AU2013230841B2 - Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios - Google Patents
Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios Download PDFInfo
- Publication number
- AU2013230841B2 AU2013230841B2 AU2013230841A AU2013230841A AU2013230841B2 AU 2013230841 B2 AU2013230841 B2 AU 2013230841B2 AU 2013230841 A AU2013230841 A AU 2013230841A AU 2013230841 A AU2013230841 A AU 2013230841A AU 2013230841 B2 AU2013230841 B2 AU 2013230841B2
- Authority
- AU
- Australia
- Prior art keywords
- isotope
- individual
- healthy
- oscillation
- time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000010355 oscillation Effects 0.000 title claims description 233
- 238000012544 monitoring process Methods 0.000 title claims description 26
- 238000001514 detection method Methods 0.000 title description 8
- 230000037353 metabolic pathway Effects 0.000 title description 4
- 230000009897 systematic effect Effects 0.000 title description 2
- 238000000034 method Methods 0.000 claims description 87
- 230000003534 oscillatory effect Effects 0.000 claims description 51
- 229910052799 carbon Inorganic materials 0.000 claims description 36
- 230000008859 change Effects 0.000 claims description 29
- 235000005911 diet Nutrition 0.000 claims description 29
- 238000005259 measurement Methods 0.000 claims description 29
- 230000037213 diet Effects 0.000 claims description 28
- 208000015181 infectious disease Diseases 0.000 claims description 28
- 238000012360 testing method Methods 0.000 claims description 27
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 13
- 239000005864 Sulphur Substances 0.000 claims description 13
- 230000007704 transition Effects 0.000 claims description 11
- 238000000180 cavity ring-down spectroscopy Methods 0.000 claims description 5
- 238000000354 decomposition reaction Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 description 33
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 30
- 229920006008 lipopolysaccharide Polymers 0.000 description 30
- 238000004458 analytical method Methods 0.000 description 28
- 241001465754 Metazoa Species 0.000 description 25
- 241000699670 Mus sp. Species 0.000 description 23
- 230000036541 health Effects 0.000 description 15
- 241000699666 Mus <mouse, genus> Species 0.000 description 13
- 238000004422 calculation algorithm Methods 0.000 description 13
- 206010007733 Catabolic state Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 230000000155 isotopic effect Effects 0.000 description 12
- 230000003862 health status Effects 0.000 description 10
- 230000009466 transformation Effects 0.000 description 10
- 241000282412 Homo Species 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 208000030090 Acute Disease Diseases 0.000 description 6
- 208000036142 Viral infection Diseases 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 239000013598 vector Substances 0.000 description 6
- 208000035143 Bacterial infection Diseases 0.000 description 5
- 102000004127 Cytokines Human genes 0.000 description 5
- 108090000695 Cytokines Proteins 0.000 description 5
- 208000022362 bacterial infectious disease Diseases 0.000 description 5
- 230000009385 viral infection Effects 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000446 fuel Substances 0.000 description 4
- 238000009499 grossing Methods 0.000 description 4
- 238000010606 normalization Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 238000001243 protein synthesis Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000014616 translation Effects 0.000 description 3
- 102000003390 tumor necrosis factor Human genes 0.000 description 3
- 206010048998 Acute phase reaction Diseases 0.000 description 2
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 2
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000037487 Endotoxemia Diseases 0.000 description 2
- 108010063738 Interleukins Proteins 0.000 description 2
- 102000015696 Interleukins Human genes 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000004658 acute-phase response Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000001925 catabolic effect Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 238000013480 data collection Methods 0.000 description 2
- 238000013523 data management Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229940047122 interleukins Drugs 0.000 description 2
- 230000010361 irregular oscillation Effects 0.000 description 2
- 230000005445 isotope effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000003909 pattern recognition Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 238000011725 BALB/c mouse Methods 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000010205 computational analysis Methods 0.000 description 1
- 238000002790 cross-validation Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000006286 nutrient intake Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/412—Detecting or monitoring sepsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4842—Monitoring progression or stage of a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- General Physics & Mathematics (AREA)
- Physiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/414,061 US8512676B1 (en) | 2012-03-07 | 2012-03-07 | Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios |
| US13/414,061 | 2012-03-07 | ||
| PCT/US2013/020496 WO2013133904A2 (en) | 2012-03-07 | 2013-01-07 | Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013230841A1 AU2013230841A1 (en) | 2014-09-11 |
| AU2013230841B2 true AU2013230841B2 (en) | 2018-09-27 |
Family
ID=47628440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013230841A Active AU2013230841B2 (en) | 2012-03-07 | 2013-01-07 | Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8512676B1 (enExample) |
| EP (1) | EP2839277A2 (enExample) |
| JP (1) | JP6396218B2 (enExample) |
| CN (1) | CN104272107B (enExample) |
| AU (1) | AU2013230841B2 (enExample) |
| CA (1) | CA2865492C (enExample) |
| IN (1) | IN2014DN07247A (enExample) |
| WO (1) | WO2013133904A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104458603A (zh) * | 2013-09-23 | 2015-03-25 | 苏州青山生物科技有限公司 | 一种新型幽门螺杆菌检测方法、装置及其应用 |
| US20150196248A1 (en) | 2014-01-10 | 2015-07-16 | The United States Of America, As Represented By The Secretary Of Agriculture | Methods of determining energy balance using breath carbon isotope ratios |
| US10226484B2 (en) | 2014-12-01 | 2019-03-12 | Peter Y Novak | Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof |
| US10165965B1 (en) | 2015-10-22 | 2019-01-01 | Roy Pinchot | Noninvasive method for measuring lactic acid and detection of anaerobic exercise for evaluating fitness |
| CN105954504B (zh) * | 2016-06-01 | 2018-10-26 | 苏州科技学院 | 快速酒精定性信号处理方法以及初测装置 |
| US10183041B2 (en) | 2017-04-12 | 2019-01-22 | Vector Vitale Ip Llc | Antibacterial composition and its use in treating bacterial infections |
| US11484610B2 (en) | 2019-11-22 | 2022-11-01 | Vector Vitale Ip Llc | Method of treating melanoma |
| US10799530B1 (en) | 2019-12-20 | 2020-10-13 | Vector Vitale Ip Llc | Composition and method for the prevention and treatment of obesity |
| US10933091B1 (en) | 2019-12-20 | 2021-03-02 | Vector Vitale Ip Llc | Composition and method for the treatment of type I diabetes |
| US11596650B2 (en) | 2019-12-20 | 2023-03-07 | Vector Vitale Ip Llc | Composition and method for the treatment of type 2 diabetes |
| JP7718650B2 (ja) * | 2021-05-19 | 2025-08-05 | 国立大学法人東北大学 | 感染症のバイオマーカ |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5912178A (en) * | 1994-02-16 | 1999-06-15 | Wisconsin Alumni Research Foundation | Passive measurement of isotopes to monitor health |
| US7465276B2 (en) * | 2005-11-30 | 2008-12-16 | Wisconsin Alumni Research Foundation | Identification of disease characteristics using isotope ratios in breath |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1087512A (ja) * | 1996-09-18 | 1998-04-07 | Isao Nishi | ▲１３▼ｃ標識尿素試薬によるリアルタイムヘリコバクターピロリ感染検査方法 |
| US6609068B2 (en) * | 2000-02-22 | 2003-08-19 | Dow Global Technologies Inc. | Personal computer breath analyzer for health-related behavior modification and method |
| GB0120027D0 (en) * | 2001-08-16 | 2001-10-10 | Isis Innovation | Spectroscopic breath analysis |
| US8512258B2 (en) * | 2005-11-11 | 2013-08-20 | Exalenz Bioscience Ltd. | Breath test device and method |
| WO2007054940A2 (en) * | 2005-11-11 | 2007-05-18 | Breathid (2006) | Breath test device and method |
| US8288727B2 (en) * | 2006-12-18 | 2012-10-16 | Picomole Instruments Inc. | Apparatus and method for rapid and accurate quantification of an unknown, complex mix |
| US8026049B2 (en) * | 2007-03-23 | 2011-09-27 | Wisconsin Alumni Research Foundation | Noninvasive measurement and identification of biomarkers in disease state |
| CN102027344B (zh) * | 2008-02-15 | 2015-03-18 | 科学技术设备委员会 | 红外分光计 |
| DE102009055321B4 (de) * | 2009-12-24 | 2013-04-18 | Humedics Gmbh | Verfahren zur Bestimmung der Leberleistung eines Lebewesens mittels quantitativer Messung der Metabolisierung von Substraten |
-
2012
- 2012-03-07 US US13/414,061 patent/US8512676B1/en active Active
-
2013
- 2013-01-07 WO PCT/US2013/020496 patent/WO2013133904A2/en not_active Ceased
- 2013-01-07 EP EP13701877.6A patent/EP2839277A2/en active Pending
- 2013-01-07 CN CN201380012753.8A patent/CN104272107B/zh active Active
- 2013-01-07 JP JP2014560911A patent/JP6396218B2/ja active Active
- 2013-01-07 CA CA2865492A patent/CA2865492C/en active Active
- 2013-01-07 IN IN7247DEN2014 patent/IN2014DN07247A/en unknown
- 2013-01-07 AU AU2013230841A patent/AU2013230841B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5912178A (en) * | 1994-02-16 | 1999-06-15 | Wisconsin Alumni Research Foundation | Passive measurement of isotopes to monitor health |
| US7465276B2 (en) * | 2005-11-30 | 2008-12-16 | Wisconsin Alumni Research Foundation | Identification of disease characteristics using isotope ratios in breath |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130236925A1 (en) | 2013-09-12 |
| WO2013133904A2 (en) | 2013-09-12 |
| CN104272107B (zh) | 2017-05-17 |
| EP2839277A2 (en) | 2015-02-25 |
| CA2865492C (en) | 2021-06-01 |
| CA2865492A1 (en) | 2013-09-12 |
| US8512676B1 (en) | 2013-08-20 |
| IN2014DN07247A (enExample) | 2015-04-24 |
| AU2013230841A1 (en) | 2014-09-11 |
| JP2015511009A (ja) | 2015-04-13 |
| JP6396218B2 (ja) | 2018-09-26 |
| CN104272107A (zh) | 2015-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013230841B2 (en) | Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios | |
| Sabeti et al. | Entropy and complexity measures for EEG signal classification of schizophrenic and control participants | |
| US20110105856A1 (en) | Diagnostic testing | |
| US20250258156A1 (en) | Method, computer system, and program for predicting characteristic of target | |
| Tataraidze et al. | Bioradiolocation-based sleep stage classification | |
| Sanchez-Brito et al. | A machine-learning strategy to evaluate the use of FTIR spectra of saliva for a good control of type 2 diabetes | |
| Mei et al. | Identifying sleep spindles with multichannel EEG and classification optimization | |
| US20190037810A1 (en) | Device and method of automatic classification of animal behaviors using vocalizations | |
| US20190042692A1 (en) | Device and method of using rodent vocalizations for automatic classification of animal behavior | |
| Cserpan et al. | Variation of scalp EEG high frequency oscillation rate with sleep stage and time spent in sleep in patients with pediatric epilepsy | |
| Haba et al. | A remote and personalised novel approach for monitoring asthma severity levels from EEG signals utilizing classification algorithms | |
| Lee et al. | Automated detection of obstructive apnea and hypopnea events from oxygen saturation signal | |
| Zhu et al. | First insights into the urinary metabolome of captive giraffes by proton nuclear magnetic resonance spectroscopy | |
| US10440939B2 (en) | Device and method of correlating rodent vocalizations with rodent behavior | |
| CN106419884B (zh) | 一种基于小波分析的心率计算方法与系统 | |
| Amoroso et al. | PRISMA-CAD: Fully automated method for Computer-Aided Diagnosis of Dementia based on structural MRI data | |
| Malikhah et al. | A New Approach for Detection of Viral Respiratory Infections Using E-nose Through Sweat from Armpit with Fully Connected Deep Network | |
| Guo et al. | A sparse representation method for magnetic resonance spectroscopy quantification | |
| US20240032825A1 (en) | Photoplethysmography Based Non-Invasive Blood Glucose Prediction by Neural Network | |
| CN116721777A (zh) | 基于神经网络的药物药效评价方法、装置、设备及介质 | |
| Navarro et al. | Performance analysis of Hurst exponent estimators using surrogate-data and fractional lognormal noise models: Application to breathing signals from preterm infants | |
| Khoa et al. | Testing for nonlinearity in functional near-infrared spectroscopy of brain activities by surrogate data methods | |
| Wang et al. | Analysis of the Complexity Pattems in Respiratory Data | |
| Bottenhorn et al. | Estimating individual-level changes in functional brain connectivity and correspondence with topology changes | |
| Frohlich et al. | The complexity of event-related MEG signals decreases with maturation in human fetuses and newborns |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |