CN104254532A - 磷酸肌醇3-激酶抑制剂 - Google Patents

磷酸肌醇3-激酶抑制剂 Download PDF

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Publication number
CN104254532A
CN104254532A CN201380013216.5A CN201380013216A CN104254532A CN 104254532 A CN104254532 A CN 104254532A CN 201380013216 A CN201380013216 A CN 201380013216A CN 104254532 A CN104254532 A CN 104254532A
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CN
China
Prior art keywords
compound
alkyl
independently
optionally substituted
halogen
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201380013216.5A
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English (en)
Chinese (zh)
Inventor
斯蒂芬·约瑟夫·沙特勒沃斯
弗兰克·亚历山德勒·希尔瓦
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Karus Therapeutics Ltd
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Karus Therapeutics Ltd
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Application filed by Karus Therapeutics Ltd filed Critical Karus Therapeutics Ltd
Publication of CN104254532A publication Critical patent/CN104254532A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201380013216.5A 2012-03-08 2013-03-08 磷酸肌醇3-激酶抑制剂 Pending CN104254532A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1204125.7A GB201204125D0 (en) 2012-03-08 2012-03-08 Compounds
GB1204125.7 2012-03-08
PCT/GB2013/050583 WO2013132270A1 (en) 2012-03-08 2013-03-08 Phosphoinositide 3-kinase inhibitors

Publications (1)

Publication Number Publication Date
CN104254532A true CN104254532A (zh) 2014-12-31

Family

ID=46026238

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380013216.5A Pending CN104254532A (zh) 2012-03-08 2013-03-08 磷酸肌醇3-激酶抑制剂

Country Status (6)

Country Link
US (2) US9663487B2 (cg-RX-API-DMAC10.html)
EP (1) EP2822943B1 (cg-RX-API-DMAC10.html)
CN (1) CN104254532A (cg-RX-API-DMAC10.html)
GB (1) GB201204125D0 (cg-RX-API-DMAC10.html)
IN (1) IN2014DN07509A (cg-RX-API-DMAC10.html)
WO (1) WO2013132270A1 (cg-RX-API-DMAC10.html)

Cited By (1)

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CN108135855A (zh) * 2015-08-19 2018-06-08 卡鲁斯治疗有限公司 包含三环杂环化合物的组合物

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GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
EP2917202B1 (en) 2012-11-07 2018-05-02 Karus Therapeutics Limited Novel histone deacetylase inhibitors and their use in therapy
JP6434416B2 (ja) 2012-11-08 2018-12-05 ライゼン・ファーマシューティカルズ・エスアー ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物
CA2911856A1 (en) 2013-05-10 2014-11-13 Karus Therapeutics Ltd Tri-substituted amino hydroxamate compounds and pharmaceutical compositions thereof for use as histone deacetylase inhibitors
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
JP6557436B1 (ja) 2018-03-12 2019-08-07 アッヴィ・インコーポレイテッド チロシンキナーゼ２媒介性シグナル伝達の阻害剤

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CN101228161A (zh) * 2005-05-20 2008-07-23 沃泰克斯药物股份有限公司 适用作蛋白激酶抑制剂的吡咯并吡啶类
CN101663276A (zh) * 2007-01-31 2010-03-03 沃泰克斯药物股份有限公司 用作激酶抑制剂的2-氨基吡啶衍生物
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108135855A (zh) * 2015-08-19 2018-06-08 卡鲁斯治疗有限公司 包含三环杂环化合物的组合物

Also Published As

Publication number Publication date
EP2822943B1 (en) 2018-10-03
GB201204125D0 (en) 2012-04-25
IN2014DN07509A (cg-RX-API-DMAC10.html) 2015-04-24
US10035785B2 (en) 2018-07-31
EP2822943A1 (en) 2015-01-14
WO2013132270A1 (en) 2013-09-12
US20180072699A1 (en) 2018-03-15
US20150080395A1 (en) 2015-03-19
US9663487B2 (en) 2017-05-30

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