CN104255925A - Skin whitening and peeling milk with chloasma removal function and preparation method thereof - Google Patents
Skin whitening and peeling milk with chloasma removal function and preparation method thereof Download PDFInfo
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Abstract
The invention discloses skin whitening and peeling milk with a chloasma removal function and a preparation method thereof. The skin whitening and peeling milk is prepared by raw materials in parts by mass as follows: 35.0-85.0 parts of fresh milk, 5.0-15.0 parts of grape seed extracts, 6.0-17.0 parts of corn, 6.00-17.5 parts of Avemar, 0.15-0.60 part of a stabilizer, 2.0-8.0 parts of lycoypene, 3.0-7.0 parts of propolis, 8.0-15.0 parts of vitamin C, 0.20-0.80 part of an acidity regulator, 2.0-8.0 parts of a sweetening agent and an appropriate amount of water. The milk has a remarkable chloasma removal effect, is relapse-free and does not have any toxic and side effects.
Description
Technical field
The present invention relates to field of health care food, particularly relate to a kind of whitening with functions of removing chloasma effect and change skin milk and preparation method thereof.
Background technology
Chloasma is a kind of common skin disease, and more common in young women, the only a few male sex also can fall ill, and is a kind of difficult disease being difficult to cure in a short time.Chloasma is a kind of chromatodermatosis betiding face.Because this disease is normal relevant with the irritability stasis of feelings depression and the traditional Chinese medical science, therefore also known as " chloasma hepaticum ".It has been generally acknowledged that and change relevant with endocrine function.See woman gestationperiod or oral contraceptive person and other factors.The chloasma (gestational chloasma) of woman gestationperiod, starts from gestation 3 ~ 5 months, and after childbirth, pigmented spots die down.Facial pigmentation may be due to estrogen and progesterone synergy, stimulation melanin cell, and progestational hormone impels transhipment and the diffusion of melanosome, adds melanic generation and impels pigmentation.Also chronic gastrointestinal diseases, hepatopathy, tuberculosis, cancer knurl, malignant lymphoma and chronic alcoholism etc. are seen.All can there is chloasma in prolonged application some drugs such as dilantin sodium, wintermin, contraceptive.In addition, strong Exposure to Sunlight, the application of cosmetics also can bring out chloasma.Chloasma also sees normal female or the male sex of unmarried, unpregnancy, and it is agnogenio.If the medium-term and long-term shortage glutathione of diet, the tyrosinase activity in skin can be made to increase, and tyrosine forms DOPA quinone under the effect of tyrosinase, and then form DOPA element, pigmentation occurs, causes chloasma.
Through observational study clinically for many years, the cause of disease is different, to show disease type, symptom and color spot different in the distribution of face.Therefore, Chinese medical discrimination, on diagnosis typing, divides substantially and has three kinds, comprising: liver qi stagnation type, renal deficiency type, spleen-deficient.1, liver qi stagnation type.Clinical manifestation: being irritable and getting angry easily, distending pain in the chest and hypochondrium, dysmenorrhoea or menstrual period are delayed, and through dark purplish blood with clots, petechia of the tongue, common climacteric or have liver and gall medical history and have the women of genital system diseases, chloasma is distributed in around canthus, the chloasma based on pitchy.Caused by the retardance of genus mechanism of qi is smooth.Treatment main points: easypro liver falls apart strongly fragrant, blood circulation and channel invigorating, myogenic of fostering the spirit of nobility, clean skin nti-freckle.Therapy: easypro liver falls apart strongly fragrant nti-freckle.2, renal deficiency type.Clinical manifestation: for complexion is pale, shape limb of trembling with fear is cold, and soreness and weakness of waist and knees is unable, and urine is many, pale tongue with white fur, the brown refractory of spot color depth, and chloasma is distributed in full-face based on large stretch of chloasma and point-like freckle.Caused by genus negative and positive two are lost.Treatment main points: nourishment for vitality, tonifying Qi is fallen apart strongly fragrant, sensible blood vessels, clean skin nti-freckle.Therapy: kidney tonifying gas, nti-freckle of promoting blood circulation.3, spleen-deficient.Clinical table: pale or sallow complexion, spiritlessness and weakness, breathes hard nervous, and diet reduces, fullness and oppression of chest and abdomen, paramenia, and menses are rare light, and tongue nature is light, and arteries and veins is thin, foxiness distribution wing of nose both sides, the chloasma based on yellowish-brown.Belong to hypoactivity of spleen-YANG, caused by damp and hot friendship resistance.Treatment main points: strengthening the spleen and replenishing qi, clearing heat and promoting diuresis, clean skin nti-freckle.Therapy: nourishing qi and blood, spot is moved back in invigorating the spleen.
Application publication number CN 102008083 A(application number 201010501558.X) Chinese patent literature provide the health food of a kind of alleviating physical fatigue, functions of removing chloasma, be made up of the raw material of following weight proportioning: 10 ~ 100 parts, deer tire, ginseng 50 ~ 200 parts, grape pip 200 ~ 500 parts, propolis 5 ~ 15 parts, vitamin E powder 1 ~ 3 part.Application publication number CN 102205007 A(application number 201110136612.X) Chinese patent literature provide a kind of pharmaceutical composition with chloasma-dispelling function.It is the oral formulations made for active ingredient with Salvia root P.E, angelica extract, tea extract Tea Polyphenols, Flos Rosae Rugosae extract, grape seed extract.Application publication number CN 103300364 A(application number 201310220904.0) Chinese patent literature provide a kind of health-caring capsule and its preparation method of functions of removing chloasma, the health-caring capsule of described functions of removing chloasma by pearl powder, grape seed extract, Aloe original juice spray powder three kinds have the pure natural raw material of beauty and health care function and vitamin C, vitamin E two kinds of human bodies must organic matter mix by formula rate after through sieving, mixing, the capsule health and beauty care product that is prepared from of filling, polishing, the step such as quality inspection.
In a word, in clinical, oral relevant Western medicine or outer serial cosmetics of wiping are difficult to obtain promising result.As seen little effect, standing Ultraviolet radiation again and again and for example in the past, easily recurring.The health products of functions of removing chloasma are a lot, but too emphasize the curative effect of product, and ignore the absorption of human body, and a lot of product quality can not be guaranteed.Chinese medicine mouthfeel is not good, and DeGrain.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of whitening with functions of removing chloasma effect and change skin milk and preparation method thereof.Functions of removing chloasma Be very effective of the present invention, mouthfeel is good, easily absorbs, without recurrence and without any side effects.
Technical scheme of the present invention is:
Skin milk is changed in the whitening with functions of removing chloasma effect, is prepared from, is mass parts by following raw material: fresh milk 35.0-85.0, grape seed extract 5.0-15.0, corn 6.0-17.0, Avemar 6.0-17.5, stabilizing agent 0.15-0.60, lycopene 2.0-8.0, propolis 3.0-7.0, vitamin C 8.0-15.0, acidity regulator 0.20-0.80, sweetener 2.0-8.0, suitable quantity of water.
Skin milk is changed in the whitening with functions of removing chloasma effect, and preferred scheme is, is prepared from by following raw material, be mass parts: fresh milk 48.0-78.0, grape seed extract 8.0-12.5, corn 9.0-14.5, Avemar 9.5-13.0, stabilizing agent 0.20-0.40, lycopene 4.5-6.0, propolis 4.0-6.0, vitamin C 10.2-13.0, acidity regulator 0.40-0.65, sweetener 4.5-7.0, suitable quantity of water.
Skin milk is changed in the whitening with functions of removing chloasma effect, and the scheme be more preferably is, is prepared from by following raw material, be mass parts: fresh milk 74.0, grape seed extract 10.5, corn 11.0, Avemar 11.5, stabilizing agent 0.30, lycopene 5.5, propolis 4.5, vitamin C 11.8, acidity regulator 0.55, sweetener 5.2, suitable quantity of water.
The preparation method of skin milk is changed in the above-mentioned whitening with functions of removing chloasma effect, and step is as follows:
(1) be placed in marmite by grape seed extract and corn, add water, amount of water is that doubly (preferred, amount of water is 2.5-3.5 times of grape seed extract and corn quality to the 2-4 of grape seed extract and corn quality; Be more preferably, amount of water is 2.8 times of grape seed extract and corn quality), be placed on smokeless stove fire and heat 15-50 minute (preferred 20-40 minute; Be more preferably 30 minutes), then decoct with big fire and stir 10-35 minute (preferred 15-30 minute; Be more preferably 22 minutes), 160-230 order screen pack (the preferred screen pack of 170-200 order excessively excessively; Be more preferably 180 order screen packs), filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating boiling 8-17 minute (preferred 10-15 minute; Be more preferably 12 minutes), change little fire and decoct 6-18 minute (preferred 8-14 minute slowly; Be more preferably 12 minutes), filter, filtrate is for subsequent use;
(3) (preferred 70-80 DEG C when the temperature of step (2) gained filtrate is down to 65 DEG C-85 DEG C; Be more preferably 75 DEG C), add stabilizing agent (mixture of sodium carboxymethylcellulose, pectin or sodium carboxymethylcellulose and pectin), acidity regulator (mixed acid of lactic acid, citric acid or lactic acid and citric acid), sweetener (mixture of xylitol, honey, HFCS or xylitol, honey and HFCS), abundant dissolving mixes, again by fresh milk filtering and impurity removing, mix filtrate mixing with gained above, be prepared into mixed liquor;
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 60-80 DEG C of (preferred 67-75 DEG C; Be more preferably 70 DEG C), cross high pressure homogenizer and carry out homogeneous process, then through 132 DEG C-145 DEG C (preferably 135 DEG C-140 DEG C; Be more preferably 138 DEG C), (preferred 6-10 second 4-15 second; Be more preferably 8 seconds) carry out sterile filling after high-temperature short-time sterilization, to obtain final product.
Preferably be, stabilizing agent described in step (3) is the mixture (preferred, sodium carboxymethylcellulose: pectin=(0.13 ~ 0.21): (0.09 ~ 0.28), mass ratio) of sodium carboxymethylcellulose and pectin.
Preferably be, acidity regulator described in step (3) is the mixed acid (preferred, lactic acid: citric acid=(0.06 ~ 0.14): (0.05 ~ 0.12), mass ratio) of lactic acid and citric acid.
Preferably be, sweetener described in step (3) is that the mixture of xylitol, honey and HFCS is (preferred, xylitol: honey: HFCS=(1.00 ~ 5.00): (2.00 ~ 7.50): (2.00 ~ 9.50), mass ratio).
Be more preferably, stabilizing agent described in step (3) is the mixture (sodium carboxymethylcellulose: pectin=0.16:0.18, mass ratio) of sodium carboxymethylcellulose and pectin.
Be more preferably, described acidity regulator described in step (3) is the mixed acid (lactic acid: citric acid=0.10:0.08, mass ratio) of lactic acid and citric acid.
Be more preferably, sweetener described in step (3) is the mixture (xylitol: honey: HFCS=3.00:3.50:6.00, mass ratio) of xylitol, honey and HFCS.
The effect of the present invention's primary raw material used is as follows:
Fresh milk: fresh milk is the milk of cow secretion, the drink directly drunk after sterilization.Fresh milk be a kind of nutrition being only second to human breast milk the most complete/liquid food that nutritive value is the highest.Containing the various constant such as rich in protein, fat, amino acid, carbohydrate, salt, calcium, phosphorus, iron, mcg vitamin, enzyme and antibody etc. in fresh milk, the most digested.Study proof according to external expert, drink one glass of fresh milk every morning, 10% of needed by human body heat can be met, 40% of the various mcg vitamin of needed by human body can be met.If everyone drinks 500 grams of milk for 1 day, then can meet 80% of vitamin needed for human body every day and calcium amount, and tool protective effect on cancer risk.Therefore, scientist thinks: milk is the best nutrient source of new life, and the primary trophism that milk has is that other any artificial nutriment is all incomparable.
Grape seed extract: the new and effective natural material that can not synthesize in a kind of human body extracted from grape pip.It is anti-oxidant, the material that Scavenging ability is the strongest that current occurring in nature finds, its antioxidation activity is 50 times, ascorbic 20 times of the plain E of dimension, it can effectively remove free radical unnecessary in human body, has superpower delaying senility and the effect of develop immunitypty.Anti-oxidant, antiallergy, antifatigue, build up health, improve sub-health state, delay senility, improve the symptom such as irritable, dizzy weak, failure of memory.Main component: OPC 1. OPC is a kind of new and effective antioxidant is one of found so far the most potent free radical scavenger.2. the initiation potential of the illnesss such as heart disease, cancer, early ageing, arthritis can be reduced.3. vascular wall resistance is strengthened.4. the initiation potential of diabetes is reduced.5. strengthen skin elasticity and smoothness, prevention sunray is to effects such as the radiation injuries of skin.
Corn: corn is the health-care good product in coarse food grain, rather favourable to the health of human body.The compositions such as the vitamin B6 in corn, nicotinic acid, have stimulating gastrointestinal and wriggle, accelerate the characteristic of defecate, can prevent treating constipation, stomach trouble, enteritis, intestinal cancer etc.Corn is rich in vitamin C, isomalto-oligosaccharide etc., has longevity, beautification function.Nutriment contained by maize point has enhancing human metabolism, adjustment nervous function.Can play and make skin delicacy smooth, suppress, delay wrinkle generation effect.Corn to have in tune effect of appetizing and reducing blood lipid, reduction serum cholesterol.It is relevant with their main edible corn that hypertension is not easily suffered from by Central America American Indian.
Propolis: propolis is the resin that honeybee gathers from plant gemma or trunk, is mixed into palatine gland on it, a kind of colloidal solid thing with aromatic odor that the secretion of wax gland processes.The property of medicine: bitter, acrid, cold.Return spleen, stomach warp.Effect: antibacterial, the beautifying face and moistering lotion that propolis has, the effect of promotion cytothesis, this has just been doomed the critical role of propolis in skin care item industry, it not only can eliminate fungal infection, pigment can also be decomposed, calm down wrinkle, delaying senility, accelerate the healing of histiocytic regeneration and wound, also have good curative effect to small pox left acne scar acne print.Recent studies proves, enriching and the bioactivator of uniqueness contained by propolis, make it have antibacterial, anti-inflammatory, antipruritic, anti-oxidant, strengthen immune, hypoglycemic, reducing blood lipid, the several functions such as antitumor, medical treatment, health-care effect is widely had to human body, now become the focus of various countries' scientific research, and become emerging health products and extremely praise highly.
Lycopene: lycopene is a kind of natural colouring matter contained in plant.Mainly be present in the ripening fruits of plant of Solanaceae tomato.It is one of most powerful antioxidant be found in natural plant at present.Science proves, the singlet oxygen in human body and oxygen radical are the arch-criminals of infringement human body self immune system.Effect of lycopene scavenging free radicals outclass other carotenoid and vitamin E, and its singlet-oxygen quenching speed constant is 100 times of vitamin E.It can effectively preventing because of aging, the various diseases that immunity degradation causes.Therefore, it receives the concern of countries in the world expert.Effect of lycopene: 1, contribute to delaying senility; 2, contribute to strengthening capability of resistance to radiation; 3, adjusting blood lipid is contributed to; 4, effect is improved to male sterility; 5, the healthy development of female breast is helped lend some impetus to.
Vitamin C: vitamin C (English: Vitamin C, also known as L-AA) is the essential nutrients of High Primates animal and other minority biologies.Ascorbic acid can create by metabolism most organism, but the mankind make an exception the most significantly.What be widely known by the people most is that the C that is deficient in vitamin can cause scurvy.In vivo, vitamin C is a kind of antioxidant, and protection health avoids the threat of free radical, and vitamin C is also a kind of coenzyme simultaneously.Its widely food source be all kinds of fresh vegetables and fruits.Ascorbic drug effect: vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), the metabolism of phenylalanine, tyrosine, folic acid, the utilization of iron, carbohydrate, the synthesis of fat, protein, maintains immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has anti-oxidant simultaneously, Green Tea Extract, suppress the formation of Tyrosinase, thus reach whitening, effect of light spot.
Acidity regulator: or pH value controlling agent, make for adjustment or a kind of food additives keeping pH value (acid or alkali).Acidity regulator can be organic acid or inorganic acid, alkali, nertralizer or buffer.Acidity regulator by its E code identification, as E260(acetic acid), or under being listed in " food acidity agent ".The acidity regulator of frequent use is citric acid, acetic acid and lactic acid.Sodium carbonate, potash can be used in flour-made food, and hydrochloric acid, NaOH belong to strong acid, strong alkaline substance, and it has corrosivity to human body, can only be used as processing aid, in will giving before food completes processing and.
Sweetener: describe according to " food additives handbook ": sweetener (Sweeteners) refers to that imparting food or feed are with sweet taste, improve food quality, meet the food additive of people to food demand.Sucrose, fructose and starch sugar, be not classified as food additives in China, is considered as raw-food material.Sweetener should possess following characteristics: security is high, cause that the sense of taste is good, stability is high, good water solubility, and reasonable price.The Main Function of sweetener in food is as follows: (1) mouthfeel: sugariness is one of index of numerous food product, and for making food, beverage has agreeable to the taste sensation, needs to add a certain amount of sweetener.(2) adjustment of local flavor and enhancing, generally all need sweet taste in cake; In the beverage, the adjustment of local flavor just has " sugar-acid ratio ".The local flavor that sweetener can make product obtain, can retain fresh taste again.(3) formation of local flavor, the local flavor of sweet taste and numerous food product mutually supplements, and the taste of many products is produced, so numerous food product all adds sweetener by the combination of flavor substance and sweetener.
Stabilizing agent: stabilizing agent is the food additives having a class of extensive use important in the food industry.Stabilizing agent can change protein deposition speed, makes it have good suspension effect, extends the shelf life.
Avemar: commercial goods, American BioSciences product, main active is 2,6-dimethoxy 1,4-benzoquinone (2,6-DMBQ) and 2-methoxyl-p-benzoquinone.2,6-dimethoxy 1,4-benzoquinone, English name: 2,6-Dimethoxy-1,4-benzoquinone are called for short 2,6-DMBQ.Have bibliographical information, in wheat embryo culture propagation extract 2,6-dimethoxy 1,4-benzoquinone (2,6-DMBQ) has following effect, the effect of (1) antifungal and bacteria growing inhibiting; (2) to malignant cell, there is cytotoxicity, restriction growth of cancer cells, triggering tumor cell apoptosis.(3) immunity moderation system, has stronger immunostimulation and metastasis suppressor effect, successfully can be used as the active material in immunostimulation and transfer pharmaceutical purpose composition.The product A vemar of American BioSciences is the extract of Saccharomyces cerevisiae fermentation wheat embryo, a kind of diet nutritional complementary goods of pure natural, main active is 2,6-dimethoxy 1,4-benzoquinone (2,6-DMBQ) with 2-methoxyl-p-benzoquinone, can be had additional nutrients supply, regulates physiological function, helps to take a tonic or nourishing food to build up one's health after being ill, promote appetite, strengthen muscle power, make spirit vigorous, enhance metabolism, adjustment physique, maintain healthy (bibliography [1] Andr ' as Telekes, M ' arta Heged us, Chang-Hoon Chae, et al. Avemar (Wheat Germ Extract) in Cancer Prevention and Treatment [J]. Nutrition and Cancer, 61 (6): 2009, 891 – 899. [2] Philipp Saiko, Maria Ozsvar-Kozma, Sibylle Madlener, et al. Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells [J]. Cancer Letters, 2007, 250:323 – 328).The product A vemar of American BioSciences company, by saccharomycete by wheat embryo extract ferment after made by, containing 0.04%(percentage by weight) natural 2,6-dimethoxy 1,4-benzoquinone composition.FDA allows Avemar to be used in food, beverage and ordinary meal complementary goods.
It is simple that skin milk preparation method is changed in the whitening with functions of removing chloasma effect provided by the invention, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, take good care of inside and outside, treat both principal and secondary aspect of disease;
2, absorb fast, potently not rebound;
3, safe without toxic side effect.Not containing hormone, antibiotic composition, to human non-toxic's side effect;
4, be of high nutritive value;
5, the whitening effect such as grape seed extract, vitamin C nti-freckle composition is contained in formula, the cellulosic growth of tissue divots can be accelerated, start with from color spot root, potent decomposition melanin, the regeneration of check melanin, repairs skin compromised immune net, strengthens skin self resistance, from inside to outside, while elimination color spot, reach whitening and change skin and antidotal object.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1skin milk is changed in the whitening with functions of removing chloasma effect, be prepared from by the raw material of following weight: fresh milk 35.0g, grape seed extract 5.0g, corn 6.0g, Avemar 6.00g, stabilizing agent 0.15g, lycopene 2.0g, propolis 3.0g, vitamin C 8.0g, acidity regulator 0.20g, sweetener 2.0g, suitable quantity of water.
The preparation method of skin milk is changed in the whitening with functions of removing chloasma effect:
(1) grape seed extract and corn are placed in marmite, add water (amount of water is 2 times of grape seed extract and corn quality), is placed on smokeless stove fire and heats 15 minutes, then decoct with big fire and stir 10 minutes, cross 160 order screen packs, filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating seethes with excitement 8 minutes, changes little fire and decocts 6 minutes slowly, and filter, filtrate is for subsequent use;
(3) when the temperature of step (2) gained filtrate is down to 65 DEG C, add stabilizing agent (sodium carboxymethylcellulose), acidity regulator (lactic acid), sweetener (xylitol), abundant dissolving mixes, again by fresh milk filtering and impurity removing, mix filtrate mixing with gained above, be prepared into mixed liquor;
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 60 DEG C, cross high pressure homogenizer and carry out homogeneous process, then carried out sterile filling through 132 DEG C, 4 seconds after high-temperature short-time sterilization, to obtain final product.
Instructions of taking: morning and evening every day twice, each 250-300mL.
embodiment 2skin milk is changed in the whitening with functions of removing chloasma effect, be prepared from by the raw material of following weight: fresh milk 85.0g, grape seed extract 15.0g, corn 17.0g, Avemar 17.5g, stabilizing agent 0.60g, lycopene 8.0g, propolis 7.0g, vitamin C 15.0g, acidity regulator 0.80g, sweetener 8.0g, suitable quantity of water.
The preparation method of skin milk is changed in the whitening with functions of removing chloasma effect:
(1) grape seed extract and corn are placed in marmite, add water (amount of water is 4 times of grape seed extract and corn quality), is placed on smokeless stove fire and heats 50 minutes, then decoct with big fire and stir 35 minutes, cross 230 order screen packs, filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating seethes with excitement 17 minutes, changes little fire and decocts 18 minutes slowly, and filter, filtrate is for subsequent use;
(3) when the temperature of step (2) gained filtrate is down to 85 DEG C, add stabilizing agent (pectin), acidity regulator (citric acid), sweetener (HFCS), fully dissolve and mix, then by fresh milk filtering and impurity removing, mix filtrate mixing with gained above, be prepared into mixed liquor;
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 80 DEG C, cross high pressure homogenizer and carry out homogeneous process, then carried out sterile filling through 145 DEG C, 15 seconds after high-temperature short-time sterilization, to obtain final product.
model case one:yellow XX, female, 29 years old.Mrs Huang have left after original unit comes the work of chemical plant the year before, just starts on the face to occur fleckiness." yellow one piece, black one piece, just the same with a flower map on the face, I dare not look in the mirror myself." Mrs Huang says.Originally she of temper docility also becomes impatient gradually.Be diagnosed as chloasma.Liking to be beautiful is the nature of woman, and she is no exception, and she has also spent a lot of money in order to spot on the face, and various famous and precious nti-freckle product all tried, can effect but less obvious.Take the whitening that the present embodiment gained has functions of removing chloasma effect and change skin milk, every day sooner or later twice, each 250mL.Take 10 days, color spot is desalinated, and the colour of skin bleaches fair-skinned.Continue to take 15 days, chloasma on the face all comes off totally, and her skin becomes not only tender but also sliding.Her happy saying: " effect of really failing to give attention to can be so good, simply than I tens years old time skin also want.Have now that people is in-plant to be seen me I has not been afraid of yet, I am very confident.”
embodiment 3skin milk is changed in the whitening with functions of removing chloasma effect, be prepared from by the raw material of following weight: fresh milk 48.0g, grape seed extract 8.0g, corn 9.0g, Avemar 9.5g, stabilizing agent 0.20g, lycopene 4.5g, propolis 4.0g, vitamin C 10.2g, acidity regulator 0.40g, sweetener 4.5g, suitable quantity of water.
The preparation method of skin milk is changed in the whitening with functions of removing chloasma effect:
(1) grape seed extract and corn are placed in marmite, add water (amount of water is 2.5 times of grape seed extract and corn quality), is placed on smokeless stove fire and heats 20 minutes, then decoct with big fire and stir 15 minutes, cross 170 order screen packs, filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating seethes with excitement 10 minutes, changes little fire and decocts 8 minutes slowly, and filter, filtrate is for subsequent use;
(3) when the temperature of step (2) gained filtrate is down to 70 DEG C, (stabilizing agent is the mixture of sodium carboxymethylcellulose and pectin to add stabilizing agent, sodium carboxymethylcellulose: pectin=0.13:0.28, mass ratio), acidity regulator (the mixed acid of lactic acid and citric acid, lactic acid: citric acid=0.06: 0.12, mass ratio), sweetener (xylitol, the mixture of honey and HFCS, xylitol: honey: HFCS=1.00:7.50:9.50, mass ratio), abundant dissolving mixes, again by fresh milk filtering and impurity removing, filtrate mixing is mixed with gained above, be prepared into mixed liquor,
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 67 DEG C, cross high pressure homogenizer and carry out homogeneous process, then carried out sterile filling through 135 DEG C, 6 seconds after high-temperature short-time sterilization, to obtain final product.
model case two:field XX, female, 45 years old.Along with involutional arrival, Mrs Tian overgrows with chloasma on the face.In the past few years, mistake used for cosmetic, the nti-freckle product of specialty also tried, and beauty treatment was also done, can the always substantial effect of nothing.This allows originally is that her temper involutional becomes more irritated, irritability.See that this is unsatisfactory, see that is incurring dislike, always family members is jumped on someone.Not bad household knows that the people at her this age arrives easily like this climacteric, and they also have to bear.Her badtempered Another reason is because grown the chloasma of whole face in fact, this allow once liked to be beautiful she enjoy strike, think that oneself is quickly old a lot, ugly much suddenly.Take the whitening that the present embodiment gained has functions of removing chloasma effect and change skin milk, every day sooner or later twice, each 300mL.Take 20 days, spot is cleared away, and fair complexion, complexion is ruddy.
embodiment 4skin milk is changed in the whitening with functions of removing chloasma effect, be prepared from by the raw material of following weight: fresh milk 78.0g, grape seed extract 12.5g, corn 14.5g, Avemar 13.0g, stabilizing agent 0.40g, lycopene 6.0g, propolis 6.0g, vitamin C 13.0g, acidity regulator 0.65g, sweetener 7.0g, suitable quantity of water.
The preparation method of skin milk is changed in the whitening with functions of removing chloasma effect:
(1) grape seed extract and corn are placed in marmite, add water (amount of water is 3.5 times of grape seed extract and corn quality), is placed on smokeless stove fire and heats 40 minutes, then decoct with big fire and stir 30 minutes, cross 200 order screen packs, filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating seethes with excitement 15 minutes, changes little fire and decocts 14 minutes slowly, and filter, filtrate is for subsequent use;
(3) when the temperature of step (2) gained filtrate is down to 80 DEG C, add the stabilizing agent (mixture of sodium carboxymethylcellulose and pectin, sodium carboxymethylcellulose: pectin=0.21:0.09, mass ratio), acidity regulator (the mixed acid of lactic acid and citric acid, lactic acid: citric acid=0.14:0.05, mass ratio), sweetener (xylitol, mixture (the xylitol: honey: HFCS=5.00:2.00:2.00 of honey and HFCS, mass ratio), abundant dissolving mixes, again by fresh milk filtering and impurity removing, filtrate mixing is mixed with gained above, be prepared into mixed liquor,
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 75 DEG C, cross high pressure homogenizer and carry out homogeneous process, then carried out sterile filling through 140 DEG C, 10 seconds after high-temperature short-time sterilization, to obtain final product.
model case three:king XX, female, 38 years old.Mrs Wang in 38 years old this year, child just at primary school, is the housewife of standard, upper to obtain the hall, lower kitchen, help the husband and teach the children, typical virtuous wife and good mother.Be exactly because of like this, she can fine home care, fine husband's son cared, only oneself could not be looked after, the exerting a gradual, corrupting influence on by oil smoke because frequent hardworking household laundry is cooked, oneself does not note again maintenance, the face of having climbed up her that chloasma is like this quiet.Once have a parents meeting, classmate ridicules son to have " paint face " mother of a long chloasma, and her heart of this deep shouting pain, so she determines functions of removing chloasma, chloasma be not one day two days long on where have so good controlling, it is all undesirable that she has attempted a lot of method.Take the whitening that the present embodiment gained has functions of removing chloasma effect and change skin milk, every day sooner or later twice, each 300mL.Take 15 days, skin dark yellow on the face becomes ruddy, and thin out also slowly of the color of spot, and after seeing effect, she exposes the smile that how long it is since we last met, and head of a family sees her happiness, and they are also very delight, also allows her hold on use.Continue to take 10 days, she eliminates chloasma on the face like this, and skin also becomes and become better and better.
embodiment 5skin milk is changed in the whitening with functions of removing chloasma effect, be prepared from by the raw material of following weight: fresh milk 74.0g, grape seed extract 10.5g, corn 11.0g, Avemar 11.5g, stabilizing agent 0.30g, lycopene 5.5g, propolis 4.5g, vitamin C 11.8g, acidity regulator 0.55g, sweetener 5.2g, suitable quantity of water.
The preparation method of skin milk is changed in the whitening with functions of removing chloasma effect:
(1) grape seed extract and corn are placed in marmite, add water (amount of water is 2.8 times of grape seed extract and corn quality), is placed on smokeless stove fire and heats 30 minutes, then decoct with big fire and stir 22 minutes, cross 180 order screen packs, filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating seethes with excitement 12 minutes, changes little fire and decocts 12 minutes slowly, and filter, filtrate is for subsequent use;
(3) when the temperature of step (2) gained filtrate is down to 75 DEG C, add the stabilizing agent (mixture of sodium carboxymethylcellulose and pectin, sodium carboxymethylcellulose: pectin=0.16:0.18, mass ratio), acidity regulator (the mixed acid of lactic acid and citric acid, lactic acid: citric acid=0.10:0.08, mass ratio), sweetener (xylitol, mixture (the xylitol: honey: HFCS=3.00:3.50:6.00 of honey and HFCS, mass ratio), abundant dissolving mixes, again by fresh milk filtering and impurity removing, filtrate mixing is mixed with gained above, be prepared into mixed liquor,
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 70 DEG C, cross high pressure homogenizer and carry out homogeneous process, then carried out sterile filling through 138 DEG C, 8 seconds after high-temperature short-time sterilization, to obtain final product.
test example 1the clinical practice of skin milk is changed in the whitening that embodiment 5 gained has functions of removing chloasma effect: in May ,-2012 in September, 2009, screen 268 routine patient with chloasma carry out clinical observation in 8 hospitals.And be divided into two groups at random, experimental group and control group (often organizing 134 people).Man 10 example in experimental group, female 124 example, at minimum 26 years old of age, maximum 66 years old, average 39.35 years old, the course of disease was the shortest 2 months, the longest 10 years, average 33.84 months; Man 8 example in control group, female 126 example, at minimum 23 years old of age, maximum 65 years old, average 41.05 years old, the course of disease was the shortest 3 months, the longest 11 years, average 35.50 months.The sex of two groups of patients, age, course of disease physical data no significant difference (equal P > 0.05), have comparativity.Experimental group takes embodiment 5 products obtained therefrom, and control group is with other nti-freckle product (content in freckle cream as white in silk, Hydrochinone Cream, freckle-diminishing capsule, spot-dispelling liquid etc.).Embodiment 5 products obtained therefrom instructions of taking: morning and evening every day twice, each 250-300mL.
diagnostic criteria
With reference to the clinical criteria of the chloasma that Dermatology Professional Committee of CAIM pigment disease group is formulated.1. facial filbert to dark brown, well-defined patch, usual symmetry distribution, NIP performance and the scales of skin that peel off; 2. without obvious subjective symptoms; Women is multiple, after mainly occurring in puberty; 3. the state of an illness can have seasonality, and the Chang Xiachong winter is light; 4. the pigmentation that other diseases (as naevus fuscocaerules zygomaticus, Riehl melanose and pigmentosa lichen planus actinicus etc.) causes is got rid of.
efficacy assessment standard
Curative effect determinate standard with reference to the chloasma that CAIM Dermatology Professional Committee pigment disease group is formulated: recovery from illness: naked eyes depending on color spot area disappear >=90%, color is normal; Effective: naked eyes depending on color spot area disappear >=60%, color is obviously thin out; Take a turn for the better: naked eyes depending on color spot area disappear >=30%, lighter; Invalid: naked eyes depending on color spot area disappear≤30%, color change not obvious.Total effective rate adds effective calculating with recovery from illness.Treat the effect after 20 days as shown in table 1.
Table 1: skin milk compliance test result is changed in the whitening that embodiment 5 gained has functions of removing chloasma effect
Result for the treatment of: experimental group total effective rate 98.51%, control group 55.97%, both compare has significant difference.And the cure rate of experimental group is 70.90%, and the cure rate of control group is 39.55%, and the result for the treatment of of experimental group is significantly higher than control group.The inefficiency of experimental group is only 0.746%, and the inefficiency of control group is up to 34.33%, and Comparatively speaking, the inefficiency of experimental group significantly reduces.
The present invention is with fresh milk, grape seed extract, corn, vitamin C etc. for primary raw material, and composition used is worked in coordination with mutually, therefore can obtain good effect.Containing the whitening effect such as grape seed extract, vitamin C nti-freckle composition in formula, the cellulosic growth of tissue divots can be accelerated, start with from color spot root, enhance metabolism, oxidation and removing free radicals, potent decomposition melanin, the regeneration of check melanin, repairs skin compromised immune net, strengthen skin self resistance, supplement the nutrients, from inside to outside, while elimination color spot, reach whitening change skin and antidotal object.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. skin milk is changed in the whitening with functions of removing chloasma effect, it is characterized in that, is prepared from by following raw material, be mass parts: fresh milk 35.0-85.0, grape seed extract 5.0-15.0, corn 6.0-17.0, Avemar 6.0-17.5, stabilizing agent 0.15-0.60, lycopene 2.0-8.0, propolis 3.0-7.0, vitamin C 8.0-15.0, acidity regulator 0.20-0.80, sweetener 2.0-8.0, suitable quantity of water.
2. skin milk is changed in the whitening with functions of removing chloasma effect according to claim 1, it is characterized in that, is prepared from by following raw material, be mass parts: fresh milk 48.0-78.0, grape seed extract 8.0-12.5, corn 9.0-14.5, Avemar 9.5-13.0, stabilizing agent 0.20-0.40, lycopene 4.5-6.0, propolis 4.0-6.0, vitamin C 10.2-13.0, acidity regulator 0.40-0.65, sweetener 4.5-7.0, suitable quantity of water.
3. skin milk is changed in the whitening with functions of removing chloasma effect according to claim 1, it is characterized in that, is prepared from by following raw material, be mass parts: fresh milk 74.0, grape seed extract 10.5, corn 11.0, Avemar 11.5, stabilizing agent 0.30, lycopene 5.5, propolis 4.5, vitamin C 11.8, acidity regulator 0.55, sweetener 5.2, suitable quantity of water.
4. change skin milk according to the arbitrary described whitening with functions of removing chloasma effect of claim 1-3, it is characterized in that, described stabilizing agent is mixture (mixture of preferably carboxymethyl cellulose sodium and pectin, the sodium carboxymethylcellulose: pectin=(0.13 ~ 0.21): (0.09 ~ 0.28) of sodium carboxymethylcellulose, pectin or sodium carboxymethylcellulose and pectin; Be more preferably, sodium carboxymethylcellulose: pectin=0.16:0.18, mass ratio).
5. change skin milk according to the arbitrary described whitening with functions of removing chloasma effect of claim 1-3, it is characterized in that, described acidity regulator is mixed acid (mixed acid of preferred lactic acid and citric acid, the lactic acid: citric acid=(0.06 ~ 0.14): (0.05 ~ 0.12) of lactic acid, citric acid or lactic acid and citric acid; Be more preferably, lactic acid: citric acid=0.10:0.08, mass ratio).
6. change skin milk according to the arbitrary described whitening with functions of removing chloasma effect of claim 1-3, it is characterized in that, described sweetener is mixture (mixture of preferred xylitol, honey and HFCS, the xylitol: honey: HFCS=(1.00 ~ 5.00): (2.00 ~ 7.50): (2.00 ~ 9.50) of xylitol, honey, HFCS or xylitol, honey and HFCS; Be more preferably, xylitol: honey: HFCS=3.00:3.50:6.00, mass ratio).
7. change the preparation method of skin milk according to the arbitrary described whitening with functions of removing chloasma effect of claim 1-3, it is characterized in that, step is as follows:
(1) grape seed extract and corn are placed in marmite, add water, be placed on smokeless stove fire and heat 15-50 minute (preferred 20-40 minute; Be more preferably 30 minutes), then decoct with big fire and stir 10-35 minute (preferred 15-30 minute; Be more preferably 22 minutes), 160-230 order screen pack (the preferred screen pack of 170-200 order excessively excessively; Be more preferably 180 order screen packs), filtrate is stand-by;
(2) lycopene, vitamin C and propolis are smashed, mix with step (1) gained filtrate, be placed in non iron container, be heated to rapidly boiling, continuous heating seethes with excitement, and changes little fire and decocts slowly, and filter, filtrate is for subsequent use;
(3) (preferred 70-80 DEG C when the temperature of step (2) gained filtrate is down to 65 DEG C-85 DEG C; Be more preferably 75 DEG C), add stabilizing agent, acidity regulator, sweetener, fully dissolve and mix, then by fresh milk filtering and impurity removing, mix filtrate mixing with gained above, be prepared into mixed liquor;
(4) Avemar to be added in step (3) gained mixed liquor until completely dissolved, be warming up to 60-80 DEG C of (preferred 67-75 DEG C; Be more preferably 70 DEG C), cross high pressure homogenizer and carry out homogeneous process, then through 132 DEG C-145 DEG C (preferably 135 DEG C-140 DEG C; Be more preferably 138 DEG C), (preferred 6-10 second 4-15 second; Be more preferably 8 seconds) carry out sterile filling after high-temperature short-time sterilization, to obtain final product.
8. the preparation method of skin milk is changed in the whitening with functions of removing chloasma effect according to claim 7, it is characterized in that, in step (1), amount of water is that doubly (preferred, amount of water is 2.5-3.5 times of grape seed extract and corn quality to the 2-4 of grape seed extract and corn quality; Be more preferably, amount of water is 2.8 times of grape seed extract and corn quality).
9. the preparation method of skin milk is changed in the whitening with functions of removing chloasma effect according to claim 7, it is characterized in that, continuous heating boiling 8-17 minute (preferably, continuous heating boiling 10-15 minute in step (2); Be more preferably, continuous heating seethes with excitement 12 minutes).
10. the preparation method of skin milk is changed in the whitening with functions of removing chloasma effect according to claim 7, it is characterized in that, change in step (2) little fire decoct slowly 6-18 minute (preferred, change little fire and decoct 8-14 minute slowly; Be more preferably, change little fire and decoct 12 minutes slowly).
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| CN106306024A (en) * | 2015-06-17 | 2017-01-11 | 吴景太 | Organically high-nutritional function-type milk |
| CN109077311A (en) * | 2018-09-18 | 2018-12-25 | 薛泉 | A kind of whitening food formulation and preparation method thereof containing white tomato |
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Application publication date: 20150107 |