CN104288639A - Capsule for improving memory - Google Patents

Abstract

The invention discloses a capsule for improving memory. The capsule comprises the following medicinal ingredients in percentage by mass: 40% of schisandra chinensis, 20% of rhizoma acori graminei, 18% of sheep brain powder, 19.8% of fructus alpiniae oxyphyllae, 2% of folic acid, 0.1% of huperzine A and 0.1% of mecobalamine. The capsule is orally taken by 1-1.5g three times a day, and is swallowed with warm water after a meal, so that the memory is improved, and especially the capsule has magic effects on improvement of the memory of old people.

Description

A kind of capsule improving memory

Technical field

The invention belongs to biomedicine field, more specifically a kind of capsule improving memory, particularly improve the capsule of old man's memory.

Background technology

Because people moves towards decline gradually to old brain function, intelligence progressively declines, and memory obviously goes down, thinking creativeness is weak, psychology very flexible, can not correctly process situation about occurring in life, emotion is not easily stablized, easily enrage, along with brain function goes down and old and feeble further, there is the symptoms such as forgetful in many old peoples too early, about has 3% old people to suffer from senile dementia in various degree, and have the trend of rising every year, there is hypomnesis, the symptom such as forgetful in early days in many old men.Its reason: one is disease factor.The arteriosclerosis that old people easily suffers from, hypertension, diabetes etc., can affect cerebral nervous system function, have influence on the supply of brain cell nutrition, and make brain cell activity not enough, intelligence fails gradually.If particularly people suffers from hypertension, arteriosclerosis in the middle age, after entering old age, the group of people at high risk of senile dementia will be become.Two is effects of inherited genetic factors.The impact of inherited genetic factors on people is widely, can cause various diseases and physiological abnormalities, no exception on the impact of intelligence.Three is results of self identification.In some subconsciousnesss, conscious and receive the fact of " always " unconsciously, sensation head is more and more not obedient, all all dying, being disinclined at ordinary times beats one's brains requires mental skill, and cause brain to be in inhibitory state for a long time, brain cell lacks stimulation, brain function is not used and strengthens, and causes brain aging, decay gradually.Four is impacts of social factor.The medicine of existing market rare raising old man memory, in order to make up this technological deficiency, have developed the capsule improving old man's memory. summary of the invention

The traditional Chinese medical science is thought, " brain being the marrow sea ", the essence of five ZANG-organs and six FU-organs notes brain, and brain is full, and then people's thinking is clear, and memory is quick.Middle treatment improves mental with the kidney invigorating essence, and reaches the object that Fructus Alpiniae Oxyphyllae keeps fit.The technical program makes capsule in order to lower medical material by peace mass percent.Fructus Schisandrae Chinensis 40%, Rhizoma Acori Graminei 20%, Medulla caprae seuovis powder 18%, Fructus Alpiniae Oxyphyllae 19.8%, folic acid 2%, huperzine A 0.1%, mecobalamin 0.1%.

Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils.." Newly Revised Canon of Materia Medica " carries " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Fructus Schisandrae Chinensis is divided into two kinds, south, north.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, list in the top grade Chinese medicine in Sheng Nong's herbal classic the earliest, the power of energy strengthening by means of tonics, medical value is high, has the effect of building body. pharmacological action: 1. on the impact of hepatic injury: schisandrol extract can reduce the laboratory animal glutamate pyruvate transaminase caused by carbon tetrachloride, thioethanolamine etc. and raise. the effect of wuweizisu B (schisandrin B) tool anti-liver injury.2. the effect of couple central nervous system: Fructus Schisandrae Chinensis have central inhibitory action widely, and the feature having stable effect.Schisandrol extract 5-10mg/kg gavage can reduce spontaneous activity in mice, and collaborative pentobarbital sodium is to the sleep effect of mice, and the mice that antagonism amfetamine causes is excited, the mice convulsion that antagonism caffeine, nicotine cause.Schizandrin (schisandrin) 10 ~ 100mg/kg lumbar injection, reduces spontaneous activity in mice with the increase of dosage, and the mice that 10mg/kg lumbar injection antagonism caffeine, amfetamine cause is excited; 60 ~ 120mg/kg lumbar injection obviously extends the mouse sleep time that mice barbital sodium and pentobarbital sodium cause; The convulsions that antagonism galvanic shock, pentylenetetrazole etc. cause.Fructus Schisandrae Chinensis have central inhibitory action widely, and has the feature of stable effect.3. pair cardiovascular effect: Fructus Schisandrae Chinensis has cardiotonic, its infusion and rare alcohol immersion, can strengthen myocardial contraction, increases antiotasis.Decoct isolated experiment has inhibitory action to rat myocardial cell film atpase activity; And have hypotensive effect to anesthetized dog.4. on the impact of immunologic function: energy enhancing body is to the defence capability of nonspecific stimulation.5. antibacterial action: ethanol immersion all has inhibitory action to anthrax bacillus, staphylococcus aureus, Staphylococcus albus, Bacillus typhi, vibrio cholera etc. in vitro. toxicity. the toxicity research of schisandrin B: once with 2g/kg B prime gavage, 10 none death of mice.200mg/kg gavage continuous 30 days of every day 1 time, to the growth of mice, the tissue morphology of hemoglobin content and main organs all has no significant effect.Once gave two dogs with B prime 10mg/kg gavage continuous 4 weeks of every day 1 time, its appetite, body weight, hemogram, liver function (BSP and SGPT), renal function (NPN) and liver impedance rheograph, all front without significant difference with administration.Doctor trained in Western medicine clinical practice: with Fructus Schisandrae Chinensis simply or compound treatment body void insomnia.For old people's slow down aging etc. therefore be the active drug for the treatment of senile disease.In a word, these product can improve muscle power.Allaying tiredness, improves intelligence and increases work efficiency.Kidney essense is gradually empty with increasing age for old people, and energy day declines, amnesia, and Fructus Schisandrae Chinensis the kidney invigorating essence is improved mental, therefore can Fructus Alpiniae Oxyphyllae keep fit, and experimentation shows that Fructus Schisandrae Chinensis has certain anti-aging effects in genitourinary system.Therefore, Fructus Schisandrae Chinensis is useful to slow down aging simply and can treats the active drug of some senile disease.

Rhizoma Acori Graminei (Classification system: Acorus tatarinowii), belongs to Araeceae, Acorus graminoid herbaceos perennial.Removing dampness is whetted the appetite, and eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, controls forgetful.Rhizoma Acori Graminei has sedation.Decoct or volatile oil all can make spontaneous activity in mice reduce, and remove the aggressive behavior that mice raised by single cage; Also can extend the length of one's sleep caused by pentobarbital sodium, have synergism to the pentobarbital sodium of subthreshold hypnotic dosage.In addition, still can the anesthesia duration of significant prolongation pentobarbital sodium.Research shows: the asaricin in volatile oil is calm effective ingredient, but still has sedation after removing volatile oil, points out its calm composition not only a kind of.The tablet that Rhizoma Acori Graminei rhizome water extract is made, is used for the treatment of epileptics and other nervous system diseases clinically, has good therapeutic effect, and its volatile oil has significant physiologically active to some neural animal model.To calm the nerves calmness: water extract 4g/kg, has sedation to mice.The volatile oil 10-100mg/kg of Rhizoma Acori Calami, to mice, rat, cat, Canis familiaris L. and monkey all in sedation, reduces the tonicity of spontaneous activity and muscle, greatly weakens the reaction of audition, tactual stimulation.α-asaricin 3mg/kg rats by intraperitoneal injection, present obvious sedation, and continue more than 4 hours, its action intensity is similar to the chlorpromazine of 3mg/kg with action time, and the rat avoidance conditioned reflex set up can be made to destroy, in addition, over-activity that hallucinogen South America cactus alkaloid (mescaline) causes rat can also be resisted and cause unreal behavior.Monkey subcutaneous injection α-asaricin 1mg/kg, showed obvious sedation after 1 hour, can eliminate aggressive behavior completely, shows decline to the interest of surrounding and investigatory reaction; When dosage is 5mg/kg, sedation is more obvious, and sustainable 90 hours of its action time, even if still show as indifferent and have no hostility when monkey is subject to provoking.The injection of 50mg/kg intravenous rabbit can produce the anesthetic action of average 7.2 minutes, is extended down to 15.5 minutes and stiff with extremity during 100mg/kg.

Medulla caprae seuovis powder latin name Medulla caprae seuovis is the dry powder of the brains of bovid goat or sheep.Tonify deficiency brain-strengthening.Sweet in the mouth; Warm in nature.Gui Jing: the heart; Liver; Kidney channel.Cure mainly body deadhead dusk; Chapped skin; The injury of tendon and muscle is fractured.Medulla caprae seuovis contains abundant ascorbic acid (ascorbic acid), riboflavin (ribolavine), nicotinic acid (nicotinic acid), thiamine (thiamin), lecithin (lecthin), cerebroside (cerebroside), protein, fat, and calcium, phosphorus, ferrum etc.Every 100g Medulla caprae seuovis is about moisture content 76g, protein 11g, fatty 11.4g, ash 1.6g; Calcium 21mg, phosphorus 358mg, ferrum 6.7mg, thiamine 0.14mg, riboflavin 0.27mg, nicotinic acid 3.5mg.In addition still containing multiple hormone, as somatostatin (somatosatin) etc.Tonify deficiency brain-strengthening, is conducive to improving memory.

Fructus Alpiniae Oxyphyllae classification systemfructus Alpinae Oxyphyllae is the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.Nature and flavor:; Acrid in the mouth; Warm in nature. Gui Jing: enter the heart, spleen; Kidney channel modern studyfructus Alpiniae Oxyphyllae is containing volatile oil, Fructus Alpiniae Oxyphyllae ketone, multivitamin and several amino acids, fatty acid etc.Fructus Alpiniae Oxyphyllae decoct has the effect of stomach invigorating, diuresis, minimizing salivation.Its water extract has suppression ascitogenous sarcoma.The effect that cell increases.Its water extract and ethanol extraction have the effect suppressing ileum contraction.In addition, its methanolic extract have strengthen left atrium contracts power, suppress potassium chloride to cause exempt from the effect such as activity that aorta shrinks and suppress prostaglandin synthetase.Pharmacological action: 1. experiment shows: the methanolic extract of intelligent promoting fruit has the effect suppressing prostaglandin synthetase activity, .2. the methanolic extract of intelligent promoting fruit has the activity strengthening guinea pig left atrium contractility, its minimum effective dose is the methanolic extract of 10-6g/ml.3. intelligence fruit, in the large artery trunks of rabbit, have antagonism to the activity of calcium, its effective ingredient is Fructus Alpiniae Oxyphyllae alcohol; When the dosage of 3 × 10-5mol, Fructus Alpiniae Oxyphyllae alcohol shrinks the large artery trunks that potassium chloride causes obvious inhibitory action, 4. to the effect of metabolism,fructus Alpiniae Oxyphyllae can improve energy metabolism, promotes the synthesis of CA class material and cAMT. 5. to the improvement result of learning memory disorder,with Fructus Alpiniae Oxyphyllae methanolic extract 25mg/kg, 50g/kg to mouse stomach 7 days, can antagonism scopolamine 0.001g/kg and pentobarbital sodium 0.03g to the destruction of Memory acquisition, improve memory consolidation that chloromycetin 0.2g/kg and sodium nitrite 0.12g/kg causes bad and improve.Fructus Alpiniae Oxyphyllae energy kidney invigorating and YANG supporting all said by ancient Chinese medicine doctor and herbal treatise, controlling nocturnal emission with astringent drugs reducing urination, warming the spleen stopping leak, and happy color is prolonged life, and improves memory.And be " for a long time clothes make light of one's life by commiting suicide ", the good medicine of the kidney invigorating health care simply really.Confirm according to modern pharmacological research, Fructus Alpiniae Oxyphyllae contains multiple compounds, the spleen of yang deficiency animal can be strengthened and increase thymic weight, and the nutrition of yang deficiency animal, body weight and tolerance etc. can be improved, have significantly strong and therapeutical effect to the patient that yang deficiency is afraid of cold.

One of folic acid (folic acid) vitamin B complex, be equivalent to pteroylglutamic acid (pteroylglutamic acid, PGA), is Michele (H.K.Mitchell, 1941) extraction purification from the leaf of spinach, so called after folic acid.Have the effect promoting juvenile cell maturation in bone marrow, the mankind can cause megaloblastic anemia and leukopenia as lacked folic acid, are even more important to old man and anemia of pregnant woman.Sino-U.S. utilizes folic acid supplementation for neural tube defects collaborative project to obtain the approval of US Congress very soon in addition, starts smoothly, discusses in developing country, in China, needs the folic acid how much dose is taken just can play the effect of prevention neural tube defects.Visible folic acid plays very important effect to raising old man memory.

China fir alkali first English name: Huperzine-A is by a kind of alkaloid extracted in Huperziaceae plant Herba Lycopodii serrati Huperzinaserrata (Thumb.) Trev, it is a potent acetylcholine esterase reversible inhibitor, its action character is similar to neostigmine, but effect is held time than the latter as long.Have true cholinesterase and optionally suppress, inhibition strength is thousands of times of pseudocholinesterase; Suppressor mode is that competitive and noncompetitive mixed type suppresses, and has significantly different from atomistic competition inhibitor; Easily enter maincenter by blood brain barrier, with maincenter and periphery therapeutical effect; Effective time is long; Good from gastrointestinal absorption; Safety index is large; Good stability.Through injection or this medicine of ig, have and obviously promote study, the effect of Memory Process or obviously Improving memory obstacle, and selective distribution is in cortex Hippocampus etc. and study, remember relevant brain district. huperzine A it easily through blood brain barrier, to acetylcholine esterase in brain (AchE), there is potent inhibitory action, significantly improve levels of acetylcholine in brain, that the reversible inhibitor Huperzine-A Tablets, Tests for Uniformity of AchE mono-kind is used for the treatment of optimum Aging amnesia (Beniga Senescent Forgetfulners BSF) and alzheimers disease (Alzeheimers Disease, AD) good efficacy is had.Be applicable to benign memory deficits, cerebrovascular disease, brain trauma, organic mental disorders, peripheral blood vessel occlusive disease, diabetic neuropathy, acute and chronic heel string pain, exercise-induced muscular wound.

Mecobalamin [English name] Mecobalamin Tablets.Its chemical name is: Co α-[α-(5,6)-dimethylbenzimidazole base]-Co β-first cobalt amide, molecular formula: C63H91CoN13O14P, it is a kind of endogenic actimide, participation one carbon unit circulates, and plays an important role in by the transmethylase course of reaction of homocysteine synthetic methionine.In vitro study shows, mecobalamin can promote that the synthesis of lecithin in the rat tissue of cultivating and neuron myelin are formed, and is applicable to peripheral neuropathy.

Detailed description of the invention

This seven flavor medicine thing is stirred by following mass percent, and superfine grinding, makes capsule: Fructus Schisandrae Chinensis 40%, Rhizoma Acori Graminei 20%, Medulla caprae seuovis powder 18%, Fructus Alpiniae Oxyphyllae 19.8%, folic acid 2%, huperzine A 0.1%, mecobalamin 0.1%.

Each oral 1-1.5 gram, every day three times, warm water is swallowed after meal.

25 examples on probation, effective percentage 100%, without occurring how toxicity.As retired professor Hu, man, 71 years old.Have the phenomenon of hypomnesis, take the capsule one month improving memory, forgetful phenomenon takes a turn for the better, and can write smoothly, teaches, and work efficiency improves.And for example retired accounting Zeng, female 81 years old, often forgets band key, forgets pass combustion gas, slow in action, and take the capsule one month improving memory, thinking is clearly better, and word speed is accelerated, and mood is optimistic, healthy.Other trier's situations are substantially similar.

Claims (1)

1. improve a capsule for memory, it is characterized in that its medicinal ingredient and mass percent as follows:

Fructus Schisandrae Chinensis 40%, Rhizoma Acori Graminei 20%, Medulla caprae seuovis powder 18%, Fructus Alpiniae Oxyphyllae 19.8%, folic acid 2%, huperzine A 0.1%, mecobalamin 0.1%.