CN1042656A - The manufacture method of " chicken is happy " - Google Patents
The manufacture method of " chicken is happy " Download PDFInfo
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- CN1042656A CN1042656A CN 88107679 CN88107679A CN1042656A CN 1042656 A CN1042656 A CN 1042656A CN 88107679 CN88107679 CN 88107679 CN 88107679 A CN88107679 A CN 88107679A CN 1042656 A CN1042656 A CN 1042656A
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- chicken
- happy
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Abstract
" chicken is happy " is for the herb of Rhizoma Fagopyri Dibotryis being the medicine of the control fowl disease of raw material development face one-tenth first; main effective ingredient is the dimercyanidin; the treatment Staphylococcus gallinarum; the effective percentage of Hakuri and mycoplasma is respectively 82.84%; 86.54%; 85.77%; the protective rate of prevention chicken staphylococcosis and Hakuri is respectively 96.12% and 94.38%; the comprehensive prevention protective rate is 93.13%; above-mentioned prevention effect all is better than or is equivalent to gentamycin; streptomycin; oxytetracycline and furazolidone; Western medicine such as Hakuri spirit; this product consumption is few; safety non-toxic; chicken there is appetite strengthening, the effect of feather good luster and weightening finish.
Description
The invention belongs to a kind of manufacturing process of preventing and treating the fowl disease medicine.
Chicken staphylococcosis, Hakuri and mycoplasma all belong to acute or chronic infectious disease.Chicken staphylococcosis is a kind of acute septic or the chronic infectious disease that is caused by staphylococcus aureus (Staphylococcus aureus).Gallisepticum chicken disease is the respiratory infectious disease that is caused by mycoplasma gallisepticum (M.gallisepticum).At present, the main Therapeutic Method of above-mentioned two kinds of fowl disease is to select responsive antibiotics class medicine to control.Pullorum Disease is the common a kind of acute septic infectious disease of chickling.The method of preventing and treating is extensive use of antibiotics and furans and sulfa drugs.Antibiotics price height, and can cause some bacterial strains generation drug resistance owing to grow use, make the curative effect reduction.When drug residue is too much in the chicken body, also human health is caused harmful effect.By retrieval with consult documents and materials, find the relevant report identical as yet with the present invention.
In order to solve the problem that existing fowl disease control medicine exists, be necessary to seek a kind of Chinese herbal medicine with high-efficiency low-toxicity of treatment preventive effect.The present invention has carried out the development and the observation of curative effect research of " chicken is happy " medicine, so that root, stem, leaf, the flower of " chicken is happy " raw material Rhizoma Fagopyri Dibotryis developed and utilized, provides a kind of comparatively ideal fowl disease control medicine.
The preparation method of the happy medicine of chicken:
This product is the Rhizoma Fagopyri Dibotryis extract powder, and every 1g is equivalent to Rhizoma Fagopyri Dibotryis 7-9g.
(prescription) Rhizoma Fagopyri Dibotryis root 50kg
Rhizoma Fagopyri Dibotryis stem, leaf, flower 25kg
(method for making) Rhizoma Fagopyri Dibotryis root is ground into coarse powder, and with 50% alcohol reflux three times, 3 hours for the first time, second and third time each 1 hour filtered, and merging filtrate reclaims ethanol, and concentrating under reduced pressure is dry below 70 ℃.
Rhizoma Fagopyri Dibotryis stem, leaf, flower mixed extraction 3 hours, 1 hour for the second time, extract secondary altogether, its method is identical with the root method for making.
Extract medicament mixed with above-mentioned two kinds and be ground into fine powder, add 10% protogenic medicinal powder, be mixed 40 mesh sieves promptly.This product is a sepia, and it is little puckery to distinguish the flavor of.Its manufacturing process is shown in flow chart.
Cream rate 9-12% is received in the extraction of Rhizoma Fagopyri Dibotryis root, and stem, leaf, flower mix receives the cream rate more than 14%.
The quality control of " chicken is happy " medicine:
Rhizoma Fagopyri Dibotryis (Fahopyrum cymosum(Trev.) Meisn.) main effective ingredient is that dimercyanidin (Dimeric Procyanidin) is a condensation proanthocyanidin chemical compound, structure is 5,7,3 ', 4 '-C of tetrahydroxy flavan-3-alcohol
4-C
8Dimer.
(discriminating) gets this product 1g, adds 50% ethanol 20ml, and heating and refluxing extraction 1 hour is got supernatant and done following test:
Get supernatant 2-3 and drip, put in the test tube, add copperas solution (annotating 1) 2ml, put in the boiling water and heated 5 minutes, show cherry red.
Paper electrophoresis: get filter paper (watman Nol), long 25-33cm, wide 5cm, the long straight line of horizontal standardized 1cm apart from bottom 5-7cm place; get this product supernatant along this line point sample; be stripe shape is poured boric acid-borate buffer solution (PH8.7-8.8) (annotating 2) in the electrophoresis tank into, with filter paper point sample end to negative pole; end is to positive pole in addition; put on the electrophoresis truss, the filter paper two ends are immersed respectively in the buffer, after filter paper is all moistening; adjust voltage to 100V; electrophoresis 5-6 hour, take out filter paper, dry; spray developer (annotating 3) was in 100 ℃ of dryings 5 minutes; put ultra-violet lamp and inspect, F8-12cm place, apparent brown speckle.(also can use long 12-16cm, the paper electrophoresis of wide 2.5cm shows brown speckle at the 3-6cm place).
To remain supernatant concentration to 2ml, as need testing solution, other is depletion Semen Fagopyri Esculenti control medicinal material powder 2g, press the preparation of need testing solution preparation method, solution in contrast, with paper chromatography (36 pages of appendix of Chinese Pharmacopoeia version in 1985) test, draw above-mentioned two kinds of each 3ml of solution, put respectively on same chromatography polyamide slices, just become point-like, with ethanol: water (3: 2) is developing solvent, ascending development, and exhibition is apart from 10cm, take out, dry, spray is dried under ultra-violet lamp (3650A °) and is inspected with 10% aluminum chloride alcoholic solution.For test agent solution with the contrast solution relevant position on, show the fluorescence speckle of same color.
Annotate:
1, copperas solution: get ferrous sulfate (FeSo
47H
2O) 15mg is dissolved in the 100ml n-butyl alcohol: in the mixed liquor of hydrochloric acid (3: 2).
2, boric acid-borate buffer solution (PH8.7-8.8):
0.05m the preparation of borax soln: take by weighing Borax (Na
2B
4O
710H
2O) 19.07g adds water to 1000ml.
0.2m the preparation of boric acid solution: take by weighing boric acid (H
3BO
3) 12.37g adds water to 1000ml.
Press the 0.05M borax soln and mix at 6: 4, adjust PH8.7-8.8 with acidometer with the volume ratio of 0.2M boric acid solution.
3, developer: get p-methyl benzenesulfonic acid 20g; Add ethanol to 100ml.
4, differentiate 2,3, get final product with 1.
(assay) effective ingredient-dimercyanidin (condensation proanthocyanidin) assay
Principle: utilize the principle of differentiating (1) reaction, the color-sensitive that this reaction generates, stable, concentration meets Beer law when 100ug/ml is following.
Method: because condensation proanthocyanidin very easily oxidation, polymerization in air, very difficult separation obtains pure product, Chinese Academy of Medical Sciences's medicine plant institute, medicine once developed eight methyl ether compounds of condensation proanthocyanidin as standard substance (the two all can be converted into the anthocyanin unit of cherry red this chemical compound and condensation proanthocyanidin in the presence of acid condition and ferrous sulfate), carrying out colorimetric identifies, this law high specificity, color stability.
The standard curve preparation:
Precision takes by weighing a certain amount of chloroformic solution that is made into concentration 1ml/ml of condensation proanthocyanidin eight methyl ethers.Absorption 20,40,60,80,100ml to going in the 20ml test tube, respectively add the 10ml developer respectively, and heating is 15 minutes on the boiling water Lip river, putting coldly, is blank with the developer, in 545nm place mensuration trap, with the trap is ordinate, and concentration is abscissa, the drawing standard curve.
Preparation is measured:
Get this product porphyrize, precision takes by weighing the amount of the contained this product of suitable 1g crude drug, puts in the 100ml flask, add 50% ethanol 30ml, on boiling water bath, refluxed 2 hours, put cold, move in the 50ml volumetric flask, to scale, shake up with 50% ethanol dilution, filter, discard filtrate just, precision is measured subsequent filtrate 0.25ml, put in the dry test-tube, precision adds developer 10ml, shakes up, to boiling water bath, heated 15 minutes.Put cold.With the developer is blank, measures trap at the 545nm place.Look into its respective concentration by standard curve, calculate content.
According to the measurement result of laboratory test and 6 batches of trial production samples, drafting content is the 35-60mg/lg preparation, (trap is 0.15-0.30).
The crude drug quality control:
Available above-mentioned content assaying method.Get the 1g crude drug, undertaken by preparation content determining method, intending content is (trap 0.7-1.1) more than 5%.
Because difficulty is identified in producing, separating of condensation proanthocyanidin, can directly represent with trap.
Agent trap: the 0.15-0.30 that draws up, crude drug root 0.7 above stem, leaf, flower aggregate sample are more than 0.15.
(function with cure mainly) heat-clearing and toxic substances removing is arranged dense dissipating blood stasis, lung heat clearing expectoration, invigorating the spleen for eliminating dampness, infection.Be used for the treatment and the prevention of chicken staphylococcosis, Hakuri, mycoplasma etc.
(usage and consumption) is oral, and treatment is that 0.2% ratio is allocated feedstuff into, feeds 5-7 days.Or every chicken 0.1-0.2g/ days, fed 3-5 days.Prevention consumption 0.1% ratio is allocated feedstuff into, feeds 5-7 days.
" chicken happy " medicine is to the extracorporeal bacteria inhibitor test result of several pathogenic bacterium:
The ethanol extract of the root (01) of " chicken is happy " raw material-Rhizoma Fagopyri Dibotryis, stem, leaf (02), (03) three kind of different medicinal part of flower is measured by the inhibitory potency of test tube, paper disk method: Pullorum Disease Salmonella (serotype O
123), gold-coloured staphylococci (Ji Yuan), pasteurella multocida (C
46-1), bacillus rhusiopathiae suis (C
43-5) bacteriostasis is preferably all arranged, it is as shown in the table:
The minimum inhibitory concentration of Rhizoma Fagopyri Dibotryis extracting solution
Annotate: above two tables are to repeat twice average
To gallisepticum chicken disease, bacterial strain (M.gallisepticum BG44T), the bacteriostatic test result, least concentration is that 1: 64 fungistatic effect is comparatively obvious, it is as shown in the table:
The bacteriostasis of Rhizoma Fagopyri Dibotryis extracting solution
The toxicity test result:
1 age in days parts in Beijing opera spoken in Beijing dialect chickling is with " chicken is happy " 0.1%, 0.3%, 0.6%, 1%, 3%, 6% mixed was fed 15-30 days, and body weight is than the matched group 102.28-112.73% that increases weight respectively, (subordinate list), liver, spleen bursa of Fabricius be better contrast weightening finish all, but no significant difference, chick growth is good.
Pathomorphism and histological observation:, to organizing nontoxic pair of effect of organ pipe, after the 0.1-6% ratio was fed 30 days kidney and spleen are had the infringement phenomenon after ratio was fed 15 days with 0.1-1%.
The little acid, sweet, puckery of distinguishing the flavor of of this medicine.Mixed feeding, the chickling palatability is better, and appetite strengthens.
" chicken is happy " medicine is observed chicken staphylococcosis, Hakuri and three kinds of infectious disease prevention effects of Mycoplasma:
The prevention effect of chicken staphylococcosis:
Treatment to artificial challenge's chicken staphylococcosis, with this product 0.2% spice mixed feeding or every day 0.2g/ only, cure the disease 31 of artificial challenge's arthritis type chicken staphylococcosis, result " chicken is happy " group is respectively 80.64% and 50% with the matched group total effective rate, " chicken happy " curative effect is apparently higher than matched group, its result such as following table:
P＜0.05
To the chicken staphylococcosis on-scene care, fed 7 days with this product 0.2% spice, to the ophthalmia type, 839 of arthritis type and eye, arthritis mixed type cases, therapeutic effect: effective percentage " chicken is happy " group 82.84%, Western medicine group 68.75%, matched group 35.71%, " chicken is happy " curative effect is better than the Western medicine gentamycin, significant difference, and its result such as following table:
" chicken is happy " medicine is to the Staphylococcus gallinarum therapeutic effect
★P＜0.01 ☆P＜0.05
Prevention to chicken staphylococcosis; at 30-35 age in days and 50-55 between the length of time; feed secondary with this product 0.1% ratio spice mixed feeding; observe 5900 altogether; its protective rate " chicken is happy " group is 96.12%, Western medicine group 93.22%, matched group 88.59%; medicine is apparently higher than matched group and be better than Western medicine gentamycin, oxytetracycline and kanamycin, its result such as following table for proof preventive effect " chicken is happy ":
" chicken is happy " medicine is to the preventive effect of chicken staphylococcosis
Test chicken kind: Huang Yu, Luo Ke, Hai Saikesi, parts in Beijing opera spoken in Beijing dialect II III system
☆P＜0.05
To the control of Pullorum Disease, with this product 0.2% ratio spice 52 of Pullorum Disease of treatment of feeding, total effective rate " chicken is happy " group is 86.54%, and Western medicine group 78.57% prove that " chicken pleasure " medicine is equivalent to Western medicine furazolidone and kanamycin.
With 0.1% ratio spice feeding chickling 1-7 age in days; count 14388; " chicken is happy " group; Western medicine (1); Western medicine (2), the protective rate that reaches matched group is respectively 94.38%, 92.77%, 95.43% and 92.58% and shows that the prevention Hakuri effect of " chicken is happy " medicine is better than or is equivalent to Western medicine furazolidone, oxytetracycline or Hakuri spirit, penicillin, streptomycin.
" chicken is happy " medicine is to the prevention effect of the white scour of chicken
Chicken kind: parts in Beijing opera spoken in Beijing dialect, Huang Yu, B
4Hybridization, Luo Ke, Hai Saikesi
Chicken is to the comprehensive prevention of staphylococcosis and Hakuri; at chicken 1-7 age in days; during 30-35, the 50-55 age in days; feed three times with this product 0.1% ratio spice; 800 of comprehensive prevention Pullorum Disease and staphylococcosiss, the integrated protection rate of " chicken is happy " group, matched group and matched group is respectively 93.13%, 88.50%, 83.23%.The result shows that " chicken is happy " medicine is better than Western medicine furazolidone, oxytetracycline and gentamycin, its result such as following table:
＊P＜0.05
Western medicine: furazolidone+oxytetracycline+gentamycin
Treatment to gallisepticum chicken disease, feed with this product 0.2%, 0.5% ratio spice, treat 281 of disease chickens, the effective percentage of " chicken is happy " group, Herba Houttuyniae group, Western medicine group, matched group is respectively 85.77%, 55.9%, 64.7%, 52.1%, show that " chicken is happy " medicine is better than medium-height grass Herba Houttuyniae and Western medicine streptomycin sulfate, its result such as following table to the curative effect of mycoplasma:
* compares with the blank group, P＜0.01
Western medicine: streptomycin sulfate
" chicken is happy " medicine is to yellow-feather broiler, because it has appetite stimulator, active, the glossy effect of feather of spirit to chicken, and tangible gaining effect is arranged, its result such as following table:
＊＊P＜0.01 ＊＊P＜0.05
Other nutritional labeling in " chicken happy ": after measured " chicken is happy " medicine and raw material-Rhizoma Fagopyri Dibotryis root, stem, leaf, spend in except that containing the former Chrysanthemin of effective composition double focusing do not have, and contain several amino acids as arginine, lysine, methionine etc.Various trace elements is as Cu, Fe, Zn, Mn, Se, Co etc.Multivitamin is as V
A, V
Z, V
B, V
BDeng." chicken happy " medicine except that the physiological activity of effective ingredient, can replenish to the chicken necessary aminoacid of growing in control fowl disease process simultaneously, and nutrient substance such as trace element and vitamin have good action to growth and the resistance against diseases of promotion chicken.
Advantage of the present invention and good effect:
" chicken happy " preparation be extract with a kind of raw material of Rhizoma Fagopyri Dibotryis formulated, aboundresources, technology is simple, and is with low cost, method of quality control is easy, it is feasible to stablize." chicken is happy " with this method preparation except that containing effective composition dimercyanidin, and contains the essential several amino acids of poultry: arginine, lysine, methionine etc., various trace elements: Cu, Fe, Zn, Mn, Se, Co etc., multivitamin: V
A, V
Z, V
B, V
BDeng.And can replenish the above-mentioned nutrient substance of supply except that the physiology of effective ingredient or property in control fowl disease process, growth and the enhancing resistance against diseases of chicken played good action.
Description of drawings:
Fig. 1 to Fig. 3 is " chicken is happy " raw material-Rhizoma Fagopyri Dibotryis plant picture
Fig. 1 Rhizoma Fagopyri Dibotryis plant figure
Fig. 2 herb of Rhizoma Fagopyri Dibotryis
Fig. 3 Rhizoma Fagopyri Dibotryis wheat root
Fig. 4 to Fig. 7 is chicken staphylococcosis type and therapeutic effect
Fig. 4 ophthalmia type staphylococcosis
Fig. 5 arthritis staphylococcosis
Fig. 6 mixed type staphylococcosis
Fig. 7 " chicken is happy " cures chicken
Fig. 8 to Figure 10 is " chicken is happy " treatment chicken staphylococcosis effect
Fig. 8 " chicken is happy " treatment group
Fig. 9 Western medicine gentamycin group
Figure 10 matched group
Figure 11 to Figure 12 is " chicken is happy " treatment gallisepticum chicken disease effect
Figure 11 gallisepticum chicken disease
Figure 12 " chicken is happy " cures chicken
Figure 13 white scour of chicken
The toxicity test of Figure 14 " chicken is happy " various dose relatively
The happy preparation technology's flow chart of Figure 15 chicken
The happy preparation technology's flow chart of Figure 16 chicken
Claims (6)
1, a kind of manufacture method of preventing and treating fowl disease is characterized in that " chicken is happy " raw material Rhizoma Fagopyri Dibotryis root coarse powder and stem, leaf, spends coarse powder under optimum conditions respectively with emitting medicine behind the alcohol reflux several times.Medicinal liquid is dried to extract powder under optimum conditions through concentrating under reduced pressure.
2, by the described manufacture method of claim 1, it is characterized in that the medicinal liquid of three reflux, extract, gained of root coarse powder is merged, concentrating under reduced pressure was placed 4 hours behind the recovery ethanol, got upper strata medicinal liquid and precipitate.
3, by the described manufacture method of claim 2, it is characterized in that precipitate and medicinal liquid concentrated extract are descended drying at 65-70 ℃ respectively, merge dried cream then.
4, by the described manufacture method of claim 1, it is characterized in that stem, leaf, spend mixing coarse powder secondary back extraction gained medicinal liquid to merge, decompression, concentrated behind the recovery ethanol, was placed 4 hours, got upper strata medicinal liquid and precipitate.
5, by the described manufacture method of claim 4, it is characterized in that precipitate and medicinal liquid concentrated extract are descended drying at 65-70 ℃ respectively, merge dried cream then.
6, by the described manufacture method of claim 1, it is characterized in that root coarse powder and stem thereof, leaf, flower are mixed two parts of dried cream that coarse powder makes to be merged, close envelope and preserve, pulverize the back and heavily add 10% stem, leaf by cream, mix coarse powder, cross packing finished product behind 40 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88107679 CN1026657C (en) | 1988-11-12 | 1988-11-12 | Manufacturing method of "Jile" (a health medicine for fowls) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88107679 CN1026657C (en) | 1988-11-12 | 1988-11-12 | Manufacturing method of "Jile" (a health medicine for fowls) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1042656A true CN1042656A (en) | 1990-06-06 |
| CN1026657C CN1026657C (en) | 1994-11-23 |
Family
ID=4834742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88107679 Expired - Fee Related CN1026657C (en) | 1988-11-12 | 1988-11-12 | Manufacturing method of "Jile" (a health medicine for fowls) |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1026657C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063957C (en) * | 1997-09-29 | 2001-04-04 | 北京华颐中药制药厂 | Method for preparing fagopyrum cymosum preparation |
| CN107412352A (en) * | 2017-05-08 | 2017-12-01 | 宁波检验检疫科学技术研究院 | The extracting method of flavone compound and extraction utensil in a kind of cymose buckwheat rhizome root |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058880C (en) * | 1996-08-19 | 2000-11-29 | 吉海平 | Compound antibacterial and antiviral veterinary medicine capable of raising immunity |
-
1988
- 1988-11-12 CN CN 88107679 patent/CN1026657C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063957C (en) * | 1997-09-29 | 2001-04-04 | 北京华颐中药制药厂 | Method for preparing fagopyrum cymosum preparation |
| CN107412352A (en) * | 2017-05-08 | 2017-12-01 | 宁波检验检疫科学技术研究院 | The extracting method of flavone compound and extraction utensil in a kind of cymose buckwheat rhizome root |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1026657C (en) | 1994-11-23 |
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