CA2865492C - Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios - Google Patents

Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios Download PDF

Info

Publication number
CA2865492C
CA2865492C CA2865492A CA2865492A CA2865492C CA 2865492 C CA2865492 C CA 2865492C CA 2865492 A CA2865492 A CA 2865492A CA 2865492 A CA2865492 A CA 2865492A CA 2865492 C CA2865492 C CA 2865492C
Authority
CA
Canada
Prior art keywords
isotope
individual
oscillations
systematic
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2865492A
Other languages
English (en)
French (fr)
Other versions
CA2865492A1 (en
Inventor
Hamid R. Eghbalnia
Mark E. Cook
Warren Paul Porter
Daniel Elmer BUTZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of CA2865492A1 publication Critical patent/CA2865492A1/en
Application granted granted Critical
Publication of CA2865492C publication Critical patent/CA2865492C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • General Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2865492A 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios Active CA2865492C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/414,061 US8512676B1 (en) 2012-03-07 2012-03-07 Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios
US13/414,061 2012-03-07
PCT/US2013/020496 WO2013133904A2 (en) 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios

Publications (2)

Publication Number Publication Date
CA2865492A1 CA2865492A1 (en) 2013-09-12
CA2865492C true CA2865492C (en) 2021-06-01

Family

ID=47628440

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2865492A Active CA2865492C (en) 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios

Country Status (8)

Country Link
US (1) US8512676B1 (enExample)
EP (1) EP2839277A2 (enExample)
JP (1) JP6396218B2 (enExample)
CN (1) CN104272107B (enExample)
AU (1) AU2013230841B2 (enExample)
CA (1) CA2865492C (enExample)
IN (1) IN2014DN07247A (enExample)
WO (1) WO2013133904A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104458603A (zh) * 2013-09-23 2015-03-25 苏州青山生物科技有限公司 一种新型幽门螺杆菌检测方法、装置及其应用
US20150196248A1 (en) 2014-01-10 2015-07-16 The United States Of America, As Represented By The Secretary Of Agriculture Methods of determining energy balance using breath carbon isotope ratios
US10226484B2 (en) 2014-12-01 2019-03-12 Peter Y Novak Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof
US10165965B1 (en) 2015-10-22 2019-01-01 Roy Pinchot Noninvasive method for measuring lactic acid and detection of anaerobic exercise for evaluating fitness
CN105954504B (zh) * 2016-06-01 2018-10-26 苏州科技学院 快速酒精定性信号处理方法以及初测装置
US10183041B2 (en) 2017-04-12 2019-01-22 Vector Vitale Ip Llc Antibacterial composition and its use in treating bacterial infections
US11484610B2 (en) 2019-11-22 2022-11-01 Vector Vitale Ip Llc Method of treating melanoma
US10799530B1 (en) 2019-12-20 2020-10-13 Vector Vitale Ip Llc Composition and method for the prevention and treatment of obesity
US10933091B1 (en) 2019-12-20 2021-03-02 Vector Vitale Ip Llc Composition and method for the treatment of type I diabetes
US11596650B2 (en) 2019-12-20 2023-03-07 Vector Vitale Ip Llc Composition and method for the treatment of type 2 diabetes
JP7718650B2 (ja) * 2021-05-19 2025-08-05 国立大学法人東北大学 感染症のバイオマーカ

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912178A (en) * 1994-02-16 1999-06-15 Wisconsin Alumni Research Foundation Passive measurement of isotopes to monitor health
JPH1087512A (ja) * 1996-09-18 1998-04-07 Isao Nishi ▲１３▼ｃ標識尿素試薬によるリアルタイムヘリコバクターピロリ感染検査方法
US6609068B2 (en) * 2000-02-22 2003-08-19 Dow Global Technologies Inc. Personal computer breath analyzer for health-related behavior modification and method
GB0120027D0 (en) * 2001-08-16 2001-10-10 Isis Innovation Spectroscopic breath analysis
US8512258B2 (en) * 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
WO2007054940A2 (en) * 2005-11-11 2007-05-18 Breathid (2006) Breath test device and method
US7465276B2 (en) * 2005-11-30 2008-12-16 Wisconsin Alumni Research Foundation Identification of disease characteristics using isotope ratios in breath
US8288727B2 (en) * 2006-12-18 2012-10-16 Picomole Instruments Inc. Apparatus and method for rapid and accurate quantification of an unknown, complex mix
US8026049B2 (en) * 2007-03-23 2011-09-27 Wisconsin Alumni Research Foundation Noninvasive measurement and identification of biomarkers in disease state
CN102027344B (zh) * 2008-02-15 2015-03-18 科学技术设备委员会 红外分光计
DE102009055321B4 (de) * 2009-12-24 2013-04-18 Humedics Gmbh Verfahren zur Bestimmung der Leberleistung eines Lebewesens mittels quantitativer Messung der Metabolisierung von Substraten

Also Published As

Publication number Publication date
US20130236925A1 (en) 2013-09-12
WO2013133904A2 (en) 2013-09-12
CN104272107B (zh) 2017-05-17
EP2839277A2 (en) 2015-02-25
CA2865492A1 (en) 2013-09-12
US8512676B1 (en) 2013-08-20
IN2014DN07247A (enExample) 2015-04-24
AU2013230841A1 (en) 2014-09-11
JP2015511009A (ja) 2015-04-13
JP6396218B2 (ja) 2018-09-26
CN104272107A (zh) 2015-01-07
AU2013230841B2 (en) 2018-09-27

Similar Documents

Publication Publication Date Title
CA2865492C (en) Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios
Aaij et al. Measurements of the Λb0→ J/ψΛ decay amplitudes and the Λb0 polarisation in pp collisions at s= 7 TeV
WO2012145600A3 (en) Robust rate calculation in an implantable cardiac stimulus or monitoring device
MX348392B (es) Sistemas y metodos para diagnostico de la salud.
WO2014150871A3 (en) Management system for point of care testing
EP4340409A3 (en) Systems and methods for proactively identifying and surfacing relevant content on a touch-sensitive device
EP2542148A4 (en) ACTIVE PHYSICAL DISTURBANCES TO STRENGTHEN INTELLIGENT MEDICAL MONITORING
NZ630770A (en) Fatigue monitoring and management system
WO2014116367A3 (en) Realtime inspection management
BR112016021493A8 (pt) método de processamento de dados de ritmo cardíaco, produto de programa de computador e sistema para processamento de dados de ritmo cardíaco
IN2014DN10121A (enExample)
GB2511978A (en) Determining social sentiment using physiological data
MX2014015941A (es) Metodos y aparato para usar los datos de vibracion para determinar una condicion de un dispositivo de control de procesos.
WO2015168250A8 (en) Decision support system for hospital quality assessment
EP4307316A3 (en) Indicator and analytics for sensor insertion in a continuous analyte monitoring system and related methods
WO2014055987A3 (en) Hygiene monitoring system and methods thereof
EP2897001A3 (en) Multi-level/multi-threshold/multi-persistency GPS/GNSS atomic clock monitoring
MX2014007127A (es) Metodos de transferencia de calibracion para un instrumento de pruebas.
MY176971A (en) Monitoring device, monitoring method and recording medium
NZ716643A (en) Methods for predicting the risk of having a cardiovascular event and for monitoring the treatment of a cardiovascular event
WO2011072055A3 (en) Methods and arrangements for analysis, diagnosis, and treatment monitoring of vocal folds by optical coherence tomography
GB2525316A (en) System and method for generating profile-based alerts/alarms
GB201205472D0 (en) Method for monitoring a heart rate
MX2016002627A (es) Sistema de medicion de dioxido de carbono de neonatos.
WO2011085083A3 (en) Apparatus and method for pulsed neutron measurement