CN104274821A - Bacitracin methylene disalicylate- and dinitolmide-containing soluble powder - Google Patents
Bacitracin methylene disalicylate- and dinitolmide-containing soluble powder Download PDFInfo
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- CN104274821A CN104274821A CN201310284633.5A CN201310284633A CN104274821A CN 104274821 A CN104274821 A CN 104274821A CN 201310284633 A CN201310284633 A CN 201310284633A CN 104274821 A CN104274821 A CN 104274821A
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- Prior art keywords
- dinitolmide
- methylene disalicylate
- soluble powder
- bacitracin methylene
- bacitracin
- Prior art date
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Abstract
The invention belongs to the technical field of veterinary anticoccidial drugs and preparation methods thereof and discloses bacitracin methylene disalicylate- and dinitolmide-containing soluble powder and a preparation method thereof. The bacitracin methylene disalicylate- and dinitolmide-containing soluble powder comprises (a), a bacitracin methylene disalicylate raw drug, (b), a dinitolmide raw drug and (c), accessory materials. The bacitracin methylene disalicylate- and dinitolmide-containing soluble powder is prepared by a mixing method and is off-white power. The bacitracin methylene disalicylate- and dinitolmide-containing soluble powder has good stability and good palatability and can be used as a veterinary oral preparation.
Description
Technical field
The invention belongs to treating animal coccidiosis medicine and preparation method technical field, be specifically related to a kind of preparation method of soluble powder of bacitracin methylene disalicylate+dinitolmide.
Technical background
Coccidiosis is the parasitic infection often occurred in animal.Protozoacide such as from eimeria tenella genus (Eimeria), isospora genus (Isospora), neospora genus (Neospora), Miescheria (Sarcosporidia) and toxoplasma (Toxoplasma) causes coccidiosis in the whole world.It is significant for control poultry infection coccidiosis that research is used for anticoccidial preparation for animals.
Bacitracin to most of gram positive bacteria as staphylococcus aureus, streptococcus, enterococcus, clostridium and corynebacterium etc. have good antibacterial activity, to actinomycetes and spirillum also effective.Sensitive organism seldom produces drug resistance phenomenon to it.
Dinitolmide is faint yellow or khaki powder; Odorless, bitter in the mouth.This product is dissolved in acetone, in ethanol slightly soluble, soluble,very slightly in chloroform or ether, insoluble in water.Dinitolmide is Nitrobenzol amide compound, is once widely used in China's veterinary clinic, is the anticoccidial drug that a kind of existing prevention has again therapeutic effect.
Dinitolmide mainly acts on first generation schizont, and formed the zygoblast of egg capsule also has inhibitory or killing effect simultaneously.Someone thinks recently, and dinitolmide is used in conjunction 6 days, only to coccidiosis performance inhibitory action, if prolonged application, is worm medicine of killing.The anticoccidial mechanism of Nitrobenzol amides compound is also not clear.After dinitolmide absorption for oral administration, rapid metabolization in animal body, drug withdrawal 24h, Carnis Gallus domesticus residual quantity is namely lower than 0.1mg/kg.Dinitolmide is poisoned chicken, tender, Bu Shi, Eimeria maxima all have good prevention effect, particularly best to small intestinal the strongest pathogenic Eimeria Necatrix effect, but this product is slightly poor to the effect of heap-type Eimeria.Dinitolmide also has splendid preventing iron-smelting effect to the little intestinal coccidiosis of turkey, can continuous use until 16 week age.
Bacitracin methylene disalicylate is present in animal body with di-2-ethylhexylphosphine oxide salicylic acid and bacitracin two kinds of material forms, under di-2-ethylhexylphosphine oxide salicylic acid existent condition, can further improve the antibacterial efficacy of bacitracin.This product is added in feedstuff as medicated feed additive, has obvious growth promoting function to animals such as poultry, and this product also normal antibacterials (as colistin and neomycin) with having against gram-negative bacteria is share, to improve antibacterial effectiveness.
Bacitracin methylene disalicylate+dinitolmide is prepared into soluble powder by prominent features of the present invention exactly.The bacitracin methylene disalicylate prepared by this method+dinitolmide soluble powder good stability, good palatability, the insect resistant effect that tool is good, for China's veterinary clinic utilizes bacitracin methylene disalicylate+dinitolmide to provide a kind of new preparation better.
Summary of the invention
The object of the invention is to develop a kind of bacitracin methylene disalicylate+dinitolmide soluble powder, heighten the effect of a treatment, improve stability and the palatability of medicine, the pest-resistant effect of tool.
The present invention, for achieving the above object, provides a kind of containing bacitracin methylene disalicylate+dinitolmide soluble powder, it is characterized in that preparation specifically consists of:
A () is containing bacitracin methylene disalicylate crude drug 2-10% (W/V);
(b) dinitolmide crude drug 2-10% (W/V);
(c) adjuvant 80-90% (W/V);
Described a kind of soluble powder containing bacitracin methylene disalicylate+dinitolmide, is characterized in that the preparation invented is based on adjuvant, glucose, silicon dioxide, carboxymethyl cellulose etc., preferred glucose.
Described a kind of soluble powder containing bacitracin methylene disalicylate+dinitolmide, is characterized in that preparation method is as follows:
Measure bacitracin methylene disalicylate+dinitolmide and adjuvant according to prescription to stir and form uniform mixture, get final product soluble powder.
Detailed description of the invention
Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example: 5% bacitracin methylene disalicylate+dinitolmide soluble powder
[prescription] bacitracin methylene disalicylate 5% (W/V)
Dinitolmide 10% (W/V)
Glucose adds to 100% (V/V)
[preparation]
Get prescription and measure bacitracin methylene disalicylate+dinitolmide and above-mentioned adjuvant is prepared according to aforementioned preparation process, be i.e. obtained bacitracin methylene disalicylate+dinitolmide soluble powder.
Claims (2)
1., containing a soluble powder for bacitracin methylene disalicylate+dinitolmide, it is characterized in that preparation specifically consists of:
(a) bacitracin methylene disalicylate crude drug 2-10% (W/V);
(b) dinitolmide crude drug 2-10% (W/V);
(c) adjuvant 80-90% (W/V);
By a kind of soluble powder containing bacitracin methylene disalicylate+dinitolmide according to claim 1, it is characterized in that the preparation invented is based on adjuvant, glucose, silicon dioxide, carboxymethyl cellulose etc., preferred glucose.
2., by a kind of soluble powder containing bacitracin methylene disalicylate+dinitolmide according to claim 1, it is characterized in that preparation method is as follows:
Measure bacitracin methylene disalicylate+dinitolmide and adjuvant according to prescription to stir and form uniform mixture, get final product soluble powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310284633.5A CN104274821A (en) | 2013-07-09 | 2013-07-09 | Bacitracin methylene disalicylate- and dinitolmide-containing soluble powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310284633.5A CN104274821A (en) | 2013-07-09 | 2013-07-09 | Bacitracin methylene disalicylate- and dinitolmide-containing soluble powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104274821A true CN104274821A (en) | 2015-01-14 |
Family
ID=52250482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310284633.5A Pending CN104274821A (en) | 2013-07-09 | 2013-07-09 | Bacitracin methylene disalicylate- and dinitolmide-containing soluble powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104274821A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971041A (en) * | 2015-06-29 | 2015-10-14 | 浙江汇能动物药品有限公司 | Dinitolmide dry suspension and preparation method thereof |
| CN108743543A (en) * | 2018-07-11 | 2018-11-06 | 南京福斯特牧业科技有限公司 | A kind of dinitolmide soluble powder of modified water-soluble and preparation method thereof |
-
2013
- 2013-07-09 CN CN201310284633.5A patent/CN104274821A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971041A (en) * | 2015-06-29 | 2015-10-14 | 浙江汇能动物药品有限公司 | Dinitolmide dry suspension and preparation method thereof |
| CN104971041B (en) * | 2015-06-29 | 2017-09-19 | 浙江汇能生物股份有限公司 | A kind of dinitolmide dry suspensoid agent and preparation method thereof |
| CN108743543A (en) * | 2018-07-11 | 2018-11-06 | 南京福斯特牧业科技有限公司 | A kind of dinitolmide soluble powder of modified water-soluble and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150114 |