CN104288172A - Composition for preventing and treating inclusion body hepatitis of poultry and preparation method thereof - Google Patents
Composition for preventing and treating inclusion body hepatitis of poultry and preparation method thereof Download PDFInfo
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- CN104288172A CN104288172A CN201410534964.4A CN201410534964A CN104288172A CN 104288172 A CN104288172 A CN 104288172A CN 201410534964 A CN201410534964 A CN 201410534964A CN 104288172 A CN104288172 A CN 104288172A
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- poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a composition for preventing and treating inclusion body hepatitis of poultry. The composition is prepared from the following components in parts by weight: 10-30 parts of thiamine hydrochloride, 10-30 parts of glucurolactone, 10-20 parts of astragalus polysaccharide, 0.01-0.02 part of polyinosinic cell and 10-20 parts of lentinan. The composition has the advantages of scientific and reasonable formula composition, simple process, convenience in use and relatively low cost, and can be used for effectively improving liver of poultry, promoting expelling of toxin, promoting normal physiological functions and promoting growth.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of composition and method of making the same preventing and treating poultry inclusion body hepatitis.
Background technology
Extensively there is nature in family's aviadenovirus, family's avian adenovirus infection causes the concern of world's poultry circle day by day.At the report that world many countries has chicken house to pollute or fall ill.Examining mainly the facing of adenovirus infection and levying Hou Qun with pathology is inclusion body hepatitis, and to occur in hepatic steatosis and focal necrosis and hepatocyte that inclusion body is for feature, aplastic anemia, respiratory tract infection, hemorrhagic enteritis and egg production reduce.Immunity of organisms declines, and body resistance against diseases declines.Fertility performance declines.
Summary of the invention
The object of the present invention is to provide a kind of compositions of preventing and treating poultry inclusion body hepatitis, said composition formula composition is scientific and reasonable, and technique is simple; easy to use, cost is lower, can the liver of effective poultry; promote that toxin is discharged, protect normal physiological function, growth promoting effects.
Another object of the present invention is to provide a kind of preparation method of preventing and treating the compositions of poultry inclusion body hepatitis.
The present invention is achieved through the following technical solutions:
Prevent and treat a compositions for poultry inclusion body hepatitis, component and the ratio of weight and number thereof of its Chinese medicine composition are respectively:
And component and the optimum ratio of weight and number thereof of this Chinese medicine composition are respectively:
Prevent and treat a preparation method for the compositions of poultry inclusion body hepatitis, its preparation methods steps is:
(1) take thiamine hydrochloride respectively according to weight proportion, glucurolactone, astragalus polysaccharides, polyinosini, lentinan carry out pulverizing and cross 200 mesh sieves;
(2) the thiamine hydrochloride after sieving, glucurolactone, astragalus polysaccharides, polyinosini, lentinan are put into 45 degree, combination drying case dry 2 hours respectively;
(3) will put in mixing tank after dried thiamine hydrochloride, glucurolactone, astragalus polysaccharides, polyinosini, lentinan mixing, Homogeneous phase mixing 35 minutes, namely obtains the compositions finished product preventing and treating poultry inclusion body hepatitis.
Advantage of the present invention and beneficial effect are:
1. the breeding of the present invention by suppressing the DNA replication dna of virus to play blocking virus, bioactive ingredients forms protecting film, from the infringement of adenovirus to liver at liver, kidney.
2. formula composition of the present invention is scientific and reasonable, and technique is simple, and easy to use, cost is lower, effectively can improve immunity of livestock, to the poultry liver enlargement that adenovirus causes, hemorrhage, rotten, and function of detoxification declines good control action.
3. the present invention can alleviate rapidly because the pain that causes such as inflammation and ulcer, and the misery of body is alleviated, and recovers to search for food, and promotes body Liver immunity system and epithelial sound.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Prevent and treat a compositions for poultry inclusion body hepatitis, component and the weight thereof of its compositions are respectively: thiamine hydrochloride 30kg, glucurolactone 30kg, astragalus polysaccharides 20kg, polyinosini 0.02kg, lentinan 20kg.
Prevent and treat a preparation method for the compositions of poultry inclusion body hepatitis, the step of its preparation method is:
(1) take thiamine hydrochloride respectively according to weight proportion, glucurolactone, astragalus polysaccharides, polyinosini, lentinan carry out pulverizing and cross 200 mesh sieves;
(2) the thiamine hydrochloride after sieving, glucurolactone, astragalus polysaccharides, polyinosini, lentinan are put into 45 degree, combination drying case dry 2 hours respectively;
(3) will put in mixing tank after dried thiamine hydrochloride, glucurolactone, astragalus polysaccharides, polyinosini, lentinan mixing, Homogeneous phase mixing 35 minutes, namely obtains a kind of compositions finished product preventing and treating poultry inclusion body hepatitis.
Embodiment 2
Prevent and treat a compositions for poultry inclusion body hepatitis, component and the weight thereof of its compositions are respectively: thiamine hydrochloride 10kg, glucurolactone 10kg, astragalus polysaccharides 10kg, polyinosini 0.01kg, lentinan 10kg.
The step of its preparation method is with embodiment 1.
Embodiment 3
Prevent and treat a compositions for poultry inclusion body hepatitis, component and the weight thereof of its compositions are respectively: thiamine hydrochloride 20kg, glucurolactone 20kg, astragalus polysaccharides 15kg, polyinosini 0.01kg, lentinan 15kg.
The step of its preparation method is with embodiment 1.
Clinical practice
Qinhuangdao honest cultivation company AA broiler, 20000,28 age in days generation chicken inclusion body hepatitis, sick chicken down in spirits, drop-head, wing is sagging, draw stock white pasty state loose stool, anus is often sticked by feces, sends cry, liver is pale, matter is crisp, swelling, liver, skeleton, skeletal muscle has point-like or ecchymosis during defecation.Inclusion body is had in hepatocyte, rounded.Kidney, splenomegaly, the swelling of kidney height, in canescence.Clinical pathology main manifestations is liver enlargement, and in khaki, matter is crisp, and there is hemorrhage speckle in various degree on surface, the necrosis region sometimes differed in size as seen.Some cases can see bone marrow lesion, and femur bone marrow is hemorrhage in pink, meanwhile, chest muscle and lower limb flesh pale and have hemorrhage speckle, subcutaneous tissue, fatty tissue and intestinal serous coat, mucosa are obviously hemorrhage as seen.In addition, the also low capsule atrophy of common method, thymus edema, spleen and kidney enlargement, spleen is khaki, frangible.Judge it is that fowl adenovirus infects through veterinarian, randomly draw 150 chickens and be divided into 3 groups, treat according to 0.5g/L water drug treatment with the present composition for 1 group, freely drink water, 2 groups according to commercially available prod according to this explanation 0.8 gram/L water, freely drink water, observe after 3 days, see chicken group state.
Table 1 Experimental Comparison table
| Group | Usage usage | Quantity | Sickness rate | Dead number of elements | Cure rate |
| 1 of the present invention group and thing | 0.5g/L water | 50 | 100％ | 2 | 96％ |
| 2 commercially available prod groups | 0.8g/L water | 50 | 100％ | 5 | 90％ |
| Blank group | Non-administration | 50 | 100％ | 27 | 54％ |
Conclusion: the cure rate contrast being drawn this invention treatment group and commercially available prod treatment group and blank group by above-mentioned conclusion (of pressure testing), the present invention is obviously remarkable to the therapeutic effect of the inclusion body hepatitis that fowl adenovirus causes.
Claims (3)
1. prevent and treat a compositions for poultry inclusion body hepatitis, it is characterized in that: component and the ratio of weight and number thereof of this Chinese medicine composition are respectively:
2. the compositions of control poultry inclusion body hepatitis according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this Chinese medicine composition are respectively:
3. a preparation method for the compositions of control poultry inclusion body hepatitis as claimed in claim 1, is characterized in that: this preparation method step is:
(1) take thiamine hydrochloride respectively according to weight proportion, glucurolactone, astragalus polysaccharides, polyinosini, lentinan carry out pulverizing and cross 200 mesh sieves;
(2) the thiamine hydrochloride after sieving, glucurolactone, astragalus polysaccharides, polyinosini, lentinan are put into 45 degree, combination drying case dry 2 hours respectively;
(3) will put in mixing tank after dried thiamine hydrochloride, glucurolactone, astragalus polysaccharides, polyinosini, lentinan mixing, Homogeneous phase mixing 35 minutes, namely obtains the compositions finished product preventing and treating poultry inclusion body hepatitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410534964.4A CN104288172B (en) | 2014-10-10 | 2014-10-10 | Prevent and treat composition of poultry inclusion body hepatitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410534964.4A CN104288172B (en) | 2014-10-10 | 2014-10-10 | Prevent and treat composition of poultry inclusion body hepatitis and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN104288172A true CN104288172A (en) | 2015-01-21 |
| CN104288172B CN104288172B (en) | 2018-03-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410534964.4A Active CN104288172B (en) | 2014-10-10 | 2014-10-10 | Prevent and treat composition of poultry inclusion body hepatitis and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850149A (en) * | 2006-03-02 | 2006-10-25 | 上海慈瑞医药科技有限公司 | Compounded preparation of Radix As tragali seu Hedy ari extract and mushroom polysaccharide and preparing method |
| CN101810694A (en) * | 2009-12-21 | 2010-08-25 | 张熙欣 | Traditional Chinese medicine and western medicine composition for adjunctive therapy of hepatitis |
-
2014
- 2014-10-10 CN CN201410534964.4A patent/CN104288172B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850149A (en) * | 2006-03-02 | 2006-10-25 | 上海慈瑞医药科技有限公司 | Compounded preparation of Radix As tragali seu Hedy ari extract and mushroom polysaccharide and preparing method |
| CN101810694A (en) * | 2009-12-21 | 2010-08-25 | 张熙欣 | Traditional Chinese medicine and western medicine composition for adjunctive therapy of hepatitis |
Non-Patent Citations (2)
| Title |
|---|
| 徐蜀远: "维生素B1治疗慢性乙型肝炎感染", 《国外医学内科学分册》 * |
| 秦绍明: "聚肌胞治疗病毒性肝炎", 《人民军医》 * |
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| CN104288172B (en) | 2018-03-13 |
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Effective date of registration: 20180124 Address after: No. 8, Hong Wang Road, Beijing Tianjin Electronic Commerce Industrial Park, Wuqing District, Tianjin Applicant after: Tianjin Heelion Te biological science and Technology Co Ltd Address before: 300384 Tianjin city Alex Hua Tian Huayuan Industrial Zone Binhai Road No. 6, building H, room -802, Haitai Applicant before: Tianjin Ruibeite Science & Technology Development Co., Ltd. |
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