CN104288229B - The Chinese medicine finish and its production technology of a kind of Transdermal absorption treatment diabetes B - Google Patents
The Chinese medicine finish and its production technology of a kind of Transdermal absorption treatment diabetes B Download PDFInfo
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Abstract
The invention discloses the Chinese medicine finish that a kind of Transdermal absorption treats diabetes B, it is made up of the raw material of following parts by weight：Base oil, essential oil of traditional Chinese medicine and fruit essence, essential oil of traditional Chinese medicine constitutes Essential Oil From Pine Needles, seabuckthorn essential oil, ganoderma lucidum essential oil, ginseng essential oil, Geranium Essential and cinnamon essential oil by the raw material of following parts by weight, base oil is one or more kinds of mixtures in grape-kernel oil, olive oil, aloe, sunflower oil, Apricot kernel oil, and fruit essence is one or more kinds of mixtures in flavoring pineapple essence, mango essence, fragrant citrus essence, Hami melon essence, flavoring banana essence.The present invention is by being applied to skin surface, the active ingredient in finish is set to infiltrate into skin corium rapidly, the mitochondrial membrane of cell may be acted on, open cellular energy path, increase its utilization rate to glucose, and present invention, avoiding the loss of effective component of chinese medicine caused by being heated in conventional method, gained essential oil of traditional Chinese medicine purity is high, impurity is few, it is easy to large-scale industrial production.
Description
Technical field
The present invention relates to the field of Chinese medicines, the Chinese medicine finish of specifically a kind of Transdermal absorption treatment diabetes B and its production
Technique.
Background technology
Diabetes B is a kind of common disease, and its incidence of disease is improved year by year, and its diseased colonies is close to 100,000,000, and high risk group is near
1.5 hundred million people, the incidence of disease is up to 11.6%.Traditional Chinese herbal decoction has great advantage in the treatment of diabetes B, can not only effectively reduce trouble
Person's blood glucose, moreover it is possible to be obviously improved diabetic's constitution, improves its quality of life, and can delay the hair of complication to a certain extent
Raw and development.But due to decoction decocting inconvenience, poor taste, carry many factors such as difficulty so that traditional Chinese herbal decoction is in diabetes B
Treatment on be unable to reach certain scale all the time.
If traditional Chinese medicine method of administration can be changed, oral medicinal herb is changed into Chinese medicine external, what is do not lessened the curative effect
Under the premise of, it can necessarily be received by numerous diabetics.
Skin is the maximum organ of human body, the 5%~15% of gross weight percentage of liveweight, the gross area is 1.5~2 square metres, thick
Degree is because of people or different because of position, is 0.5~4 millimeter.Skin covers whole body, and it makes various in vivo organize with organ from physics
Property, mechanicalness, invasion and attack chemically with pathogenic microorganism.Skin has the barrier action of two aspects：On the one hand body is prevented
The loss of interior moisture, electrolyte and other materials；On the other hand the intrusion of extraneous harmful substance is prevented.Skin is remain in human body
The stabilization of environment, is physiologically playing important defencive function, while also assisting in the metabolic process of human body.
Cutaneous penetration is the third generation medication that WHO recommends, and proposes that transdermal drug delivery system is controlled first from the U.S. in 1974
Treatment scheme and be made winter hyoscyamine paster listing since, transdermal drug delivery system constantly improve has simultaneously obtained swift and violent development.It is transdermal
" first pass effect " of the delivery system without liver, is not destroyed, it is possible to provide predetermined, longer action time by pipe intestinal digesting liquid,
Drug toxicity and adverse reaction can be reduced, can maintain to stablize and lasting blood concentration, so as to improve curative effect.In recent years, it is clinical
On use nitroglycerin percutaneous drug delivery novel form treatment coronary insufficiency, achieve better than be administered orally curative effect.
In recent years, due to the development of the newborn abstraction technique such as critical carbon dioxide abstraction technique, molecular distillation technique and general
And so that the abstraction technique of Chinese medicine has obtained tremendous increase, also provides huge development space for the development of Chinese medicine finish.
The content of the invention
It is an object of the invention to provide the Chinese medicine oil that the Transdermal absorption that a kind of purity is high, impurity is few treats diabetes B
Agent and its production technology, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of Transdermal absorption treats the Chinese medicine finish of diabetes B, is made up of the raw material of following parts by weight：Base oil 800-
3200 parts, 60-240 parts of essential oil of traditional Chinese medicine, 20-30 parts of fruit essence, the essential oil of traditional Chinese medicine is made up of the raw material of following parts by weight：Pine
10-40 parts of pin essential oil, 10-40 parts of seabuckthorn essential oil, 10-40 parts of ganoderma lucidum essential oil, 10-40 parts of ginseng essential oil, Geranium Essential 10-40
Part, 10-40 parts of cinnamon essential oil.
It is used as further scheme of the invention：The Transdermal absorption treats the Chinese medicine finish of diabetes B, by following weight
The raw material of part is made：800-2400 parts of base oil, 60-240 parts of essential oil of traditional Chinese medicine, 20-25 parts of fruit essence, the essential oil of traditional Chinese medicine by
The raw material of following parts by weight is made：10-30 parts of Essential Oil From Pine Needles, 10-30 parts of seabuckthorn essential oil, 10-30 parts of ganoderma lucidum essential oil, ginseng essential oil
10-30 parts, 10-30 parts of Geranium Essential, 10-30 parts of cinnamon essential oil.
It is used as further scheme of the invention：The Transdermal absorption treats the Chinese medicine finish of diabetes B, by following weight
The raw material of part is made：800 parts of base oil, 60 parts of essential oil of traditional Chinese medicine, 20 parts of fruit essence, the essential oil of traditional Chinese medicine is by following parts by weight
Raw material is made：10 parts of Essential Oil From Pine Needles, 10 parts of seabuckthorn essential oil, 10 parts of ganoderma lucidum essential oil, 10 parts of ginseng essential oil, 10 parts of Geranium Essential,
10 parts of cinnamon essential oil.
It is used as further scheme of the invention：The base oil is grape-kernel oil, olive oil, aloe, sunflower oil, apricot
One or more kinds of mixtures in kernel oil.
It is used as further scheme of the invention：The fruit essence is flavoring pineapple essence, mango essence, fragrant citrus essence, Kazakhstan
One or more kinds of mixtures in close melon essence, flavoring banana essence.
The production technology of the Chinese medicine finish of the Transdermal absorption treatment diabetes B, is comprised the following steps that：
(1) pine needle 150-250g, sea-buckthorn 150-250g, ginseng 150-250g, Chinese cassia tree 150-250g, fish pelargonium are weighed respectively
150-250g and ganoderma lucidum 150-250g is cleaned, natural air drying, and 20- is crossed after pine needle, sea-buckthorn, ginseng, Chinese cassia tree and fish pelargonium are crushed
40 mesh sieves；Ganoderma lucidum is ground into lucidum spore powder；
(2) above-mentioned pine needle particle is taken, Essential Oil From Pine Needles are prepared with supercritical carbon dioxide extracting, pine needle particle is placed in super face
In boundary's carbon dioxide abstraction kettle, set extraction conditions as:Extracting pressure is 15-20Mpa, and extraction temperature is 30-55 DEG C, titanium dioxide
Carbon fluid flow is 15-35L/h, and extraction time is 2-3h；Pressure is 6-15Mpa in separator I, and temperature is 20-40 DEG C；Separation
Pressure is 4-l0Mpa in device II, and temperature is 15-35 DEG C；Extraction collects Essential Oil From Pine Needles after terminating, and sealing preserve is standby；
(3) above-mentioned sea-buckthorn particle is taken, seabuckthorn essential oil is prepared with supercritical carbon dioxide extracting, sea-buckthorn particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 25-35Mpa, and extraction temperature is 30-45
DEG C, CO 2 fluid flow is 15-35L/h, and extraction time is 2-3h；Pressure is 6-15Mpa in separator I, and temperature is 20-
40℃；Pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects seabuckthorn essential oil after terminating, and sealing preserve is standby
With；
(4) above-mentioned ginseng granules are taken, ginseng essential oil is prepared with supercritical carbon dioxide extracting, ginseng granules are placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 30-40Mpa, and extraction temperature is 30-45
DEG C, CO 2 fluid flow is 25-30L/h, and extraction time is 1-2h；Pressure is 6-15Mpa in separator I, and temperature is 20-
40℃；Pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects ginseng essential oil after terminating, and sealing preserve is standby
With；
(5) above-mentioned Chinese cassia tree particle is taken, cinnamon essential oil is prepared with supercritical carbon dioxide extracting, Chinese cassia tree particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 30-40Mpa, and extraction temperature is 30-55
DEG C, CO 2 fluid flow is 30-35L/h, extraction time 2-3h；Pressure is 6-15Mpa in separator I, and temperature is 20-40
DEG C, pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects cinnamon essential oil after terminating, and sealing preserve is standby；
(6) above-mentioned fish pelargonium particle is taken, Geranium Essential is prepared with supercritical carbon dioxide extracting, fish pelargonium particle is put
In in the supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 15-20Mpa, and extraction temperature is
30-55 DEG C, CO 2 fluid flow is 15-20L/h, and extraction time is 2-3h；Pressure is 6-15Mpa, temperature in separator I
For 20-40 DEG C, pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects Geranium Essential after terminating, and seals
Save backup；
(7) above-mentioned lucidum spore powder is taken, ganoderma lucidum essential oil is prepared with supercritical carbon dioxide extracting, lucidum spore powder is placed in
In supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 20-30Mpa, and extraction temperature is
50-60 DEG C, CO 2 fluid flow is 30-35L/h, and extraction time is 3-4h；Pressure is 6-15Mpa, temperature in separator I
For 20-40 DEG C；Pressure is 4-10Mpa in separator II, and temperature is 15-35 DEG C；Ganoderma lucidum essential oil is collected in extraction after terminating, sealing is protected
Deposit standby；
(8) above-mentioned essential oil of traditional Chinese medicine is taken 10-40 parts and by volume 1 according to parts by weight:1:1:1:1:1 ratio mixing is simultaneously
Carry out ultrasonic mixing；
(9) 20-30 parts of 800-3200 parts of base oil and fruit essence are weighed according to parts by weight, by above-mentioned essential oil of traditional Chinese medicine and base
Plinth oil, fruit essence carry out ultrasonic mixing, produce the product.
Pharmacological action：α-the amino acid injection-800 contained in Essential Oil From Pine Needles, can promote the decomposition of glucose, have promotion brain metabolism to make
With other compositions such as glycerine quinine, with hypoglycemic effect, can control diabetes.Have in seabuckthorn essential oil containing 206 kinds to human body
The active material of benefit, wherein having 46 kinds of bioactive substances, containing substantial amounts of vitamin E, vitamin A, flavones etc., with anti-tired
Labor and the enhancing special pharmacological performance such as body energy and anticancer.Ganoderma lucidum essential oil can not only reduce blood glucose, also can obviously reduce blood courage
Sterol, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque, have been formed for atherosclerotic plaque
Person, then play the role of reduction Arterial Cholesterol content, softening blood vessel, prevent from further damaging, to prevention of diabetic vascular
Lesion has important value.Ginseng essential oil can increase intake of the brain to glucose, while reducing lactic acid, pyruvic acid and lactic acid/the third
The ratio of ketone acid, and the utilization of glucose can be made to be changed into aerobic metabolism from anaerobic metabolism approach, increase body is to glucose
Availability.Active ingredient in Geranium Essential has very strong compatibility with natural alicyclic organic, affine with congealed fat while
Also compatibility is produced with skin epidermis, this compatibility has surmounted the compatibility with water.It is many containing flavanols in cinnamon essential oil
Phenols polyphenoils, can improve insulin to the stabilization of blood sugar level and reduction insulin resistance.These protein pair
Insulin receptor, blood glucose transport and inflammatory reaction have material impact, thus can promote insulin active or increase body to pancreas
The sensitiveness of island element.In addition, and also studies have found that, some of cinnamon essential oil composition has the property similar to insulin,
Contribute to the control of blood sugar level.In addition, cinnamon essential oil has significant transdermal facilitation, work is cooperateed with Geranium Essential
With promoting various effective component of chinese medicine rapid osmotic skins, into blood circulation.
Compared with prior art, the beneficial effects of the invention are as follows：
Finish prepared by the present invention makes the active ingredient in finish infiltrate into corium rapidly by being applied to skin surface
Layer, into peripheral blood circulation, may act on the mitochondrial membrane of cell, open cellular energy path, increase it to glucose
Utilization rate, reach reduction blood glucose effect, good auxiliary therapeutic action can be played in the therapeutic process of diabetes B；
Production technology of the present invention is compared with the existing technology, it is to avoid the loss of effective component of chinese medicine caused by being heated in conventional method, solution
Residual organic solvent determined the drawbacks of can not be fully erased, and gained essential oil of traditional Chinese medicine purity is high, impurity is few, it is easy to large-scale industry
Metaplasia is produced.
Embodiment
The technical scheme of this patent is described in more detail with reference to embodiment.
Embodiment 1
In the present embodiment, a kind of Transdermal absorption treats the Chinese medicine finish of diabetes B, by the raw material system of following parts by weight
Into：400 parts of grape-kernel oil, 400 parts of olive oil, 10 parts of flavoring pineapple essence, 10 parts of mango essence, 10 parts of Essential Oil From Pine Needles, seabuckthorn essential oil
10 parts, 10 parts of ganoderma lucidum essential oil, 10 parts of ginseng essential oil, 10 parts of Geranium Essential, 10 parts of cinnamon essential oil.
The production technology of the Chinese medicine finish of the Transdermal absorption treatment diabetes B, is comprised the following steps that：
(1) pine needle 150g, sea-buckthorn 150g, ginseng 150g, Chinese cassia tree 150g, fish pelargonium 150g and ganoderma lucidum 150g is weighed respectively to wash
Only, natural air drying, 20 mesh sieves are crossed after pine needle, sea-buckthorn, ginseng, Chinese cassia tree and fish pelargonium are crushed；Ganoderma lucidum is ground into lucidum spore powder；
(2) above-mentioned pine needle particle is taken, Essential Oil From Pine Needles are prepared with supercritical carbon dioxide extracting, pine needle particle is placed in super face
In boundary's carbon dioxide abstraction kettle, set extraction conditions as:Extracting pressure is 15Mpa, and extraction temperature is 30 DEG C, CO 2 fluid
Flow is 15L/h, and extraction time is 2h；Pressure is 6Mpa in separator I, and temperature is 20 DEG C；Pressure is 4Mpa in separator II,
Temperature is 15 DEG C；Extraction collects Essential Oil From Pine Needles after terminating, and sealing preserve is standby；
(3) above-mentioned sea-buckthorn particle is taken, seabuckthorn essential oil is prepared with supercritical carbon dioxide extracting, sea-buckthorn particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 25Mpa, and extraction temperature is 30 DEG C, dioxy
It is 15L/h to change carbon fluid flow, and extraction time is 2h；Pressure is 6Mpa in separator I, and temperature is 20 DEG C；Pressed in separator II
Power is 4Mpa, and temperature is 15 DEG C；Extraction collects seabuckthorn essential oil after terminating, and sealing preserve is standby；
(4) above-mentioned ginseng granules are taken, ginseng essential oil is prepared with supercritical carbon dioxide extracting, ginseng granules are placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 30Mpa, and extraction temperature is 30 DEG C, dioxy
It is 25L/h to change carbon fluid flow, and extraction time is 1h；Pressure is 6Mpa in separator I, and temperature is 20 DEG C；Pressed in separator II
Power is 4Mpa, and temperature is 15 DEG C；Extraction collects ginseng essential oil after terminating, and sealing preserve is standby；
(5) above-mentioned Chinese cassia tree particle is taken, cinnamon essential oil is prepared with supercritical carbon dioxide extracting, Chinese cassia tree particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 30Mpa, and extraction temperature is 30 DEG C, dioxy
It is 30L/h, extraction time 2h to change carbon fluid flow；Pressure is 6Mpa in separator I, and temperature is pressure in 20 DEG C, separator II
For 4Mpa, temperature is 15 DEG C；Extraction collects cinnamon essential oil after terminating, and sealing preserve is standby；
(6) above-mentioned fish pelargonium particle is taken, Geranium Essential is prepared with supercritical carbon dioxide extracting, fish pelargonium particle is put
In in the supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 15Mpa, and extraction temperature is 30
DEG C, CO 2 fluid flow is 15L/h, and extraction time is 2h；Pressure is 6Mpa in separator I, and temperature is 20 DEG C, separator
Pressure is 4Mpa in II, and temperature is 15 DEG C；Extraction collects Geranium Essential after terminating, and sealing preserve is standby；
(7) above-mentioned lucidum spore powder is taken, ganoderma lucidum essential oil is prepared with supercritical carbon dioxide extracting, lucidum spore powder is placed in
In supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 20Mpa, and extraction temperature is 50 DEG C,
CO 2 fluid flow is 30L/h, and extraction time is 3h；Pressure is 6Mpa in separator I, and temperature is 20 DEG C；Separator II
Middle pressure is 4Mpa, and temperature is 15 DEG C；Extraction collects ganoderma lucidum essential oil after terminating, and sealing preserve is standby；
(8) above-mentioned essential oil of traditional Chinese medicine is taken 10 parts and by volume 1 according to parts by weight:1:1:1:1:1 ratio mixing is gone forward side by side
Row ultrasound is mixed；
(9) 400 parts of grape-kernel oil, 400 parts of olive oil, 10 parts of flavoring pineapple essence and mango essence 10 are weighed according to parts by weight
Part, above-mentioned essential oil of traditional Chinese medicine and grape-kernel oil, olive oil, flavoring pineapple essence, mango essence are subjected to ultrasonic mixing, the production is produced
Product.
Embodiment 2
In the present embodiment, a kind of Transdermal absorption treats the Chinese medicine finish of diabetes B, by the raw material system of following parts by weight
Into：600 parts of aloe, 600 parts of sunflower oil, 10 parts of fragrant citrus essence, 10 parts of Hami melon essence, 15 parts of Essential Oil From Pine Needles, sea-buckthorn essence
15 parts of oil, 15 parts of ganoderma lucidum essential oil, 15 parts of ginseng essential oil, 15 parts of Geranium Essential, 15 parts of cinnamon essential oil.
The production technology of the Chinese medicine finish of the Transdermal absorption treatment diabetes B, is comprised the following steps that：
(1) pine needle 200g, sea-buckthorn 200g, ginseng 200g, Chinese cassia tree 200g, fish pelargonium 200g and ganoderma lucidum 200g is weighed respectively to wash
Only, natural air drying, 30 mesh sieves are crossed after pine needle, sea-buckthorn, ginseng, Chinese cassia tree and fish pelargonium are crushed；Ganoderma lucidum is ground into lucidum spore powder；
(2) above-mentioned pine needle particle is taken, Essential Oil From Pine Needles are prepared with supercritical carbon dioxide extracting, pine needle particle is placed in super face
In boundary's carbon dioxide abstraction kettle, set extraction conditions as:Extracting pressure is 18Mpa, and extraction temperature is 40 DEG C, CO 2 fluid
Flow is 25L/h, and extraction time is 2.5h；Pressure is 8Mpa in separator I, and temperature is 25 DEG C；Pressure is in separator II
6Mpa, temperature is 25 DEG C；Extraction collects Essential Oil From Pine Needles after terminating, and sealing preserve is standby；
(3) above-mentioned sea-buckthorn particle is taken, seabuckthorn essential oil is prepared with supercritical carbon dioxide extracting, sea-buckthorn particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 30Mpa, and extraction temperature is 35 DEG C, dioxy
It is 30L/h to change carbon fluid flow, and extraction time is 2.5h；Pressure is 8Mpa in separator I, and temperature is 25 DEG C；In separator II
Pressure is 6Mpa, and temperature is 25 DEG C；Extraction collects seabuckthorn essential oil after terminating, and sealing preserve is standby；
(4) above-mentioned ginseng granules are taken, ginseng essential oil is prepared with supercritical carbon dioxide extracting, ginseng granules are placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 30Mpa, and extraction temperature is 40 DEG C, dioxy
It is 25L/h to change carbon fluid flow, and extraction time is 1.5h；Pressure is 8Mpa in separator I, and temperature is 25 DEG C；In separator II
Pressure is 6Mpa, and temperature is 25 DEG C；Extraction collects ginseng essential oil after terminating, and sealing preserve is standby；
(5) above-mentioned Chinese cassia tree particle is taken, cinnamon essential oil is prepared with supercritical carbon dioxide extracting, Chinese cassia tree particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 35Mpa, and extraction temperature is 40 DEG C, dioxy
It is 30L/h, extraction time 2.5h to change carbon fluid flow；Pressure is 8Mpa in separator I, and temperature is pressure in 20 DEG C, separator II
Power is 6Mpa, and temperature is 20 DEG C；Extraction collects cinnamon essential oil after terminating, and sealing preserve is standby；
(6) above-mentioned fish pelargonium particle is taken, Geranium Essential is prepared with supercritical carbon dioxide extracting, fish pelargonium particle is put
In in the supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 18Mpa, and extraction temperature is 40
DEG C, CO 2 fluid flow is 20L/h, and extraction time is 2.5h；Pressure is 8Mpa in separator I, and temperature is 20 DEG C, separation
Pressure is 6Mpa in device II, and temperature is 20 DEG C；Extraction collects Geranium Essential after terminating, and sealing preserve is standby；
(7) above-mentioned lucidum spore powder is taken, ganoderma lucidum essential oil is prepared with supercritical carbon dioxide extracting, lucidum spore powder is placed in
In supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 22Mpa, and extraction temperature is 60 DEG C,
CO 2 fluid flow is 35L/h, and extraction time is 3.5h；Pressure is 8Mpa in separator I, and temperature is 35 DEG C；Separator
Pressure is 5Mpa in II, and temperature is 30 DEG C；Extraction collects ganoderma lucidum essential oil after terminating, and sealing preserve is standby；
(8) above-mentioned essential oil of traditional Chinese medicine is taken 15 parts and by volume 1 according to parts by weight:1:1:1:1:1 ratio mixing is gone forward side by side
Row ultrasound is mixed；
(9) 600 parts of aloe, 600 parts of sunflower oil, 10 parts of fragrant citrus essence and Hami melon essence 10 are weighed according to parts by weight
Part, above-mentioned essential oil of traditional Chinese medicine and base oil, fruit essence are subjected to ultrasonic mixing, the product is produced.
Embodiment 3
In the present embodiment, a kind of Transdermal absorption treats the Chinese medicine finish of diabetes B, by the raw material system of following parts by weight
Into：2000 parts of Apricot kernel oil, 25 parts of flavoring banana essence, 25 parts of Essential Oil From Pine Needles, 25 parts of seabuckthorn essential oil, 25 parts of ganoderma lucidum essential oil, ginseng essential oil
25 parts, 25 parts of Geranium Essential, 25 parts of cinnamon essential oil.
The production technology of the Chinese medicine finish of the Transdermal absorption treatment diabetes B, is comprised the following steps that：
(1) pine needle 250g, sea-buckthorn 250g, ginseng 250g, Chinese cassia tree 250g, fish pelargonium 250g and ganoderma lucidum 250g is weighed respectively to wash
Only, natural air drying, 40 mesh sieves are crossed after pine needle, sea-buckthorn, ginseng, Chinese cassia tree and fish pelargonium are crushed；Ganoderma lucidum is ground into lucidum spore powder；
(2) above-mentioned pine needle particle is taken, Essential Oil From Pine Needles are prepared with supercritical carbon dioxide extracting, pine needle particle is placed in super face
In boundary's carbon dioxide abstraction kettle, set extraction conditions as:Extracting pressure is 20Mpa, and extraction temperature is 55 DEG C, CO 2 fluid
Flow is 35L/h, and extraction time is 3h；Pressure is 15Mpa in separator I, and temperature is 40 DEG C；Pressure is in separator II
L0Mpa, temperature is 35 DEG C；Extraction collects Essential Oil From Pine Needles after terminating, and sealing preserve is standby；
(3) above-mentioned sea-buckthorn particle is taken, seabuckthorn essential oil is prepared with supercritical carbon dioxide extracting, sea-buckthorn particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 35Mpa, and extraction temperature is 45 DEG C, dioxy
It is 35L/h to change carbon fluid flow, and extraction time is 3h；Pressure is 15Mpa in separator I, and temperature is 40 DEG C；Pressed in separator II
Power is l0Mpa, and temperature is 35 DEG C；Extraction collects seabuckthorn essential oil after terminating, and sealing preserve is standby；
(4) above-mentioned ginseng granules are taken, ginseng essential oil is prepared with supercritical carbon dioxide extracting, ginseng granules are placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 40Mpa, and extraction temperature is 45 DEG C, dioxy
It is 30L/h to change carbon fluid flow, and extraction time is 2h；Pressure is 15Mpa in separator I, and temperature is 40 DEG C；Pressed in separator II
Power is l0Mpa, and temperature is 35 DEG C；Extraction collects ginseng essential oil after terminating, and sealing preserve is standby；
(5) above-mentioned Chinese cassia tree particle is taken, cinnamon essential oil is prepared with supercritical carbon dioxide extracting, Chinese cassia tree particle is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 40Mpa, and extraction temperature is 55 DEG C, dioxy
It is 35L/h, extraction time 3h to change carbon fluid flow；Pressure is 15Mpa in separator I, and temperature is pressure in 40 DEG C, separator II
For l0Mpa, temperature is 35 DEG C；Extraction collects cinnamon essential oil after terminating, and sealing preserve is standby；
(6) above-mentioned fish pelargonium particle is taken, Geranium Essential is prepared with supercritical carbon dioxide extracting, fish pelargonium particle is put
In in the supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 20Mpa, and extraction temperature is 55
DEG C, CO 2 fluid flow is 20L/h, and extraction time is 3h；Pressure is 15Mpa in separator I, and temperature is 40 DEG C, separation
Pressure is l0Mpa in device II, and temperature is 35 DEG C；Extraction collects Geranium Essential after terminating, and sealing preserve is standby；
(7) above-mentioned lucidum spore powder is taken, ganoderma lucidum essential oil is prepared with supercritical carbon dioxide extracting, lucidum spore powder is placed in
In supercritical carbon dioxide extracting kettle after cleaning, set extraction conditions as:Extracting pressure is 30Mpa, and extraction temperature is 60 DEG C,
CO 2 fluid flow is 35L/h, and extraction time is 4h；Pressure is 15Mpa in separator I, and temperature is 40 DEG C；Separator II
Middle pressure is 10Mpa, and temperature is 35 DEG C；Extraction collects ganoderma lucidum essential oil after terminating, and sealing preserve is standby；
(8) above-mentioned essential oil of traditional Chinese medicine is taken 25 parts and by volume 1 according to parts by weight:1:1:1:1:1 ratio mixing is gone forward side by side
Row ultrasound is mixed；
(9) 25 parts of 2000 parts of Apricot kernel oil and flavoring banana essence are weighed according to parts by weight, by above-mentioned essential oil of traditional Chinese medicine and base oil, water
Fruity is progressed greatly, and row is ultrasonic to be mixed, and produces the product.
Embodiment 4
Clinical data analysis：
69 diabetes B patients are divided into treatment group and control group by this group of case totally 69 by the method for random table.Control
Treatment group 35, wherein man 24, female 11, average age 47.25 ± 5.36 years old, average course of disease 5.26 ± 2.13 years；Control group
34, wherein man 21, female 13, average age 44.79 ± 2.35 years old, average course of disease 4.56 ± 1.88 years.Two groups of cases
Sex, age, course of disease distribution are compared, and are statistically analyzed no significant difference, P ＞ 0.05, with comparativity.
Diabetes diagnostic criterion：The diabetes diagnosis formally announced according to WHO diabetologists Advisory Board in 1999
Standard, it is all that there is diabetic symptom, there are diuresis, polydipsia and the weight loss of other explanations can not be used, and meet following bar
The one of part, you can be diagnosed as diabetes：(1) fasting blood-glucose FPG >=7.0mmol/L (126mg/dl)；(2) random blood sugar >=
11.1mmol/L(200mg/dl)；(3) 2 hours blood glucoses >=11.1mmol/L in oral glucose tolerance experiment (OGTT, 75g glucose)
(200mg/dl)。
This Chinese medicine compound prescription finish is made by the methods described of above-described embodiment one in treatment group, 3 times a day be applied to patient back,
At belly and calf skin, coordinate popular treatment for sunstroke by scraping the patient's neck, chest or back, massage manipulation, promote to absorb；Control group gives Metformin hydrochloride 0.5g, daily
It is 3 times, oral during meal.The course for the treatment of 12 weeks.During treatment, treatment group and control group do not use any Chinese and Western with blood sugar reducing function
Medicine.
From two groups are observed certainly, that is, coordinate Primary Care.Diet：Difference is substantially provided by different labor intensity and the bodily form
Staple food intake.Slight manual labor or the body severe one that is above standard, daily staple food control is in 250-300g, and labor in general person is every
Day 300-350g, moderate physical labourer 350-450g；Institute's calorific requirement takes the circumstances into consideration to be supplemented by non-staple foodstuff beyond staple food.Motion：Rationally transport
It is dynamic, including daily rest, activity and work.
Fasting blood-glucose FPG, after the meal 2 hours blood glucose P2hPG, glycosylated hemoglobin HbA1C, inspection are detected before and after treatment respectively
Survey result as shown in table 1：
FPG, P2hPG, HbA1C compare (X ± S) before and after the treatment group of table 1, control group treatment
Upper table data display：Treatment group after the treatment fasting blood-glucose, 2 hours blood glucoses and glycosylated hemoglobin are obvious after the meal
Decline, difference has statistical significance.
Statistical method carries out statistical analysis using statistic software SPSS ll.0.Measurement data is recorded using x ± s methods,
Compare before and after measurement data treatment and between group and examined using t；Ranked data treatment cross-reference is used in non-parametric test
Ridit is examined, and two groups of treated effects use Chi-square Test.
Treatment group is effective 11 (31.43%), effective 21 (60.00%), invalid 3 (8.57%), total effective rate
91.43%.It is above-mentioned test result indicates that, using in the present invention preparation method prepare Chinese medicine compound prescription finish can effectively reduce patient
Blood glucose and glycosylated hemoglobin, auxiliary treatment diabetes B.
Model case：
Case 1：Liu, man, 39 years old, civil servant
Because unit bodies check diabetes, usually move less, occasionally have dinner party, eating meat, its pink tongue, tongue is slightly greasy,
Arteries and veins moistens, stomach receive can, it is convenient to both adjust.Fasting blood-glucose highest 18.4mmol/l, minimum 7.42mmol/l.The past aglycosuria medical history.
Give this Chinese medicine compound prescription finish, advising it, 2 times a day, all over being applied to back, belly, calf skin, and impose popular treatment for sunstroke by scraping the patient's neck, chest or back and
Massage to promote to absorb.After continuous treatment 2 weeks, fasting blood-glucose is down to highest 10.1mmol/l, minimum 5.3mmol/l；Persistently control
January is treated, is kept without hypoglycemic medicine intervention, fasting blood-glucose is more than 3 days less than 6.1mmol/l；Maintain diet light always afterwards, and protect
Hold jog daily, swimming exercise, monitoring blood glucose is so far in normal index.
Case 2：Field, man, 38 years old, company manager
Taijiquan is liked usually, it is healthy.Casual testing blood glucose, measures random blood sugar 9.2mmol/l, in succession three skies
Abdomen：7.9、7.8、8.6mmol/l.Its tongue is slightly red, and tongue is thin white, arteries and veins moisten it is slightly profound, stomach receive can, it is convenient to both to adjust.
This Chinese medicine compound prescription finish is given, it is advised for multiple daily, belly, calf skin is applied to, and impose popular treatment for sunstroke by scraping the patient's neck, chest or back and massage
To promote to absorb, while strengthening tai chi exercise.Average fasting blood-glucose is down to 5.0-6.0mmol/l after 1 first quarter moon, at random
8.0mmol/l it is following；Blood sugar test is normal so far.
Case 3：Cao, man, 58 years old, unit leader
Diabetes more than 7 years, the general 8-9mmol/l of fasting blood-glucose, 12mmol/l or so, takes Western medicine Diamicron, lattice after the meal
China stops, while with hypertension, blood fat disorder.Its tongue purple secretly has ecchymosis, and greasy and thin fur, arteries and veins is fine and smooth, and two chis are not enough, left cun short.Cause
Its course of disease is longer, and sick position is deeper, first gives oral medicinal herb to nurse one's health, and Glucophage is disabled after January；Diamicron is changed to Acarbose 1 after two months
Grain；Acarbose makes half into after April, and Acarbose is disabled after May.Afterwards because of its people's reason, it has not been convenient to take Chinese medicine, this is given then
Chinese medicine compound prescription finish is used.Disable Chinese medicine after, its fasting blood-glucose slightly has rise, continuously using this Chinese medicine compound prescription finish 4 weeks after, blood
Sugar is down to normal range (NR).This finish is disabled after seven months, outer once in a while to control maintenance, Household diet, locomotive regulation, blood glucose are maintained just
Normal scope.
Case 4：Poplar, man, 52 years old, logistics management
The pungent savoury of happy event, motion is few, falls asleep evening, and it is poor to sleep.Feel in December, 2013 it is uncomfortable, to examination in hospital：
Fasting blood-glucose 9.8mmol/l, 14mmol/l, gives and takes Western medicine gliclazide 2, Acarbose 3, glycemic control is general after the meal.
Its tongue is purplish red, yellow and greasy fur, arteries and veins moisten it is dry, it is left close it is slightly profound.Through dialectical analysis, in May, 2014, oral medicinal herb is given to merge this Chinese medicine compound prescription
Finish external application.After March, it is 1 gliclazide to subtract medicine, and fasting blood-glucose is down to 5.5-6.0mmol/l.Withdraw Chinese medicine, advise its diet
It is light, go to bed early and get up early, be continuing with this Chinese medicine compound prescription finish, blood glucose keeps stable.At present in still lasting tracking.
Case 5：Slowly certain, male, 50 years old
It was found that diabetes 8 years, blood glucose rise triggers lower limb infection.Fasting blood-glucose 9.7mmol/l is measured, after the meal 2 hours blood
Sugared 15.2mmol/l, glycosylated hemoglobin 12.7%.There is diabetic cardiopathy, nephrosis, illness in eye complication simultaneously.In institute of traditional Chinese medicine
Lower limb infection control, takes Ya Moli, Acarbose, melbine to control blood glucose after in hospital.Its tongue is dark slightly purple, yellow and greasy fur, arteries and veins
It is profound slightly heavy to moisten, right cun, right chi deficiency.Give diabetes wholistic therapy, based on oral medicinal herb, using this Chinese medicine compound prescription finish outside
With cooperation characteristic finger needling strictly controls its diet, strengthens taking exercise.Ya Moli is disabled after January；Physical examination HbAle after April
Albumen 6.8%, hepatic and renal function, Urine proteins index recover normal, and eyes are without significant discomfort, in current continued treatment.
Finish prepared by the present invention makes the active ingredient in finish infiltrate into corium rapidly by being applied to skin surface
Layer, into peripheral blood circulation, may act on the mitochondrial membrane of cell, open cellular energy path, increase it to glucose
Utilization rate, reach reduction blood glucose effect, good auxiliary therapeutic action can be played in the therapeutic process of diabetes B；
Production technology of the present invention is compared with the existing technology, it is to avoid the loss of effective component of chinese medicine caused by being heated in conventional method, solution
Residual organic solvent determined the drawbacks of can not be fully erased, and gained essential oil of traditional Chinese medicine purity is high, impurity is few, it is easy to large-scale industry
Metaplasia is produced.
The better embodiment to this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
, can also be on the premise of this patent objective not be departed from formula, the knowledge that one skilled in the relevant art possesses
Various changes can be made.
Claims (6)
1. a kind of Transdermal absorption treats the Chinese medicine finish of diabetes B, it is characterised in that be made up of the raw material of following parts by weight：
800-3200 parts of base oil, 60-240 parts of essential oil of traditional Chinese medicine, 20-30 parts of fruit essence, the essential oil of traditional Chinese medicine is by following parts by weight
Raw material is made：10-40 parts of Essential Oil From Pine Needles, 10-40 parts of seabuckthorn essential oil, 10-40 parts of ganoderma lucidum essential oil, 10-40 parts of ginseng essential oil, India
10-40 parts of certain herbaceous plants with big flowers essential oil, 10-40 parts of cinnamon essential oil.
2. Transdermal absorption according to claim 1 treats the Chinese medicine finish of diabetes B, it is characterised in that by following heavy
The raw material of amount part is made：800-2400 parts of base oil, 60-240 parts of essential oil of traditional Chinese medicine, 20-25 parts of fruit essence, the essential oil of traditional Chinese medicine
It is made up of the raw material of following parts by weight：10-30 parts of Essential Oil From Pine Needles, 10-30 parts of seabuckthorn essential oil, 10-30 parts of ganoderma lucidum essential oil, panax ginseng extractum
Oily 10-30 parts, 10-30 parts of Geranium Essential, 10-30 parts of cinnamon essential oil.
3. Transdermal absorption according to claim 1 treats the Chinese medicine finish of diabetes B, it is characterised in that by following heavy
The raw material of amount part is made：800 parts of base oil, 60 parts of essential oil of traditional Chinese medicine, 20 parts of fruit essence, the essential oil of traditional Chinese medicine is by following parts by weight
Raw material be made：10 parts of Essential Oil From Pine Needles, 10 parts of seabuckthorn essential oil, 10 parts of ganoderma lucidum essential oil, 10 parts of ginseng essential oil, Geranium Essential 10
Part, 10 parts of cinnamon essential oil.
4. the Transdermal absorption according to one of claim 1-3 treats the Chinese medicine finish of diabetes B, it is characterised in that institute
It is one or more kinds of mixtures in grape-kernel oil, olive oil, aloe, sunflower oil, Apricot kernel oil to state base oil.
5. the Transdermal absorption according to one of claim 1-3 treats the Chinese medicine finish of diabetes B, it is characterised in that institute
It is the one or more in flavoring pineapple essence, mango essence, fragrant citrus essence, Hami melon essence, flavoring banana essence to state fruit essence
Mixture.
6. the production technology of the Chinese medicine finish of the Transdermal absorption treatment diabetes B described in a kind of one of use claim 1-5,
Characterized in that, comprising the following steps that：
(1) pine needle 150-250g, sea-buckthorn 150-250g, ginseng 150-250g, Chinese cassia tree 150-250g, fish pelargonium 150- are weighed respectively
250g and ganoderma lucidum 150-250g, is cleaned, natural air drying, and 20-40 mesh is crossed after pine needle, sea-buckthorn, ginseng, Chinese cassia tree and fish pelargonium are crushed
Sieve；Ganoderma lucidum is ground into lucidum spore powder；
(2) above-mentioned pine needle particle is taken, Essential Oil From Pine Needles are prepared with supercritical carbon dioxide extracting, pine needle particle is placed in overcritical two
In carbonoxide extraction kettle, set extraction conditions as:Extracting pressure is 15-20Mpa, and extraction temperature is 30-55 DEG C, carbon dioxide stream
Body flow is 15-35L/h, and extraction time is 2-3h；Pressure is 6-15Mpa in separator I, and temperature is 20-40 DEG C；Separator II
Middle pressure is 4-l0Mpa, and temperature is 15-35 DEG C；Extraction collects Essential Oil From Pine Needles after terminating, and sealing preserve is standby；
(3) above-mentioned sea-buckthorn particle is taken, seabuckthorn essential oil is prepared with supercritical carbon dioxide extracting, sea-buckthorn particle is placed in after cleaning
In supercritical carbon dioxide extracting kettle, set extraction conditions as:Extracting pressure is 25-35Mpa, and extraction temperature is 30-45 DEG C, two
Carbon oxide fluid flow is 15-35L/h, and extraction time is 2-3h；Pressure is 6-15Mpa in separator I, and temperature is 20-40 DEG C；
Pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects seabuckthorn essential oil after terminating, and sealing preserve is standby；
(4) above-mentioned ginseng granules are taken, ginseng essential oil is prepared with supercritical carbon dioxide extracting, ginseng granules are placed in after cleaning
In supercritical carbon dioxide extracting kettle, set extraction conditions as:Extracting pressure is 30-40Mpa, and extraction temperature is 30-45 DEG C, two
Carbon oxide fluid flow is 25-30L/h, and extraction time is 1-2h；Pressure is 6-15Mpa in separator I, and temperature is 20-40 DEG C；
Pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects ginseng essential oil after terminating, and sealing preserve is standby；
(5) above-mentioned Chinese cassia tree particle is taken, cinnamon essential oil is prepared with supercritical carbon dioxide extracting, Chinese cassia tree particle is placed in after cleaning
In supercritical carbon dioxide extracting kettle, set extraction conditions as:Extracting pressure is 30-40Mpa, and extraction temperature is 30-55 DEG C, two
Carbon oxide fluid flow is 30-35L/h, extraction time 2-3h；Pressure is 6-15Mpa in separator I, and temperature is 20-40 DEG C, point
It is 4-l0Mpa from pressure in device II, temperature is 15-35 DEG C；Extraction collects cinnamon essential oil after terminating, and sealing preserve is standby；
(6) above-mentioned fish pelargonium particle is taken, Geranium Essential is prepared with supercritical carbon dioxide extracting, fish pelargonium particle is placed in clearly
In supercritical carbon dioxide extracting kettle after clean, set extraction conditions as:Extracting pressure is 15-20Mpa, and extraction temperature is 30-
55 DEG C, CO 2 fluid flow is 15-20L/h, and extraction time is 2-3h；Pressure is 6-15Mpa in separator I, and temperature is
20-40 DEG C, pressure is 4-l0Mpa in separator II, and temperature is 15-35 DEG C；Geranium Essential is collected in extraction after terminating, sealing is protected
Deposit standby；
(7) above-mentioned lucidum spore powder is taken, ganoderma lucidum essential oil is prepared with supercritical carbon dioxide extracting, lucidum spore powder is placed in cleaning
In supercritical carbon dioxide extracting kettle afterwards, set extraction conditions as:Extracting pressure is 20-30Mpa, and extraction temperature is 50-60
DEG C, CO 2 fluid flow is 30-35L/h, and extraction time is 3-4h；Pressure is 6-15Mpa in separator I, and temperature is 20-
40℃；Pressure is 4-10Mpa in separator II, and temperature is 15-35 DEG C；Extraction collects ganoderma lucidum essential oil after terminating, and sealing preserve is standby
With；
(8) above-mentioned essential oil of traditional Chinese medicine is taken 10-40 parts and by volume 1 according to parts by weight:1:1:1:1:1 ratio is mixed and carried out
Ultrasound is mixed；
(9) 20-30 parts of 800-3200 parts of base oil and fruit essence are weighed according to parts by weight, by above-mentioned essential oil of traditional Chinese medicine and basis
Oil, fruit essence carry out ultrasonic mixing, produce the product.
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