CN104288386A - Pharmaceutical composition for treating rheumatic arthritis - Google Patents
Pharmaceutical composition for treating rheumatic arthritis Download PDFInfo
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- CN104288386A CN104288386A CN201410572449.5A CN201410572449A CN104288386A CN 104288386 A CN104288386 A CN 104288386A CN 201410572449 A CN201410572449 A CN 201410572449A CN 104288386 A CN104288386 A CN 104288386A
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Abstract
The invention provides pharmaceutical composition for treating rheumatic arthritis. The preparation method mainly comprises the following steps: cleaning Radix Aconiti Kusenzoffii, radix aconite, smoked plum, cassia twig, garden balsam stem, schizophragma integrifolium, prepared rehmannia root, honeysuckle, liquorice and obscured homalomena rhizome, decocting the materials for three times according to a conventional method by using water, merging the filtrate, and concentrating the filtrate to 1/3 volume, so that the medicine can be taken. The pharmaceutical composition is rapid and effective in treatment of the rheumatic arthritis, the rheumatic arthritis is difficult to reoccur, and the pharmaceutical composition is simple in formula, low in cost and easy to produce and is suitable for needs of most of patients suffering from rheumatic arthritis.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of rheumatic arthritis.
Background technology
Rheumatic arthritis is a kind of common acute or chronic ICT, can recurrent exerbation involve heart.Clinical with joint and migrans miserable, the pain of muscle for feature.Belong to allergic disease.One of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.
Typical performance is slight or moderate heating, migratory polyarthritis, affected joints mostly is the large joint such as knee joint, ankle, shoulder, elbow, wrist, is commonly transferred to another joint by a joint; pathological changes local presents red, swollen, scorching hot, severe pain, and some patients also has several joint to fall ill simultaneously.Atypical patient only has arthralgia and shows without other inflammation, and acute inflammation generally disappeared in 2 ~ 4 weeks, but normal recurrent exerbation.If active rheumatism affects heart, then can there is myocarditis, even leave over valve disorder.
The traditional Chinese medical science thinks that pathogenic factor and pathogenic process have substantially: the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, wind-cold damp pathogen impatency meridians and joint, stagnation of QI and blood may bring about pain, so cause joint swelling and pain.Ying-qi defends blood imbalance, disharmony of nutrient QI with defensive QI, and pathogen is taken advantage of a weak point, and causes rheumatism outbreak.Internal organs negative and positive internal injury, negative and positive are uneven, occur that inclined Sheng declines partially, are subject to pathogen and invade, and rheumatismal heat and cold Symptoms occur.Raw in phlegm-turbidity and blood stasis blood, pathogenic factor going from the exterior into the interior, by light and weigh, causes visceral dysfunction, and the result of the visceral dysfunction just turbid and blood stasis of generation expectorant, these are exactly the basic reason of rheumatism Relapse rate and refractory.For rheumatic arthritis treatment, be generally divided into that Western medicine alleviates pain, the pain relieving of medicine for external use relaxing muscles and tendons and activating QI and blood in the collateral.As with Salicylic Acid Formulations and on-steroidal preparation with alleviating pain, diminish inflammation, control active rheumatism.In medicinal dog skin plaster functions dispelling wind and clearing away cold, removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral pain relieving.In addition ZHUIFENG GAO etc. is also had.Due to " curing the symptoms, not the disease ", and easily recur after drug withdrawal, therefore the treatment of rheumatic arthritis be it is generally acknowledged do not have specific drug.
Prevalence is high, and relapse rate height is the main feature of rheumatic arthritic diseases, also reflects that the demand in rheumatic arthritic diseases medicine market is huge simultaneously.Because Chinese medicine side effect is little, determined curative effect is suitable for long-term prescription, and adapted to the feature that rheumatic arthritic diseases easily recurs, therefore clinical practice widely.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of pharmaceutical composition for the treatment of rheumatic arthritis.
Technical scheme: the object of the invention is to be achieved by the following scheme:
Treat a pharmaceutical composition for rheumatic arthritis, the active component contained by it is prepared from by following raw materials in part by weight proportioning: Radix Aconiti 6-12, Radix Aconiti Kusnezoffii 6-12, Fructus Mume 6-12, Ramulus Cinnamomi 6-12, Herba speranskiae tuberculatae 6-12, Cortex schizophragmatis integrifolii radicis 6-12, Radix Rehmanniae Preparata 6-12, Flos Lonicerae 6-12, Radix Glycyrrhizae 8-16, Rhizoma Homalomenae 6-12.
For can for the purpose of concise description problem, below to a kind of pharmaceutical composition for the treatment of rheumatic arthritis of the present invention referred to as this compositions.
By this compositions use water fried three times according to a conventional method, merging filtrate, can take after filtrate is concentrated into 1/3 amount.
A kind of pharmaceutical composition for the treatment of rheumatic arthritis, it is characterized in that, the active component contained by it is prepared from by following raw materials in part by weight proportioning: Radix Aconiti 9 parts, Radix Aconiti Kusnezoffii 9 parts, Fructus Mume 9 parts, Ramulus Cinnamomi 9 parts, Herba speranskiae tuberculatae 9 parts, Cortex schizophragmatis integrifolii radicis 9 parts, Radix Rehmanniae Preparata 9 parts, Flos Lonicerae 9 parts, 12 parts, Radix Glycyrrhizae, Rhizoma Homalomenae 9 parts.
By this compositions use water fried three times according to a conventional method, merging filtrate, can take after filtrate is concentrated into 1/3 amount.
In the present invention, Radix Aconiti is the parent root of Ranunculaceae aconitum plant Aconitum carmichjaelii Debx..Late June excavated to early August, and removing aerial parts stem and leaf, takes daughter root (Radix Aconiti Lateralis Preparata), get parent root, dry.Property pungent, bitter, heat, greatly poison.GUIXIN, liver,spleen,kidney warp.There is expelling wind and removing dampness, warming the meridian, dispersing cold for relieving pain.For anemofrigid-damp arthralgia, numb limbs and tense tendons, hemiplegia, wind syndrome of head is had a headache, trusted subordinate's cold type of pain, and colic of cold type is had a pain, traumatic injury stasis of blood pain, carbuncle of yin nature toxic swelling.And can be used for narcotic analgesic.
Radix Aconiti Kusnezoffii is the tuber of Ranunculaceae herbaceos perennial Aconitum carmichjaelii Debx. (wild species) or Aconitum kusnezoffii Reichb.Excavate when autumn, stem and leaf was withered, removing fibrous root and silt, dry.Property pungent, heat, greatly poison.GUIXIN, liver,spleen,kidney warp.There is expelling wind and removing dampness, dispelling cold by warming the meridian, reducing swelling and alleviating pain.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Fructus Mume is that the maturescent fruit of Rosaceae cherry prunus mume (sieb.) sieb.et zucc. processes through smoked training.Between the 5-6 month, when fruit is HUANGBAI(sic) or bluish yellow color, not yet pluck during full maturity.Roast with smokeless heated kang, black to be programmed.Property acid, flat.Return liver, spleen, lung, large intestine channel.Have astringing lung-QI and relieving cough, relieving diarrhea with astringents, hemostasis, promotes the production of body fluid, relieving colic caused by ascaris.More than for chronic cough, chronic diarrhea and dysentery, hematuria is had blood in stool, metrorrhagia, deficiency-heat excessive thirst.
Ramulus Cinnamomi is dried bark, the branch skin of Lauraceae platymiscium Cortex Cinnamomi.The age of tree more than 10 years, can adopt stripping when phloem has amassed into oil reservoir, and season in spring and autumn all can peeling, is excellent to adopt the quality of stripping the 8-9 month in autumn.Property pungent, sweet, heat.Return kidney, spleen, the heart, Liver Channel.There is benefit fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.For insufficiency of kidney-YANG, soreness of the waist and knees, impotence and seminal emission, dysuria, all cards of edema oliguria.
Herba speranskiae tuberculatae is the dry stem of Balsaminaceae plant Flos Impatientis.Summer extracts, and except defoliation, Hua Heguo, dries.Property acid, temperature, slightly poisonous.There is rheumatic arthralgia, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness.For easing pain and diminishing inflammation, wind-expelling pain-stopping.
Cortex schizophragmatis integrifolii radicis is the root bark of Saxifragaceae Cortex schizophragmatis integrifolii radicis platymiscium Cortex schizophragmatis integrifolii radicis.The whole year can adopt, and takes root, strips root bark, dries.Property is light, cool.There is relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and activating blood circulation.For bones and muscles pain due to rheumatism, extremities joint is ached.
Radix Rehmanniae Preparata is Scrophulariaceae, Radix Rehmanniae platymiscium, and the tuber of Radix Rehmanniae forms through Processing methods.Property is sweet, tepor.Return liver, kidney channel.Have YIN nourishing of enriching blood, beneficial essence fills out marrow.For blood deficiency and yellow complexion, cardiopalmus severe palpitation, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, interior-heat is quenched one's thirst.
Flos Lonicerae is dry flower or the first flower opened of band of caprifoliaceae plant Radix Ophiopogonis.Early summer the flowers are in blossom put before gather, dry.Property sweet, cold.Return lung, the heart, stomach warp.There is heat-clearing and toxic substances removing, dispelling wind and heat pathogens.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Radix Glycyrrhizae is the dry root welding technology of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and removing fibrous root, dries.Property sweet, flat.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Rhizoma Homalomenae is the dry rhizome of aroid Rhizoma Homalomenae.Spring, Qiu Erji excavate, and clean, and removing crust, dries.Property bitter, pungent, temperature.Return liver, kidney channel.There is wind-damp dispelling, strengthening bone and muscle.For anemofrigid-damp arthralgia, chills and pain of the waist and kness, contracture is numb, and muscles and bones flaccidity is soft.
Beneficial effect:
1, from theory of Chinese medical science, be monarch in we with Rhizoma Homalomenae, remove rheumatism, strong muscles and bones, energy activating collaterals and eliminating stagnation, subduing swelling and relieving pain, the heresy for rheumatism scurries into meridians, is cause the contracture of muscle arteries and veins, and joint stuffiness person is especially good.Radix Aconiti, Radix Aconiti Kusnezoffii, can expelling wind and removing dampness, antalgic, with auxiliary monarch drug, and can dispelling cold and removing dampness, current meridians.Herba speranskiae tuberculatae expelling wind and removing dampness, the pungent temperature of these product, Xin Nenghang falls apart, and temperature overcomes the coldness wet.Enter Liver Channel, therefore energy expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, blood-activating analgetic.To upper and lower, trusted subordinate's waist knee joint, inside and outside various pain, all can select and control it, and get its pungent temperature and be apt to away, the merit of promoting the circulation of QI of invigorating blood circulation, vim and vigour general rule is not bitterly.Radix Rehmanniae Preparata returns liver, kidney channel.Get final product nourishing YIN and supplementing blood, beneficial essence fills out marrow, pungent temperature medicine can be suppressed again excessively dry, hinder essence and blood.Four Chinese medicine is ministerial drug altogether, mutually 5 can expelling wind and removing dampness with monarch drug, strengthening the tendons and bones, promoting blood circulation and stopping pain, enriching kidney essence.Cortex schizophragmatis integrifolii radicis is light, cool.Relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and activating blood circulation.Flos Lonicerae, heat-clearing and toxic substances removing, wind-heat dissipating.Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, and suppresses the property of the drying of medicine.Be adjuvant drug altogether, principal drug assistance wind-damp dispelling the meridian dredging, blood circulation promoting and blood stasis dispelling stopping numbness pain, replenishing body fluid and clearing away heat pathogen is only dry.Make the invigorating middle warmer of medicine Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.Make a general survey of full side, medicine is precise and appropriate, and compatibility is rigorous, and medicine is concentrated one's efforts grand.All medicine compatibilities, give attacking and give benefit, attack benefit and have both, and qi and pathogen is in a stove, therefore satisfactory effect.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, and determined curative effect.
3, the present invention consists of Chinese crude drug, low price.
detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
In conjunction with detailed description of the invention, the present invention is further described as follows:
According to the form below, listed weight proportion takes raw material required for the present invention, unit: part
| ? | Radix Aconiti | Radix Aconiti Kusnezoffii | Fructus Mume | Ramulus Cinnamomi | Cortex schizophragmatis integrifolii radicis | Herba speranskiae tuberculatae | Radix Rehmanniae Preparata | Flos Lonicerae | Radix Glycyrrhizae | Rhizoma Homalomenae |
| 1 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 8 | 6 |
| 2 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 12 | 9 |
| 3 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 16 | 12 |
1. prepare embodiment
More than showing Raw proportioning is example, comprises the following steps:
Embodiment 1: Radix Aconiti 6 parts, Radix Aconiti Kusnezoffii 6 parts, Fructus Mume 6 parts, Ramulus Cinnamomi 6 parts, Cortex schizophragmatis integrifolii radicis 6 parts, Herba speranskiae tuberculatae 6 parts, Radix Rehmanniae Preparata 6 parts, Flos Lonicerae 6 parts, 8 parts, Radix Glycyrrhizae, Rhizoma Homalomenae 6 parts, by this compositions use water fried three times according to a conventional method, merging filtrate, can take after filtrate is concentrated into 1/3 amount.
Embodiment 2: Radix Aconiti 9 parts, Radix Aconiti Kusnezoffii 9 parts, Fructus Mume 9 parts, Ramulus Cinnamomi 9 parts, Cortex schizophragmatis integrifolii radicis 9 parts, Herba speranskiae tuberculatae 9 parts, Radix Rehmanniae Preparata 9 parts, Flos Lonicerae 9 parts, 12 parts, Radix Glycyrrhizae, Rhizoma Homalomenae 9 parts, by this compositions use water fried three times according to a conventional method, merging filtrate, can take after filtrate is concentrated into 1/3 amount.
Embodiment 3: Radix Aconiti 12 parts, Radix Aconiti Kusnezoffii 12 parts, Fructus Mume 12 parts, Ramulus Cinnamomi 12 parts, Cortex schizophragmatis integrifolii radicis 12 parts, Herba speranskiae tuberculatae 12 parts, Radix Rehmanniae Preparata 12 parts, Flos Lonicerae 12 parts, 16 parts, Radix Glycyrrhizae, Rhizoma Homalomenae 12 parts, by this compositions use water fried three times according to a conventional method, merging filtrate, can take after filtrate is concentrated into 1/3 amount.
2. clinical observation material
Sample preparation: Radix Aconiti 9 parts, Radix Aconiti Kusnezoffii 9 parts, Fructus Mume 9 parts, Ramulus Cinnamomi 9 parts, Cortex schizophragmatis integrifolii radicis 9 parts, Herba speranskiae tuberculatae 9 parts, Radix Rehmanniae Preparata 9 parts, Flos Lonicerae 9 parts, 12 parts, Radix Glycyrrhizae, Rhizoma Homalomenae 9 parts, by this compositions use water fried three times according to a conventional method, merging filtrate, filtrate is concentrated into 1/3 amount.
The present inventor is to 130 routine cases (test group 80 example, matched group 50 example) clinical observation, and wherein, man 67 example, female 63 example, at minimum 28 years old of age, maximum 76 years old, the course of disease was the longest 14 years, the shortest person 1 year, average 7 years.Case selection is diagnosed as the patient of rheumatic arthritis according to symptom and examination in hospital.Wherein, test group 80 example, comprise man 45 example, female 35 example, at minimum 28 years old of age, maximum 72 years old, the course of disease was the longest 14 years, the shortest person 1 year, average 7. 2 years.Matched group 50 example, comprise man 22 example, female 28 example, at minimum 33 years old of age, maximum 76 years old, the course of disease was the longest 12 years, the shortest person 1 year, average 6. 7 years.The course of disease, degrees of symptoms etc. of two groups of cases, comprehensive average rear there was no significant difference, has comparability between each group.
3. diagnostic criteria:
Rheumatic arthritis is a kind of chronic rheumatoid arthritic conditions, is clinically divided into three types:
(1) the light-duty phase: petit mal, sick type is comparatively light, and their early stage unexpected joint trick is ached 2-3 days, occurs without lump.
(2) the medium-sized phase: random wind rains and will shift to an earlier date outbreak in 2-3 days whenever, and lump, pain, appear in locality trick arthralgia, and even trick can numb 2-3 days, trick feels that fiber crops bitterly, inconvenience, does not have power.
(3) grand mal, no matter have and do not have random wind to rain, patient understands general joint and tingles unbearably, trick splenalgia even modification, and motion is inconvenient, and whole body is uncomfortable, and patient can't take care of oneself.
4. Therapeutic Method
Test group adopts the pharmaceutical composition of the present invention to treat, and during treatment, administrated method is: daily three times, early, middle and late each once, a 20mL, period in a medicine fasting raw food raw meat food, serve on 2 months.Matched group gives domestic ibuprofen 0. 4g oral, every day three times, serve on 2 months.
Two groups of cases all observe cardinal symptom and sign in the 1st week, the 2nd week, the 1st month, the 2nd month after medication.
5. efficacy assessment standard
Effective: after drug treatment, health takes a turn for the better, and the intermission extends, and observes in two and half and does not have recidivist.
Effective: physical condition takes a turn for the better, and the intermission extends relatively.
Invalid: not reach improvement standard person.
6. efficacy result
| Group | Effective | Effectively | Invalid | Total effective rate |
| Test group | 63 | 11 | 6 | 92.50% |
| Matched group | 21 | 16 | 13 | 74.00% |
As can be seen from the above table, the total effective rate of test group is 92.50%, and the total effective rate of matched group is 74.00%.The effective percentage of test group has positive effect compared with matched group.The cure rate of test group is 78.75%, the cure rate 42.00% of matched group.The cure rate of test group has significance effect compared with matched group.Healing case in test group, pays a return visit after half a year, 1 year respectively, all without recurrence.In sum, the therapeutic effect of the pharmaceutical composition of the present invention is obviously better than matched group.
7. model case
Case 1: Wang, female 39 years old.When examining, bone joint, coxarthropathy are very, and meet cold rnning play, when morning rises, pain increases the weight of, and limb activity is dumb.Chemical examination: erythrocyte sedimentation rate 48mm/h, x-ray display is without sclerotin change, and feeling of numbness alleviates, and takes the embodiment of the present invention 2, and after two months, symptom disappears completely, and freely, erythrocyte sedimentation rate 16mm/h, follows up a case by regular visits to and do not recur so far joint motion.
Case 2: grandson, man 56 years old.General joint pain recurrent exerbation 8 years, limbs are heavy, and morning rises stiff, joint joint stuffiness, meet cold rnning weight.Chemical examination: erythrocyte sedimentation rate 55mm/h, rheumatoid factor negative.Clinical diagnosis: rheumatic arthritis, it is sick that card belongs to cold warm numbness.Take the embodiment of the present invention 2, after 30 days, arthralgia alleviates, and after adhering to medication 3 wheat harvesting period continuously, play stiff all diseases in arthralgia, morning and disappear, functional rehabilitation, laboratory indexes is all normal.
Case 3: in certain, man 47 years old.Suffer from rheumatoid arthritis 10 years, extremities joint swells and ache, and refers to that toe is out of shape, restriction of neck motion, very painful.Through examination in hospital, erythrocyte sedimentation rate 78mm/h, rheumatoid factor positive (+), Long-term Hormone, medicine such as analgesia sheet etc., walking function obstacle, amyotrophy, agonizing, take the embodiment of the present invention 2 and treat 4 months, patient symptom obviously alleviates, and treats 2 months again, and erythrocyte sedimentation rate, rheumatoid factor recover normal, general joint pain takes a turn for the better, waist can straighten up, and patients clinical is cured, and follows up a case by regular visits to and has no recurrence in 2 years.
8. toxicological study
Acute toxicity test shows, rat oral gavage pharmaceutical composition of the present invention fails to measure LD
50.
Long term toxicity test: rat divides into groups, pharmaceutical composition decocting gavage of the present invention, every day three times, connect note 90 days, result, administration group rat and control rats movable, search for food, drink water, body weight and the multinomial observation index such as substantial viscera pathologic finding and pathological tissue detect, result of the test does not all find any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
This pharmaceutical composition is all negative to the zest of blood vessel, allergy and hemolytic test.
In sum, the present invention is a kind of pharmaceutical composition of excellent treatment rheumatic arthritis, and obviously can strengthen its dehumidifying and dispel the wind, dispelling cold by warming the meridian, long-term taking safety, therefore, clinic is applied.
Claims (1)
1. treat the pharmaceutical composition of rheumatic arthritis for one kind, mixed by the weight ratio of Radix Aconiti 6-12, Radix Aconiti Kusnezoffii 6-12, Fructus Mume 6-12, Ramulus Cinnamomi 6-12, Herba speranskiae tuberculatae 6-12, Cortex schizophragmatis integrifolii radicis 6-12, Radix Rehmanniae Preparata 6-12, Flos Lonicerae 6-12, Radix Glycyrrhizae 8-16, Rhizoma Homalomenae 6-12 and form, by this compositions use water fried three times according to a conventional method during preparation, merging filtrate, can take after filtrate is concentrated into 1/3 amount.
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Application publication date: 20150121 |