CN104288229A - Chinese medicinal oil solution for treating type 2 diabetes by transdermal absorption, and production process thereof - Google Patents
Chinese medicinal oil solution for treating type 2 diabetes by transdermal absorption, and production process thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention discloses a Chinese medicinal oil solution for treating type 2 diabetes by transdermal absorption. The Chinese medicinal oil solution comprises the following raw materials in parts by weight: base oil, Chinese medicinal essential oil and fruit essence, wherein the Chinese medicinal essential oil comprises the following raw materials in parts by weight: pine needle essential oil, sea bulkthorn essential oil, lucid ganoderma essential oil, ginseng essential oil, geranium essential oil and cinnamon essential oil; the base oil is one or a mixture of more than one of grape seed oil, olive oil, aloe oil, sunflower oil and almond oil; the fruit essence is one or a mixture of more than one of pineapple essence, mango essence, fragrant orange essence, Hami melon essence and banana essence. The Chinese medicinal oil solution disclosed by the invention is smeared on the surface of skin, so that effective ingredients in the oil solution quickly infiltrate to a corium layer and possibly act on mitochondrial membranes of cells; a cell energy path is opened, so that the utilization rate of the Chinese medicinal oil solution for glucose is increased. In addition, the loss of the effective ingredients of the Chinese medicine caused by heating in the traditional method is avoided; the obtained Chinese medicinal essential oil is high in purity and fewer in impurities, and facilitates large-scale industrial production.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Transdermal absorption treats Chinese medicine oil preparation and the production technology thereof of type 2 diabetes mellitus.
Background technology
Type 2 diabetes mellitus is a kind of commonly encountered diseases, and its sickness rate improves year by year, and its diseased colonies is close to 100,000,000, and nearly 1.5 hundred million people of high risk group, sickness rate reaches 11.6%.Chinese medicine decoction has great advantage in the treatment of type 2 diabetes mellitus, effectively can not only reduce patient blood glucose, can also obviously improve diabetics body constitution, improve its quality of life, and can delay generation and the development of complication to a certain extent.But because decoction decocting is inconvenient, mouthfeel is poor, carry the many factors such as difficulty, make Chinese medicine decoction cannot reach certain scale all the time in the treatment of type 2 diabetes mellitus.
If Chinese medicine route of administration can be changed, oral medicinal herb is changed into Chinese medicine external, under the prerequisite do not lessened the curative effect, must be accepted by vast diabetics.
Skin is the maximum organ of human body, and 5% ~ 15% of gross weight percentage of liveweight, the gross area is 1.5 ~ 2 square metres, and thickness, because of people or different because of position, is 0.5 ~ 4 millimeter.Skin covers whole body, and it to make in body various tissue and organ from the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism.Skin has the barrier action of two aspects: prevent moisture in body on the one hand, the loss of electrolyte and other materials; Stop the intrusion of extraneous harmful substance on the other hand.Skin remains the stable of human internal environment, and physiology plays important defencive function, also participates in the metabolic process of human body simultaneously.
Transdermal administration is the third generation medication that WHO recommends, and since first the U.S. in 1974 propose transdermal drug delivery system therapeutic scheme and make winter hyoscyamine paster listing, transdermal drug delivery system constantly improves and obtains swift and violent development.Transdermal drug delivery system, without " first pass effect " of liver, is not destroyed by pipe intestinal digesting liquid, can provide predetermined, longer action time, can reduce drug toxicity and untoward reaction, can maintain stable and lasting blood drug level, thus improves curative effect.In recent years, the nitroglycerin percutaneous drug delivery novel form treatment coronary insufficiency used clinically, achieved the curative effect being better than oral administration.
In recent years, due to the development of the newborn abstraction techniques such as critical carbon dioxide abstraction technique, molecular distillation technique and universal, the abstraction technique of Chinese medicine is made to obtain tremendous increase, also for the development of Chinese medicine oil preparation provides huge development space.
Summary of the invention
The object of the present invention is to provide Chinese medicine oil preparation and the production technology thereof of the Transdermal absorption treatment type 2 diabetes mellitus that a kind of purity is high, impurity is few, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of Chinese medicine oil preparation of Transdermal absorption treatment type 2 diabetes mellitus, comprise according to the raw material of weight portion: base oil 800-3200 part, essential oil of traditional Chinese medicine 60-240 part, fruit essence 20-30 part, described essential oil of traditional Chinese medicine comprises according to the raw material of weight portion: Essential Oil From Pine Needles 10-40 part, seabuckthorn essential oil 10-40 part, Ganoderma quintessence oil 10-40 part, ginseng essential oil 10-40 part, Geranium Essential 10-40 part, cinnamon essential oil 10-40 part.
As the further scheme of the present invention: the Chinese medicine oil preparation of described Transdermal absorption treatment type 2 diabetes mellitus, comprise according to the raw material of weight portion: base oil 800-2400 part, essential oil of traditional Chinese medicine 60-240 part, fruit essence 20-25 part, described essential oil of traditional Chinese medicine comprises according to the raw material of weight portion: Essential Oil From Pine Needles 10-30 part, seabuckthorn essential oil 10-30 part, Ganoderma quintessence oil 10-30 part, ginseng essential oil 10-30 part, Geranium Essential 10-30 part, cinnamon essential oil 10-30 part.
As the further scheme of the present invention: the Chinese medicine oil preparation of described Transdermal absorption treatment type 2 diabetes mellitus, comprise according to the raw material of weight portion: base oil 800 parts, essential oil of traditional Chinese medicine 60 parts, fruit essence 20 parts, described essential oil of traditional Chinese medicine comprises according to the raw material of weight portion: Essential Oil From Pine Needles 10 parts, seabuckthorn essential oil 10 parts, Ganoderma quintessence oil 10 parts, ginseng essential oil 10 parts, Geranium Essential 10 parts, cinnamon essential oil 10 parts.
As the further scheme of the present invention: described base oil is one or more the mixture in Oleum Vitis viniferae, olive oil, aloe, Oleum helianthi, Apricot kernel oil.
As the present invention's further scheme: described fruit essence is one or more the mixture in flavoring pineapple essence, Fructus Mangifera Indicae essence, fragrant citrus essence, Hami melon essence, flavoring banana essence.
The production technology of the Chinese medicine oil preparation of described Transdermal absorption treatment type 2 diabetes mellitus, concrete steps are as follows:
(1) take Folium Pini 150-250g, Fructus Hippophae 150-250g, Radix Ginseng 150-250g, Cortex Cinnamomi 150-250g, Flos Pelargonii 150-250g and Ganoderma 150-250g respectively to clean, natural air drying, crosses 20-40 mesh sieve after Folium Pini, Fructus Hippophae, Radix Ginseng, Cortex Cinnamomi and Flos Pelargonii being pulverized; Ganoderma powder is broken into Ganoderma spore powder;
(2) above-mentioned Folium Pini granule is got, Essential Oil From Pine Needles is prepared with supercritical carbon dioxide extraction, Folium Pini granule is placed in supercritical carbon dioxide extraction still, setting extraction conditions is: extracting pressure is 15-20Mpa, extraction temperature is 30-55 DEG C, CO 2 fluid flow is 15-35L/h, and extraction time is 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection Essential Oil From Pine Needles, and sealing saves backup;
(3) above-mentioned sea-buckthorn particle is got, seabuckthorn essential oil is prepared with supercritical carbon dioxide extraction, sea-buckthorn particle is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 25-35Mpa, extraction temperature is 30-45 DEG C, CO 2 fluid flow is 15-35L/h, and extraction time is 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection seabuckthorn essential oil, and sealing saves backup;
(4) above-mentioned ginseng granules is got, ginseng essential oil is prepared with supercritical carbon dioxide extraction, ginseng granules is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30-40Mpa, extraction temperature is 30-45 DEG C, CO 2 fluid flow is 25-30L/h, and extraction time is 1-2h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection ginseng essential oil, and sealing saves backup;
(5) above-mentioned Cortex Cinnamomi granule is got, cinnamon essential oil is prepared with supercritical carbon dioxide extraction, Cortex Cinnamomi granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30-40Mpa, extraction temperature is 30-55 DEG C, CO 2 fluid flow is 30-35L/h, extraction time 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C, and in separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection cinnamon essential oil, and sealing saves backup;
(6) above-mentioned Flos Pelargonii granule is got, Geranium Essential is prepared with supercritical carbon dioxide extraction, Flos Pelargonii granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 15-20Mpa, extraction temperature is 30-55 DEG C, CO 2 fluid flow is 15-20L/h, and extraction time is 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C, and in separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection Geranium Essential, and sealing saves backup;
(7) above-mentioned Ganoderma spore powder is got, Ganoderma quintessence oil is prepared with supercritical carbon dioxide extraction, Ganoderma spore powder is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 20-30Mpa, extraction temperature is 50-60 DEG C, CO 2 fluid flow is 30-35L/h, and extraction time is 3-4h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-10Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection Ganoderma quintessence oil, and sealing saves backup;
(8) above-mentioned essential oil of traditional Chinese medicine is got 10-40 part according to weight portion and the ratio of 1:1:1:1:1:1 by volume mixes and carries out ultrasonic mixing;
(9) take base oil 800-3200 part and fruit essence 20-30 part according to weight portion, above-mentioned essential oil of traditional Chinese medicine and base oil, fruit essence are carried out ultrasonic mixing, obtains Chinese medicine oil preparation of the present invention.
Pharmacological action: the α-aminobutyric acid contained in Essential Oil From Pine Needles, can promote
glucosedecomposition, have and promote brain metabolism, other compositions, as glycerol quinine, have hypoglycemic effect, can control diabetes.Containing 206 kinds of active substances useful to human body in seabuckthorn essential oil, wherein there are 46 kinds of bioactive substances, containing a large amount of vitamin Es, vitamin A, flavone etc., there is resisting fatigue and enhancing body vigor and the special pharmacological performance such as anticancer.Ganoderma quintessence oil can not only reduce blood glucose, also can obviously reduce cholesterolemia,
lipoproteinwith
triglyceride, and energy prevention of arterial is atherosis
speckleformation, for atherosclerotic plaque former, then have and reduce Arterial Cholesterol content, vessel softening, prevent the effect of damage further, have important value to prevention of diabetic vascular pathological changes.Ginseng essential oil can increase the picked-up of brain to glucose, reduces the ratio of lactic acid, acetone acid and lactic acid/acetone acid simultaneously, and the utilization of glucose can be made to change aerobic metabolism into from anaerobic metabolism approach, increases body to the availability of glucose.Effective ingredient in Geranium Essential and natural alicyclic organic have very strong affinity, and while affine with lipoid, also produce affinity with skin epidermal area, this affinity has surmounted the affinity with water.Containing flavonol Polyphenols antioxidant in cinnamon essential oil, insulin can be improved to the Stabilization of blood sugar level and reduction insulin resistant.These protein have material impact to Insulin receptor INSR, blood glucose transport and inflammatory reaction, thus can promote insulin active or increase body to the sensitivity of insulin.In addition, also studies have found that, some composition in cinnamon essential oil has the character being similar to insulin, also contributes to the control of blood sugar level.In addition, cinnamon essential oil has significant Penetration enhance, with Geranium Essential synergism, impels various Effective Component of Chinese Medicine rapid osmotic skin, enters blood circulation.
Compared with prior art, the invention has the beneficial effects as follows:
Oil preparation prepared by the present invention is by being applied in skin surface, make effective ingredient rapid permeability in oil preparation to skin corium, enter peripheral blood circulation, the mitochondrial membrane of cell may be acted on, open cellular energy path, increase its utilization rate to glucose, reach and fall hypoglycemic effect, good auxiliary therapeutic action can be played in the therapeutic process of type 2 diabetes mellitus; Production technology of the present invention compared with the existing technology, avoid in traditional method the loss of heating the Effective Component of Chinese Medicine caused, solve the drawback that residual organic solvent cannot be removed completely, and gained essential oil of traditional Chinese medicine purity is high, impurity is few, is easy to large-scale industrial production.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
In the present embodiment, a Chinese medicine oil preparation for Transdermal absorption treatment type 2 diabetes mellitus, comprises according to the raw material of weight portion: Oleum Vitis viniferae 400 parts, 400 parts, olive oil, flavoring pineapple essence 10 parts, 10 parts, Fructus Mangifera Indicae essence, Essential Oil From Pine Needles 10 parts, seabuckthorn essential oil 10 parts, Ganoderma quintessence oil 10 parts, ginseng essential oil 10 parts, Geranium Essential 10 parts, cinnamon essential oil 10 parts.
The production technology of the Chinese medicine oil preparation of described Transdermal absorption treatment type 2 diabetes mellitus, concrete steps are as follows:
(1) take Folium Pini 150g, Fructus Hippophae 150g, Radix Ginseng 150g, Cortex Cinnamomi 150g, Flos Pelargonii 150g and Ganoderma 150g respectively to clean, natural air drying, after Folium Pini, Fructus Hippophae, Radix Ginseng, Cortex Cinnamomi and Flos Pelargonii being pulverized, cross 20 mesh sieves; Ganoderma powder is broken into Ganoderma spore powder;
(2) get above-mentioned Folium Pini granule, prepare Essential Oil From Pine Needles with supercritical carbon dioxide extraction, Folium Pini granule is placed in supercritical carbon dioxide extraction still, setting extraction conditions is: extracting pressure is 15Mpa, extraction temperature is 30 DEG C, and CO 2 fluid flow is 15L/h, and extraction time is 2h; In separator I, pressure is 6Mpa, and temperature is 20 DEG C; In separator II, pressure is 4Mpa, and temperature is 15 DEG C; Extraction terminates rear collection Essential Oil From Pine Needles, and sealing saves backup;
(3) above-mentioned sea-buckthorn particle is got, seabuckthorn essential oil is prepared with supercritical carbon dioxide extraction, sea-buckthorn particle is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 25Mpa, extraction temperature is 30 DEG C, CO 2 fluid flow is 15L/h, and extraction time is 2h; In separator I, pressure is 6Mpa, and temperature is 20 DEG C; In separator II, pressure is 4Mpa, and temperature is 15 DEG C; Extraction terminates rear collection seabuckthorn essential oil, and sealing saves backup;
(4) above-mentioned ginseng granules is got, ginseng essential oil is prepared with supercritical carbon dioxide extraction, ginseng granules is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30Mpa, extraction temperature is 30 DEG C, CO 2 fluid flow is 25L/h, and extraction time is 1h; In separator I, pressure is 6Mpa, and temperature is 20 DEG C; In separator II, pressure is 4Mpa, and temperature is 15 DEG C; Extraction terminates rear collection ginseng essential oil, and sealing saves backup;
(5) above-mentioned Cortex Cinnamomi granule is got, cinnamon essential oil is prepared with supercritical carbon dioxide extraction, Cortex Cinnamomi granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30Mpa, extraction temperature is 30 DEG C, CO 2 fluid flow is 30L/h, extraction time 2h; In separator I, pressure is 6Mpa, and temperature is 20 DEG C, and in separator II, pressure is 4Mpa, and temperature is 15 DEG C; Extraction terminates rear collection cinnamon essential oil, and sealing saves backup;
(6) above-mentioned Flos Pelargonii granule is got, Geranium Essential is prepared with supercritical carbon dioxide extraction, Flos Pelargonii granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 15Mpa, extraction temperature is 30 DEG C, CO 2 fluid flow is 15L/h, and extraction time is 2h; In separator I, pressure is 6Mpa, and temperature is 20 DEG C, and in separator II, pressure is 4Mpa, and temperature is 15 DEG C; Extraction terminates rear collection Geranium Essential, and sealing saves backup;
(7) above-mentioned Ganoderma spore powder is got, Ganoderma quintessence oil is prepared with supercritical carbon dioxide extraction, Ganoderma spore powder is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 20Mpa, extraction temperature is 50 DEG C, CO 2 fluid flow is 30L/h, and extraction time is 3h; In separator I, pressure is 6Mpa, and temperature is 20 DEG C; In separator II, pressure is 4Mpa, and temperature is 15 DEG C; Extraction terminates rear collection Ganoderma quintessence oil, and sealing saves backup;
(8) above-mentioned essential oil of traditional Chinese medicine is got 10 parts according to weight portion and the ratio of 1:1:1:1:1:1 by volume mixes and carries out ultrasonic mixing;
(9) Oleum Vitis viniferae 400 parts, 400 parts, olive oil, flavoring pineapple essence 10 parts and 10 parts, Fructus Mangifera Indicae essence is taken according to weight portion, above-mentioned essential oil of traditional Chinese medicine and Oleum Vitis viniferae, olive oil, flavoring pineapple essence, Fructus Mangifera Indicae essence are carried out ultrasonic mixing, obtains Chinese medicine oil preparation of the present invention.
Embodiment 2
In the present embodiment, a Chinese medicine oil preparation for Transdermal absorption treatment type 2 diabetes mellitus, comprises according to the raw material of weight portion: aloe 600 parts, Oleum helianthi 600 parts, 10 parts, fragrant citrus essence, Hami melon essence 10 parts, Essential Oil From Pine Needles 15 parts, seabuckthorn essential oil 15 parts, Ganoderma quintessence oil 15 parts, ginseng essential oil 15 parts, Geranium Essential 15 parts, cinnamon essential oil 15 parts.
The production technology of the Chinese medicine oil preparation of described Transdermal absorption treatment type 2 diabetes mellitus, concrete steps are as follows:
(1) take Folium Pini 200g, Fructus Hippophae 200g, Radix Ginseng 200g, Cortex Cinnamomi 200g, Flos Pelargonii 200g and Ganoderma 200g respectively to clean, natural air drying, after Folium Pini, Fructus Hippophae, Radix Ginseng, Cortex Cinnamomi and Flos Pelargonii being pulverized, cross 30 mesh sieves; Ganoderma powder is broken into Ganoderma spore powder;
(2) get above-mentioned Folium Pini granule, prepare Essential Oil From Pine Needles with supercritical carbon dioxide extraction, Folium Pini granule is placed in supercritical carbon dioxide extraction still, setting extraction conditions is: extracting pressure is 18Mpa, extraction temperature is 40 DEG C, and CO 2 fluid flow is 25L/h, and extraction time is 2.5h; In separator I, pressure is 8Mpa, and temperature is 25 DEG C; In separator II, pressure is 6Mpa, and temperature is 25 DEG C; Extraction terminates rear collection Essential Oil From Pine Needles, and sealing saves backup;
(3) above-mentioned sea-buckthorn particle is got, seabuckthorn essential oil is prepared with supercritical carbon dioxide extraction, sea-buckthorn particle is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30Mpa, extraction temperature is 35 DEG C, CO 2 fluid flow is 30L/h, and extraction time is 2.5h; In separator I, pressure is 8Mpa, and temperature is 25 DEG C; In separator II, pressure is 6Mpa, and temperature is 25 DEG C; Extraction terminates rear collection seabuckthorn essential oil, and sealing saves backup;
(4) above-mentioned ginseng granules is got, ginseng essential oil is prepared with supercritical carbon dioxide extraction, ginseng granules is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30Mpa, extraction temperature is 40 DEG C, CO 2 fluid flow is 25L/h, and extraction time is 1.5h; In separator I, pressure is 8Mpa, and temperature is 25 DEG C; In separator II, pressure is 6Mpa, and temperature is 25 DEG C; Extraction terminates rear collection ginseng essential oil, and sealing saves backup;
(5) above-mentioned Cortex Cinnamomi granule is got, cinnamon essential oil is prepared with supercritical carbon dioxide extraction, Cortex Cinnamomi granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 35Mpa, extraction temperature is 40 DEG C, CO 2 fluid flow is 30L/h, extraction time 2.5h; In separator I, pressure is 8Mpa, and temperature is 20 DEG C, and in separator II, pressure is 6Mpa, and temperature is 20 DEG C; Extraction terminates rear collection cinnamon essential oil, and sealing saves backup;
(6) above-mentioned Flos Pelargonii granule is got, Geranium Essential is prepared with supercritical carbon dioxide extraction, Flos Pelargonii granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 18Mpa, extraction temperature is 40 DEG C, CO 2 fluid flow is 20L/h, and extraction time is 2.5h; In separator I, pressure is 8Mpa, and temperature is 20 DEG C, and in separator II, pressure is 6Mpa, and temperature is 20 DEG C; Extraction terminates rear collection Geranium Essential, and sealing saves backup;
(7) above-mentioned Ganoderma spore powder is got, Ganoderma quintessence oil is prepared with supercritical carbon dioxide extraction, Ganoderma spore powder is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 22Mpa, extraction temperature is 60 DEG C, CO 2 fluid flow is 35L/h, and extraction time is 3.5h; In separator I, pressure is 8Mpa, and temperature is 35 DEG C; In separator II, pressure is 5Mpa, and temperature is 30 DEG C; Extraction terminates rear collection Ganoderma quintessence oil, and sealing saves backup;
(8) above-mentioned essential oil of traditional Chinese medicine is got 15 parts according to weight portion and the ratio of 1:1:1:1:1:1 by volume mixes and carries out ultrasonic mixing;
(9) take aloe 600 parts, Oleum helianthi 600 parts, 10 parts, fragrant citrus essence and Hami melon essence 10 parts according to weight portion, above-mentioned essential oil of traditional Chinese medicine and base oil, fruit essence are carried out ultrasonic mixing, obtains Chinese medicine oil preparation of the present invention.
Embodiment 3
In the present embodiment, a Chinese medicine oil preparation for Transdermal absorption treatment type 2 diabetes mellitus, comprises according to the raw material of weight portion: Apricot kernel oil 2000 parts, flavoring banana essence 25 parts, Essential Oil From Pine Needles 25 parts, seabuckthorn essential oil 25 parts, Ganoderma quintessence oil 25 parts, ginseng essential oil 25 parts, Geranium Essential 25 parts, cinnamon essential oil 25 parts.
The production technology of the Chinese medicine oil preparation of described Transdermal absorption treatment type 2 diabetes mellitus, concrete steps are as follows:
(1) take Folium Pini 250g, Fructus Hippophae 250g, Radix Ginseng 250g, Cortex Cinnamomi 250g, Flos Pelargonii 250g and Ganoderma 250g respectively to clean, natural air drying, after Folium Pini, Fructus Hippophae, Radix Ginseng, Cortex Cinnamomi and Flos Pelargonii being pulverized, cross 40 mesh sieves; Ganoderma powder is broken into Ganoderma spore powder;
(2) get above-mentioned Folium Pini granule, prepare Essential Oil From Pine Needles with supercritical carbon dioxide extraction, Folium Pini granule is placed in supercritical carbon dioxide extraction still, setting extraction conditions is: extracting pressure is 20Mpa, extraction temperature is 55 DEG C, and CO 2 fluid flow is 35L/h, and extraction time is 3h; In separator I, pressure is 15Mpa, and temperature is 40 DEG C; In separator II, pressure is l0Mpa, and temperature is 35 DEG C; Extraction terminates rear collection Essential Oil From Pine Needles, and sealing saves backup;
(3) above-mentioned sea-buckthorn particle is got, seabuckthorn essential oil is prepared with supercritical carbon dioxide extraction, sea-buckthorn particle is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 35Mpa, extraction temperature is 45 DEG C, CO 2 fluid flow is 35L/h, and extraction time is 3h; In separator I, pressure is 15Mpa, and temperature is 40 DEG C; In separator II, pressure is l0Mpa, and temperature is 35 DEG C; Extraction terminates rear collection seabuckthorn essential oil, and sealing saves backup;
(4) above-mentioned ginseng granules is got, ginseng essential oil is prepared with supercritical carbon dioxide extraction, ginseng granules is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 40Mpa, extraction temperature is 45 DEG C, CO 2 fluid flow is 30L/h, and extraction time is 2h; In separator I, pressure is 15Mpa, and temperature is 40 DEG C; In separator II, pressure is l0Mpa, and temperature is 35 DEG C; Extraction terminates rear collection ginseng essential oil, and sealing saves backup;
(5) above-mentioned Cortex Cinnamomi granule is got, cinnamon essential oil is prepared with supercritical carbon dioxide extraction, Cortex Cinnamomi granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 40Mpa, extraction temperature is 55 DEG C, CO 2 fluid flow is 35L/h, extraction time 3h; In separator I, pressure is 15Mpa, and temperature is 40 DEG C, and in separator II, pressure is l0Mpa, and temperature is 35 DEG C; Extraction terminates rear collection cinnamon essential oil, and sealing saves backup;
(6) above-mentioned Flos Pelargonii granule is got, Geranium Essential is prepared with supercritical carbon dioxide extraction, Flos Pelargonii granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 20Mpa, extraction temperature is 55 DEG C, CO 2 fluid flow is 20L/h, and extraction time is 3h; In separator I, pressure is 15Mpa, and temperature is 40 DEG C, and in separator II, pressure is l0Mpa, and temperature is 35 DEG C; Extraction terminates rear collection Geranium Essential, and sealing saves backup;
(7) above-mentioned Ganoderma spore powder is got, Ganoderma quintessence oil is prepared with supercritical carbon dioxide extraction, Ganoderma spore powder is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30Mpa, extraction temperature is 60 DEG C, CO 2 fluid flow is 35L/h, and extraction time is 4h; In separator I, pressure is 15Mpa, and temperature is 40 DEG C; In separator II, pressure is 10Mpa, and temperature is 35 DEG C; Extraction terminates rear collection Ganoderma quintessence oil, and sealing saves backup;
(8) above-mentioned essential oil of traditional Chinese medicine is got 25 parts according to weight portion and the ratio of 1:1:1:1:1:1 by volume mixes and carries out ultrasonic mixing;
(9) take Apricot kernel oil 2000 parts and flavoring banana essence 25 parts according to weight portion, above-mentioned essential oil of traditional Chinese medicine and base oil, fruit essence are carried out ultrasonic mixing, obtains Chinese medicine oil preparation of the present invention.
Embodiment 4
Clinical data analysis:
This group case is totally 69 examples, and 69 routine type 2 diabetes mellitus patients are divided into treatment group and matched group by the method for random table.Treatment group 35 example, wherein man 24 example, female 11 example, 47.25 ± 5.36 years old mean age, average course of disease 5.26 ± 2.13 years; Matched group 34 example, wherein man 21 example, female 13 example, 44.79 ± 2.35 years old mean age, average course of disease 4.56 ± 1.88 years.The sex of two groups of cases, age, course of disease distribution are compared, and through statistical procedures no significant difference, P > 0.05, has comparability.
Diabetes diagnostic criterion: the diabetes diagnostic criterion formally announced according to WHO diabetologist Advisory Board in 1999, all have diabetic symptom, there are polyuria, excessive thirst and cannot losing weight with other explanation, and meet the one of following condition, can diabetes be diagnosed as: (1) fasting glucose FPG >=7.0mmol/L(126mg/dl); (2) random blood sugar >=11.1mmol/L(200mg/dl); (3) 2 hours blood glucoses >=11.1mmol/L(200mg/dl in oral glucose tolerance test (OGTT, 75g glucose)).
Treatment group obtains this Chinese medicine compound oil preparation by method described in above-described embodiment one, is applied in patient back, abdominal part and calf skin place every day for 3 times, coordinates scrape therapy, massage manipulation, penetration enhancement; Matched group gives metformin hydrochloride 0.5g, every day 3 times, oral during meal.12 weeks courses for the treatment of.Treatments period, treatment group and matched group all do not re-use any Chinese and western drugs with blood sugar reducing function.
From two groups of oneself observations, namely coordinate Primary Care.Diet: roughly specify different staple food intakes by different labor intensity and the bodily form.Slight physical work or the body severe one that is above standard, every day, staple food controlled at 250-300g, labor in general person 300-350g every day, moderate physical labourer 350-450g; Beyond staple food, institute's calorific requirement is supplemented by non-staple foodstuff as one sees fit.Motion: suitable exercise, comprises daily rest, activity and work.
Detect fasting glucose FPG, after the meal 2 hours blood glucose P2hPG, glycosylated hemoglobin HbA1C respectively before and after treatment, testing result is as shown in table 1:
Before and after table 1 treatment group, treatment of control group, FPG, P2hPG, HbA1C compare (X ± S)
Upper table data display: treatment group after the treatment fasting glucose, after the meal 2 hours blood glucoses and glycolated hemoglobin all obviously declines, and difference has statistical significance.
Statistical method adopts statistic software SPSS ll.0 to carry out statistical analysis.Measurement data all adopts x ± s method record, contrasts and adopt t inspection before and after measurement data treatment and between group; Ranked data treatment cross-reference adopts the Ridit inspection in non parametric tests, and two groups of treated effects adopt X 2 test.
Effective 11 examples (31.43%) for the treatment of group, effective 21 examples (60.00%), invalid 3 examples (8.57%), total effective rate 91.43%.Above-mentioned experimental result shows, the Chinese medicine compound oil preparation that in application the present invention prepared by preparation method can effectively reduce patient blood glucose and glycolated hemoglobin, auxiliary treatment type 2 diabetes mellitus.
Model case:
Case 1: Liu, man, 39 years old, civil servant
Because unit bodies checks out diabetes, move at ordinary times less, occasionally have dinner party, eating meat, its light red tongue, tongue is slightly greasy, soft pulse, stomach receive can, tune convenient to both.The highest 18.4mmol/l of fasting glucose, minimum 7.42 mmol/l.Previously aglycosuria medical history.
Giving this Chinese medicine compound oil preparation, advise its every day 2 times, all over being applied to back, abdominal part, calf skin, and imposing scrape therapy and massage with penetration enhancement.Continuous treatment is after 2 weeks, and fasting glucose is down to the highest 10.1 mmol/l, minimum 5.3mmol/l; Continued treatment January, keep without hypoglycemic medicine intervention, fasting glucose lower than 6.1mmol/l more than 3 days; After to maintain diet light always, and keep jog every day, swimming exercise, Monitoring Blood Glucose is so far all in normal index.
Case 2: field, man, 38 years old, company manager
Usually like taijiquan, healthy.7.9,7.8,8.6mmol/l casual testing blood glucose, records random blood sugar 9.2mmol/l, and three days on an empty stomach in succession:.Its tongue is slightly red, white and thin fur, and soft pulse is slightly profound, stomach receive can, tune convenient to both.
Give this Chinese medicine compound oil preparation, advise its every day repeatedly, be applied in abdominal part, calf skin, and impose scrape therapy and massage with penetration enhancement, strengthen tai chi exercise simultaneously.After 1 first quarter moon, average fasting glucose is down to 5.0-6.0mmol/l, random below 8.0mmol/l; Blood sugar test is all normal so far.
Case 3: Cao, man, 58 years old, unit leader
Diabetes more than 7 years, the general 8-9mmol/l of fasting glucose, about 12mmol/l after the meal, take Western medicine diamicron, glucophage, simultaneously with hypertension, blood fat disorder.Its purplish tongue secretly has ecchymosis, greasy and thin fur, thready and rolling pulse, and two chis are not enough, and left cun short.Because its course of disease is longer, sick position is comparatively dark, first gives oral medicinal herb conditioning, glucophage of stopping using after January; Bimester after diamicron change acarbose 1 into; After April, acarbose makes half into, acarbose of stopping using after May.Afterwards because of its people's reason, be inconvenient to take Chinese medicine, then give this Chinese medicine compound oil preparation and use.Stop using after Chinese medicine, its fasting glucose is slightly gone up, and use this Chinese medicine compound oil preparation after 4 weeks continuously, blood glucose is down to normal range.This oil preparation inactive after seven months, external treatment maintenance once in a while, Household diet, locomotive regulation, blood glucose maintains normal range.
Case 4: poplar, man, 52 years old, logistics management
The pungent savoury of happy event, motion is few, falls asleep evening, sleeps poor.In December, 2013 is conscious uncomfortable, to examination in hospital: fasting glucose 9.8mmol/l, after the meal 14mmol/l, and give and take Western medicine gliclazide 2, acarbose 3, glycemic control is general.Its purplish tongue is red, yellow and greasy fur, and soft pulse is dry, and left pass is slightly profound.Through dialectical analysis, in May, 2014, give oral medicinal herb and merge the external of this Chinese medicine compound oil preparation.After March, subtracting medicine is 1 gliclazide, and fasting glucose is down to 5.5-6.0mmol/l.Withdraw Chinese medicine, advise its diet light, go to bed early and get up early, continue to use this Chinese medicine compound oil preparation, blood glucose keeps stable.Still continue at present in tracking.
Case 5: Xu certain, man, 50 years old
Find diabetes 8 years, blood glucose raises and causes lower limb infection.Record fasting glucose 9.7mmol/l, after the meal 2 hours blood glucose 15.2 mmol/l, glycolated hemoglobin 12.7%.There is diabetic cardiopathy, nephropathy, oculopathy complication simultaneously.Lower limb infection control after institute of traditional Chinese medicine is in hospital, takes Ya Moli, acarbose, metformin to control blood glucose.Its tongue is dark slightly purple, yellow and greasy fur, and soft pulse is profound slightly heavy, right cun, right chi deficiency.Give diabetes wholistic therapy, based on oral medicinal herb, use the external of this Chinese medicine compound oil preparation, coordinate characteristic finger needling, strict its diet of control, strengthens taking exercise.After January, Ya Moli stops using; Health check-up glycolated hemoglobin 6.8% after April, hepatic and renal function, urine protein index recover normal, eyes without significant discomfort, in current continued treatment.
Oil preparation prepared by the present invention is by being applied in skin surface, make effective ingredient rapid permeability in oil preparation to skin corium, enter peripheral blood circulation, the mitochondrial membrane of cell may be acted on, open cellular energy path, increase its utilization rate to glucose, reach and fall hypoglycemic effect, good auxiliary therapeutic action can be played in the therapeutic process of type 2 diabetes mellitus; Production technology of the present invention compared with the existing technology, avoid in traditional method the loss of heating the Effective Component of Chinese Medicine caused, solve the drawback that residual organic solvent cannot be removed completely, and gained essential oil of traditional Chinese medicine purity is high, impurity is few, is easy to large-scale industrial production.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (6)
1. the Chinese medicine oil preparation of a Transdermal absorption treatment type 2 diabetes mellitus, it is characterized in that, comprise according to the raw material of weight portion: base oil 800-3200 part, essential oil of traditional Chinese medicine 60-240 part, fruit essence 20-30 part, described essential oil of traditional Chinese medicine comprises according to the raw material of weight portion: Essential Oil From Pine Needles 10-40 part, seabuckthorn essential oil 10-40 part, Ganoderma quintessence oil 10-40 part, ginseng essential oil 10-40 part, Geranium Essential 10-40 part, cinnamon essential oil 10-40 part.
2. the Chinese medicine oil preparation of Transdermal absorption treatment type 2 diabetes mellitus according to claim 1, it is characterized in that, comprise according to the raw material of weight portion: base oil 800-2400 part, essential oil of traditional Chinese medicine 60-240 part, fruit essence 20-25 part, described essential oil of traditional Chinese medicine comprises according to the raw material of weight portion: Essential Oil From Pine Needles 10-30 part, seabuckthorn essential oil 10-30 part, Ganoderma quintessence oil 10-30 part, ginseng essential oil 10-30 part, Geranium Essential 10-30 part, cinnamon essential oil 10-30 part.
3. the Chinese medicine oil preparation of Transdermal absorption treatment type 2 diabetes mellitus according to claim 1, it is characterized in that, comprise according to the raw material of weight portion: base oil 800 parts, essential oil of traditional Chinese medicine 60 parts, fruit essence 20 parts, described essential oil of traditional Chinese medicine comprises according to the raw material of weight portion: Essential Oil From Pine Needles 10 parts, seabuckthorn essential oil 10 parts, Ganoderma quintessence oil 10 parts, ginseng essential oil 10 parts, Geranium Essential 10 parts, cinnamon essential oil 10 parts.
4., according to the Chinese medicine oil preparation of the Transdermal absorption treatment type 2 diabetes mellitus one of claim 1-3 Suo Shu, it is characterized in that, described base oil is one or more the mixture in Oleum Vitis viniferae, olive oil, aloe, Oleum helianthi, Apricot kernel oil.
5. according to the Chinese medicine oil preparation of the Transdermal absorption treatment type 2 diabetes mellitus one of claim 1-3 Suo Shu, it is characterized in that, described fruit essence is one or more the mixture in flavoring pineapple essence, Fructus Mangifera Indicae essence, fragrant citrus essence, Hami melon essence, flavoring banana essence.
6. a production technology for the Chinese medicine oil preparation of the Transdermal absorption treatment type 2 diabetes mellitus adopting one of claim 1-5 described, it is characterized in that, concrete steps are as follows:
(1) Folium Pini 150-250g, Fructus Hippophae 150-250g, Radix Ginseng 150-250g, Cortex Cinnamomi 150-250g, Flos Pelargonii 150-250g and Ganoderma 150-250g is taken respectively, clean, natural air drying, crosses 20-40 mesh sieve after Folium Pini, Fructus Hippophae, Radix Ginseng, Cortex Cinnamomi and Flos Pelargonii being pulverized; Ganoderma powder is broken into Ganoderma spore powder;
(2) above-mentioned Folium Pini granule is got, Essential Oil From Pine Needles is prepared with supercritical carbon dioxide extraction, Folium Pini granule is placed in supercritical carbon dioxide extraction still, setting extraction conditions is: extracting pressure is 15-20Mpa, extraction temperature is 30-55 DEG C, CO 2 fluid flow is 15-35L/h, and extraction time is 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection Essential Oil From Pine Needles, and sealing saves backup;
(3) above-mentioned sea-buckthorn particle is got, seabuckthorn essential oil is prepared with supercritical carbon dioxide extraction, sea-buckthorn particle is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 25-35Mpa, extraction temperature is 30-45 DEG C, CO 2 fluid flow is 15-35L/h, and extraction time is 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection seabuckthorn essential oil, and sealing saves backup;
(4) above-mentioned ginseng granules is got, ginseng essential oil is prepared with supercritical carbon dioxide extraction, ginseng granules is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30-40Mpa, extraction temperature is 30-45 DEG C, CO 2 fluid flow is 25-30L/h, and extraction time is 1-2h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection ginseng essential oil, and sealing saves backup;
(5) above-mentioned Cortex Cinnamomi granule is got, cinnamon essential oil is prepared with supercritical carbon dioxide extraction, Cortex Cinnamomi granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 30-40Mpa, extraction temperature is 30-55 DEG C, CO 2 fluid flow is 30-35L/h, extraction time 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C, and in separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection cinnamon essential oil, and sealing saves backup;
(6) above-mentioned Flos Pelargonii granule is got, Geranium Essential is prepared with supercritical carbon dioxide extraction, Flos Pelargonii granule is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 15-20Mpa, extraction temperature is 30-55 DEG C, CO 2 fluid flow is 15-20L/h, and extraction time is 2-3h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C, and in separator II, pressure is 4-l0Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection Geranium Essential, and sealing saves backup;
(7) above-mentioned Ganoderma spore powder is got, Ganoderma quintessence oil is prepared with supercritical carbon dioxide extraction, Ganoderma spore powder is placed in the supercritical carbon dioxide extraction still after cleaning, setting extraction conditions is: extracting pressure is 20-30Mpa, extraction temperature is 50-60 DEG C, CO 2 fluid flow is 30-35L/h, and extraction time is 3-4h; In separator I, pressure is 6-15Mpa, and temperature is 20-40 DEG C; In separator II, pressure is 4-10Mpa, and temperature is 15-35 DEG C; Extraction terminates rear collection Ganoderma quintessence oil, and sealing saves backup;
(8) above-mentioned essential oil of traditional Chinese medicine is got 10-40 part according to weight portion and the ratio of 1:1:1:1:1:1 by volume mixes and carries out ultrasonic mixing;
(9) take base oil 800-3200 part and fruit essence 20-30 part according to weight portion, above-mentioned essential oil of traditional Chinese medicine and base oil, fruit essence are carried out ultrasonic mixing, obtains Chinese medicine oil preparation of the present invention.
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