CN104258202A - Traditional Chinese medicine composition for treating hypertension due to vital energy and blood deficiency and preparation method of composition - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating hypertension due to vital energy and blood deficiency and a preparation method of the composition. The traditional Chinese medicine composition comprises the following raw materials: rose flowers, nardostachys chinensis, aspongopus, malt, endothelium corneum gigeriae galli, paederia foetida, valerian, lucid ganoderma, vine of multiflower knotweed, mother of pearl, liquorice, sea-buckthorn, black sesame, glossy privet fruit, mulberries, sealwort, eclipta, dace, siberian nitraria fruit, concentrated beef extract, affine cudweed, prepared liquorice root, polyalthia nemoralis, phyllanthus virgatus, perilla stems, elk horn, placenta hominis, ternate buttercup root, metaplexis japonica, native copper, oxhide gelatin, aster and grub. The traditional Chinese medicine composition has the effects of nourishing vital energy and blood and benefiting the spleen and stomach, and is mainly used for treating symptoms due to vital energy and blood deficiency. According to the traditional Chinese medicine composition, the treatment based on syndrome differentiation is performed by adjusting the overall vital energy and blood circulation, the nerves, the humoral regulation system and the like, the targeted treatment is performed on similar diseases, the range of indications is relatively wide, the treatment effect is remarkable, the course of treatment is short, the drug resistance is hardly generated, few adverse reactions are produced, the drug administration operation is convenient, the composition can be easily accepted by patients, and the living quality of the patients can be remarkably improved.

Description

One treats hypertensive Chinese medicine composition of deficiency of both QI and blood type and preparation method thereof

 

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly one treats hypertensive Chinese medicine preparation of deficiency of both QI and blood type and preparation method thereof.

 

Background technology

Hypertension is the disease of lasting hyperpiesia, the diseases such as apoplexy, heart disease, hemangioma, renal failure can be caused, hypertension be a kind of with arterial pressure rising for feature, can with the systemic disease of the functional or organic change of heart, blood vessel, brain and kidney and other organs, it have essential hypertension and secondary hypertension point.The reason of hypertension incidence is a lot, can be divided into h and E two aspects.Do not using in antihypertensive situation, systolic pressure >=139mmHg and/or diastolic pressure >=89mmHg, is divided into 1 by blood pressure level by hypertension, 2,3 grades.Systolic pressure >=140mmHg and diastolic pressure <90mmHg is single-row is isolated systolic hypertension.Patient previously has history of hypertension, uses antihypertensive at present, although blood pressure is lower than 140/90mmHg, also should be diagnosed as hypertension.

With the relevant factor of morbidity: 1. the age: sickness rate has and increases with the age and the trend that increases, and person's sickness rate was high in more than 40 years old.2. Sal: take in Sal many persons, Hypertension incidence is high, has and thinks and Sal <2g/ day hardly hypertension occurs; 3-4g/ day, 3%, 4-15g/ day of Hypertension incidence, 33.15%, >20g/ day of sickness rate sickness rate 30%.3. body weight: overweight people's sickness rate is high.4. heredity: approximately half hyperpietic has family history.5. environment and occupation.

Regulating blood pressure mechanism: many factors can cause elevation of the blood pressure.Cardiac pumping ability strengthens (as cardiac contractile force increase etc.), and making to pump blood each second increases.Another kind of factor is that large artery trunks loses normal elasticity, becomes stiff, when heart pumps blood, can not effectively expand, and therefore, the blood flow that each heartbeat pumps, by than normal narrow space, causes pressure to raise.Hypertension that Here it is mostly occurs and causes arterial wall to thicken in atherosclerosis and become the reason of stiff old people.Due to the stimulation of hormone in neural and blood, whole body small artery temporary contraction can equally also cause increasing of blood pressure.3rd factor that blood pressure may be caused to raise is that in circulation, liquid capacity increases.When this is common in kidney disease, kidney fully can not discharge sodium salt and moisture in body, and in body, blood volume increases, and causes blood pressure to increase.On the contrary, if cardiac pumping limited ability, vasodilation or too much body fluid are lost, all blood pressure drops can be caused.These factors are are mainly regulated and controled by the change of renal function and autonomic nervous system (automatically regulating health to be permitted multi-functional part in nervous system).

Symptom and sign: by onset emergency and course advancement, can be divided into and delay into type and radical type, common to delay into type.

One, benign hypertension (one) Early manifestation: early stage how asymptomatic, find that blood pressure increases once in a while during health check-up, or at psychentonia, feeling dizziness, headache, dim eyesight, tinnitus, insomnia, the symptom such as weak, absent minded after excited or tired, may be caused by higher mental functional disorder.Early stage blood pressure only temporarily raises, and continue to raise with course advancement blood pressure, internal organs are got involved.(2) brain performance: headache, dizzy common.Many due to excited, overtired, climate change or inactive depressor and bring out.The hurried rising of blood pressure.Severe headache, visual disorder, Nausea and vomiting, tic, stupor, transient hemiplegia, aphasia etc.(3) Cardiac Manifestation: early stage, cardiac functional compensation, symptom is not obvious, the later stage, and cardiac function loses compensatory, and heart failure occurs.(4) kidney performance: long-term hypertension causes renal arteriolosclerosis.During renal hypofunction, nocturia can be caused, containing albumen, cast and erythrocyte in polyuria, urine.Urine concentrating power is low, phenol red excretion and urea clearance obstacle.There is azotemia and uremia.(5) tremulous pulse changes.(6)) Fundus oculi changes.

Two, accelerated hypertension also claims malignant hypertension, accounts for 1% of hypertension, can change suddenly by delaying into type, also can onset.Malignant hypertension can occur in any age, but is the most common with 30-40 year.Blood pressure obviously raises, and diastolic pressure is many to be had weak at more than 17.3Kpa (130mmHg), the symptom such as thirsty, polyuria.Vision goes down rapidly, and there is retinal hemorrhage on optical fundus and oozes out, and often has bilateral papilloedema.There is albuminuria rapidly, hematuria and renal insufficiency.Also heart failure can occur, hypertensive encephalopathy and hypertensive crisis, course advancement rapidly more dies from uremia.

Hypertension is by stages: the first phase: blood pressure reaches Definite Hypertension level, not clinically to be in the mood for, brain, renal damage sign.The second phase: blood pressure reaches Definite Hypertension level, and have following person's 1. health check-up, x-ray, electrocardiogram or ultrasonic cardiography diagram left ventricle dilation.2. examination of ocular fundus, the general or local stenosis of Fundus oculi artery.3. albuminuria or creatinine concentration of plasma slightly increase.The third phase: blood pressure reaches Definite Hypertension level, and have a following person; 1. cerebral hemorrhage or hypertensive encephalopathy.2. heart failure.3. renal failure.4. retinal hemorrhage or ooze out, companion or without papilloedema.5. angina pectoris, myocardial infarction, cerebral thrombosis.

The hypertension of different crowd: children's's hypertension: essential hypertension is rare children's, accounts for 20% ~ 30%, but have the trend of increase in recent years; Secondary hypertension is more, accounts for 65% ~ 80%.Secondly in children's's secondary hypertension, kidney disease accounts for 79%, and hypertension is cardiovascular disease, endocrinopathy, nervous system disease and poisoning etc.Pregnancy induced hypertension syndrome: i.e. pregnancy-hypertension syndrome, being also said hypertensive state of pregnancy, preeclampsia etc. in the past, is the distinctive disease of anemia of pregnant woman, and majority occurs in gestation 20 weeks and two weeks puerperal, accounts for all anemia of pregnant woman's 5%.Systolic Hypertension In The Aged: diastolic pressure is normal higher than normal level to refer to old people's systolic pressure of more than 60 years old, it is a kind of disease of separate type, being the independent hazard factor that old cardiovascular disease and apoplexy occur, is the important diseases affecting senior health and fitness.

Constitutional and secondary hypertension: essential hypertension: hypertension can be divided into constitutional and the large class of Secondary cases two.In most patient, hypertensive etiology unknown, is referred to as essential hypertension, and account for that total hypertension more than 95%.

Secondary hypertension: be secondary to other diseases.Modal is caused by kidney and adrenal gland diseases, and endocrine hypertension.

Complication: in China, the modal complication of hypertension is cerebrovas-cularaccident, is secondly hypertensive heart disease heart failure, then is renal failure.More rare but serious complication is dissecting aneurysm of aorta.During hypertensive patients lower limb atherosclerosis, lower limb pain, limping can be caused.

Hypertensive crisis: be the concurrent a kind of extremely critical disease of hyperpietic, under bad inducement of being everlasting impact, blood pressure is raised to more than 26.6/16 kPa (200/120 millimetres of mercury) suddenly, occurs the critical disease of the acute lesion of the heart, brain, kidney.

Hypertensive retinopathy: refer to that systemic arterial blood pressure persistence raises, blood-retina barrier destruction, plasma leakage, Ink vessel transfusing visible component is caused to ooze out, producing retinal edema, hemorrhage, ischemia or ooze out the pathological changes such as speckle, can there is detachment of retina in severe patient.

Chinese medicine is thought, hypertension belongs to the categories such as motherland's medical science " dizzy ".Dizzy is that cause wind, fire, expectorant, stasis of blood pathogen upward attacking orifices in head or damage of essence insufficiency of blood, YANG-orifices failing to be nourished is basic pathogenesis, the class disease being main clinical manifestation with dizzy, dim eyesight due to feelings will, diet internal injury, the empty prolonged illness of body, lose blood overstrain and the cause of disease such as wound, operation.Etiology and pathogenesis: 1. feelings will internal injury innate excess of YANG in the body, in addition excessively angry, excessive rising of liver-YANG, sun rises pneumatic, sends out as dizzy; Or because of long-term melancholy angry, stagnated QI transforming into fire, makes liver-yin secretly consume, excessive rising of liver-YANG, and sun rises pneumatic, pathogen upward attacking orifices in head, sends out as dizzy.2, eating and drinking without temperance, impairing the spleen and stomach, weakness of the spleen and stomach, no resource of generating and transforming QI and blood, YANG-orifices failing to be nourished and do dizzy; Or delicious food of being addicted to drink, hungry full overstrain, hinders in taste, strong fortune mistake department, so that indigestion is precise and tiny, accumulatively wet raise phlegm, stagnation of phlegm-damp in middle-JIAO, and turbid YIN failing to descend, causes dizzy.3. wound, operation injury of head or Post operation, qi depression to blood stasis, numbness hinders clear key, sends out as dizzy.4. body void, prolonged illness, lose blood, the kidney being the origin of congenital constitution for overstrain, the raw marrow of store essential substances, if congenital defect, kidney essense is not filled, or old deficiency of the kidney, or prolonged illness is impairment of the kidney, or excess of sexual intercourse, cause deficiency of kidney-essence, can not marrow be given birth to, and the brain being the reservoir of the marrow, deficiency of marrow-reservoir, all empty up and down, and occur dizzy.Or chronic deficiency of kidney-YIN, the liver failing to be nourished, so that deficiecny of liver-YIN, the moon sun not processed, excessive rising of liver-YANG, sends out as dizzy.Serious disease prolonged illness or after losing blood, empty and multiple, or overstrain, QI and blood declines few, QI and blood deficiency, and the deficiency of vital energy then clear sun is not opened up, and blood deficiency then brain is become homeless foster, all can occur dizzy.

Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs: 1, excessive rising of liver-YANG symptom: vertigo and tinnitus, headache and swollen, meet labor, angryly to increase the weight of, limb fiber crops are trembled, insomnia and dreamful sleep, being irritable and getting angry easily, red tongue with yellow fur, stringy pulse.2, flaming up of liver-fire symptom: dizzy and pain, its gesture is more acute, red eyes and bitter taste in the mouth, distending pain in the chest and hypochondrium, irritable, few dreaminess of sleeping, yellow urine, constipation with dry stool, red tongue with yellow fur, wiry and frequent pulse.3, the turbid upper illiteracy symptom of expectorant: dizzy, heaviness of the head as being covered, rotates depending on thing, uncomfortable in chestly to do evil, and vomiting sputum, lack of appetite drowsirness, tongue is greasy in vain, stringy and rolling pulse.4, obstruction of the orifices by blood stasis symptom: dizziness and headache, is doublely shown in forgetful, and insomnia, cardiopalmus, lassitude, Hiccough and deaf, face purple lip is dark, tongue petechia or ecchymosis, stringy and hesitant pulse or carefully puckery.5, deficiency of qi and blood symptom: have a dizzy spell, dynamic then aggravate, meet Lao Zefa, complexion an ancient wine vessel made of horn is white, lustrelessness of the nails, spiritlessness and weakness, palpitation and sleeplessness, poor appetite lack of appetite, loose stool, and pale tongue with thin fur is white, thready and weak pulse.6, hepatic and renal YIN deficiency symptom: dizzy of a specified duration endlessly, visual deterioration, two dryness and uneasy feeling of the eye, sleep forgetful less, vexed xerostomia, tinnitus, spiritlessness and weakness, soreness of waist and knee, seminal emission, red tongue with thin fur, stringy and thready pulse.

Western medical treatment hypertension medicine is treated: (one) angiotensin converting enzyme inhibitor: apply captopril, enalapril at present.(2) calcium antagonist: be that one group of chemical constitution is different, the medicine that mechanism of action is also not quite similar.Owing to suppressing calcium ion by flowing in calcium channel on cell membrane, be thus called calcium-channel antagonists.Common drug has verapamil, diltiazem and nifedipine, nitrendipine.(3) vasodilation: directly lax vascular smooth muscle, blood vessel dilating, reduces blood pressure.Common drug has: 1. sodium nitroprusside.2. Minoxidil.3. Aiselazine.(4) depressor of sympathetic nervous system is acted on.1. central sympathetic nerve depressant: (1) clonidine; (2) methyldopa.2. sympathetic block agent.Dust head has arfonad, for the treatment of hypertensive encephalopathy.3. blocker after sympathetic ganglion.In making sympathetic nerve end slightly, norepinephrine storage is exhausted, and reaches the object of blood pressure lowering.Common drug has: (1) guanethidine.(2) reserpine.4. adrenergic receptor blocker.(1) beta-blocker; Labetalol is the depressor that WHO recommends.Acebutolol.(2) α receptor blocking agent: dust head has prazosin.Doxazosin.(5) diuretic antihypertensive medicine.1. thiazide: be most widely used oral diuretic antihypertensive medicine, hydrochlorothiazide; 2. chlortalidone; 3. furosemide; 4. triamterene.But western medical treatment hypertension is longer for the course for the treatment of, drug usage individuation, the a large amount of depressor of long-term use in conjunction easily produces drug resistance, and lessen the curative effect, adverse effect is more, clinical efficacy is not satisfactory, causes certain stress to patient, affects the quality of life of patient.

But Chinese medicine hypertension, utilizes Traditional Chinese medical theory, there is unique advantage and feature: with complete System of Chinese medicine for instructing, by adjusting overall QI-blood circulation, regulating neural and Humoral immunity system etc., carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, for similar disease magnetic target therapy, indication is wider, evident in efficacy, the course for the treatment of is shorter, not easily produces drug resistance, untoward reaction is less, convenient drug administration, patient is easy to accept, and can significantly improve the quality of life of patient.

 

Summary of the invention

Technical problem to be solved by this invention is, provides one and has invigorating QI and blood, effect of invigorating the spleen and stomach, cures mainly the Chinese medicine composition of hypertension deficiency of qi and blood card.The present invention utilizes Traditional Chinese medical theory, has unique advantage and feature: with complete System of Chinese medicine for instructing, by adjusting overall QI-blood circulation, regulate neural and Humoral immunity system etc., carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, for similar disease magnetic target therapy, indication is wider, evident in efficacy, the course for the treatment of is shorter, not easily produces drug resistance, untoward reaction is less, convenient drug administration, patient is easy to accept, and can significantly improve the quality of life of patient.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of hypertension deficiency of qi and blood card, wherein, Flos Rosae Rugosae, Radix Et Rhizoma Nardostachyos, Aspongopus, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, fevervine, Rhizoma et radix valerianae, Ganoderma, Caulis Polygoni Multiflori, Concha Margaritifera, Radix Glycyrrhizae, Fructus Hippophae, Semen Sesami Nigrum, Fructus Ligustri Lucidi, Fructus Mori, Rhizoma Polygonati, Herba Ecliptae, Luciobrama macrocephalus (Lacepede), Herba Carlinae biebersteinii, Extract Carnis Bovis, Herba Gnaphalii Affinis, Radix Glycyrrhizae Preparata, Polyalthia nemoralis A. D C., Phyllanthus simplex Retz．, Caulis Perillae, Cornu Elaphuri pantotrichum, Placenta Hominis, Radix Ranunculi Ternati, Herba seu radix metaplexis, Pyritum, gelatinum oxhide, Radix Asteris and Holotrichia diomphalia Bates.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be: Flos Rosae Rugosae 15-30 weight portion, Radix Et Rhizoma Nardostachyos 10-25 weight portion, Aspongopus 12-24 weight portion, Fructus Hordei Germinatus 14-32 weight portion, Endothelium Corneum Gigeriae Galli 10-23 weight portion, fevervine 14-25 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Ganoderma 10-24 weight portion, Caulis Polygoni Multiflori 15-25 weight portion, Concha Margaritifera 10-20 weight portion, Radix Glycyrrhizae 10-22 weight portion, Fructus Hippophae 10-20 weight portion, Semen Sesami Nigrum 14-34 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 12-24 weight portion, Rhizoma Polygonati 10-20 weight portion, Herba Ecliptae 10-25 weight portion, Luciobrama macrocephalus (Lacepede) 10-20 weight portion, Herba Carlinae biebersteinii 13-24 weight portion, Extract Carnis Bovis 10-20 weight portion, Herba Gnaphalii Affinis 12-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Polyalthia nemoralis A. D C. 14-26 weight portion, Phyllanthus simplex Retz． 10-20 weight portion, Caulis Perillae 14-25 weight portion, Cornu Elaphuri pantotrichum 10-20 weight portion, Placenta Hominis 10-22 weight portion, Radix Ranunculi Ternati 12-24 weight portion, Herba seu radix metaplexis 10-20 weight portion, Pyritum 10-26 weight portion, gelatinum oxhide 13-26 weight portion, Radix Asteris 10-27 weight portion and Holotrichia diomphalia Bates 10-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be: Flos Rosae Rugosae 25-30 weight portion, Radix Et Rhizoma Nardostachyos 20-25 weight portion, Aspongopus 12-20 weight portion, Fructus Hordei Germinatus 14-22 weight portion, Endothelium Corneum Gigeriae Galli 10-16 weight portion, fevervine 14-20 weight portion, Rhizoma et radix valerianae 10-15 weight portion, Ganoderma 10-14 weight portion, Caulis Polygoni Multiflori 15-20 weight portion, Concha Margaritifera 10-15 weight portion, Radix Glycyrrhizae 15-22 weight portion, Fructus Hippophae 15-20 weight portion, Semen Sesami Nigrum 14-24 weight portion, Fructus Ligustri Lucidi 15-20 weight portion, Fructus Mori 12-20 weight portion, Rhizoma Polygonati 15-20 weight portion, Herba Ecliptae 10-20 weight portion, Luciobrama macrocephalus (Lacepede) 15-20 weight portion, Herba Carlinae biebersteinii 13-20 weight portion, Extract Carnis Bovis 15-20 weight portion, Herba Gnaphalii Affinis 12-20 weight portion, Radix Glycyrrhizae Preparata 15-20 weight portion, Polyalthia nemoralis A. D C. 14-20 weight portion, Phyllanthus simplex Retz． 10-15 weight portion, Caulis Perillae 14-20 weight portion, Cornu Elaphuri pantotrichum 15-20 weight portion, Placenta Hominis 15-22 weight portion, Radix Ranunculi Ternati 12-20 weight portion, Herba seu radix metaplexis 15-20 weight portion, Pyritum 10-20 weight portion, gelatinum oxhide 13-20 weight portion, Radix Asteris 10-17 weight portion, Holotrichia diomphalia Bates 15-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be: Flos Rosae Rugosae 20 weight portion, Radix Et Rhizoma Nardostachyos 15 weight portion, Aspongopus 24 weight portion, Fructus Hordei Germinatus 25 weight portion, Endothelium Corneum Gigeriae Galli 23 weight portion, fevervine 25 weight portion, Rhizoma et radix valerianae 20 weight portion, Ganoderma 24 weight portion, Caulis Polygoni Multiflori 25 weight portion, Concha Margaritifera 20 weight portion, Radix Glycyrrhizae 14 weight portion, Fructus Hippophae 12 weight portion, Semen Sesami Nigrum 30 weight portion, Fructus Ligustri Lucidi 14 weight portion, Fructus Mori 24 weight portion, Rhizoma Polygonati 12 weight portion, Herba Ecliptae 25 weight portion, Luciobrama macrocephalus (Lacepede) 13 weight portion, Herba Carlinae biebersteinii 24 weight portion, Extract Carnis Bovis 12 weight portion, Herba Gnaphalii Affinis 25 weight portion, Radix Glycyrrhizae Preparata 12 weight portion, Polyalthia nemoralis A. D C. 26 weight portion, Phyllanthus simplex Retz． 20 weight portion, Caulis Perillae 25 weight portion, Cornu Elaphuri pantotrichum 12 weight portion, Placenta Hominis 14 weight portion, Radix Ranunculi Ternati 24 weight portion, Herba seu radix metaplexis 12 weight portion, Pyritum 26 weight portion, gelatinum oxhide 26 weight portion, Radix Asteris 27 weight portion, Holotrichia diomphalia Bates 12 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material also can be: Flos Rosae Rugosae 25 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Aspongopus 12 weight portion, Fructus Hordei Germinatus 22 weight portion, Endothelium Corneum Gigeriae Galli 16 weight portion, fevervine 18 weight portion, Rhizoma et radix valerianae 15 weight portion, Ganoderma 14 weight portion, Caulis Polygoni Multiflori 20 weight portion, Concha Margaritifera 15 weight portion, Radix Glycyrrhizae 22 weight portion, Fructus Hippophae 20 weight portion, Semen Sesami Nigrum 24 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 18 weight portion, Rhizoma Polygonati 15 weight portion, Herba Ecliptae 20 weight portion, Luciobrama macrocephalus (Lacepede) 15 weight portion, Herba Carlinae biebersteinii 19 weight portion, Extract Carnis Bovis 20 weight portion, Herba Gnaphalii Affinis 15 weight portion, Radix Glycyrrhizae Preparata 15 weight portion, Polyalthia nemoralis A. D C. 15 weight portion, Phyllanthus simplex Retz． 15 weight portion, Caulis Perillae 20 weight portion, Cornu Elaphuri pantotrichum 20 weight portion, Placenta Hominis 22 weight portion, Radix Ranunculi Ternati 20 weight portion, Herba seu radix metaplexis 20 weight portion, Pyritum 20 weight portion, gelatinum oxhide 20 weight portion, Radix Asteris 17 weight portion, Holotrichia diomphalia Bates 20 weight portion.

For solving the problems of the technologies described above, present invention also offers one and treat the hypertensive Chinese medicine composition of deficiency of both QI and blood type, when the dosage form of described Chinese medicine composition is capsule, its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.12 ~ 0.4:0.15 ~ 0.3, incapsulate in housing, obtain capsule by described capsule 's content.

When the dosage form of described Chinese medicine composition is injection, its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

The dosage form of described Chinese medicine composition is: tablet, capsule, syrup, suck agent, granule, sublimed preparation, solution, electuary, injection, oral liquid, suppository, plaster, honey pill agent, powder, liniment, enema and patch.

Described Chinese medicine composition, medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, and every 7 days is a course for the treatment of; When this Chinese medicine composition is oral liquid use, 4-5 time on the one, every day 7 is a course for the treatment of; When this Chinese medicine composition is honey pill agent, capsule use, 3 times on the one, every 7 days is a course for the treatment of.

The invention has the beneficial effects as follows: the present invention has invigorating QI and blood, effect of invigorating the spleen and stomach, cure mainly hypertension deficiency of qi and blood card.The present invention treats hypertension and utilizes Traditional Chinese medical theory, has unique advantage and feature: with complete System of Chinese medicine for instructing, by adjusting overall QI-blood circulation, regulate neural and Humoral immunity system etc., carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, for similar disease magnetic target therapy, indication is wider, evident in efficacy, the course for the treatment of is shorter, not easily produces drug resistance, untoward reaction is less, convenient drug administration, patient is easy to accept, and can significantly improve the quality of life of patient.

 

Detailed description of the invention

Chinese medicine is thought, the primary disease cause of disease is many by feelings will, injury due to diet, and loses blood, caused by wound, overstrain.Its sick position is at clear key, and by brains inanition, YANG-orifices failing to be nourished and phlegm-fire, blood stasis are violated caused by clear key, relevant with the dirty functional disorder of liver,spleen,kidney three, its morbidity is in the majority with deficiency syndrome.Excess syndrome is more common in the onset of vertigo phase clinically, common with excessive rising of liver-YANG, flaming up of liver-fire, the turbid upper illiteracy of expectorant, obstruction of the orifices by blood stasis four type, respectively with TIANMAGOUTENG soup suppressing the hyperactive liver and subsiding YANG, and nourishing the liver and kidney; With Decoction of Gentiana for Purging the Liver-fire purging liver-fire, eliminating damp-heat; With banxia baizhu tianma decoction removing dampness and eliminating phlegm, invigorating the spleen and regulating the stomach; With TONGQIAOHUOXUE Decoction blood circulation promoting and blood stasis dispelling, sensible active.Deficiency syndrome are more common in the catabasis, common with deficiency of qi and blood, hepatic and renal YIN deficiency amphitypy, respectively with GUIPI TANG invigorating QI and blood, and invigorating the spleen and stomach; With Bolus as a Kidney-Yin-Tonic nourishing the liver and kidney, yin nourishing replenishing essence.Due to dizzy be the mutual conversion of deficiency syndrome and excess syndrome in pathological manifestations, or simulataneous insufficiency and excessive, therefore general anxious person is how partially real, and the methods such as the YANG hyperactivity suppressing that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., clearing away fire and eliminating phlegm, blood circulation promoting and blood stasis dispelling can be selected to be designated as master to control it; Slow person is how partially empty, when by methods such as invigorating QI and blood, kidney tonifying, nourishing the liver, spleen invigorating based on Zhi Qiben.

Therefore, the present invention treats hypertension deficiency of qi and blood card with invigorating QI and blood, invigorating the spleen and stomach is primary treatment principle, selects prescription: Flos Rosae Rugosae, Radix Et Rhizoma Nardostachyos, Aspongopus, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, fevervine, Rhizoma et radix valerianae, Ganoderma, Caulis Polygoni Multiflori, Concha Margaritifera, Radix Glycyrrhizae, Fructus Hippophae, Semen Sesami Nigrum, Fructus Ligustri Lucidi, Fructus Mori, Rhizoma Polygonati, Herba Ecliptae, Luciobrama macrocephalus (Lacepede), Herba Carlinae biebersteinii, Extract Carnis Bovis, Herba Gnaphalii Affinis, Radix Glycyrrhizae Preparata, Polyalthia nemoralis A. D C., Phyllanthus simplex Retz．, Caulis Perillae, Cornu Elaphuri pantotrichum, Placenta Hominis, Radix Ranunculi Ternati, Herba seu radix metaplexis, Pyritum, gelatinum oxhide, Radix Asteris and Holotrichia diomphalia Bates.

Wherein, Flos Rosae Rugosae, Radix Et Rhizoma Nardostachyos, Aspongopus, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, fevervine, regulating qi-flowing for strengthening spleen help digestion; Rhizoma et radix valerianae, Ganoderma, Caulis Polygoni Multiflori, Concha Margaritifera are dispeled the wind, nourishing blood to tranquillize the mind; Radix Glycyrrhizae, Fructus Hippophae, Semen Sesami Nigrum, Fructus Ligustri Lucidi, Fructus Mori, Rhizoma Polygonati, Herba Ecliptae benefiting QI and nourishing blood, nourishing the liver and kidney; Luciobrama macrocephalus (Lacepede), Herba Carlinae biebersteinii, Extract Carnis Bovis, Herba Gnaphalii Affinis, Radix Glycyrrhizae Preparata, Polyalthia nemoralis A. D C., Phyllanthus simplex Retz．, Caulis Perillae invigorating the spleen and stomach; Cornu Elaphuri pantotrichum, Placenta Hominis, Radix Ranunculi Ternati, Herba seu radix metaplexis, Pyritum, gelatinum oxhide, Radix Asteris and Holotrichia diomphalia Bates invigorating QI and blood.

Now each taste Chinese medicine is described below:

Flos Rosae Rugosae: warm in nature, sweet and slightly bitter taste, returns liver spleen channel.Supplementary Amplifications of the Compendium of Materia Medica: " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia." " book on Chinese herbal medicine is new again ": " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, loose tired pain relieving.Flos Rosae Rugosae and Herb have convergence, can be used for woman in menstrual period too much, and leucorrhea with red and white discharge and enteritis, dysentery, the red half of intestinal are hemorrhage.To regulate the flow of vital energy resolving depression and blood dissipating blood stasis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.Containing 300 various chemical components in Flos Rosae Rugosae, as the alcohol of fragrance, aldehyde, fatty acid, phenol and containing the oil of essence and fat, to wake up stomach with easing the affected liver in normal food Flos Rosae Rugosae goods, have a respite and invigorate blood circulation, looks improving and the skin nourishing, make us refreshing refreshing.

Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.Jatamansi volatile oil has faint antibacterial, wind dispelling and spasmolysis, to skin, mucosa without local irritation.Jatamansi is to rabbit hemostasis, and rabbit performance is to the bradykinesia, sleepy, the loss of appetite that stimulate.Radix Et Rhizoma Nardostachyos alcohol extract has blood pressure lowering and antiulcer action.

Aspongopus: warm in nature, salty in the mouth; Return liver,spleen,kidney warp." book on Chinese herbal medicine newly organized ": " Aspongopus, in worm to good person, enter ball loose in, weak the most suitable to hold up.But should not decoction be entered) sliding with its property, probably dynamic stool ear.The thing of Aspongopus also emerging sun, right non-Radix Ginseng.The Rhizoma Atractylodis Macrocephalae, Radix Morindae Officinalis.Herba Cistanches, Fructus Psoraleae and so on, also have no its large effect also." regulating QI to relieve pain, warming middle-JIAO is supporing yang.For cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.Aspongopus has stronger antibacterial action to staphylococcus aureus, Bacillus typhi, Salmonella paratyphi, shigella flexneri; And have promotion body metabolism.

Fructus Hordei Germinatus: sweet is flat.Return spleen, stomach warp." herbal classic is met former ": " Fructus Setariae Germinatus, opens spleen feed, alleviating distention in middle-JIAO rapid digestion of food, and can invigorating middle warmer, gram to cut also not like Fructus Hordei Germinatus." " Chinese crude drug handbook ": " control insufficiency of the spleen, the heart is had a stomachache, and distension, pyretic toxicity dysentery, excessive thirst, becomes thin." Compendium of Material Medica: " and the appetizing of fast spleen, the therapeutic method to keep the adverse QI flowing downwards and in, promoting digestion and removing stagnation." help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.It is stagnant that Fructus Setariae Germinatus (parched to brown) is apt to eliminate indigestion, do not disappear for stagnant.These product help digestion and in, effect is gentle, the aid digestion and gas that do not injure one's stomach.Normal and Fructus Hordei Germinatus mutual reinforcement between is use, to improve curative effect.Fructus Setariae Germinatus has antiallergic activity by suppressing mast cell histamine release.

Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, enter spleen, stomach, small intestinal, urinary bladder channel, " Japan hanako materia medica ": " stopping leak essence, and hematuria, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, dysentery." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition." have strengthening the spleen to promote digestion, arresting seminal emission to stop the effect of drowning, be mainly used in the distension and fullness in the abdomen of food stagnation stagnation, heating installation is suffered from diarrhoea, the symptoms such as infant malnutrition, and Endothelium Corneum Gigeriae Galli can promote gastric secretion, strengthens gastric peristalsis, accelerate the effects such as gastric emptying.Healthy People oral Grilled chicken Endothelium corneum powder 5g, through 45-60 minute, gastric secretion increases 30-37% than control value, recovers normal in 2 hours.Gastric acidity is also obviously increased.Endothelium Corneum Gigeriae Galli water decoction is got rid of radiostrontium to acceleration and is had certain effect.The food digesting action of Endothelium Corneum Gigeriae Galli be not medicine in the local action of gastric or directly stimulating intestine and stomach is kinetic, may be to enter blood after medicine digestion to stimulate gastric gland secretion increase and play indirect digestion-aid effect.

Fevervine: property is put down, sweet in the mouth, micro-hardship." the SHENGCAO property of medicine is standby to be wanted ": " its head controls new internal injury, and pot is carnivorous, and tonify deficiency kidney tonifying, except fire is enriched blood; Wash skin ulcer pain relieving, the loose poison of the heat that disappears.Its leaf beats rice with confectionery, dysentery relieving." " Zhiwu Mingshi Tukao ": " be wash, removing toxic substances, removes wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain sedation.Fevervine total alkaloids can suppress myenteron to shrink, and the myenteron contracture caused by energy antagonism acetylcholine.Fevervine decoct has inhibitory action to S. aureus in vitro and Fu Shigella flexneri, and extractum also has bacteriostasis to staphylococcus aureus and streptococcus pneumoniae.

Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel." Traditional Chinese Medicine in Sichuan will ": " control cranial nerve and the heart, stomach is weak, the not normal and urine of chronic forms collapses." control irritability, stomach is weak, lumbago, menoxenia, traumatic injury.Apply its effect of calming the nerves and can be used for the treatment disease such as malaise, cardiopalmus dreaminess, can with the compatibility such as Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori; Another with Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, the same use of Flos Carthami, can be used to the disease for the treatment of abdominal pain in menstruation, soreness of the waist and knees, bone fracture and injury.Rhizoma et radix valerianae has quelling to act on to central nervous system, can stabilize nerve when excited, then can help to refresh when fatigue.Rhizoma et radix valerianae epoxy three ester contained by Rhizoma et radix valerianae root can help to alleviate spasm and pain, contributes to relaxing neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flowers Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other disorder, also can relax one's muscles simultaneously, make environment oil recover stable state.

Ganoderma: the Ganoderma that Ganoderma makes medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma, and its property of medicine is sweet, flat.GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Zoopery and clinical trial all show, Ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.Polysaccharide contained by Ganoderma, polypeptide etc. have obvious function of delaying senility.Extract energy exciting motion suppresses, mobility is reduced, coordination exercise is lacked of proper care, presents the sick effect in dose-dependent town, can curtail sleep to hexobarbital sleep effect, the time that central stimulants caffeine causes spasm and death can be extended, these results show, Ganoderma is inhibition effect to maincenter.

Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel, have effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulate the menstrual flow, the detumescence of blood vessel dilating, blood circulation promoting, stimulating milk secretion.Have promotion hemopoietic function, strengthen immunologic function, blood fat reducing and atherosclerosis, protect the liver, and Radix Polygoni Multiflori contains the effective ingredient such as chrysophanol, emodin, chrysophanic acid, physcione, fatty oil, starch, saccharide, rhaponticin, lecithin.Pharmacological research proves, Radix Polygoni Multiflori can promote the conversion of human lymphoblastoid cell.Still there is effects such as reducing serum cholesterol, arteriosclerosis, anti-light poison.

Concha Margaritifera: salty, cold.Return liver, heart channel." Chinese medicine voluminous dictionary ": " liver nourishing is cloudy, clearing away liver-fire.Control demented infantile convulsion, dizziness, tinnitus, heart beating, pleuroperitoneum is swollen, women's heat in blood, metrorrhagia, and frightened the jerking of children's sends out convulsion." suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia.The nacreous layer injection such as Pteria martensii Dunker and scrimp hat freshwater mussel have protective effect to carbon tetrachloride hepatic injury, and hepatocellular damage can be made to alleviate, and the recovery of glutamate pyruvate transaminase is accelerated.The contraction of the guinea pig in vitro intestinal tube that hydrochloric acid or sulphuric acid hydrolysis product all can suppress histamine to cause.With Margarita powder to mouse stomach, can obviously reduce its autonomic activities, and have obvious synergism to the CNS inhibition of pentobarbital sodium; The sulfate hydrolyzate of Concha Margaritifera, can increase the heartbeat amplitude of isolated heart.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.

Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, and allevating angina pectoris shows effect, and prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can gastric duodenal ulcer and dyspepsia etc. be treated, evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Good therapeutical effect is had to burn, scald, cutter burning, cold injury; Good therapeutic effect is had to cervical erosion.Containing 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside, Quercetin, nimbecetin in sea buckthorn fruit, there is cough-relieving, the usefulness of eliminating the phlegm, expanding coronary vasodilator, reducing cholesterol of relievining asthma, be usually used in treating ischemic heart desease, 94% is reached to treatment angina pectoris effective percentage.In Fructus Hippophae, SOD active component enriches, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical because substance in vivo peroxidating produces, and the generation of this free radical and human senility, disease is closely related.

Semen Sesami Nigrum: sweet, flat.Return liver, kidney, large intestine channel.Invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.The multiple essential amino acid that Semen Sesami Nigrum contains, under the effect of vitamin E and vitamin B1 participates in, can accelerate the metabolic function of human body; The ferrum that Semen Sesami Nigrum contains and vitamin E are the important component of prevention anemia, activating brain cell, elimination blood vessel cholesterol; The fat that Semen Sesami Nigrum contains is mostly unsaturated fatty acid, has the effect of life lengthening.Chinese medicine theory is thought, Semen Sesami Nigrum has invigorating the liver and kidney, moistening five ZANG-organs, physical strength profiting, longue meat, fills out the effect of brains, can be used for treating dizzy, early whitening of beard and hair, alopecia, soreness of the waist and knees, limbs fatigue caused by Liver and kidney asthenia of essence and blood, walk with difficulty, the dry dried and withered hairs of deficient five internal organs, skin, the disease such as dryness of the intestine constipation, effect in blacking hair and nourishing face, celebrated especially.Arisaema Cum Bile: bitter cold, micro-pungent, cool.Return lung, liver, spleen channel." book on Chinese herbal medicine converges and says ": " control infantile convulsion and shy expectorant, tic of the limbs, adult's deficiency of vital energy interior-heat, the raw expectorant of heat stagnation." " medicineization justice ": " cures mainly all apoplexy, acute infantile convulsion, infantile convulsion, wind syndrome of head, dizzy, and old god is slow-witted, and children's sends out and jerks, puerperal severe palpitation." Compendium of Material Medica: " makes Arisaema Cum Bile method: grind into powder so that Rhizoma Arisaematis is raw, twelfth month gets yellow withered Fel Bovis seu Bubali, and mediating recipe is included in gallbladder, and be that it is done by outstanding wind place, Nian Jiuzhe is more good." clearing away fire and eliminating phlegm, relieving convulsion fixed chronic.Control middle wind-phlegm fan, infantile convulsion epilepsy, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo." book on Chinese herbal medicine converges and says ": " control infantile convulsion and shy expectorant, tic of the limbs, adult's deficiency of vital energy interior-heat, the raw expectorant of heat stagnation." removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins Herba Ecliptae, and Fructus Mori are equal to use, controls fever due to yin deficiency, often joins Cortex Lycii, and Radix Rehmanniae is equivalent to be used.Compendium of Material Medica is recorded: " to insult winter verdant for this wood, has the behaviour that chastity is kept, therefore with Fructus Ligustri Lucidi shape it ... to put wax insect time near, therefore be commonly called as wax tree." Fructus Ligustri Lucidi can promote leukocyte, strengthens effect of immunologic function, has stronger inhibitory action to staphylococcus aureus, dysentery bacterium.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.

Fructus Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.Containing trypsininhibitory substance in Fructus Mori, cause the digestive enzyme in intestinal can not destroy C type and produce bacillus capsulatus B toxin, and causing bleeding property enteritis.Fructus Mori fatty acids, excessive eating can produce irritation to digestive tract.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.In vitro tests shows, Rhizoma Polygonati water extraction fluid (1: 320) has inhibitory action to Bacillus typhi, staphylococcus aureus, acid-fast bacilli, and 2% Rhizoma Polygonati has inhibitory action in various degree to common causative fungus in sabouraud culture medium.Rabbit gavage Rhizoma Polygonati extractum, its blood sugar content increases gradually, then reduces.The blood glucose that Rhizoma Polygonati extractum causes epinephrine is too high in remarkable inhibitory action.Rhizoma Polygonati decoct, 20% concentration is soaked Folium Mori and is fed silkworm, has the effect extending the silkworm larva phase.

Herba Ecliptae: cool in nature, sweet in the mouth acid.Tang Materia Medica: " main dysentery.Acupuncture skin ulcer is sent out, and big vast blood can not the person of stopping apply it; Juice is coated with sends out an eyebrow, raw speed and numerous." " classifying herbal ": " hemostasis, the kidney invigorating, annealing, detumescence.Control pouring, collapse." there is effect of cooling blood for hemostasis, the kidney invigorating and essence nourishing, be usually used in treatment haematemesis, epistaxis, hematuria, have blood in stool, the disease such as dysentery, knife injury are hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.Apply hemorrhage place with Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) blade of grass powder and oppress a little, having good haemostatic effect.The acute liver damage of Female guinea pigs to Carbon Tetrachloride Induced giving Herba Ecliptae extract in advance has significant protective effect.Herba Ecliptae has the effect increasing guinea pig isolated heart coronary flow, and ECG T wave is improved.Herba Ecliptae can improve the survival rate of mice in hypobaric hypoxia situation; Also the life of mice in normobaric hypoxia situation can obviously be extended.

Luciobrama macrocephalus (Lacepede): ecological environment: move in lower floor in rivers is the larger fish of ferociousness, is mainly food with Fish.Resource distribution: be distributed in the Changjiang river, the Zhujiang River and the Min River, tributary thereof.Nature and flavor are sweet; Property is put down.Return through spleen; Stomach; Kidney channel function cures mainly tonify deficiency strengthening the spleen stomach; Bone and muscle strengthening.Main eipathia asthenia; Incoordination between the spleen and stomach; Inappetence; Soreness of the waist and knees; Walk unfavorable.

Herba Carlinae biebersteinii: the sweet acid of nature and flavor; Micro-salty; Temperature.Return through spleen; Liver; Kidney channel.Function cures mainly strengthening the spleen and stomach; Replenishing QI and blood; Tune have through.Main insufficiency of the spleen lack of appetite; Dyspepsia; Deficiency of both QI and blood; Asthenic body; Have through uncomfortable.

Extract Carnis Bovis: nature and flavor are sweet; Warm in nature.Return through spleen channel.Function cures mainly strengthening the spleen and stomach; Fill blood; Moistening the lung and resolving the phlegm.Main asthenia is won thin; Apoplexy is attached undue importance to one thing to the neglect of the other; Phlegm retention painful abdominal mass is amassed; Skin sucutaneous nodule.

Herba Gnaphalii Affinis: nature and flavor are sweet is flat.1. " not Lu ": " sour in the mouth is nontoxic." 2. supplement to the Herbal: " sweet in the mouth is flat, nontoxic." 3. 《 Lv Cliff rock book on Chinese herbal medicine ": " warm in nature flat, nontoxic." 4. " medicine class on the analogy of natural things ": " gas heat, sour in the mouth." returning through " Thunder God concocts property of medicine solution ": " enters lung meridian." function cures mainly and reduces phlegm, cough-relieving, cold-dispelling.Control cough with copious phlegm, asthma, cold, favism, bones and muscles pain, leucorrhea, carbuncle and ulcer.1. " not Lu ": " main numbness cold and heat, cough-relieving.QI invigorating in " 2. " Japan hanako materia medica ": " tune, stopping leak, expectorant, pressure seasonal epidemic pathogens, reduces phlegm and internal heat and coughs." 3. 《 Lv Cliff rock book on Chinese herbal medicine ": " is controlled greatly taste and is done to ache." 4. " medicine class on the analogy of natural things ": " controls cough of cold type and expectorant, and except the lung being invaded by pathogenetic cold, rise higher lung qi." 5. " product remittance essence is wanted ": " controls cold, the phlegmatic cough of cold physique drink, and be not recovered person year in year out for a long time." 6. " book on Chinese herbal medicine just ": " large warming the lung gas, only cough of cold type, loose mental disorder, separate wind and cold cold and heat, also stopping leak rushes down." 7. " detailed outline is picked up any lost article from the road ": " controls capsule pruritus due to wind-damp pathogen, decocts soup and washes; More youngster's infantile malnutrition, syphilis, primary sore, decocts with Radix Glycyrrhizae and washes." 8. " Tian Bao book on Chinese herbal medicine ": " deinsectization, analgesic therapy.Control infantile convulsion, the stagnation of QI as all." 9. " modern Practical Chinese medicinal ": " controls non-infectious ulcer and wound, takes the curative into hypotensive agent and gastric ulcer orally." 10. " Nanjing medicinal herbs among the people ": " clothes of steeping in wine, control bones and muscles pain."

Radix Glycyrrhizae Preparata: nature and flavor are sweet is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

Polyalthia nemoralis A. D C.: ecological environment: under being born in mountain half way up the mountain thick forest.Resource distribution: the ground such as distribution Guangdong.Containing the alkaloid pyrithione zinc (zincpolyanemine) containing zinc in chemical analysis root.Nature and flavor are sweet; Flat.Return through spleen; Stomach; Kidney channel.Function cures mainly and strengthens the spleen and stomach; Nourishing kidney controlling nocturnal emission with astringent drugs.Main chronic gastritis; Taste lose; Inappetence; Myasthenia of limbs; Seminal emission.

Phyllanthus simplex Retz．: nature and flavor are " Nanning City's medicine will " 1.: " sweetness and bitterness." 2. " Guangxi Chinese medicinal herbal ": " is sweet, flat." 1. function cures mainly " Nanning City's medicine will ": " herb: help digestion, nebula removing.Control infantile malnutrition and infantile malnutrition is pleasing to the eye." 2. " register planted by Guangxi medicine ": " herb: tonifying the spleen and stomach, controls gonorrhea, and bone is choked larynx, infantile malnutrition.Root: control galactapostema."

Caulis Perillae: property acrid-sweet flavor, tepor.1. " detailed outline ": " pungent, temperature, nontoxic." 2. " medicineization justice ": " sweet in the mouth is micro-pungent, slightly warm in nature." 3. " book on Chinese herbal medicine is high former ": " abnormal smells from the patient is pungent, flat." returning through " medicineization justice ": " enters spleen, stomach, lung three warp." function cures mainly and regulates the flow of vital energy, Shu Yu, and pain relieving is antiabortive.Control the stagnation of QI, dyspepsia, chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well.1. " Bencao Tujing ": " a surname is ventilated malicious." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " lower all gas is slightly slow, and the slightly empty person of body is with suitable.The circulation of qi promoting of " 3. " explaining abstruseness of the canon of materia medica ": " energy is antiabortive." 4. " book on Chinese herbal medicine is high former ": " main alleviating distention in middle-JIAO circulation of qi promoting, disappear diet, and reduce phlegm saliva.Control dysphagia and regurgitation, only cardiac and abdominal pain." 5. " must join book on Chinese herbal medicine ": " is soothing the liver, and sharp lung, regulates the flow of vital energy, and blood, resolving depression, and pain relieving is coughed surely, antiabortive."

Cornu Elaphuri pantotrichum: nature and flavor are sweet, temperature.1. " book on Chinese herbal medicine covers bamboo fish trap ": " hot in nature." 2. " detailed outline ": " is sweet, temperature, nontoxic." return through 1. " key medicine divides agent ": " enters kidney channel." 2. " book on Chinese herbal medicine brief points ": " enters lunar, the shaoyin channel of foot." function cures mainly tonifying YANG, mends essence, strong muscle, beneficial blood.Control asthenia weakness and emaciation, soreness of the waist and knees, bones and muscles pain, impotence in male, infertilitas feminis.1. Tang Materia Medica: " the power victory Cornu Cervi Pantotrichum of clothes." 2. " book on Chinese herbal medicine cover bamboo fish trap ": " bone is soft is good for, and stem flaccidity can be held up." 3. " detailed outline ": " controls deficiency of YIN strain, all disorders of blood, muscles and bones soreness of waist and knee joint, nourishing YIN for benefiting the kidney."

Placenta Hominis: property sweet-salty, temperature.1. " book on Chinese herbal medicine covers bamboo fish trap ": " sweet in the mouth, the large temperature of gas, nontoxic." 2. " detailed outline ": " sweet-salty, temperature, nontoxic." 3. " medical center bun is wanted ": " sweetness and bitterness is salty, temperature." return through entering lung, liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter the heart, spleen, kidney three warp." 2. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, spleen meridian, kidney meridian." 3. " book on Chinese herbal medicine is new again ": " enters liver, lung, kidney three warp." function cures mainly QI invigorating, nourishes blood, benefit essence.Control deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, infertile or newborn few.1. supplement to the Herbal: " main vim and vigour weakness and emaciation, married woman strains, and face snore skin is black, all diseases gradually thin worried person in abdomen." 2. Wu's ball: " controls deficient labor pole, epilepsy, and mental confusion is in a trance, feels at ease to nourish blood, and QI invigorating mends essence." 3. " book on Chinese herbal medicine covers bamboo fish trap ": " is treated all void and is damaged in vain, and tuberculosis passes corpse, and control five kinds of strain and seven kinds of impairment, osteopyrexia and fever, larynx coughs hoarseness, the thin dried and withered hairs of body, tells nosebleed and comes red." 4. " about can cure mirror ": " ulna steams night sweat, and lumbago knee joint is soft, and the thin essence of body is withered, all can tonification." 5. " book on Chinese herbal medicine is new again ": " strongly invigorating primordial QI, treating blood disorders divides, and training the mind hinders nocturnal emission." 6. " modern Practical Chinese medicinal ": ", for neurasthenia, sexual impotence, infertile, urges into agent for paroxysmal pain again and promotes galactopoiesis agent." 7. " Shandong Chinese herbal medicine handbook ": " prevention measles."

Radix Ranunculi Ternati: nature and flavor sweet, acrid, warm.1. " Chinese crude drug handbook ": " taste is micro-sweet." 2. " Guangxi Chinese medicinal herbal ": " sour in the mouth is sweet, and property is put down, nontoxic." 3. " Henan Chinese herbal medicine handbook ": " acrid in the mouth, warm in nature." returning through " Guangxi Chinese medicinal herbal ": " enters liver, lung two warp." function cures mainly and controls scrofula, pulmonary tuberculosis, malaria.1. " Chinese crude drug handbook ": " control scrofula tuberculosis on neck." 2. " Henan Chinese herbal medicine handbook ": " subsides a swelling, preventing the attack (or recurrence) of malaria.Control scrofula, pulmonary tuberculosis."

Herba seu radix metaplexis: nature and flavor are sweet pungent is flat.1. " product remittance essence is wanted ": " sweet in the mouth is pungent, warm in nature, nontoxic." 2. " detailed outline ": " is sweet, micro-pungent." 3. " Sichuan rushes medicine will ": " property is put down, lightly seasoned, nontoxic." function cures mainly nourishing the essence and strengthening QI, lactogenesis, removing toxic substances.Control deficient impairment caused by overstrain, sexual impotence, leukorrhagia, galactostasis, red carbuncle toxin.1. TAO Hong-Jing: " nourishing the essence and strengthening QI, prosperous and powerful vagina." 2. " something lost lifted by book on Chinese herbal medicine ": " main Aranea, silkworm sting, folding extracting juice, in some skin ulcer, and the rotten silk of this juice, tonification of cooking.Leaf: argument heat is red, in Norway broken order.It is red swollen and snakeworm is malicious that " 3. " detailed outline ": " extracting juice applies erysipelas.Aranea hinders, and frequently controls unhealed, smashes inside back cover degree, and the rotten silk poison of energy, namely turns pus into also." 4. " medicine will is planted in Jiangsu ": " is decocted in water for oral dose, and controls temperature poison, antipyretic." 5. " Traditional Chinese Medicine in Sichuan will ": " circulation of qi promoting of enriching blood.Control deficient consumptive disease wound, lower milk." 6. " Chongqing medical herbs ": " controls weak leucorrhea."

Pyritum: nature and flavor are worked hard is flat.1. " Japan hanako materia medica ": " cool." 2. " Kaibao Bencao ": " acrid in the mouth is flat, nontoxic." 3. " medical center bun is wanted ": " is arduous, flat." returning through " beautiful Chinese catalpa medicine solution ": " enters kidney meridian, liver channel of foot-Jueyin." function cures mainly eliminating stasis to stop pain, reunion of bone.Control traumatic injury, tendon breaking is fractured, and blood stasis pain, gathers, goiter, skin infection, scalds.1. " Japan hanako materia medica ": " evacuation of pus, repercussive blood, reuniting the fractured tendons and bones.After managing property, blood is evil, and feel at ease, spasmolytic is throbbed with fear.With wine mill clothes." 2. " Kaibao Bencao ": " treats injured, and loose blood and relieving pain, removing mass gathers." 3. " beautiful Chinese catalpa medicine solution ": " removing blood stasis disappears wart, treats the genus of rheumatism paralysis.The power of removing dampness, same with pyrolusitum."

Gelatinum oxhide: nature and flavor are " detailed outline " 1.: " sweet, flat, nontoxic." 2. " book on Chinese herbal medicine converges and says ": " is sweet, puckery." return through entering lung, large intestine channel.1. " book on Chinese herbal medicine converges and says ": " just bright, Taiyin channels of starting with." 2. " about can cure mirror ": " enters Liver Channel." function cures mainly nourshing Yin and drynsessmoistening prescription, hemostasia and detumescence.Control asthenia consumptive lung disease, cough spitting of blood, tells nosebleed, metrorrhagia, injury from falling down.Carbuncle, scalds.1. supplement to the Herbal: " treat wind, stopping leak, tonify deficiency." 2. " detailed outline ": " controls haematemesis, epistaxis.Hematochezia, stranguria with blood, dysentery, under pregnant woman's fetal movement blood, rheumatism migratory arthralgia caused by wind pain, beats and flutters damage, and the bright skin ulcer of soup fire, all swollen ulcer drugs, promoting blood circulation and stopping pain, moisturizes, sharp intestine and small intestine." 3. " medical center bun is wanted ": " tonifying the lung clearing heat in the lung, nourishing YIN and benefiting blood, row water, sharp large intestine."

Radix Asteris: nature and flavor are bitter, temperature.1. " herbal classic ": " bitter in the mouth, temperature." 2. " not Lu ": " be pungent, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is flat." 4. " explaining abstruseness of the canon of materia medica ": " Xin Gan, tepor." return through entering lung meridian.1. " Thunder God concocts property of medicine solution ": " enter the heart, lung two warp." 2. " Bencao Jingshu ": " starts with lunar, double enter foot sun bright." function cures mainly warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, cough-relieving.Control cough due to wind and cold's asthma, asthenia coughs vomiting bloody pus, sore throat, dysuria.1. " herbal classic ": " main cough with dyspnea, in the heart cold and heat stagnation of QI remove diseases due to noxious agents produced by various parasites, flaccidity Jue, An Wuzang." 2. " not Lu ": " treats spitting bloody pus, and Zhichuan is throbbed with fear, and five kinds of over strain body is empty, tonifying for the deficiency, pediatric epilepsy scared." 3. " property of medicine opinion ": " tonify deficiency therapeutic method to keep the adverse QI flowing downwards, controls the inverse gas of the breast side of body, consumptive disease deficiency-heat." 4. Tang Materia Medica: " controls asthma, impotence." 5. " Japan hanako materia medica ": " adjust in and consumptive lung disease spit blood, stopping coughing and removing phlegm." 6. amplification on Canon of Materia Medica: " lung benefiting gas." 7. Wang Haogu: " main lump at the right hypochondrium." 8. rather former " food mirror book on Chinese herbal medicine ": " main lung meridian deficiency-heat, opens sore throat, gets evil saliva." 9. " Bencao Congxin ": " specially controls bloody sputum, is blood labor panacea.Again can tonneau small intestinal." 10. " book on Chinese herbal medicine is new again ": " nourishing the lung to keep the adverse QI downward, cold-phlegm and dyspnea due to deficiency person should it."

Holotrichia diomphalia Bates: nature and flavor are " herbal classic " 1.: " salty in the mouth, tepor." 2. " not Lu ": " be slightly cold, poisonous." returning through " book on Chinese herbal medicine converges and says ": " enters liver channel of foot-Jueyin." function cures mainly removing blood stasis, clots absorbing, eliminating stagnation, lactogenesis.Control and lose stasis of blood pain, gout, tetanus, sore throat, corneal nebula, erysipelas, carbuncle, anal fistula.1. " herbal classic ": " main stagnant blood blood stasis stagnated QI, the full pain of broken folding blood stagnating in the hypochondriac region heavily fortified point, the moon closes, excessive skin, blue or green nebula tunica albuginea in order." 2. " not Lu ": " be treated to spit blood and not to be gone and broken bone Wei rolls over blood agglomeration, plug in incised wound at breast abdomen, puerperal invasion by pathogenic cold, lower milk." 3. " property of medicine opinion ": " juice drips in order, and removing nebula hinders, main blood, pain relieving." 4. supplement to the Herbal: " main red white trip rash, rash is frayed, and broken Holotrichia diomphalia Bates extracting juice is coated with it." 5. " Japan hanako materia medica ": " can apply malignant boil."

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be: Flos Rosae Rugosae 15-30 weight portion, Radix Et Rhizoma Nardostachyos 10-25 weight portion, Aspongopus 12-24 weight portion, Fructus Hordei Germinatus 14-32 weight portion, Endothelium Corneum Gigeriae Galli 10-23 weight portion, fevervine 14-25 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Ganoderma 10-24 weight portion, Caulis Polygoni Multiflori 15-25 weight portion, Concha Margaritifera 10-20 weight portion, Radix Glycyrrhizae 10-22 weight portion, Fructus Hippophae 10-20 weight portion, Semen Sesami Nigrum 14-34 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 12-24 weight portion, Rhizoma Polygonati 10-20 weight portion, Herba Ecliptae 10-25 weight portion, Luciobrama macrocephalus (Lacepede) 10-20 weight portion, Herba Carlinae biebersteinii 13-24 weight portion, Extract Carnis Bovis 10-20 weight portion, Herba Gnaphalii Affinis 12-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Polyalthia nemoralis A. D C. 14-26 weight portion, Phyllanthus simplex Retz． 10-20 weight portion, Caulis Perillae 14-25 weight portion, Cornu Elaphuri pantotrichum 10-20 weight portion, Placenta Hominis 10-22 weight portion, Radix Ranunculi Ternati 12-24 weight portion, Herba seu radix metaplexis 10-20 weight portion, Pyritum 10-26 weight portion, gelatinum oxhide 13-26 weight portion, Radix Asteris 10-27 weight portion and Holotrichia diomphalia Bates 10-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be: Flos Rosae Rugosae 25-30 weight portion, Radix Et Rhizoma Nardostachyos 20-25 weight portion, Aspongopus 12-20 weight portion, Fructus Hordei Germinatus 14-22 weight portion, Endothelium Corneum Gigeriae Galli 10-16 weight portion, fevervine 14-20 weight portion, Rhizoma et radix valerianae 10-15 weight portion, Ganoderma 10-14 weight portion, Caulis Polygoni Multiflori 15-20 weight portion, Concha Margaritifera 10-15 weight portion, Radix Glycyrrhizae 15-22 weight portion, Fructus Hippophae 15-20 weight portion, Semen Sesami Nigrum 14-24 weight portion, Fructus Ligustri Lucidi 15-20 weight portion, Fructus Mori 12-20 weight portion, Rhizoma Polygonati 15-20 weight portion, Herba Ecliptae 10-20 weight portion, Luciobrama macrocephalus (Lacepede) 15-20 weight portion, Herba Carlinae biebersteinii 13-20 weight portion, Extract Carnis Bovis 15-20 weight portion, Herba Gnaphalii Affinis 12-20 weight portion, Radix Glycyrrhizae Preparata 15-20 weight portion, Polyalthia nemoralis A. D C. 14-20 weight portion, Phyllanthus simplex Retz． 10-15 weight portion, Caulis Perillae 14-20 weight portion, Cornu Elaphuri pantotrichum 15-20 weight portion, Placenta Hominis 15-22 weight portion, Radix Ranunculi Ternati 12-20 weight portion, Herba seu radix metaplexis 15-20 weight portion, Pyritum 10-20 weight portion, gelatinum oxhide 13-20 weight portion, Radix Asteris 10-17 weight portion, Holotrichia diomphalia Bates 15-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be: Flos Rosae Rugosae 20 weight portion, Radix Et Rhizoma Nardostachyos 15 weight portion, Aspongopus 24 weight portion, Fructus Hordei Germinatus 25 weight portion, Endothelium Corneum Gigeriae Galli 23 weight portion, fevervine 25 weight portion, Rhizoma et radix valerianae 20 weight portion, Ganoderma 24 weight portion, Caulis Polygoni Multiflori 25 weight portion, Concha Margaritifera 20 weight portion, Radix Glycyrrhizae 14 weight portion, Fructus Hippophae 12 weight portion, Semen Sesami Nigrum 30 weight portion, Fructus Ligustri Lucidi 14 weight portion, Fructus Mori 24 weight portion, Rhizoma Polygonati 12 weight portion, Herba Ecliptae 25 weight portion, Luciobrama macrocephalus (Lacepede) 13 weight portion, Herba Carlinae biebersteinii 24 weight portion, Extract Carnis Bovis 12 weight portion, Herba Gnaphalii Affinis 25 weight portion, Radix Glycyrrhizae Preparata 12 weight portion, Polyalthia nemoralis A. D C. 26 weight portion, Phyllanthus simplex Retz． 20 weight portion, Caulis Perillae 25 weight portion, Cornu Elaphuri pantotrichum 12 weight portion, Placenta Hominis 14 weight portion, Radix Ranunculi Ternati 24 weight portion, Herba seu radix metaplexis 12 weight portion, Pyritum 26 weight portion, gelatinum oxhide 26 weight portion, Radix Asteris 27 weight portion, Holotrichia diomphalia Bates 12 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material also can be: Flos Rosae Rugosae 25 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Aspongopus 12 weight portion, Fructus Hordei Germinatus 22 weight portion, Endothelium Corneum Gigeriae Galli 16 weight portion, fevervine 18 weight portion, Rhizoma et radix valerianae 15 weight portion, Ganoderma 14 weight portion, Caulis Polygoni Multiflori 20 weight portion, Concha Margaritifera 15 weight portion, Radix Glycyrrhizae 22 weight portion, Fructus Hippophae 20 weight portion, Semen Sesami Nigrum 24 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 18 weight portion, Rhizoma Polygonati 15 weight portion, Herba Ecliptae 20 weight portion, Luciobrama macrocephalus (Lacepede) 15 weight portion, Herba Carlinae biebersteinii 19 weight portion, Extract Carnis Bovis 20 weight portion, Herba Gnaphalii Affinis 15 weight portion, Radix Glycyrrhizae Preparata 15 weight portion, Polyalthia nemoralis A. D C. 15 weight portion, Phyllanthus simplex Retz． 15 weight portion, Caulis Perillae 20 weight portion, Cornu Elaphuri pantotrichum 20 weight portion, Placenta Hominis 22 weight portion, Radix Ranunculi Ternati 20 weight portion, Herba seu radix metaplexis 20 weight portion, Pyritum 20 weight portion, gelatinum oxhide 20 weight portion, Radix Asteris 17 weight portion, Holotrichia diomphalia Bates 20 weight portion.

For solving the problems of the technologies described above, present invention also offers one and treat the hypertensive Chinese medicine composition of deficiency of both QI and blood type, when the dosage form of described Chinese medicine composition is capsule, its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.12 ~ 0.4:0.15 ~ 0.3, incapsulate in housing, obtain capsule by described capsule 's content.

When the dosage form of described Chinese medicine composition is injection, its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

The dosage form of described Chinese medicine composition is: tablet, capsule, syrup, suck agent, granule, sublimed preparation, solution, electuary, injection, oral liquid, suppository, plaster, honey pill agent, powder, liniment, enema and patch.

Described Chinese medicine composition, medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, and every 7 days is a course for the treatment of; When this Chinese medicine composition is oral liquid use, 4-5 time on the one, every day 7 is a course for the treatment of; When this Chinese medicine composition is honey pill agent, capsule use, 3 times on the one, every 7 days is a course for the treatment of.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 capsule

Flos Rosae Rugosae 20 weight portion, Radix Et Rhizoma Nardostachyos 15 weight portion, Aspongopus 24 weight portion, Fructus Hordei Germinatus 25 weight portion, Endothelium Corneum Gigeriae Galli 23 weight portion, fevervine 25 weight portion, Rhizoma et radix valerianae 20 weight portion, Ganoderma 24 weight portion, Caulis Polygoni Multiflori 25 weight portion, Concha Margaritifera 20 weight portion, Radix Glycyrrhizae 14 weight portion, Fructus Hippophae 12 weight portion, Semen Sesami Nigrum 30 weight portion, Fructus Ligustri Lucidi 14 weight portion, Fructus Mori 24 weight portion, Rhizoma Polygonati 12 weight portion, Herba Ecliptae 25 weight portion, Luciobrama macrocephalus (Lacepede) 13 weight portion, Herba Carlinae biebersteinii 24 weight portion, Extract Carnis Bovis 12 weight portion, Herba Gnaphalii Affinis 25 weight portion, Radix Glycyrrhizae Preparata 12 weight portion, Polyalthia nemoralis A. D C. 26 weight portion, Phyllanthus simplex Retz． 20 weight portion, Caulis Perillae 25 weight portion, Cornu Elaphuri pantotrichum 12 weight portion, Placenta Hominis 14 weight portion, Radix Ranunculi Ternati 24 weight portion, Herba seu radix metaplexis 12 weight portion, Pyritum 26 weight portion, gelatinum oxhide 26 weight portion, Radix Asteris 27 weight portion, Holotrichia diomphalia Bates 12 weight portion.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.12:0.15, incapsulate in housing, obtain capsule by described capsule 's content.

Embodiment 2 injection

Flos Rosae Rugosae 25 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Aspongopus 12 weight portion, Fructus Hordei Germinatus 22 weight portion, Endothelium Corneum Gigeriae Galli 16 weight portion, fevervine 18 weight portion, Rhizoma et radix valerianae 15 weight portion, Ganoderma 14 weight portion, Caulis Polygoni Multiflori 20 weight portion, Concha Margaritifera 15 weight portion, Radix Glycyrrhizae 22 weight portion, Fructus Hippophae 20 weight portion, Semen Sesami Nigrum 24 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 18 weight portion, Rhizoma Polygonati 15 weight portion, Herba Ecliptae 20 weight portion, Luciobrama macrocephalus (Lacepede) 15 weight portion, Herba Carlinae biebersteinii 19 weight portion, Extract Carnis Bovis 20 weight portion, Herba Gnaphalii Affinis 15 weight portion, Radix Glycyrrhizae Preparata 15 weight portion, Polyalthia nemoralis A. D C. 15 weight portion, Phyllanthus simplex Retz． 15 weight portion, Caulis Perillae 20 weight portion, Cornu Elaphuri pantotrichum 20 weight portion, Placenta Hominis 22 weight portion, Radix Ranunculi Ternati 20 weight portion, Herba seu radix metaplexis 20 weight portion, Pyritum 20 weight portion, gelatinum oxhide 20 weight portion, Radix Asteris 17 weight portion, Holotrichia diomphalia Bates 20 weight portion.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 2 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 2 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 hours under the condition of 5 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 minutes at this, the micron particles of acquisition 2 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 2 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 10g that second step obtains, adds propylene glycol 30g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 30 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 3 decoction

Flos Rosae Rugosae 25g, Radix Et Rhizoma Nardostachyos 20g, Aspongopus 12g, Fructus Hordei Germinatus 22g, Endothelium Corneum Gigeriae Galli 16g, fevervine 18g, Rhizoma et radix valerianae 15g, Ganoderma 14g, Caulis Polygoni Multiflori 20g, Concha Margaritifera 15g, Radix Glycyrrhizae 22g, Fructus Hippophae 20g, Semen Sesami Nigrum 24g, Fructus Ligustri Lucidi 15g, Fructus Mori 18g, Rhizoma Polygonati 15g, Herba Ecliptae 20g, Luciobrama macrocephalus (Lacepede) 15g, Herba Carlinae biebersteinii 19g, Extract Carnis Bovis 20g, Herba Gnaphalii Affinis 15g, Radix Glycyrrhizae Preparata 15g, Polyalthia nemoralis A. D C. 15g, Phyllanthus simplex Retz． 15g, Caulis Perillae 20g, Cornu Elaphuri pantotrichum 20g, Placenta Hominis 22g, Radix Ranunculi Ternati 20g, Herba seu radix metaplexis 20g, Pyritum 20g, gelatinum oxhide 20g, Radix Asteris 17g, Holotrichia diomphalia Bates 20g.

Its preparation method comprises the following steps: step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2cm, soak 3 hours; Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 100ml, filters, obtain filtrate a, for subsequent use; Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2cm, soaks 3 hours; Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Toxicity test

Long term toxicity test: the capsule of the embodiment of the present invention 1 is pressed 6.5,19.5 and 33g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine composition of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine composition of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The decoction prepared by embodiments of the invention 3 carries out gavage, and gavage volume is 5ml/kg, and matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>5ml crude drug/kg of the present invention, every day, maximum dosage-feeding was 10ml crude drug/kg/ day.Chinese medicine clinical application amount of the present invention be 5ml crude drug/day/people, adult body weight in 60KG, average dosage is 0.083ml crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 120 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

 

Clinical trial

Data and method

During selecting in February ,-2012 in February, 2010, the deficiency of both QI and blood type hyperpietic that my institute receives amounts to 600 examples.Wherein, in 600 routine patients, the case patient of age the right side of fifty has 150 examples, age 50-60 year case patient 200 example, the case patient of age above 60 years has 250 examples.This 600 routine patient is divided into treatment one group at random, treats two groups, treats three groups and western medicine group, and each 150 examples, carry out treatment contrast.Four groups of patients comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.

Diagnostic criteria

Namely check for 3 times after examining, be divided into normal arterial pressure, borderline hypertension and office hypertension by the height of pressure value.

(1) normal arterial pressure: systolic pressure is at 18.7kPa (140mmHg) or following, diastolic pressure 12.0kPa (90mmHg) or following, and non-hypotensive, should be considered as normal arterial pressure.

(2) borderline hypertension: person between 12.1 ~ 12.5kPa (91 ~ 95mmHg) is yes to systolic pressure at 18.8 ~ 21.2kPa (141 ~ 159mmHg) and diastolic pressure.

(3) Definite Hypertension: systolic pressure meets or exceeds 21.3kPa (160mmHg) and diastolic pressure, and to meet or exceed 12.7kPa (95mm Hg) person be yes.

(4) Symptoms is: have a dizzy spell, dynamic then aggravate, and meets Lao Zefa, and complexion an ancient wine vessel made of horn is white, lustrelessness of the nails, spiritlessness and weakness, palpitation and sleeplessness, poor appetite lack of appetite, loose stool, and pale tongue with thin fur is white, thready and weak pulse.

Therapeutic Method

Treat one group: this is organized 150 routine patients and adopts the capsule of embodiments of the invention 1 to treat.Every day 2 times, one time one, within 7 days, be a course for the treatment of, treatment carry out 3 courses for the treatment of.Half a year is observed recurrence in follow-up.

Treat two groups: this is organized 150 routine patients and adopts the injection of embodiments of the invention 2 to treat.Intramuscular injection every day once, 7 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.Half a year is observed recurrence in follow-up.

Treat three groups: this is organized 150 routine patients and adopts the decoction of embodiments of the invention 3 to treat.Every day 2 times 7 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.Half a year is observed recurrence in follow-up.

Western medicine group: this is organized 150 routine patients and adopts FUSAIMI PIAN to treat.Initial every day, 40 ~ 80mg, point took for 2 times.Within 7 days, be a course for the treatment of, 3 courses for the treatment of are carried out in treatment.Half a year is observed recurrence in follow-up.

Criterion of therapeutical effect

(1) effective: 1, diastolic pressure declines 10 millimetress of mercury or more reach normal range.Though 2, diastolic pressure is not down to normally, declined 20 millimetress of mercury or more.

(2) effective: 1, diastolic pressure declines not as good as 10 millimetress of mercury, but reaches normal range.2, diastolic pressure comparatively treats front 10,19 millimetress of mercury that decline, but does not reach normal range.3, systolic pressure comparatively treats more than front 30 millimetress of mercury that decline.

(3) invalid: not reach above standard person.

Therapeutic outcome

Table 1 is the treatment situation contrast of each group

Group	Effective	Effectively	Invalid
				Treat one group	148（98.67%）	2（1.33%）	0（0%）
Treat two groups	147（98%）	3（2%）	0（0%）
				Treat three groups	148（98.67%）	2（1.33%）	0（0%）
Western medicine group	100（66.67%）	8（5.33%）	42（28%）

As can be seen from Table 1, the treatment situation of three treatment groups is better than western medicine group far away, it can thus be appreciated that Chinese medicine composition of the present invention, treatment deficiency of both QI and blood type hypertension, therapeutic effect is good, determined curative effect.

Table 2 is the effective treatment time contrast of each group

Group	Effective number	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of
					Treat one group	148	100（67.57%）	46（31.08%）	2（1.35%）
Treat two groups	147	102（69.39%）	40（27.21%）	5（3.4%）
					Treat three groups	148	101（68.25%）	41（27.7%）	6（4.05%）
Western medicine group	100	30（30%）	20（20%）	50（50%）

As can be seen from Table 2, the treatment situation of three treatment groups, after Short-course therapy, effect is better than western medicine group.It can thus be appreciated that this traditional Chinese medicine composition for treating deficiency of both QI and blood type hypertension, curative effect is fast.

The recurrence that the effective patient that table 3 is each group follows up half a year

Group	Effective	Recurrence
			Treat one group	148	0
Treat two groups	147	0
			Treat three groups	148	0
Western medicine group	100	10（10%）

As can be seen from Table 3, patient effective after three treatment group treatments, follow-up is not recurred after half a year.It can thus be appreciated that this traditional Chinese medicine composition for treating deficiency of both QI and blood type hypertension, not easily recurs.

In sum, this Chinese medicine composition, in treatment deficiency of both QI and blood type hypertension, good effect, determined curative effect, curative effect is fast, and not easily recurs, and is free from side effects.

Model case: Lee, female, 55 years old, suffer from deficiency of both QI and blood type hypertension existing 2 years, Symptoms is for having a dizzy spell, dynamic then aggravate, meet Lao Zefa, complexion an ancient wine vessel made of horn is white, lustrelessness of the nails, spiritlessness and weakness, palpitation and sleeplessness, poor appetite lack of appetite, loose stool, pale tongue with thin fur is white, thready and weak pulse, uses the injection of the embodiment of the present invention 2 to treat.Intramuscular injection every day 1 time 7 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.After treatment, symptom is effective, has no side effect.With nearly half a year, not recurrence.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. the hypertensive Chinese medicine composition for the treatment of deficiency of both QI and blood type, it is characterized in that, comprise following raw medicinal material: Flos Rosae Rugosae, Radix Et Rhizoma Nardostachyos, Aspongopus, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, fevervine, Rhizoma et radix valerianae, Ganoderma, Caulis Polygoni Multiflori, Concha Margaritifera, Radix Glycyrrhizae, Fructus Hippophae, Semen Sesami Nigrum, Fructus Ligustri Lucidi, Fructus Mori, Rhizoma Polygonati, Herba Ecliptae, Luciobrama macrocephalus (Lacepede), Herba Carlinae biebersteinii, Extract Carnis Bovis, Herba Gnaphalii Affinis, Radix Glycyrrhizae Preparata, Polyalthia nemoralis A. D C., Phyllanthus simplex Retz．, Caulis Perillae, Cornu Elaphuri pantotrichum, Placenta Hominis, Radix Ranunculi Ternati, Herba seu radix metaplexis, Pyritum, gelatinum oxhide, Radix Asteris and Holotrichia diomphalia Bates.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Flos Rosae Rugosae 15-30 weight portion, Radix Et Rhizoma Nardostachyos 10-25 weight portion, Aspongopus 12-24 weight portion, Fructus Hordei Germinatus 14-32 weight portion, Endothelium Corneum Gigeriae Galli 10-23 weight portion, fevervine 14-25 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Ganoderma 10-24 weight portion, Caulis Polygoni Multiflori 15-25 weight portion, Concha Margaritifera 10-20 weight portion, Radix Glycyrrhizae 10-22 weight portion, Fructus Hippophae 10-20 weight portion, Semen Sesami Nigrum 14-34 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 12-24 weight portion, Rhizoma Polygonati 10-20 weight portion, Herba Ecliptae 10-25 weight portion, Luciobrama macrocephalus (Lacepede) 10-20 weight portion, Herba Carlinae biebersteinii 13-24 weight portion, Extract Carnis Bovis 10-20 weight portion, Herba Gnaphalii Affinis 12-25 weight portion, Radix Glycyrrhizae Preparata 10-20 weight portion, Polyalthia nemoralis A. D C. 14-26 weight portion, Phyllanthus simplex Retz． 10-20 weight portion, Caulis Perillae 14-25 weight portion, Cornu Elaphuri pantotrichum 10-20 weight portion, Placenta Hominis 10-22 weight portion, Radix Ranunculi Ternati 12-24 weight portion, Herba seu radix metaplexis 10-20 weight portion, Pyritum 10-26 weight portion, gelatinum oxhide 13-26 weight portion, Radix Asteris 10-27 weight portion and Holotrichia diomphalia Bates 10-20 weight portion.

3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Flos Rosae Rugosae 25-30 weight portion, Radix Et Rhizoma Nardostachyos 20-25 weight portion, Aspongopus 12-20 weight portion, Fructus Hordei Germinatus 14-22 weight portion, Endothelium Corneum Gigeriae Galli 10-16 weight portion, fevervine 14-20 weight portion, Rhizoma et radix valerianae 10-15 weight portion, Ganoderma 10-14 weight portion, Caulis Polygoni Multiflori 15-20 weight portion, Concha Margaritifera 10-15 weight portion, Radix Glycyrrhizae 15-22 weight portion, Fructus Hippophae 15-20 weight portion, Semen Sesami Nigrum 14-24 weight portion, Fructus Ligustri Lucidi 15-20 weight portion, Fructus Mori 12-20 weight portion, Rhizoma Polygonati 15-20 weight portion, Herba Ecliptae 10-20 weight portion, Luciobrama macrocephalus (Lacepede) 15-20 weight portion, Herba Carlinae biebersteinii 13-20 weight portion, Extract Carnis Bovis 15-20 weight portion, Herba Gnaphalii Affinis 12-20 weight portion, Radix Glycyrrhizae Preparata 15-20 weight portion, Polyalthia nemoralis A. D C. 14-20 weight portion, Phyllanthus simplex Retz． 10-15 weight portion, Caulis Perillae 14-20 weight portion, Cornu Elaphuri pantotrichum 15-20 weight portion, Placenta Hominis 15-22 weight portion, Radix Ranunculi Ternati 12-20 weight portion, Herba seu radix metaplexis 15-20 weight portion, Pyritum 10-20 weight portion, gelatinum oxhide 13-20 weight portion, Radix Asteris 10-17 weight portion, Holotrichia diomphalia Bates 15-20 weight portion.

4. the Chinese medicine composition as described in any one of claims 1 to 3, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Flos Rosae Rugosae 20 weight portion, Radix Et Rhizoma Nardostachyos 15 weight portion, Aspongopus 24 weight portion, Fructus Hordei Germinatus 25 weight portion, Endothelium Corneum Gigeriae Galli 23 weight portion, fevervine 25 weight portion, Rhizoma et radix valerianae 20 weight portion, Ganoderma 24 weight portion, Caulis Polygoni Multiflori 25 weight portion, Concha Margaritifera 20 weight portion, Radix Glycyrrhizae 14 weight portion, Fructus Hippophae 12 weight portion, Semen Sesami Nigrum 30 weight portion, Fructus Ligustri Lucidi 14 weight portion, Fructus Mori 24 weight portion, Rhizoma Polygonati 12 weight portion, Herba Ecliptae 25 weight portion, Luciobrama macrocephalus (Lacepede) 13 weight portion, Herba Carlinae biebersteinii 24 weight portion, Extract Carnis Bovis 12 weight portion, Herba Gnaphalii Affinis 25 weight portion, Radix Glycyrrhizae Preparata 12 weight portion, Polyalthia nemoralis A. D C. 26 weight portion, Phyllanthus simplex Retz． 20 weight portion, Caulis Perillae 25 weight portion, Cornu Elaphuri pantotrichum 12 weight portion, Placenta Hominis 14 weight portion, Radix Ranunculi Ternati 24 weight portion, Herba seu radix metaplexis 12 weight portion, Pyritum 26 weight portion, gelatinum oxhide 26 weight portion, Radix Asteris 27 weight portion, Holotrichia diomphalia Bates 12 weight portion.

5. the Chinese medicine composition as described in any one of Claims 1-4, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Flos Rosae Rugosae 25 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Aspongopus 12 weight portion, Fructus Hordei Germinatus 22 weight portion, Endothelium Corneum Gigeriae Galli 16 weight portion, fevervine 18 weight portion, Rhizoma et radix valerianae 15 weight portion, Ganoderma 14 weight portion, Caulis Polygoni Multiflori 20 weight portion, Concha Margaritifera 15 weight portion, Radix Glycyrrhizae 22 weight portion, Fructus Hippophae 20 weight portion, Semen Sesami Nigrum 24 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 18 weight portion, Rhizoma Polygonati 15 weight portion, Herba Ecliptae 20 weight portion, Luciobrama macrocephalus (Lacepede) 15 weight portion, Herba Carlinae biebersteinii 19 weight portion, Extract Carnis Bovis 20 weight portion, Herba Gnaphalii Affinis 15 weight portion, Radix Glycyrrhizae Preparata 15 weight portion, Polyalthia nemoralis A. D C. 15 weight portion, Phyllanthus simplex Retz． 15 weight portion, Caulis Perillae 20 weight portion, Cornu Elaphuri pantotrichum 20 weight portion, Placenta Hominis 22 weight portion, Radix Ranunculi Ternati 20 weight portion, Herba seu radix metaplexis 20 weight portion, Pyritum 20 weight portion, gelatinum oxhide 20 weight portion, Radix Asteris 17 weight portion, Holotrichia diomphalia Bates 20 weight portion.

6. the Chinese medicine composition as described in any one of claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine composition is capsule, its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.12 ~ 0.4:0.15 ~ 0.3, incapsulate in housing, obtain capsule by described capsule 's content.

7. the Chinese medicine composition as described in any one of claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine composition is injection, its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. a preparation method for the Chinese medicine composition described in any one of claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.12 ~ 0.4:0.15 ~ 0.3, incapsulate in housing, obtain capsule by described capsule 's content.

9. a preparation method for the Chinese medicine composition described in any one of claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine composition is injection, and its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

10. the Chinese medicine composition as described in any one of claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine composition is: tablet, capsule, syrup, suck agent, granule, sublimed preparation, solution, electuary, injection, oral liquid, suppository, plaster, honey pill agent, powder, liniment, enema and patch.