CN104272107B - 通过监测同位素比来检测代谢途径之系统性振荡的速率变化 - Google Patents

通过监测同位素比来检测代谢途径之系统性振荡的速率变化 Download PDF

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CN104272107B
CN104272107B CN201380012753.8A CN201380012753A CN104272107B CN 104272107 B CN104272107 B CN 104272107B CN 201380012753 A CN201380012753 A CN 201380012753A CN 104272107 B CN104272107 B CN 104272107B
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isotope
oscillation
individual
time
healthy
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CN104272107A (zh
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哈米德·R·埃格巴尔尼亚
马克·E·库克
瓦伦·保罗·波特
丹尼尔·埃尔默·布茨
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Wisconsin Alumni Research Foundation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201380012753.8A 2012-03-07 2013-01-07 通过监测同位素比来检测代谢途径之系统性振荡的速率变化 Active CN104272107B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/414,061 US8512676B1 (en) 2012-03-07 2012-03-07 Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios
US13/414,061 2012-03-07
PCT/US2013/020496 WO2013133904A2 (en) 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios

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CN104272107A CN104272107A (zh) 2015-01-07
CN104272107B true CN104272107B (zh) 2017-05-17

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US (1) US8512676B1 (enExample)
EP (1) EP2839277A2 (enExample)
JP (1) JP6396218B2 (enExample)
CN (1) CN104272107B (enExample)
AU (1) AU2013230841B2 (enExample)
CA (1) CA2865492C (enExample)
IN (1) IN2014DN07247A (enExample)
WO (1) WO2013133904A2 (enExample)

Families Citing this family (11)

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CN104458603A (zh) * 2013-09-23 2015-03-25 苏州青山生物科技有限公司 一种新型幽门螺杆菌检测方法、装置及其应用
US20150196248A1 (en) 2014-01-10 2015-07-16 The United States Of America, As Represented By The Secretary Of Agriculture Methods of determining energy balance using breath carbon isotope ratios
US10226484B2 (en) 2014-12-01 2019-03-12 Peter Y Novak Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof
US10165965B1 (en) 2015-10-22 2019-01-01 Roy Pinchot Noninvasive method for measuring lactic acid and detection of anaerobic exercise for evaluating fitness
CN105954504B (zh) * 2016-06-01 2018-10-26 苏州科技学院 快速酒精定性信号处理方法以及初测装置
US10183041B2 (en) 2017-04-12 2019-01-22 Vector Vitale Ip Llc Antibacterial composition and its use in treating bacterial infections
US11484610B2 (en) 2019-11-22 2022-11-01 Vector Vitale Ip Llc Method of treating melanoma
US10799530B1 (en) 2019-12-20 2020-10-13 Vector Vitale Ip Llc Composition and method for the prevention and treatment of obesity
US10933091B1 (en) 2019-12-20 2021-03-02 Vector Vitale Ip Llc Composition and method for the treatment of type I diabetes
US11596650B2 (en) 2019-12-20 2023-03-07 Vector Vitale Ip Llc Composition and method for the treatment of type 2 diabetes
JP7718650B2 (ja) * 2021-05-19 2025-08-05 国立大学法人東北大学 感染症のバイオマーカ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912178A (en) * 1994-02-16 1999-06-15 Wisconsin Alumni Research Foundation Passive measurement of isotopes to monitor health
CN102027344A (zh) * 2008-02-15 2011-04-20 科学技术设备委员会 红外分光计
CN102176863A (zh) * 2008-07-29 2011-09-07 艾克萨伦茨生物科技有限公司 呼气试验设备和方法

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Publication number Priority date Publication date Assignee Title
JPH1087512A (ja) * 1996-09-18 1998-04-07 Isao Nishi ▲１３▼ｃ標識尿素試薬によるリアルタイムヘリコバクターピロリ感染検査方法
US6609068B2 (en) * 2000-02-22 2003-08-19 Dow Global Technologies Inc. Personal computer breath analyzer for health-related behavior modification and method
GB0120027D0 (en) * 2001-08-16 2001-10-10 Isis Innovation Spectroscopic breath analysis
US8622920B2 (en) * 2005-11-11 2014-01-07 Exalenz Bioscience Ltd. Breath test device and method
US7465276B2 (en) * 2005-11-30 2008-12-16 Wisconsin Alumni Research Foundation Identification of disease characteristics using isotope ratios in breath
EP2092304A4 (en) * 2006-12-18 2013-04-17 Picomole Instr Inc APPARATUS AND METHOD FOR QUICK AND ACCURATE QUANTIFICATION OF COMPLEX, UNKNOWN MIXTURE
US8026049B2 (en) * 2007-03-23 2011-09-27 Wisconsin Alumni Research Foundation Noninvasive measurement and identification of biomarkers in disease state
DE102009055321B4 (de) * 2009-12-24 2013-04-18 Humedics Gmbh Verfahren zur Bestimmung der Leberleistung eines Lebewesens mittels quantitativer Messung der Metabolisierung von Substraten

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912178A (en) * 1994-02-16 1999-06-15 Wisconsin Alumni Research Foundation Passive measurement of isotopes to monitor health
CN102027344A (zh) * 2008-02-15 2011-04-20 科学技术设备委员会 红外分光计
CN102176863A (zh) * 2008-07-29 2011-09-07 艾克萨伦茨生物科技有限公司 呼气试验设备和方法

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Publication number Publication date
CN104272107A (zh) 2015-01-07
WO2013133904A2 (en) 2013-09-12
EP2839277A2 (en) 2015-02-25
JP2015511009A (ja) 2015-04-13
AU2013230841B2 (en) 2018-09-27
AU2013230841A1 (en) 2014-09-11
CA2865492A1 (en) 2013-09-12
US8512676B1 (en) 2013-08-20
US20130236925A1 (en) 2013-09-12
CA2865492C (en) 2021-06-01
IN2014DN07247A (enExample) 2015-04-24
JP6396218B2 (ja) 2018-09-26

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