CN104225603A - Paeonol and glyceryl polyether complex compound - Google Patents
Paeonol and glyceryl polyether complex compound Download PDFInfo
- Publication number
- CN104225603A CN104225603A CN201310244444.5A CN201310244444A CN104225603A CN 104225603 A CN104225603 A CN 104225603A CN 201310244444 A CN201310244444 A CN 201310244444A CN 104225603 A CN104225603 A CN 104225603A
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- China
- Prior art keywords
- paeonol
- complex compound
- present
- glyceryl polyether
- glycerin polyether
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a paeonol and glyceryl polyether complex compound which is a glyceryl polyether complex compound containing paeonol. The paeonol and glyceryl polyether complex compound is composed of the following materials: glyceryl polyether, paeonol and citric acid. Equipment for complexing the paeonol and glyceryl polyether complex compound is a stainless steel (or enamel or glass) reaction kettle with returning and heating functions. The paeonol and glyceryl polyether complex compound is a light yellow thick liquid in appearance, is dissolved into water, ethanol, isopropanol and acetone and has the pH value (1% water solution) of 5-7, the water content (%) of less than or equal to 1.0, the viscosity (25 DEG C CPS) of 250-400 and the paeonol content of 5-10%. The paeonol and glyceryl polyether complex compound has a favorable sterilizing effect on various microorganisms such as staphylococcus aureus, Escherichia coli, fungi and mycete under an effective concentration, is an intermediate for producing drug gel for treating rheumatism and skin itch and is an intermediate for producing facial beauty, dandruff removal, itching alleviation and hair growth promoting agents and lotions.
Description
[technical field]
Paeonol glycerin polyether complex of the present invention is a kind of glycerin polyether complex made containing paeonol, and its composition is made up of glycerin polyether, paeonol, citric acid.
[background technology]
Paeonol has another name called paeonol, and white crystals body, is insoluble in water, fusing point 52-53 DEG C, being the principle active component of Chinese medicine Cortex Moutan and Radix Cynanchi Paniculati, is that a kind of daily use chemicals additive of Nantural non-toxic has biological activity widely, as anti-inflammation, analgesia, antitumor and prevention cardiovascular system diseases etc.Pharmacological research finds that paeonol all has obvious inhibitory action to esophageal carcinoma, hepatocarcinoma, colon cancer, leukemia etc., has good antibacterial anti-inflammatory, antipyretic-antalgic, anticoagulation, antiallergic, immunomodulating, atherosclerosis and suppresses the effects such as central nervous system.Paeonol blood circulation promoting and blood stasis dispelling, promotes that microcirculatory effect is obviously better than aspirin.
[summary of the invention]
Feature of the present invention is to use non-ionic surface active agent glycerin polyether as carrier, manufactures paeonol glycerin polyether complex.
The present invention, by the complexation of glycerin polyether, changes the physical property of paeonol, and from the water that is insoluble in of paeonol, to become arbitrary proportion water-soluble.
The present invention is the intermediate manufacturing treatment rheumatism, skin pruritus treatment medicine gel, is manufacture beautifying face, and hair is anti-dandruff, the intermediate of only overworked, hair growth promoter and lotion.
The present invention's complex used carrier glycerin polyether has excellent dissolubility, wettability, compatibility.Glycerin polyether is widely used in the various fields such as household chemicals, food industry, pharmacy industry.Glycerin polyether toxicity is extremely low, to human body skin and human body mucosa nonirritant.
Glycerin polyether molecular weight of the present invention needs to control at 1600-2500.
The present invention, under valid density, has good bactericidal effect to multiple-microorganisms such as Staphylococcus aureus bacillus, escherichia coli, fungus, mycetes.
The synthesis of paeonol glycerin polyether complex of the present invention completed in particular device, temperature, time response process; Device therefor is rustless steel (or enamel or glass) material, and reactor need be air-tight state, need material circulation equipment and firing equipment.Reaction temperature controls between 50-100 DEG C, and the material synthetic system pH value in building-up process is faintly acid.
Material composition of the present invention: glycerin polyether 90-95 part, paeonol 5-10 part, citric acid 0.5-1.0 part.
The present invention is with in temperature controlled chuck stainless steel cauldron, add glycerin polyether, be warming up to 50 ± 2 DEG C and add citric acid, be warming up to 60 ± 2 DEG C and add paeonol, reactor synthetic reaction is after 1 hour, temperature is down to 35 ± 2 DEG C, after testing qualified rear discharging, and material is placed in lucifuge, nonmetallic container.
Outward appearance body shape of the present invention is light yellow thick liquid, water-soluble, ethanol, isopropyl alcohol, acetone, pH value (1% aqueous solution): 5-7, moisture content (%) :≤1.0, viscosity (25 DEG C of CPS): 250-400, paeonol content 5-10%.
The present invention manufactures that raw material is easy to get, pollution-free in production process, without garbage, the requirement meeting environmental protective chemical industry production technology.
[detailed description of the invention]
Embodiment one:
By following part by weight throwing raw materials: glycerin polyether 89 parts, paeonol 10 parts, citric acid 1 part.
Synthesis route: with in temperature controlled airtight stainless steel cauldron, add glycerin polyether 89 kilograms, is warming up to 50 ± 2 DEG C and adds citric acid 1 kilogram; Heat up 60 ± 2 DEG C and add paeonol 10 kilograms; 1 hour reactor response time.Temperature is down to 35 ± 2 DEG C, after testing qualified rear discharging.Material is placed in lucifuge, nonmetallic container.
Embodiment two:
By following part by weight throwing raw materials: glycerin polyether 94.5 parts, paeonol 5 parts, citric acid 0.5 part.
Synthesis route: with in temperature controlled airtight stainless steel cauldron, add glycerin polyether 94.5 kilograms, is warming up to 50 ± 2 DEG C and adds citric acid 0.5 kilogram; Heat up 60 ± 2 DEG C and add paeonol 5 kilograms; 1 hour reactor response time.Temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing.Material is placed in lucifuge, nonmetallic container.
Claims (8)
1. paeonol glycerin polyether complex of the present invention is a kind of glycerin polyether complex made containing paeonol.Its composition is made up of glycerin polyether, paeonol, citric acid.
2. according to claim 1, the present invention, under valid density, has good bactericidal effect to multiple-microorganisms such as Staphylococcus aureus bacillus, escherichia coli, fungus, mycetes.Being the intermediate manufacturing treatment rheumatism, skin pruritus treatment medicine gel, is manufacture beautifying face, and hair is anti-dandruff, the intermediate of only overworked, hair growth promoter and lotion.
3. according to claim 1, material composition of the present invention: glycerin polyether 90-95 part, paeonol 5-10 part, citric acid 0.5-1.0 part.
4. according to claim 1, glycerin polyether molecular weight needs to control at 1600-2500.
5. according to claim 1, the synthesis of paeonol glycerin polyether complex of the present invention completed in particular device, temperature, time response process; Device therefor is rustless steel (or enamel or glass) material, and reactor need be air-tight state, need firing equipment.Reaction temperature controls between 50-80 DEG C, and the material synthetic system pH value in building-up process is faintly acid.
6. according to claim 1, the present invention is with in temperature controlled chuck stainless steel cauldron, add glycerin polyether, be warming up to 50 ± 2 DEG C and add citric acid, be warming up to 60 ± 2 DEG C and add paeonol, reactor synthetic reaction is after 1 hour, and temperature is down to 35 ± 2 DEG C, qualified rear discharging after testing, material is placed in lucifuge, nonmetallic container.
7. according to claim 1, outward appearance body shape of the present invention is light yellow thick liquid, water-soluble, ethanol, isopropyl alcohol, acetone, pH value (1% aqueous solution): 5-7, moisture content (%) :≤1.0, viscosity (25 DEG C of CPS): 250-400, paeonol content 5-10%.
8. according to claim 1, the present invention manufacture that raw material is easy to get, pollution-free in production process, without garbage, the requirement meeting environmental protective chemical industry production technology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310244444.5A CN104225603A (en) | 2013-06-18 | 2013-06-18 | Paeonol and glyceryl polyether complex compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310244444.5A CN104225603A (en) | 2013-06-18 | 2013-06-18 | Paeonol and glyceryl polyether complex compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104225603A true CN104225603A (en) | 2014-12-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310244444.5A Pending CN104225603A (en) | 2013-06-18 | 2013-06-18 | Paeonol and glyceryl polyether complex compound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104225603A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018033470A1 (en) | 2016-08-19 | 2018-02-22 | Unilever N.V. | An antimicrobial composition |
| WO2019115136A1 (en) | 2017-12-15 | 2019-06-20 | Unilever N.V. | Topical composition comprising antimicrobial lipid |
| US10617621B2 (en) | 2016-08-19 | 2020-04-14 | Conopco, Inc. | Antimicrobial composition |
-
2013
- 2013-06-18 CN CN201310244444.5A patent/CN104225603A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018033470A1 (en) | 2016-08-19 | 2018-02-22 | Unilever N.V. | An antimicrobial composition |
| CN109640930A (en) * | 2016-08-19 | 2019-04-16 | 荷兰联合利华有限公司 | Antimicrobial compositions |
| US10617621B2 (en) | 2016-08-19 | 2020-04-14 | Conopco, Inc. | Antimicrobial composition |
| CN109640930B (en) * | 2016-08-19 | 2021-11-26 | 联合利华知识产权控股有限公司 | Antimicrobial compositions |
| US11246817B2 (en) | 2016-08-19 | 2022-02-15 | Conopco, Inc. | Antimicrobial composition |
| WO2019115136A1 (en) | 2017-12-15 | 2019-06-20 | Unilever N.V. | Topical composition comprising antimicrobial lipid |
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Legal Events
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141224 |