CN104231255A - Usnic acid and fatty alcohol polyoxyethylene ether complex compound - Google Patents
Usnic acid and fatty alcohol polyoxyethylene ether complex compound Download PDFInfo
- Publication number
- CN104231255A CN104231255A CN201310244442.6A CN201310244442A CN104231255A CN 104231255 A CN104231255 A CN 104231255A CN 201310244442 A CN201310244442 A CN 201310244442A CN 104231255 A CN104231255 A CN 104231255A
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- fatty alcohol
- polyoxyethylene ether
- complex compound
- acid
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an usnic acid and fatty alcohol polyoxyethylene ether complex compound which is a fatty alcohol polyoxyethylene ether complex compound containing usnic acid. The usnic acid and fatty alcohol polyoxyethylene ether complex compound is composed of the following materials: fatty alcohol polyoxyethylene ether, usnic acid and citric acid. Equipment for complexing the usnic acid and fatty alcohol polyoxyethylene ether complex compound is a stainless steel (or enamel or glass) reaction kettle with returning and heating functions. The usnic acid and fatty alcohol polyoxyethylene ether complex compound is light yellow paste in appearance, is dissolved into water, ethanol, isopropanol and acetone and has the pH value (1% water solution) of 5-7, the water content (%) of less than or equal to 1.0 and the usnic acid content of 5-10%. The usnic acid and fatty alcohol polyoxyethylene ether complex compound has a favorable sterilizing effect on various microorganisms such as staphylococcus aureus, Escherichia coli, fungi and mycete under an effective concentration and is an intermediate for producing dandruff removal and itching alleviation hair lotions, medical mouthwashes, bactericides and disinfectants.
Description
[technical field]
Usninic acid fatty alcohol-polyoxyethylene ether complex compound of the present invention is a kind of fatty alcohol-polyoxyethylene ether complex compound made containing usninic acid.Its composition is made up of fatty alcohol-polyoxyethylene ether, usninic acid, citric acid.
[background technology]
Usninic acid has another name called usnic acid, and yellow tiltedly square plate crystal body, is insoluble in water, fusing point 205 DEG C, is be Usneaceae Usnea plant USNEA Usnea diffracta or Usnea Longissima, is used as medicine with thallus (thallus).Usninic acid shows biological activity widely, has good antifungal, antimycotic, antiviral activity to the mankind and phytopathogenic and animal pathogenic microorganism, for hemostasis, antibacterial, anti-inflammatory, wound healing, remove dental plaque, have good curative effect, the additive of Chang Zuowei toothpaste and makeup to oral cavity disease of bursting.Usninic acid has the effect such as expelling phlegm for arresting cough, clearing heat and detoxicating, eliminating dampness and dredging channels, blood-arresting catamenia-regulating, expelling parasite.Have healing to cough to breathe heavily, tuberculosis, headache, hot eyes cloudiness, carbuncle sore tumefacting virus, scrofula, acute mastitis, burn and scald, venomous snake bite, wind-warm syndrome numbness pain, wound, fracture, traumatic hemorrhage, spit blood, have blood in stool, uterine bleeding, menoxenia, leukorrhea, ascariasis, the Multifunctional curative-effect such as schistosomicide.With the gel that usninic acid glycerin polyether complex compound manufactures, be more beneficial to the treatment of body foci.
[summary of the invention]
Feature of the present invention is to use nonionogenic tenside fatty alcohol-polyoxyethylene ether as carrier, manufactures usninic acid fatty alcohol-polyoxyethylene ether complex compound.
The present invention, under effective concentration, has good sterilization effect to multiple-microorganisms such as Staphylococcus aureus bacillus, intestinal bacteria, fungi, moulds.
The present invention manufactures to have anti-dandruff, only overworked shampoo, medical collutory and sterilant, thimerosal intermediate.
The present invention's complex compound used carrier fatty alcohol-polyoxyethylene ether has excellent solvability, wettability, compatibility and detergency, fatty alcohol-polyoxyethylene ether is widely used in the various fields such as household chemicals, foodstuffs industry, pharmacy industry, fatty alcohol-polyoxyethylene ether toxicity is extremely low, to human body skin and human body mucous membrane irritation extremely low.
The present invention's complex compound carrier used fatty alcohol-polyoxyethylene ether outward appearance (more than 25 DEG C) is colourless transparent liquid, pH value (1% aqueous solution) 6-8, wherein fatty alcohol carbochain number is 11-13, chain structure is side chain or side chain, ethoxymer distribution 8-10.
The synthesis of usninic acid fatty alcohol-polyoxyethylene ether complex compound of the present invention completed in particular device, temperature, time response process; Equipment used is stainless steel (or enamel or glass) material, and reactor need be air-tight state, need material circulation equipment and heating installation.Temperature of reaction controls between 50-100 DEG C, and the material synthetic system pH value in building-up process is slightly acidic.
Material composition of the present invention: fatty alcohol-polyoxyethylene ether 90-95 part, usninic acid 5-10 part, citric acid 0.5-1.0 part.
The present invention is with in temperature controlled chuck stainless steel cauldron, add fatty alcohol-polyoxyethylene ether, be warming up to 50 ± 2 DEG C and add citric acid, be warming up to 60 ± 2 DEG C and add usninic acid, reactor building-up reactions is after 1 hour, temperature is down to 35 ± 2 DEG C, after testing qualified rear discharging, and material is placed in lucifuge, nonmetallic container.
Outward appearance body shape of the present invention is pale yellow viscous liquid, water-soluble, ethanol, Virahol, acetone, pH value (1% aqueous solution): 5-7, moisture content (%) :≤1.0, usninic acid content 5-10%.
The present invention manufactures that raw material is easy to get, pollution-free in production process, without waste, the requirement meeting environmental protective chemical industry production technique.
[embodiment]
Embodiment one:
By following part by weight throwing raw materials: fatty alcohol-polyoxyethylene ether 89 parts, usninic acid 10 parts, citric acid 1 part.
Synthesis route: with in temperature controlled airtight stainless steel cauldron, add fatty alcohol-polyoxyethylene ether 89 kilograms, is warming up to 50 ± 2 DEG C and adds citric acid 1 kilogram; Heat up 60 ± 2 DEG C and add usninic acid 10 kilograms; 1 hour reactor reaction times.Temperature is down to 35 ± 2 DEG C, after testing qualified rear discharging.Material is placed in lucifuge, nonmetallic container.
Embodiment two:
By following part by weight throwing raw materials: fatty alcohol-polyoxyethylene ether 94.5 parts, usninic acid 5 parts, citric acid 0.5 part.
Synthesis route: with in temperature controlled airtight stainless steel cauldron, add fatty alcohol-polyoxyethylene ether 94.5 kilograms, is warming up to 50 ± 2 DEG C and adds citric acid 0.5 kilogram; Heat up 90 ± 2 DEG C and add usninic acid 5 kilograms; 1 hour reactor reaction times.Temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing.Material is placed in lucifuge, nonmetallic container.
Claims (8)
1. usninic acid fatty alcohol-polyoxyethylene ether complex compound of the present invention is a kind of fatty alcohol-polyoxyethylene ether complex compound made containing usninic acid.Its composition is made up of fatty alcohol-polyoxyethylene ether, usninic acid, citric acid.
2. according to claim 1, the present invention's complex compound used carrier fatty alcohol-polyoxyethylene ether has excellent solvability, wettability, compatibility and detergency.Fatty alcohol-polyoxyethylene ether outward appearance (more than 25 DEG C) is colourless transparent liquid, pH value (1% aqueous solution) 6-8, and wherein fatty alcohol carbochain number is 11-13, and chain structure is straight chain or side chain, ethoxymer distribution 8-10.
3. according to claim 1, material composition of the present invention: fatty alcohol-polyoxyethylene ether 90-95 part, usninic acid 5-10 part, citric acid 0.5-1.0 part.
4. according to claim 1, the synthesis of usninic acid fatty alcohol-polyoxyethylene ether complex compound of the present invention completed in particular device, temperature, time response process; Equipment used is stainless steel (or enamel or glass) material, and reactor need be air-tight state, need with backflow, heating equipment.Temperature of reaction controls between 50-80 DEG C, and the material synthetic system pH value in building-up process is slightly acidic.
5. according to claim 1, the present invention is with in temperature controlled chuck stainless steel cauldron, add fatty alcohol-polyoxyethylene ether, be warming up to 50 ± 2 DEG C and add citric acid, be warming up to 60 ± 2 DEG C and add usninic acid, reactor building-up reactions is after 1 hour, and temperature is down to 35 ± 2 DEG C, qualified rear discharging after testing, material is placed in lucifuge, nonmetallic container.
6. according to claim 1, the present invention, under effective concentration, has good sterilization effect to multiple-microorganisms such as Staphylococcus aureus bacillus, intestinal bacteria, fungi, moulds.Outward appearance body shape of the present invention is light yellow lotion, water-soluble, ethanol, Virahol, acetone, pH value (1% aqueous solution): 5-7, moisture content (%) :≤1.0, usninic acid content 5-10%.
7. the present invention manufactures to have anti-dandruff, only overworked shampoo, medical collutory and sterilant, thimerosal intermediate.
8. according to claim 1, the present invention manufacture that raw material is easy to get, pollution-free in production process, without waste, the requirement meeting environmental protective chemical industry production technique.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310244442.6A CN104231255A (en) | 2013-06-18 | 2013-06-18 | Usnic acid and fatty alcohol polyoxyethylene ether complex compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310244442.6A CN104231255A (en) | 2013-06-18 | 2013-06-18 | Usnic acid and fatty alcohol polyoxyethylene ether complex compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104231255A true CN104231255A (en) | 2014-12-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310244442.6A Pending CN104231255A (en) | 2013-06-18 | 2013-06-18 | Usnic acid and fatty alcohol polyoxyethylene ether complex compound |
Country Status (1)
| Country | Link |
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| CN (1) | CN104231255A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
-
2013
- 2013-06-18 CN CN201310244442.6A patent/CN104231255A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018287A1 (en) * | 2017-07-19 | 2019-01-24 | Colgate-Palmolive Company | Personal care compositions comprising zinc:usnic acid complexes and methods of use |
| US11517512B2 (en) | 2017-07-19 | 2022-12-06 | Colgate-Palmolive Company | Personal care compositions comprising zinc : usnic acid complexes and methods of use |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141224 |