, described test card case surface has detection fenestra and well.
Preferably, also comprise printer, described printer is connected with described photoelectric processing circuit board.
The colorimetric illuminant module of the embodiment of the present invention coordinates black test card to be applied to the golden shade identification in detecting of marking, effectively prevent white to get stuck generation diffuse reflection, use the detection data of photelectric receiver more accurate, thus the sensitivity of raising detection, repeatability and accuracy.There is sensitivity for analysis more accurately, can effectively improve Product checking lower limit, expand clinical detection scope.
Accompanying drawing explanation
Fig. 1 is an example structure schematic diagram of a kind of detection paper system provided by the invention;
Fig. 2 is another example structure schematic diagram of a kind of detection paper system provided by the invention;
Fig. 3 is a kind of contour structures schematic diagram of the test card in a kind of detection paper system embodiment provided by the invention;
Fig. 4 is the another kind of contour structures schematic diagram of the test card in a kind of detection paper system embodiment provided by the invention;
Fig. 5 a, Fig. 5 b are structural representation and the light path schematic diagram of another embodiment of a kind of detection paper system provided by the invention;
Fig. 6 is the structural representation of another embodiment of a kind of detection paper system provided by the invention.
Description of reference numerals: 1 light source, 2 test strips, 3 light source circuit boards, 4 receivers, 5 photoelectric processing circuit boards.
Embodiment
In order to more specifically describe the present invention, below in conjunction with the drawings and the specific embodiments, technical scheme of the present invention and relative theory thereof are described in detail.
Referring to Fig. 1, for inventing the structural representation of an embodiment of a kind of detection paper system provided, comprising the detection module for information acquisition and the colorimetric illuminant module for information process analysis.
Detection module is a black test card, a built-in test strips, and has at least one window to expose a part for test strips, for carrying out reacting with sample and presenting its reacted color.Fig. 2, Fig. 3 each provide a kind of contour structures schematic diagram into test card.
Colorimetric illuminant module comprises luminescence unit, optical image unit, photoelectric processing unit.Fig. 4 provides the structural representation of colorimetric illuminant module in the present embodiment.
The monochromatic light exposure that luminescence unit sends is in the test strips of the window of test card, after reflecting, a part in the light reflected can be optically imaged unit and receive, reflected light is converted into electric signal by photoelectric processing unit, by the circuit function module of inside, quantitative analysis and comparison is carried out to electric signal, determine the shade in test strips.
The test card of the black gold conjugate mark that gets stuck gets stuck the universal architecture of window, the illumination that luminescence unit is launched is on black gold mark gets stuck, black gold mark gets stuck most light absorption, few a part of light is only had to produce reflection, reflex to that only can ignore on photoelectric processing unit do not remember, the reception of receiver to tested reflected light can not be affected.
For CRP (c reactive protein) project, by test figure, understand the impact of black card and white card Color pair properties of product.Consider relevant manufacturers reagent Cleaning Principle, the analysis of Binding experiment data, find that the linear dependence of T peak value in CRP project and CRP concentration is best, therefore for T peak value in CRP data, verify that test card uses black card to get stuck and Color pair CRP test result impact of getting stuck in vain respectively by experiment.Experimental result is as follows:
| ng/ml | 0 | 1 | 2.5 | 5 | 10 | 20 | 40 | 80 | 160 | 320 | 640 |
| Black card | 35.7 | 63.8 | 117.5 | 238 | 419 | 670.5 | 990 | 1340 | 1594 | 1917 | 1954 |
| Bai Ka | 0 | 0 | 82.6 | 162 | 340 | 592 | 922 | 1278 | 1508 | 1856 | 1874 |
Can be learnt by above-mentioned data analysis:
(1) the reading remolding sensitivity white that black gets stuck gets stuck to have and very significantly optimizes, even if when low concentration, also has good reaction sensitivity;
(2) when same concentrations reading, the numeric ratio black that white gets stuck read gets stuck low.This is the reflection to light because white gets stuck and scattering, has highlighted the area color of card article test paper, causes AD value reading to become large, even exceeds sensing range.
Therefore from sensitivity angle, black gets stuck to get stuck than white and has lower lowest detectable limit, sensitivity for analysis more accurately, can effectively improve Product checking lower limit, expands clinical detection scope.
Further, refer to Fig. 5, optical image unit comprises light hole, imaging subelement.Illuminator is evenly installed around light hole, and light source circuit board is placed on the front end of described imaging hole, and light hole is facing to described imaging subelement, and photoelectric processing unit is positioned over the rear end of imaging subelement and described receiver faces toward described imaging subelement.Photoelectric processing unit can be divided into these two parts of receiver, photoelectric processing circuit board.Receiver is used for opto-electronic conversion, and photoelectric processing circuit board is used for carrying out analysis contrast to the electric signal that receiver exports.
Test card just placed light hole, illuminator sends uniform monochromatic light around light hole, and the light of test card reflection, by light hole, forms real image and passes to receiver in imaging subelement.
In the present embodiment, receiver is photoelectric cell.Preferably, the acceptable effective lambda1-wavelength of photoelectric cell is 200nm to 800nm.The photoelectric cell with wider wavelength domain can be selected illuminator more neatly, be applied more broadly in the test strips of different colours.
In the present embodiment, optical imagery subelement can be a miniature imaging hole, utilizes pinhole imaging system principle, forms the real image accepted of photoelectric processing unit in imaging subelement.The diameter of imaging hole can adjust adaptation according to the shape of test strips window in test card and size, and its scope is between 0.1mm to 2.00mm.Preferably, when test card adopts size general on the market, imaging hole 4 is of a size of 1mm to 1.2mm.
Light path design cooperation black in the present embodiment gets stuck and is applied to the golden shade identification in detecting of marking, effectively prevent white to get stuck generation diffuse reflection, use the detection data of photelectric receiver more accurate, thus the sensitivity of raising detection, repeatability and accuracy.Get stuck and adopt black material and matte surface process, the light source being radiated at card article is absorbed, and produces irreflexive light few.
Refer to Fig. 6, optical imagery subelement can also be one group of convex lens.
Further, test card case surface has detection fenestra and well.Well reacts in test strips for dripping sample, detects the color change that fenestra brings for the reaction observed in test strips.
The present embodiment can also comprise a printer, by being connected with described photoelectric processing circuit board, directly can being printed by analysis result and being convenient for carrying reading.
Those skilled in the art can be well understood to, and for convenience and simplicity of description, the system of foregoing description, the specific works process of device and unit, with reference to the corresponding process in preceding method embodiment, can not repeat them here.
In several embodiments that the application provides, should be understood that, disclosed system, apparatus and method, can realize by another way.Such as, device embodiment described above is only schematic, such as, the division of described unit, be only a kind of logic function to divide, actual can have other dividing mode when realizing, such as multiple unit or assembly can in conjunction with or another system can be integrated into, or some features can be ignored, or do not perform.Another point, shown or discussed coupling each other or direct-coupling or communication connection can be by some interfaces, and the indirect coupling of device or unit or communication connection can be electrical, machinery or other form.
The described unit illustrated as separating component or can may not be and physically separates, and the parts as unit display can be or may not be physical location, namely can be positioned at a place, or also can be distributed in multiple network element.Some or all of unit wherein can be selected according to the actual needs to realize the object of the present embodiment scheme.
In addition, each functional unit in each embodiment of the present invention can be integrated in a processing unit, also can be that the independent physics of unit exists, also can two or more unit in a unit integrated.Above-mentioned integrated unit both can adopt the form of hardware to realize, and the form of SFU software functional unit also can be adopted to realize.
If described integrated unit using the form of SFU software functional unit realize and as independently production marketing or use time, can be stored in a computer read/write memory medium.Based on such understanding, the part that technical scheme of the present invention contributes to prior art in essence in other words or all or part of of this technical scheme can embody with the form of software product, this computer software product is stored in a storage medium, comprising some instructions in order to make a computer equipment (can be personal computer, server, or the network equipment etc.) perform all or part of step of method described in each embodiment of the present invention.And aforesaid storage medium comprises: USB flash disk, portable hard drive, ROM (read-only memory) (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), magnetic disc or CD etc. various can be program code stored medium.
The above, above embodiment only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a detection paper system, is characterized in that, comprises the detection module for information acquisition and the colorimetric illuminant module for information process analysis;
Described detection module is a black test card;
Described colorimetric photosensitive device comprises, luminescence unit, optical image unit, photoelectric processing unit.
2. detection paper system according to claim 1, is characterized in that, described luminescence unit comprises more than one illuminator;
Described optical image unit comprises light hole, imaging subelement;
Described photoelectric processing unit comprises receiver, photoelectric processing circuit board;
Described illuminator is evenly installed around light hole, described light source circuit board is placed on the front end of described imaging hole, described light hole is facing to described imaging subelement, and described photoelectric processing unit is positioned over the rear end of imaging subelement and described receiver faces toward described imaging subelement.
3. detection paper system according to claim 2, is characterized in that, described imaging subelement is an imaging aperture, and its diameter is between 0.1mm to 2.00mm.
4. detection paper system according to claim 3, is characterized in that, described imaging subelement is an imaging aperture, and its diameter is between 1mm to 1.20mm.
5. detection paper system according to claim 2, is characterized in that, described imaging subelement comprises two convex lens.
6. detection paper system according to claim 2, is characterized in that, described illuminator is LED.
7. detection paper system according to claim 2, is characterized in that, described receiver is photoelectric cell.
8. light channel structure according to claim 7, is characterized in that, the acceptable effective lambda1-wavelength of described photoelectric cell is 200nm to 800nm.
9. detection paper system according to claim 2, is characterized in that, described test card case surface has detection fenestra and well.
10. colorimetric photoresponse device according to claim 1, is characterized in that, also comprise printer, and described printer is connected with described photoelectric processing circuit board.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410624869.3A CN104297471A (en) | 2014-11-06 | 2014-11-06 | Detecting system for test paper |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410624869.3A CN104297471A (en) | 2014-11-06 | 2014-11-06 | Detecting system for test paper |
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| CN104297471A true CN104297471A (en) | 2015-01-21 |
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| CN201410624869.3A Pending CN104297471A (en) | 2014-11-06 | 2014-11-06 | Detecting system for test paper |
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Citations (7)
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| CN1904592A (en) * | 2006-07-28 | 2007-01-31 | 中国科学院上海光学精密机械研究所 | Reflection photometer of gold-labeled immunity test paper strip |
| CN200962084Y (en) * | 2006-07-18 | 2007-10-17 | 台湾元生生物科技股份有限公司 | Detection component and its covering shell |
| CN101093196A (en) * | 2007-07-25 | 2007-12-26 | 中华人民共和国天津出入境检验检疫局 | Meter for reading test paper tape of colloidal gold in use for detecting residue |
| CN101430274A (en) * | 2008-11-05 | 2009-05-13 | 赵中远 | Hemoglobin colour comparison detection apparatus |
| CN201408167Y (en) * | 2008-08-26 | 2010-02-17 | 深圳市恩普电子技术有限公司 | Color collecting device of urine analyzer |
| CN102095497A (en) * | 2010-12-16 | 2011-06-15 | 中国检验检疫科学研究院 | Pinhole imaging-based quantitative detector for color development signal of immunochromatography detection test strip |
| CN104081207A (en) * | 2011-12-23 | 2014-10-01 | 雅培医护站股份有限公司 | Integrated test device for optical and electrochemical assays |
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2014
- 2014-11-06 CN CN201410624869.3A patent/CN104297471A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200962084Y (en) * | 2006-07-18 | 2007-10-17 | 台湾元生生物科技股份有限公司 | Detection component and its covering shell |
| CN1904592A (en) * | 2006-07-28 | 2007-01-31 | 中国科学院上海光学精密机械研究所 | Reflection photometer of gold-labeled immunity test paper strip |
| CN101093196A (en) * | 2007-07-25 | 2007-12-26 | 中华人民共和国天津出入境检验检疫局 | Meter for reading test paper tape of colloidal gold in use for detecting residue |
| CN201408167Y (en) * | 2008-08-26 | 2010-02-17 | 深圳市恩普电子技术有限公司 | Color collecting device of urine analyzer |
| CN101430274A (en) * | 2008-11-05 | 2009-05-13 | 赵中远 | Hemoglobin colour comparison detection apparatus |
| CN102095497A (en) * | 2010-12-16 | 2011-06-15 | 中国检验检疫科学研究院 | Pinhole imaging-based quantitative detector for color development signal of immunochromatography detection test strip |
| CN104081207A (en) * | 2011-12-23 | 2014-10-01 | 雅培医护站股份有限公司 | Integrated test device for optical and electrochemical assays |
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Application publication date: 20150121 |