CN104288194B - A kind of preparation method of compound isatis root granules - Google Patents
A kind of preparation method of compound isatis root granules Download PDFInfo
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- CN104288194B CN104288194B CN201410596822.0A CN201410596822A CN104288194B CN 104288194 B CN104288194 B CN 104288194B CN 201410596822 A CN201410596822 A CN 201410596822A CN 104288194 B CN104288194 B CN 104288194B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 241000334160 Isatis Species 0.000 title claims abstract description 12
- 150000001875 compounds Chemical class 0.000 title claims abstract description 12
- 239000008187 granular material Substances 0.000 title claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 72
- 239000010231 banlangen Substances 0.000 claims abstract description 19
- 108090000790 Enzymes Proteins 0.000 claims abstract description 15
- 102000004190 Enzymes Human genes 0.000 claims abstract description 15
- 229940088598 enzyme Drugs 0.000 claims abstract description 15
- 239000000706 filtrate Substances 0.000 claims abstract description 15
- 239000002245 particle Substances 0.000 claims abstract description 13
- 108010059892 Cellulase Proteins 0.000 claims abstract description 12
- 108010029182 Pectin lyase Proteins 0.000 claims abstract description 12
- 229940106157 cellulase Drugs 0.000 claims abstract description 12
- 239000004375 Dextrin Substances 0.000 claims abstract description 11
- 229920001353 Dextrin Polymers 0.000 claims abstract description 11
- 235000019425 dextrin Nutrition 0.000 claims abstract description 11
- 229930006000 Sucrose Natural products 0.000 claims abstract description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 10
- 239000005720 sucrose Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 239000006228 supernatant Substances 0.000 claims abstract description 9
- 238000001816 cooling Methods 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001556 precipitation Methods 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 9
- 239000003814 drug Substances 0.000 description 7
- 239000004382 Amylase Substances 0.000 description 4
- 102000013142 Amylases Human genes 0.000 description 4
- 108010065511 Amylases Proteins 0.000 description 4
- COHYTHOBJLSHDF-UHFFFAOYSA-N Indigo Chemical compound N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 235000019418 amylase Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
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- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 241001062009 Indigofera Species 0.000 description 2
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 2
- 241000334154 Isatis tinctoria Species 0.000 description 2
- 208000005647 Mumps Diseases 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
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- 229940097275 indigo Drugs 0.000 description 2
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- 206010039587 Scarlet Fever Diseases 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 241000257673 Strobilanthes cusia Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 201000001028 acute contagious conjunctivitis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- -1 alkaloids class Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000005321 cobalt glass Substances 0.000 description 1
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- 201000005884 exanthem Diseases 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
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- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410596822.0A CN104288194B (en) | 2014-10-30 | 2014-10-30 | A kind of preparation method of compound isatis root granules |
Applications Claiming Priority (1)
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CN201410596822.0A CN104288194B (en) | 2014-10-30 | 2014-10-30 | A kind of preparation method of compound isatis root granules |
Publications (2)
Publication Number | Publication Date |
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CN104288194A CN104288194A (en) | 2015-01-21 |
CN104288194B true CN104288194B (en) | 2017-08-08 |
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CN201410596822.0A Active CN104288194B (en) | 2014-10-30 | 2014-10-30 | A kind of preparation method of compound isatis root granules |
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CN (1) | CN104288194B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105432899A (en) * | 2015-12-31 | 2016-03-30 | 桂林双象生物科技有限公司 | Preparation method of honeysuckle flower and grosvenor momordica fruit composite tea |
CN105477347A (en) * | 2015-12-31 | 2016-04-13 | 吉林紫鑫药业股份有限公司 | Method for preparing medicine used for treating liver-stomach disharmony and blood stasis collateral obstruction |
CN106692490A (en) * | 2016-12-13 | 2017-05-24 | 广西双蚁药业有限公司 | Sucrose-free compound isatis root granules and preparation method thereof |
CN107349247A (en) * | 2017-05-23 | 2017-11-17 | 回音必集团安徽制药有限公司 | A kind of Radix Isatidis Optimized Extraction Process |
CN107582600A (en) * | 2017-06-26 | 2018-01-16 | 安徽永生堂药业有限责任公司 | A kind of banlangen granules, banlangen keli and preparation method thereof |
CN107951910A (en) * | 2017-12-25 | 2018-04-24 | 安徽永生堂药业有限责任公司 | A kind of preparation method of compound isatis root granules electuary |
CN108969604A (en) * | 2018-08-15 | 2018-12-11 | 康美保宁(四川)制药有限公司 | A kind of pre-treating method and preparation method of compound isatis root granules |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104069142A (en) * | 2014-07-04 | 2014-10-01 | 河北万通金牛药业有限公司 | Method for improving content of effective ingredient epigoitrin in radix isatidis extract via biological catalysis method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103989231B (en) * | 2014-05-23 | 2015-09-30 | 广西灵山县宇峰保健食品有限公司 | Celestial careless drink |
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2014
- 2014-10-30 CN CN201410596822.0A patent/CN104288194B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104069142A (en) * | 2014-07-04 | 2014-10-01 | 河北万通金牛药业有限公司 | Method for improving content of effective ingredient epigoitrin in radix isatidis extract via biological catalysis method |
Non-Patent Citations (1)
Title |
---|
复合酶法提取板蓝根多糖工艺的研究;张明等;《食品科技》;20091120;第34卷(第11期);第208-211页 * |
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CN104288194A (en) | 2015-01-21 |
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TA01 | Transfer of patent application right |
Effective date of registration: 20170712 Address after: Diecai Victory Road West District of Guilin city 541001 the Guangxi Zhuang Autonomous Region two 4 Building 2 unit 102 room Applicant after: She Yanying Address before: Diecai District, Guilin city 541001 the Guangxi Zhuang Autonomous Region storage Reed Road No. 21 Applicant before: Huang Qin |
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Effective date of registration: 20200814 Address after: 528400, No. 63, Hongshan Road, Xiaolan Town, Zhongshan City, Guangdong Province, with one business place added. For details, please refer to the articles of Association (one license for multiple sites) Patentee after: GUANGDONG XIANGSHANTANG PHARMACEUTICAL Co.,Ltd. Address before: 541001, Guilin, Diecai District, the Guangxi Zhuang Autonomous Region Victory Road West two, 4, unit 102, room 2 Patentee before: She Yanying |
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Denomination of invention: A kind of preparation method of compound isatidis granules Effective date of registration: 20220921 Granted publication date: 20170808 Pledgee: Bohai Bank Co.,Ltd. Zhongshan branch Pledgor: GUANGDONG XIANGSHANTANG PHARMACEUTICAL CO.,LTD. Registration number: Y2022980015849 |