CN104257544B - A kind of linkage of tetrad method is dispelled halitosis composition toothpaste - Google Patents
A kind of linkage of tetrad method is dispelled halitosis composition toothpaste Download PDFInfo
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- CN104257544B CN104257544B CN201410476327.6A CN201410476327A CN104257544B CN 104257544 B CN104257544 B CN 104257544B CN 201410476327 A CN201410476327 A CN 201410476327A CN 104257544 B CN104257544 B CN 104257544B
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Abstract
Dispelled halitosis composition toothpaste the invention discloses a kind of linkage of tetrad method, included count by weight percentage：The active component being made up of Tea Polyphenols 0.5~1.5%, sodium ascorbyl phosphate 0.5~1%, beta cyclodextrin 1~3%, Gantrez AN-119 0.3~2%, remaining is toothpaste matrix.The present invention is by four kinds of connected effects of active compound, both effect of single component had been played, again it is mutually improved every kind of functional component, the linkage of tetrad method acts on oral cavity, make people during brushing teeth, by effective release of antipathogenic composition, suppress the smelly bacterium of cause in oral cavity, peculiar smell in adsorbent absorption oral cavity, the absorption of high-molecular copolymer and filming function, effective release and extension of guarantee the active component residence time in the oral cavity, maintain normal oral microbial environment again simultaneously, reach and treat both principal and secondary aspect of disease, the effect of lasting fresh breath, people are met to lifting self-image and the demand of green health life is pursued.
Description
Technical field
The present invention relates to one kind is green, the linkage of safe and effective tetrad method is dispelled halitosis composition toothpaste.
Technical background
With the fast development of social economy, people's contacts more frequently, more focus on self-image, oral health care
It is particularly important, particularly oral cavity has the personage of peculiar smell, adverse effect can be brought to contacts, or even reduce contacts quality.
Show that significant proportion adult perplexed in social activity by halitosis according to domestic and international epidemiology survey, its illness rate is 20~83%.
The another mouth source property halitosis for having the halitosis for studying display 80~90% because oral cavity factor is caused that is, usually said.Mouthful
Property halitosis in source is generally divided into that sulphur is smelly and ammonia is smelly, and the smelly patient of sulphur is mostly that intraoral anaerobic bacteria decomposes swill or slough tissue
In protein, produce with rotten egg smell volatile sulfur compounds；The smelly patient of ammonia is mostly intraoral and anaerobic bacteria-
Helicobacter pylori decomposes the urea in oral cavity, produces acute sordes matter ammonia, forms intractable halitosis.
Toothpaste is used as a kind of common oral care articles for use, the effect with holding oral cleaning and health.But for halitosis
Patient, traditional clean type toothpaste can not meet daily nursing requirement, and some declare the toothpaste with halitosis effect of dispelling, mostly
Using the artificial synthesized antiseptic that can suppress to produce volatile sulfur compounds bacterium, destructible oral cavity is being just while antibiotic and sterilizing
, there is certain toxic and side effect in normal microbial environment, be unfavorable for the health in oral cavity.For by the microbial intractable of helicobacter pylorus
The smelly patient of ammonia, halitosis toothpaste of dispelling alternative at present is less, and some use the chemicals with suppressing and killing helicobacter pylori, closely
Phase effect is fine, but side effect is big, oral cavity flora is lacked of proper care, and bacterial drug resistance constantly strengthens, and long-term effect is not good.Though some
So use traditional Chinese medicine ingredients, but or because composition is single, or because compatibility is bad, halitosis of dispelling effect on driving birds is not good.
The content of the invention
To solve the above problems, dispelled halitosis composition toothpaste it is an object of the invention to provide a kind of linkage of tetrad method, its profit
With the mutual synergistic function between four kinds of active components, green, safely, effectively.
The object of the present invention is achieved like this：A kind of linkage of tetrad method is dispelled halitosis composition toothpaste, it is characterised in that：Press
Percentage by weight is calculated to be included：By Tea Polyphenols 0.5~1.5%, sodium ascorbyl phosphate 0.5~1%, beta-schardinger dextrin 1~3%,
The active component of the composition of Gantrez AN-119 0.3~2%, remaining is toothpaste matrix.
The Tea Polyphenols purity is more than 90%.
The Gantrez AN-119 molecular weight is 80~3,000,000.
Described toothpaste matrix includes：NMF 30~60%, abrasive 18~30%, foaming agent 1.5~2.5% is fragrant
Essence 0.8~1.4%, adhesive 0.6~1.2%, saccharin sodium 0.15~0.3%, PH conditioning agents are appropriate, water surplus.
The NMF is one or more mixing in propane diols, polyethylene glycol, glycerine, sorbierite.
The abrasive be friction type silica, thickening type silica one or two mixing.
The foaming agent is sldium lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, lauroyl Sodium Glycinate
One or more mixing.
Described adhesive be sodium carboxymethylcellulose, carragheen, xanthans, guar gum one or more mixing.
The pH adjusting agent be sodium pyrophosphate, tertiary sodium phosphate, sodium dihydrogen phosphate, NaOH in one or more
Mixing.
The pH value of toothpaste is 5.5~7.
The present invention is directed to defect of the halitosis toothpaste in terms of effect of dispelling in the market, using natural tea extract-tea
Polyphenol, it is a kind of green, the bacteriostatic agent of safety, the smelly bacterium of cause of counterpart source property halitosis, especially to causing intractable halitosis to be imprisoned
Helicobacter pylori can play inhibitory action, eliminate the producer of halitosis；Simultaneously using the collaboration of sodium ascorbyl phosphate and Tea Polyphenols
The fungistatic effect of both synergistic effect, enhancing；Using the suction-operated of beta-schardinger dextrin, the halitosis to having produced is adsorbed；Profit
With the package action of beta-schardinger dextrin, the stability of Tea Polyphenols and sodium ascorbyl phosphate in toothpaste system is improved；Using PVM/MA
The film forming of copolymer and suction-operated, extension Tea Polyphenols, sodium ascorbyl phosphate are improved and lived in the residence time of dental surface
The bioavilability of property thing.The present invention is combined by four kinds of active components, has both played effect of single component, and every kind of effect is made again
Composition is mutually improved, and makes people during brushing teeth, and by effective release of antipathogenic composition, suppresses the smelly bacterium of cause in oral cavity, inhales
Peculiar smell in attached dose of absorption oral cavity, the absorption of high-molecular copolymer and filming function, it is ensured that effective release of active component and prolong
Residence time in the oral cavity long, while maintain normal oral microbial environment again, reach treat both principal and secondary aspect of disease, lasting fresh breath
Effect, meet people to lifting self-image and pursue green health life demand.
Specific embodiment
The present invention is that a kind of linkage of tetrad method is dispelled halitosis composition toothpaste, is included count by weight percentage：By Tea Polyphenols
0.5~1.5%, sodium ascorbyl phosphate 0.5~1%, beta-schardinger dextrin 1~3%, the composition of Gantrez AN-119 0.3~2%
Active component, remaining is toothpaste matrix.Wherein toothpaste matrix includes：NMF 30~60%, abrasive 18~30%, foaming agent
1.5~2.5%, essence 0.8~1.4%, adhesive 0.6~1.2%, saccharin sodium 0.15~0.3%, appropriate pH adjusting agent (is adjusted
Save the pH value of toothpaste to 5.5~7), water surplus.
Basic material in formula meets GB 22115-2008《Toothpaste raw material specification》.The NMF is preferably
One or more mixing in propane diols, polyethylene glycol, glycerine, sorbierite, it is ensured that the stability and frost resistance of formula will
Ask.The abrasive is preferably one or two mixing in friction type silica, thickening type silica, and silica is in
Chemical inertness, does not react with active matter, it is ensured that active matter validity in the product, while silica pH value is in
Property, it is possible to reduce metachromatism of the Tea Polyphenols in toothpaste.Described adhesive is preferably sodium carboxymethylcellulose, carragheen, Huang
One or more mixing in virgin rubber, guar gum, make lotion have good dispersed and smooth mouthfeel.The foaming
Agent is preferably the one kind or two in sldium lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, lauroyl Sodium Glycinate
Plant mixed above.The pH adjusting agent be preferably one kind in sodium pyrophosphate, tertiary sodium phosphate, sodium dihydrogen phosphate, NaOH or
Two or more mixing, between regulation lotion pH value to 5.5-7, to reduce the metachromatism of Tea Polyphenols, it is ensured that lotion has good
Outward appearance.
Active component meets GB 22115-2008《Toothpaste raw material specification》.The Tea Polyphenols be purity 90% with
On, the metachromatism in lotion is reduced, consumption is 0.5~1.5%, preferably 0.5~1.2%.The vitamin C is stability
Good sodium ascorbyl phosphate, sodium ascorbyl phosphate discharges vitamin C in the presence of phosphatase in oral cavity, plays
It should be powerful, and consumption is 0.5~1%, preferably 0.6~0.8%.The beta-schardinger dextrin fineness is 250~425 mesh, preferably 325
~380 mesh, it is ensured that lotion has fine and smooth outward appearance, consumption is 1~3%, preferably 1~2.5%.Gantrez AN-119 (the second
Alkenyl methyl ether and copolymer-maleic anhydride) molecular weight be 80~3,000,000, preferably 100~2,000,000, be conducive to dental surface into
Film, protects the health of one's teeth, and consumption is 0.3~2%, preferably 0.5~1.5%.
Mouthful source property halitosis be mainly cause oral environment to change by harmful bacteria in oral cavity, tooth change (bacterial plaque, tooth knot
Stone, carious tooth etc.) and periodontium change (bleeding gums etc.) and produce volatility sulfur compound (sulphur is smelly) or nitrogen-containing compound
(ammonia is smelly).The smelly bacterium of cause suppressed in oral cavity is the important means for dispelling halitosis.Using the bacteriostasis of Tea Polyphenols, vitamin C phosphorus
Synergistic effect of the acid esters sodium to Tea Polyphenols, the common anaerobic bacteria suppressed in oral cavity, simultaneous anaerobic bacteria (helicobacter pylori) etc. cause smelly bacterium,
Fundamentally suppress the generation of halitosis；Dimension life is discharged by the enzymolysis of phosphatase in the oral cavity using sodium ascorbyl phosphate
Plain C come promote periodontium health；The oral peculiar smell for having produced effectively is adsorbed using the suction-operated of beta-schardinger dextrin, is carried
Height is dispelled halitosis effect；Using the absorption of PVM/MA, film forming, cushioning effect, promote the validity and persistence of active matter.Four kinds of work
Property Internet of Things is acted for oral cavity, restrained effectively the generation of halitosis, makes implication persistently pure and fresh.
One method is as follows to tetrad method linkage halitosis composition of dispelling：
One method：The smelly bacterium of cause in oral cavity is killed in suppression.Using natural antimicrobial component-Tea Polyphenols, Tea Polyphenols is green as one kind
Color, safety, wide spectrum, potent antibacterial, recognized by many countries in the world.Research shows that Tea Polyphenols has stronger
Antibacterial and anti-inflammation functions, the growth of various bacteria in oral cavity can be suppressed, have very strong suppression to main cariogenic bacteria streptococcus mutans
Effect, meanwhile, the catechin in Tea Polyphenols can suppress glucosyltransferase, reduce the generation of glucan, and interference thalline needs sugar
Adhesion, reduces the generation of carious tooth.In addition, Tea Polyphenols has the very strong effect for killing helicobacter pylori, it is parasitic big in bacterial plaque
The helicobacter pylori of amount, the urease being rich in by itself, the hydrolysis of urea in catalysis oral cavity produces ammonia, forms intractable mouthful
Smelly-ammonia is smelly.So, Tea Polyphenols has the good action for dispelling halitosis.
Duplex process：Addition vitamin C enhancing Tea Polyphenols fungistatic effect, promotes gums healthy, prevents bleeding gums.Vitamin
C can participate in metabolism and the oxidation-reduction process of internal sugar, promote the biosynthesis of ossein, reduce the fragility of blood vessel, prevent tooth
Oulorrhagia, maintains the health of tooth and bone.Meanwhile, vitamin C can also suppress helicobacter pylori, it is smelly to intractable ammonia also have compared with
The good effect of dispelling.
But vitamin C keeps in dark place, hot and metal ion, easily oxidized shortcoming, so using vitamin C in toothpaste of the present invention
Sodium phosphate, sodium ascorbyl phosphate has the shortcomings that ascorbic institute is powerful and to overcome vitamin C unstable.Dimension
After the sodium phosphate of raw element C enters human body, can rapidly be digested by phosphate, the vitamin C that dissociates plays its biochemistry and makees
With.Sodium ascorbyl phosphate also has functions that enhancing white blood cell activity, can take care of one's teeth and not destroyed by periodontitis, together
Tea Polyphenols coordinates can play synergistic function.
Three furnace process：Addition adsorbent absorption halitosis.
The present invention finally filters out a kind of safe and efficient adsorbent-beta-schardinger dextrin.Beta-schardinger dextrin can be in oral cavity
The escaping gases such as sulfur compound, nitrogen-containing compound are wrapped in hydrophobic group, the embedded object of stabilization are formed, when people brush teeth
When, oral cavity can be carried over foam, reach halitosis effect of dispelling.Dispelled halitosis with unification connection method and duplex process, sample can be reached
The simultaneous effect controlled.
Tetrad method：Active matter bioavilability is improved by copolymer.
Present invention discover that Gantrez AN-119 to be used for have multi-efficiency in toothpaste, Tea Polyphenols, dimension life can be significantly improved
Plain C sodium phosphates improve bioavilability in the residence time of dental surface；Can be taken care of one's teeth in dental surface film forming simultaneously
Health；Gantrez AN-119 also has extremely strong buffer capacity, and the ammonia that can be neutralized in oral cavity is smelly, and beta-schardinger dextrin removes mouth jointly
Cavity foreign flavor.
Contained by the present invention tetrad method linkage dispel halitosis composition Tea Polyphenols, sodium ascorbyl phosphate, beta-schardinger dextrin and
Gantrez AN-119, the antibacterial factor is discharged by during brushing teeth by Tea Polyphenols, and sodium ascorbyl phosphate digests activity
Vitamin C, both suppress to cause smelly bacterium in oral cavity jointly, remove the producer of halitosis；The active vitamin C for digesting can also be prevented
Bleeding gums, protect gums healthy；Beta-schardinger dextrin is effectively adsorbed to the peculiar smell in oral cavity；Gantrez AN-119 is good
Absorption and film forming, can be such that the antibacterial factor extends after washing one's face and rinsing one's mouth in the intraoral residence time, reach the effect of lasting fresh breath
Really.The linkage of tetrad method is dispelled halitosis composition toothpaste, and by antibacterial and suction-operated, counterpart source property halitosis plays the effect treated both principal and secondary aspect of disease
Really, halitosis has both been dispelled, oral microorganism environment has been protected again, be a kind of green, safe and effective halitosis toothpaste of dispelling.
Below by way of specific example, the present invention is further elaborated, but the present invention is not limited thereto specific examples.
Embodiment 1
Count by weight percentage, it is formulated as follows：
Abrasive (friction type silica) 16%, abrasive (thickening silica) 6%, adhesive (carboxymethyl cellulose
Plain sodium) 0.5%, adhesive (carragheen) 0.3%, foaming agent (sldium lauryl sulfate) 2.0%, foaming agent (Hamposyl L
Sodium) 0.5%, saccharin sodium 0.25%, NMF (PEG-4000) 3%, NMF (sorbierite) 45%, essence 1.2%, tea
Polyphenol 0.5%, sodium ascorbyl phosphate 0.6%, beta-schardinger dextrin 1%, Gantrez AN-119 0.5%, pH adjusting agent (hydroxide
Sodium) appropriate, water surplus.
Preparation method：Tea Polyphenols, sodium ascorbyl phosphate, saccharin sodium are added to the water dissolving and form water phase；By PVM/MA
Copolymer is dispersed in polyethylene glycol, and water phase is then added under agitation, makes Gantrez AN-119 fully swelling in water；
The NaOH that a small amount of water will be dissolved in again adds water phase；Last and sorbierite, sodium lauroyl sarcosine are sucked in cream pot processed together,
Silica, sldium lauryl sulfate, sodium carboxymethylcellulose, carragheen, beta-schardinger dextrin are well mixed and inhaled in mixed powder cabin
Enter in cream pot processed, after being stirred under vacuum 30 minutes, essence is added, after deaerating 10 minutes.Detect product pH value 5.5-7 it
Between, it is ensured that the stability of Tea Polyphenols color and luster in lotion.
Embodiment 2
Count by weight percentage, it is formulated as follows：
Abrasive (height friction silica) 12%, abrasive (thickening silica) 6%, adhesive (carboxymethyl cellulose
Plain sodium) 0.5%, adhesive (carragheen) 0.3%, foaming agent (sldium lauryl sulfate) 2.0%, foaming agent (Hamposyl L
Sodium) 0.5%, saccharin sodium 0.25%, NMF (polyethylene glycol) 3%, NMF (sorbierite) 45%, essence 1.2%, Tea Polyphenols
0.8%th, sodium ascorbyl phosphate 0.8%, beta-schardinger dextrin 2%, Gantrez AN-119 1%, PH conditioning agents (NaOH) are fitted
Amount, water surplus.
Preparation method is with example 1.
Embodiment 3
Count by weight percentage, it is formulated as follows：
Abrasive (height friction silica) 18%, abrasive (thickening silica) 4%, adhesive (carboxymethyl cellulose
Plain sodium) 0.5%, adhesive (carragheen) 0.3%, foaming agent (sldium lauryl sulfate) 2.0%, foaming agent (Hamposyl L
Sodium) 0.5%, saccharin sodium 0.25%, NMF (polyethylene glycol) 3%, NMF (sorbierite) 45%, essence 1.2%, Tea Polyphenols
1.2%th, sodium ascorbyl phosphate 0.8%, beta-schardinger dextrin 2.5%, Gantrez AN-119 1.5%, PH conditioning agents (NaOH)
In right amount, water surplus.
Preparation method is with example 1.
Tetrad method linkage halitosis composition toothpaste of dispelling is dispelled halitosis validity check
1. detection is required and decision method
Subject will test paste extrusion 2cm on toothbrush, it is ensured that the brushing time of 2 minutes.
Use Halimeter breath detectors, implication value of the test subject before brushing teeth；The implication of 5 minutes after brushing teeth
Value；The implication value of 30 minutes after brushing teeth；The implication value of 60 minutes after brushing teeth；The implication value of 120 minutes after brushing teeth.With prosopyle of brushing teeth
Gas value and after brushing teeth lowest tone value difference, calculating works off one's feeling vent one's spleen rate of descent to judge halitosis effect of dispelling.
2. subjects
1st group：Selection 2 has slight implication, does not have each one an of men and women of bad habit, the age 20~30 years old it
Between, tested numbering is No. 1 and No. 2.
2nd group：Selection 2 has moderate implication, does not have each one an of men and women of bad habit, the age 30~40 years old it
Between, tested numbering is No. 3 and No. 4.
3rd group：Selection 2 has severe implication, does not have each one an of men and women of bad habit, the age 50~60 years old it
Between, tested numbering is No. 5 and No. 6.
3. sample number into spectrum
Toothpaste without halitosis active component of dispelling is control blank sample (being free of four kinds of active components), and numbering is
0#,
The toothpaste sample of embodiment 1 is 1#,
The toothpaste sample of embodiment 2 is 2#,
The toothpaste sample of embodiment 3 is 3#
Assay is shown in Table 1.Known by table 1, tetrad method of the invention linkage halitosis composition toothpaste of dispelling compares with blank sample,
With obvious, lasting halitosis effect of dispelling.
One method, duplex process, three furnace process and tetrad method linkage dispel halitosis composition toothpaste Contrast on effect inspection
1. detection is required and decision method
The same above method.
2. subjects
It is above-mentioned same crowd.
3. sample number into spectrum
One method toothpaste sample numbering is 4#, and only containing Tea Polyphenols, content is the addition in embodiment 3；
Duplex process toothpaste sample numbering is 5#, and containing Tea Polyphenols and sodium ascorbyl phosphate, content is in embodiment 3
Addition；
Three furnace process toothpaste sample numbering is 6#, and containing Tea Polyphenols, sodium ascorbyl phosphate and beta-schardinger dextrin, content is real
Apply the addition in example 3；
Tetrad method toothpaste sample numbering is the toothpaste sample numbering 3# of former embodiment 3.
Assay is shown in Table 2.Known by table 2, this composition toothpaste has more preferable than a method, duplex process, three furnace process toothpaste
, more longlasting halitosis effect of dispelling.Because the linkage combination of tetrad method can be mutually improved four kinds of functional components, active matter is improve
Bioavilability, counterpart source property halitosis can play the effect treated both principal and secondary aspect of disease.Tetrad method linkage halitosis composition toothpaste of dispelling reaches
Desired design theory, will to halitosis patient bring it is unexpected it is pleasantly surprised with it is self-confident.
Table 1.
Table 2.
Claims (6)
1. a kind of tetrad method linkage is dispelled halitosis composition toothpaste, it is characterised in that：Include count by weight percentage：Existed by purity
More than 90% Tea Polyphenols 0.5~1.5%, sodium ascorbyl phosphate 0.5~1%, beta-schardinger dextrin 1~3%, molecular weight are 80
The active component of~300 ten thousand composition of Gantrez AN-119 0.3~2%, remaining is toothpaste matrix；
Described toothpaste matrix includes：NMF 30~60%, abrasive 18~30%, foaming agent 1.5~2.5%, essence 0.8
~1.4%, adhesive 0.6~1.2%, saccharin sodium 0.15~0.3%, pH adjusting agent, addition be adjust toothpaste pH value to
5.5~7, water surplus.
2. tetrad method according to claim 1 linkage is dispelled halitosis composition toothpaste, it is characterised in that：The NMF is third
One or more mixing in glycol, polyethylene glycol, glycerine, sorbierite.
3. tetrad method according to claim 1 linkage is dispelled halitosis composition toothpaste, it is characterised in that：The abrasive is mill
Wiping type silica, thickening type silica one or two mixing.
4. tetrad method according to claim 1 linkage is dispelled halitosis composition toothpaste, it is characterised in that：The foaming agent is the moon
Lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, lauroyl Sodium Glycinate one or more mixing.
5. tetrad method according to claim 1 linkage is dispelled halitosis composition toothpaste, it is characterised in that：Described adhesive is carboxylic
Sodium carboxymethylcellulose pyce, carragheen, xanthans, guar gum one or more mixing.
6. tetrad method according to claim 1 linkage is dispelled halitosis composition toothpaste, it is characterised in that：The pH adjusting agent is
One or more mixing in sodium pyrophosphate, tertiary sodium phosphate, sodium dihydrogen phosphate, NaOH.
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Cited By (1)
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| KR102635197B1 (en) * | 2018-10-18 | 2024-02-13 | (주)아모레퍼시픽 | Oral composition for effective prevention of biofilm formation |
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| CN108078806A (en) * | 2018-02-05 | 2018-05-29 | 广州市倩采化妆品有限公司 | Effective type removing abnormal flavor in oral cavity toothpaste |
| US20210196609A1 (en) * | 2019-12-26 | 2021-07-01 | L'oreal | Compositions and methods for styling hair |
| CN111000754A (en) * | 2019-12-31 | 2020-04-14 | 合肥赛为智慧医疗有限公司 | Mouthwash for balancing oral flora and preparation method thereof |
| CN112870110A (en) * | 2021-03-22 | 2021-06-01 | 浙江爱尚日用品有限公司 | Halitosis-resisting toothpaste |
| CN113633574A (en) * | 2021-08-23 | 2021-11-12 | 合肥赛为智慧医疗有限公司 | Anti-caries mouthwash and preparation method thereof |
| CN114404311A (en) * | 2022-02-07 | 2022-04-29 | 黄萍 | Oral cavity article with function of removing halitosis |
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| US5188818A (en) * | 1992-03-30 | 1993-02-23 | Isp Investments Inc. | Toothpaste composition containing strontium salt of maleic anhydride-methyl vinyl ether copolymer |
| CN1050282C (en) * | 1992-04-30 | 2000-03-15 | 吴泰相 | Full-element health-care toothpaste |
| CN102204874B (en) * | 2011-01-28 | 2012-06-27 | 义乌市爱尚日用品有限公司 | Anti-halitosis toothpaste containing natural drug compound components |
| CN102512334B (en) * | 2012-01-10 | 2013-07-17 | 广州薇美姿个人护理用品有限公司 | Preparation method of oral care composition |
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| KR102635197B1 (en) * | 2018-10-18 | 2024-02-13 | (주)아모레퍼시픽 | Oral composition for effective prevention of biofilm formation |
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Address after: Liannan Chenghai Industrial Zone 515834 area in Guangdong city of Shantou Province Applicant after: MINGCHEN HEALTH Co.,Ltd. Address before: Under the town of Liannan Industrial Zone in Chenghai city of Shantou Province, Guangdong District 515800 Applicant before: GUANGDONG MINGCHEN Co.,Ltd. |
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Free format text: CORRECT: ADDRESS; FROM: 515800 SHANTOU, GUANGDONG PROVINCE TO: 515834 SHANTOU, GUANGDONG PROVINCE Free format text: CORRECT: APPLICANT; FROM: GUANGDONG MINGCHEN CO., LTD. TO: MINGCHEN HEALTH PRODUCT CO., LTD. |
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Effective date of registration: 20221026 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |