CN104288423A - Oral liquid for treating dairy cattle kidney-yang deficiency type ovarian infertility and preparation method of oral liquid - Google Patents
Oral liquid for treating dairy cattle kidney-yang deficiency type ovarian infertility and preparation method of oral liquid Download PDFInfo
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- CN104288423A CN104288423A CN201410537406.3A CN201410537406A CN104288423A CN 104288423 A CN104288423 A CN 104288423A CN 201410537406 A CN201410537406 A CN 201410537406A CN 104288423 A CN104288423 A CN 104288423A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention relates to oral liquid for treating dairy cattle kidney-yang deficiency type ovarian infertility. The oral liquid comprises the following components in parts by weight: 1-10 parts of astragalus, 10-20 parts of cinnamon, 5-30 parts of fructus evodiae, 1-10 parts of Angelica sinensis, 10-20 parts of dried tangerine or orange peel, 10-30 parts of teasel root, 5-30 parts of herba epimedii and 5-10 parts of cyperus rotundus. The oral liquid disclosed by the invention has the effects of dissipating stasis and warming and dispelling cold and resolving depression, is small in toxic and side effects and high in bioavailability, does not have drug residues, meets the requirements on safe veterinary drugs and animal origin food safety and is ideal traditional Chinese medicine oral liquid for treating dairy cattle kidney-yang deficiency type ovarian infertility.
Description
Technical field
The invention belongs to field of veterinary, especially a kind ofly treat oral liquid of the ovarian infertility of milch cow kidney yang deficiency syndrome and preparation method thereof.
Background technology
The infertile milch cow of kidney yang deficiency syndrome mainly enters caused by uterus by milch cow innate deficiency of YANG in the body and exogenous cold, and its body is become thin more, and estrogen level is extremely low, needs the Chinese medicine radical cure of warming uterus for dispelling cold basic.Simultaneously, Chinese medicine is the pure natural substance that animal body the most easily absorbs, and containing multiple biological effective components, toxic and side effects is very micro-, almost noresidue, without Drug resistance, meat products, milk product are had no side effect, free from environmental pollution, make Chinese medicine have unique advantage in treatment milch cow relevant disease.
Summary of the invention
The object of the present invention is to provide a kind of oral liquid for the treatment of the ovarian infertility of milch cow kidney yang deficiency syndrome, this oral liquid has that pungent loose temperature is led to, effect of blood circulation promoting and blood stasis dispelling, cold expelling resolving depression, and toxic and side effects is little, not easily produces drug resistance, and bioavailability is high, drug residue free.
Another object of the present invention is to provide a kind of preparation method for the treatment of the oral liquid of the ovarian infertility of milch cow kidney yang deficiency syndrome.
The present invention is achieved through the following technical solutions:
Treat an oral liquid for the ovarian infertility of milch cow kidney yang deficiency syndrome, component and the ratio of weight and number thereof of its oral liquid are respectively:
Radix Astragali 1-10 part;
Cortex Cinnamomi 10-20 part;
Fructus Evodiae 5-30 part;
Radix Angelicae Sinensis 1-10 part;
Pericarpium Citri Reticulatae 10-20 part;
Interrupted 10-30 part;
Herba Epimedii 5-30 part;
Rhizoma Cyperi 5-10 part.
And component and the optimum ratio of weight and number thereof of this oral liquid are respectively:
The Radix Astragali 5 parts;
Cortex Cinnamomi 15 parts;
Fructus Evodiae 28 parts;
Radix Angelicae Sinensis 6 parts;
Pericarpium Citri Reticulatae 15 parts;
Interrupted 20 parts;
Herba Epimedii 16 parts;
Rhizoma Cyperi 8 parts.
Treat a preparation method for the oral liquid of the ovarian infertility of milch cow kidney yang deficiency syndrome, the steps include:
(1) take the Radix Astragali, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi respectively according to weight proportion, pulverize;
(2) decoct three times after the Radix Astragali after middle for step (1) pulverizing, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi being soaked one hour, each amount of water is 5-10 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03, adds 95% ethanol, alcohol content is made to reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol extremely without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add ethanol and the 4-6% tween 80 of 25-45%, stir evenly, filter, subpackage, must treat the oral liquid finished product of the ovarian infertility of milch cow kidney yang deficiency syndrome.
Advantage of the present invention and beneficial effect are:
The Radix Astragali contained in the Chinese medicine oral liquid of 1, the ovarian infertility of this treatment milch cow kidney yang deficiency syndrome, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, the Chinese medicinal ingredients such as Herba Epimedii and Rhizoma Cyperi, can play the effect of warming uterus for dispelling cold, warming the kidney to invigorate YANG altogether.Simultaneously to blood stasis due to qi deficiency, damp and hotly interiorly stagnant etc. there is good therapeutic effect.
2, the Chinese medicine oral liquid of the ovarian infertility of this treatment milch cow kidney yang deficiency syndrome is by extracting the effective ingredient in Chinese medicine, add the additives such as correctives, antibacterial, and according to the oral liquid that the processing method of oral liquid is synthesized, have taking dose little, delicious, absorb fast, prove effective rapidly, steady quality, be convenient to transport, be easy to the advantages such as preservation.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Treat an oral liquid for the ovarian infertility of milch cow kidney yang deficiency syndrome, component and the weight thereof of its Chinese medicine oral liquid are respectively: Radix Astragali 10g; Cortex Cinnamomi 20g; Fructus Evodiae 30g; Radix Angelicae Sinensis 10g; Pericarpium Citri Reticulatae 20g; Radix Dipsaci 30g; Herba Epimedii 20g; Rhizoma Cyperi 10g.
Treat a preparation method for the oral liquid of the ovarian infertility of milch cow kidney yang deficiency syndrome, the step of preparation method is as follows:
(1) take the Radix Astragali, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi respectively according to weight proportion, pulverize;
(2) decoct three times after the Radix Astragali after middle for step (1) pulverizing, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi being soaked 1 hour, each amount of water is 5 times of medical material total amount, each decoction 0.5 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add ethanol and the 4% volume tween 80 of 25% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of the ovarian infertility of milch cow kidney yang deficiency syndrome.
Embodiment 2
Treat an oral liquid for the ovarian infertility of milch cow kidney yang deficiency syndrome, component and the weight thereof of its Chinese medicine oral liquid are respectively: Radix Astragali 1g; Cortex Cinnamomi 10g; Fructus Evodiae 5g; Radix Angelicae Sinensis 1g; Pericarpium Citri Reticulatae 10g; Radix Dipsaci 10g; Herba Epimedii 10g; Rhizoma Cyperi 5g.
Treat a preparation method for the oral liquid of the ovarian infertility of milch cow kidney yang deficiency syndrome, the step of preparation method is as follows:
(1) take the Radix Astragali, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi respectively according to weight proportion, pulverize;
(2) decoct three times after the Radix Astragali after middle for step (1) pulverizing, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi being soaked one hour, each amount of water is 5-10 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add ethanol and the 6% volume tween 80 of 45% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of the ovarian infertility of milch cow kidney yang deficiency syndrome.
Embodiment 3
Treat an oral liquid for the ovarian infertility of milch cow kidney yang deficiency syndrome, component and the weight thereof of its Chinese medicine oral liquid are respectively: Radix Astragali 2g; Cortex Cinnamomi 20g; Fructus Evodiae 10g; Radix Angelicae Sinensis 2g; Pericarpium Citri Reticulatae 20g; Radix Dipsaci 20g; Herba Epimedii 20g; Rhizoma Cyperi 10g.
Treat a preparation method for the oral liquid of the ovarian infertility of milch cow kidney yang deficiency syndrome, the step of preparation method is as follows:
(1) take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum respectively according to weight proportion to pulverize;
(2) decoct three times after the Flos Lonicerae after middle for step (1) pulverizing, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum being soaked one hour, each amount of water is 10 times of medical material total amount, each decoction 1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add the ethanol of 30% volume and the tween 80 of 5% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of the ovarian infertility of milch cow kidney yang deficiency syndrome.
Clinical practice
In order to verify the clinical therapeutic efficacy of the present invention to the ovarian infertility of milch cow kidney yang deficiency syndrome, collect 45,5 cattle farms in Shandong and be diagnosed as the ovarian infertility milch cow of kidney yang deficiency syndrome, all use the present invention, by the administration of 1ml/Kg body weight, every cow head every day twice, according to state of an illness emergency, be used in conjunction 3-5 days, detect that milch cow is more total, significant figure, invalid number, Oestrus rate and pregnancy rate (see table 1).
Table 1 the present invention treats the static effectiveness unit/head of kidney yang deficiency syndrome ovary
| Cattle farm | 1 | 2 | 3 | 4 | 5 | Add up to |
| Case load | 9 | 8 | 10 | 8 | 10 | 45 |
| Recovery from illness | 7 | 7 | 8 | 6 | 8 | 36 |
| Effectively | 2 | 1 | 2 | 2 | 1 | 8 |
| Invalid | 0 | 0 | 0 | 0 | 1 | 1 |
| Oestrus rate % | 100 | 100 | 100 | 100 | 90 | 98 |
| Pregnancy rate % | 77.8 | 87.5 | 80 | 75 | 80 | 80.1 |
As seen from the above table, the use the present invention only course for the treatment of (3-5 days) Oestrus rate almost just reaches 100%, pregnancy rate is average also about 80%, considerably beyond the pregnancy rate of normal milch cow, it achieves the effect for the treatment of both the principal and secondary aspects of a disease, it also avoid reproductive hormone simultaneously and treats the problems such as the endocrine regulation caused.
Claims (3)
1. treat an oral liquid for the ovarian infertility of milch cow kidney yang deficiency syndrome, it is characterized in that: component and the ratio of weight and number thereof of this oral liquid are respectively:
2. the oral liquid of the ovarian infertility for the treatment of milch cow kidney yang deficiency syndrome according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this oral liquid are respectively:
3. a preparation method for the oral liquid of the ovarian infertility for the treatment of milch cow kidney yang deficiency syndrome as claimed in claim 1, is characterized in that: this preparation method step is:
(1) take the Radix Astragali, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi respectively according to weight proportion, pulverize;
(2) decoct three times after the Radix Astragali after middle for step (1) pulverizing, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Dipsaci, Herba Epimedii and Rhizoma Cyperi being soaked one hour, each amount of water is 5-10 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03, adds 95% ethanol, alcohol content is made to reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol extremely without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add ethanol and the 4-6% tween 80 of 25-45%, stir evenly, filter, subpackage, must treat the oral liquid finished product of the ovarian infertility of milch cow kidney yang deficiency syndrome.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410537406.3A CN104288423A (en) | 2014-10-13 | 2014-10-13 | Oral liquid for treating dairy cattle kidney-yang deficiency type ovarian infertility and preparation method of oral liquid |
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| CN201410537406.3A CN104288423A (en) | 2014-10-13 | 2014-10-13 | Oral liquid for treating dairy cattle kidney-yang deficiency type ovarian infertility and preparation method of oral liquid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663521A (en) * | 2016-03-04 | 2016-06-15 | 吴正锋 | Traditional Chinese medicine teasel root extract capable of improving reproductive performance of cow |
| CN105998294A (en) * | 2016-07-27 | 2016-10-12 | 王赛 | Chinese herba preparation for curing female livestock infertility and preparation method, usage method and application of Chinese herba preparation |
| RU2648787C2 (en) * | 2016-06-22 | 2018-03-28 | Федеральное государственное бюджетное научное учреждение "Дальневосточный научно-исследовательский институт сельского хозяйства" (ФГБНУ "ДВ НИИСХ") | Means for prevention of infertility of holstein cows in the period of adaptation to monsoon climate |
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| CN101612283A (en) * | 2008-06-24 | 2009-12-30 | 徐后生 | Method for treating cow infertility by using traditional Chinese medicine |
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| CN1785338A (en) * | 2005-07-28 | 2006-06-14 | 江西汇仁药业有限公司 | Mugwort and cyperus palace warming fast dispersion solid preparation and its preparation method |
| CN101612283A (en) * | 2008-06-24 | 2009-12-30 | 徐后生 | Method for treating cow infertility by using traditional Chinese medicine |
| CN102631516A (en) * | 2012-05-02 | 2012-08-15 | 马守云 | Medicament for treating infertility |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663521A (en) * | 2016-03-04 | 2016-06-15 | 吴正锋 | Traditional Chinese medicine teasel root extract capable of improving reproductive performance of cow |
| RU2648787C2 (en) * | 2016-06-22 | 2018-03-28 | Федеральное государственное бюджетное научное учреждение "Дальневосточный научно-исследовательский институт сельского хозяйства" (ФГБНУ "ДВ НИИСХ") | Means for prevention of infertility of holstein cows in the period of adaptation to monsoon climate |
| CN105998294A (en) * | 2016-07-27 | 2016-10-12 | 王赛 | Chinese herba preparation for curing female livestock infertility and preparation method, usage method and application of Chinese herba preparation |
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Application publication date: 20150121 |
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