CN104224954A - Traditional Chinese medicine ointment for treating frostbite and preparation method thereof - Google Patents
Traditional Chinese medicine ointment for treating frostbite and preparation method thereof Download PDFInfo
- Publication number
- CN104224954A CN104224954A CN201410516244.5A CN201410516244A CN104224954A CN 104224954 A CN104224954 A CN 104224954A CN 201410516244 A CN201410516244 A CN 201410516244A CN 104224954 A CN104224954 A CN 104224954A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- weight
- radix
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a traditional Chinese medicine ointment for treating frostbite and a preparation method thereof. The traditional Chinese medicine ointment comprises the following ingredients in parts by weight: 4-12 parts of supercritical extracts of rheum officinale, 3-8 parts of astragalus extracts, 5-11 parts of sword bean extracts, 4-13 parts of clove, 3-8 parts of fructus broussonetiae, 2-5 parts of propolis, 6-13 parts of stearic acid and 5-11 parts of Vaseline. The preparation method comprises the following processes: supercritical extraction, enzymolysis, water extraction, alcohol precipitation and the like. The prepared traditional Chinese medicine ointment has a good treatment effect of treating frostbite.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of unguentum and preparation method thereof, particularly relate to a kind of Chinese medicinal ointment for the treatment of cold injury and preparation method thereof.
Background technology
Cold injury is under certain condition because cold acts on human body, cause local and even the damage of whole body.Degree of injury has direct relation with the state of cold intensity, wind speed, humidity, endure cold time and local and whole body.Wherein part frozen main clinical manifestation endure cold that position is ice-cold, pale, hard, stolidity or forfeiture.Because local is in frozen state, its damage range and degree are often difficult to judge.Part frozen damage is when epidermal area, and local skin is rubescent, swelling, and cardinal symptom is twinge, causalgia.If damage reaches skin corium, then there are contrafluxion and edema, after rewarming, occur vesicle.Bleb liquid mostly is orange yellow, transparent, and in cerise at the bottom of bleb, local pain is more acute, but insensitive, to acupuncture, and hot and cold anesthesia.The Chinese medicine of the traditional Chinese medical science being treated cold injury should focus on promoting the flow of QI in the collateral by warming the meridian, blood circulation promoting and blood stasis dispelling.Conventional Chinese medicine has Olibanum, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Ilicis Pubescentis, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, the Radix Astragali, Flos Lonicerae, Fructus Forsythiae etc.
Summary of the invention
The technical problem solved: the unguentum of the treatment cold injury common at present curative effect that it is curing gentle solution cold injury is comparatively common, can not treat cold injury preferably, therefore need Chinese medicinal ointment of a kind for the treatment of cold injury newly and preparation method thereof.
Technical scheme: for the problems referred to above, the invention discloses a kind of Chinese medicinal ointment for the treatment of cold injury and preparation method thereof, and the Chinese medicinal ointment of described treatment cold injury comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 4 ~ 12 parts,
Radix Astragali extract 3 ~ 8 parts,
Semen Canavaliae extract 5 ~ 11 parts,
Flos Caryophylli 4 ~ 13 parts,
Fructus Broussonetiae 3 ~ 8 parts,
Propolis 2 ~ 5 parts,
Stearic acid 6 ~ 13 parts,
5 ~ 11 parts, vaseline.
Preferably, described a kind of Chinese medicinal ointment for the treatment of cold injury, comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 4 ~ 12 parts,
Radix Astragali extract 3 ~ 8 parts,
Semen Canavaliae extract 5 ~ 11 parts,
Flos Caryophylli 4 ~ 13 parts,
Fructus Broussonetiae 3 ~ 8 parts,
Propolis 2 ~ 5 parts,
Stearic acid 6 ~ 13 parts,
5 ~ 11 parts, vaseline,
Retinervus Luffae Fructus water extract 4 ~ 9 parts,
Flos Buddlejae 5 ~ 10 parts.
Preferably, described a kind of Chinese medicinal ointment for the treatment of cold injury, comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 6 ~ 10 parts,
Radix Astragali extract 5 ~ 7 parts,
Semen Canavaliae extract 6 ~ 9 parts,
Flos Caryophylli 5 ~ 11 parts,
Fructus Broussonetiae 4 ~ 7 parts,
Propolis 3 ~ 4 parts,
Stearic acid 7 ~ 11 parts,
6 ~ 8 parts, vaseline,
Retinervus Luffae Fructus water extract 5 ~ 8 parts,
Flos Buddlejae 6 ~ 9 parts.
Preferred further, described a kind of Chinese medicinal ointment for the treatment of cold injury, comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 8 parts,
Radix Astragali extract 6 parts,
Semen Canavaliae extract 7 parts,
Flos Caryophylli 9 parts,
Fructus Broussonetiae 6 parts,
Propolis 3 parts,
Stearic acid 8 parts,
7 parts, vaseline,
Retinervus Luffae Fructus water extract 7 parts,
Flos Buddlejae 8 parts.
Treat a preparation method for the Chinese medicinal ointment of cold injury, described preparation method comprises the following steps:
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 4 ~ 12 parts, Radix Astragali extract 3 ~ 8 parts, Semen Canavaliae extract 5 ~ 11 parts, Flos Caryophylli 4 ~ 13 parts, Fructus Broussonetiae 3 ~ 8 parts, propolis 2 ~ 5 parts, stearic acid 6 ~ 13 parts, 5 ~ 11 parts, vaseline, Retinervus Luffae Fructus water extract 4 ~ 9 parts, Flos Buddlejae 5 ~ 10 parts is got by weight respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
Described a kind of preparation method for the treatment of the Chinese medicinal ointment of cold injury, gets Radix Et Rhizoma Rhei supercritical extract 6 ~ 10 parts, Radix Astragali extract 5 ~ 7 parts, Semen Canavaliae extract 6 ~ 9 parts, Flos Caryophylli 5 ~ 11 parts, Fructus Broussonetiae 4 ~ 7 parts, propolis 3 ~ 4 parts, stearic acid 7 ~ 11 parts, 6 ~ 8 parts, vaseline, Retinervus Luffae Fructus water extract 5 ~ 8 parts, Flos Buddlejae 6 ~ 9 parts by weight in step (5).
Described a kind for the treatment of in the preparation method step (5) of the Chinese medicinal ointment of cold injury gets Radix Et Rhizoma Rhei supercritical extract 8 parts, Radix Astragali extract 6 parts, Semen Canavaliae extract 7 parts, Flos Caryophylli 9 parts, Fructus Broussonetiae 6 parts, propolis 3 parts, stearic acid 8 parts, 7 parts, vaseline, Retinervus Luffae Fructus water extract 7 parts, Flos Buddlejae 8 parts by weight.
Beneficial effect: Chinese medicinal ointment of the present invention confirms to have the curative effect of extraordinary treatment cold injury with clinical effectiveness by experiment.In preparation method of the present invention, by carrying out extraction and isolation to the composition with the effect for the treatment of cold injury in various Chinese crude drug, and reasonable combination is carried out to its composition, obtain the unforeseeable technique effect for the treatment of cold injury, can be used as Chinese medicinal ointment and be used for the treatment of related symptoms caused by cold injury.
Detailed description of the invention
Embodiment 1
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 8g, Radix Astragali extract 6g, Semen Canavaliae extract 7g, Flos Caryophylli 9g, the sub-6g of Fructus Broussonetiae, propolis 3g, stearic acid 8g, vaseline 7g, Retinervus Luffae Fructus water extract 7g, Flos Buddlejae 8g is got respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
Embodiment 2
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 6g, Radix Astragali extract 7g, Semen Canavaliae extract 6g, Flos Caryophylli 5g, the sub-7g of Fructus Broussonetiae, propolis 4g, stearic acid 11g, vaseline 8g, Retinervus Luffae Fructus water extract 8g, Flos Buddlejae 9g is got respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
Embodiment 3
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 10g, Radix Astragali extract 5g, Semen Canavaliae extract 9g, Flos Caryophylli 11g, the sub-4g of Fructus Broussonetiae, propolis 3g, stearic acid 7g, vaseline 6g, Retinervus Luffae Fructus water extract 5g, Flos Buddlejae 6g is got respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
Embodiment 4
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 4g, Radix Astragali extract 8g, Semen Canavaliae extract 5g, Flos Caryophylli 13g, the sub-8g of Fructus Broussonetiae, propolis 5g, stearic acid 13g, vaseline 5g, Retinervus Luffae Fructus water extract 4g, Flos Buddlejae 10g is got respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
Embodiment 5
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 12g, Radix Astragali extract 3g, Semen Canavaliae extract 11g, Flos Caryophylli 4g, the sub-3g of Fructus Broussonetiae, propolis 2g, stearic acid 6g, vaseline 11g, Retinervus Luffae Fructus water extract 9g, Flos Buddlejae 5g is got respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
Embodiment 6
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) respectively Flos Caryophylli, Fructus Broussonetiae are pulverized; (6) getting Radix Et Rhizoma Rhei supercritical extract 12g, Radix Astragali extract 3g, Semen Canavaliae extract 11g, Flos Caryophylli 4g, the sub-3g of Fructus Broussonetiae, propolis 2g, stearic acid 6g, vaseline 11g respectively, mix homogeneously, is the Chinese medicinal ointment of the treatment cold injury of preparation.
Comparative example
Octadecanol 8g, stearic acid 3g, vaseline 5g, paraffin 5g, azone 2g, essence 0.08g, propylene glycol 20g, sodium lauryl sulphate 2g, ethyl hydroxybenzoate 1g, Ganoderma 10g, Semen Vaccariae 10g, mix homogeneously is Chinese medicinal ointment.
Be that the patient of cold injury is divided into 7 groups at random by symptom, often group is 30 people, and the symptom often organizing patient is edema, blister, skin are the symptoms such as purple.The painting Chinese medicinal ointment of embodiment 1 to 6 and comparative example respectively, once a day, being coated with the cycle is 5 days, and the complete Cure of patient is often organized in observation, and above-mentioned symptom disappears all completely, and without cicatrix, for curing example completely.Experimental result is as follows:
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Comparative example |
| Cure example completely | 29 | 25 | 26 | 22 | 23 | 19 | 19 |
By measuring the effect of Chinese medicinal ointment treatment cold injury, Chinese medicinal ointment of the present invention has the curative effect of extraordinary treatment cold injury.
Claims (7)
1. treat a Chinese medicinal ointment for cold injury, it is characterized in that the Chinese medicinal ointment of described treatment cold injury comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 4 ~ 12 parts,
Radix Astragali extract 3 ~ 8 parts,
Semen Canavaliae extract 5 ~ 11 parts,
Flos Caryophylli 4 ~ 13 parts,
Fructus Broussonetiae 3 ~ 8 parts,
Propolis 2 ~ 5 parts,
Stearic acid 6 ~ 13 parts,
5 ~ 11 parts, vaseline.
2. a kind of Chinese medicinal ointment for the treatment of cold injury according to claim 1, is characterized in that the Chinese medicinal ointment of described treatment cold injury comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 4 ~ 12 parts,
Radix Astragali extract 3 ~ 8 parts,
Semen Canavaliae extract 5 ~ 11 parts,
Flos Caryophylli 4 ~ 13 parts,
Fructus Broussonetiae 3 ~ 8 parts,
Propolis 2 ~ 5 parts,
Stearic acid 6 ~ 13 parts,
5 ~ 11 parts, vaseline,
Retinervus Luffae Fructus water extract 4 ~ 9 parts,
Flos Buddlejae 5 ~ 10 parts.
3. a kind of Chinese medicinal ointment for the treatment of cold injury according to claim 2, is characterized in that the Chinese medicinal ointment of described treatment cold injury comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 6 ~ 10 parts,
Radix Astragali extract 5 ~ 7 parts,
Semen Canavaliae extract 6 ~ 9 parts,
Flos Caryophylli 5 ~ 11 parts,
Fructus Broussonetiae 4 ~ 7 parts,
Propolis 3 ~ 4 parts,
Stearic acid 7 ~ 11 parts,
6 ~ 8 parts, vaseline,
Retinervus Luffae Fructus water extract 5 ~ 8 parts,
Flos Buddlejae 6 ~ 9 parts.
4. a kind of Chinese medicinal ointment for the treatment of cold injury according to claim 2, is characterized in that the Chinese medicinal ointment of described treatment cold injury comprises the composition of following weight parts:
Radix Et Rhizoma Rhei supercritical extract 8 parts,
Radix Astragali extract 6 parts,
Semen Canavaliae extract 7 parts,
Flos Caryophylli 9 parts,
Fructus Broussonetiae 6 parts,
Propolis 3 parts,
Stearic acid 8 parts,
7 parts, vaseline,
Retinervus Luffae Fructus water extract 7 parts,
Flos Buddlejae 8 parts.
5. treat a preparation method for the Chinese medicinal ointment of cold injury, it is characterized in that described preparation method comprises the following steps:
(1) Radix Et Rhizoma Rhei dries rear drying, be dried to moisture at below 6wt%, again Radix Et Rhizoma Rhei is carried out mechanical activation comminution, carry out supercritical carbon dioxide extraction after pulverizing, extracting pressure is 35MPa, and flash trapping stage still pressure is 8.5MPa, the second-order separation still pressure is 6.5MPa, extraction time is 4h, and extraction temperature is 55 DEG C, collects the extract in flash trapping stage still after extraction; (2) mechanical activation comminution after Radix Astragali drying, add the water of 5 times of weight, add 1,4 beta-glucanase again, 1,4 beta-glucanase weight is the 2wt% of water weight, adds rear stirred at ambient temperature 3h, centrifugalize, by 3 times that supernatant concentration to weight is astragalus weight, then in concentrate, add the dehydrated alcohol of the Radix Astragali 4 times of weight, leave standstill 1h, centrifugal collecting precipitation is Radix Astragali extract; (3) Semen Canavaliae is smashed to pieces, carries out water extraction after smashing to pieces, and water weight is 6 times of Semen Canavaliae weight, and Extracting temperature is 50 DEG C, and extraction time is 3h, and centrifugal rear concentrating obtains Semen Canavaliae extract; (4) get Retinervus Luffae Fructus, smash rear water extraction to pieces, water weight is 8 times of Retinervus Luffae Fructus weight, and Extracting temperature is 60 DEG C, and extraction time is 2h, extracts and terminates centrifugally, concentrated to obtain Retinervus Luffae Fructus water extract afterwards; (5) respectively Flos Caryophylli, Fructus Broussonetiae and Flos Buddlejae are pulverized; (6) Radix Et Rhizoma Rhei supercritical extract 4 ~ 12 parts, Radix Astragali extract 3 ~ 8 parts, Semen Canavaliae extract 5 ~ 11 parts, Flos Caryophylli 4 ~ 13 parts, Fructus Broussonetiae 3 ~ 8 parts, propolis 2 ~ 5 parts, stearic acid 6 ~ 13 parts, 5 ~ 11 parts, vaseline, Retinervus Luffae Fructus water extract 4 ~ 9 parts, Flos Buddlejae 5 ~ 10 parts is got by weight respectively, mix homogeneously is the Chinese medicinal ointment of the treatment cold injury of preparation.
6. a kind of preparation method for the treatment of the Chinese medicinal ointment of cold injury according to claim 5, is characterized in that getting Radix Et Rhizoma Rhei supercritical extract 6 ~ 10 parts, Radix Astragali extract 5 ~ 7 parts, Semen Canavaliae extract 6 ~ 9 parts, Flos Caryophylli 5 ~ 11 parts, Fructus Broussonetiae 4 ~ 7 parts, propolis 3 ~ 4 parts, stearic acid 7 ~ 11 parts, 6 ~ 8 parts, vaseline, Retinervus Luffae Fructus water extract 5 ~ 8 parts, Flos Buddlejae 6 ~ 9 parts in step (5) by weight.
7. a kind of preparation method for the treatment of the Chinese medicinal ointment of cold injury according to claim 5, is characterized in that getting Radix Et Rhizoma Rhei supercritical extract 8 parts, Radix Astragali extract 6 parts, Semen Canavaliae extract 7 parts, Flos Caryophylli 9 parts, Fructus Broussonetiae 6 parts, propolis 3 parts, stearic acid 8 parts, 7 parts, vaseline, Retinervus Luffae Fructus water extract 7 parts, Flos Buddlejae 8 parts in step (5) by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410516244.5A CN104224954A (en) | 2014-09-30 | 2014-09-30 | Traditional Chinese medicine ointment for treating frostbite and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410516244.5A CN104224954A (en) | 2014-09-30 | 2014-09-30 | Traditional Chinese medicine ointment for treating frostbite and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104224954A true CN104224954A (en) | 2014-12-24 |
Family
ID=52214431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410516244.5A Pending CN104224954A (en) | 2014-09-30 | 2014-09-30 | Traditional Chinese medicine ointment for treating frostbite and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104224954A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107432929A (en) * | 2016-05-27 | 2017-12-05 | 华南农业大学 | Animal composite immune reinforcing agent and application and the method for determining the reinforcing agent best composition content |
| CN108671067A (en) * | 2018-07-27 | 2018-10-19 | 吉林大学珠海学院 | A kind of oxidation resistant compound Chinese medicine extraction isolate and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966057A (en) * | 2006-11-02 | 2007-05-23 | 张新成 | Externally applied Chinese medicinal liquid for preventing and treating chilblain |
| CN101284109A (en) * | 2007-04-09 | 2008-10-15 | 王兴礼 | Medicine for curing the burnt, scalded and frostbited corium to regenerate |
| CN102125606A (en) * | 2010-12-16 | 2011-07-20 | 丁文武 | External ointment for treating chilblain |
| CN102784375A (en) * | 2012-07-24 | 2012-11-21 | 马千里 | Externally-used traditional Chinese medicament for treating chilblain and preparation method of same |
-
2014
- 2014-09-30 CN CN201410516244.5A patent/CN104224954A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966057A (en) * | 2006-11-02 | 2007-05-23 | 张新成 | Externally applied Chinese medicinal liquid for preventing and treating chilblain |
| CN101284109A (en) * | 2007-04-09 | 2008-10-15 | 王兴礼 | Medicine for curing the burnt, scalded and frostbited corium to regenerate |
| CN102125606A (en) * | 2010-12-16 | 2011-07-20 | 丁文武 | External ointment for treating chilblain |
| CN102784375A (en) * | 2012-07-24 | 2012-11-21 | 马千里 | Externally-used traditional Chinese medicament for treating chilblain and preparation method of same |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107432929A (en) * | 2016-05-27 | 2017-12-05 | 华南农业大学 | Animal composite immune reinforcing agent and application and the method for determining the reinforcing agent best composition content |
| CN108671067A (en) * | 2018-07-27 | 2018-10-19 | 吉林大学珠海学院 | A kind of oxidation resistant compound Chinese medicine extraction isolate and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103251769B (en) | Gynecological menstruation-regulating tablet and preparation method thereof | |
| CN106176784B (en) | It is a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof | |
| WO2016180070A1 (en) | Topical drug for treating breast cancer and preparation method thereof | |
| CN104224954A (en) | Traditional Chinese medicine ointment for treating frostbite and preparation method thereof | |
| CN101361911A (en) | External skin composition with wrinkle-dispelling function and production method thereof | |
| CN103736017A (en) | Traditional Chinese medicine composition for treating intercostal neuralgia and preparation method of traditional Chinese medicine composition | |
| CN101653562B (en) | Traditional Chinese medicine for treating erythrodermic psoriasis | |
| CN110538279A (en) | External traditional Chinese medicine and preparation method thereof | |
| CN104127522A (en) | Composition with effects of promoting circulation, removing stasis, dispelling wind and eliminating dampness | |
| CN1990010A (en) | Chinese medicinal herb liquid | |
| CN103721063B (en) | A kind of preoperative care substance for anorectal operation | |
| CN104258277A (en) | Traditional Chinese medicinal liquor with effects of promoting blood circulation to remove blood stasis and preparation method thereof | |
| CN110403980A (en) | A kind of burn and scald composition and preparation method thereof | |
| CN105311306A (en) | Medicine for treating severe body odor | |
| CN104001140A (en) | Paste for treating PICC (Peripherally Inserted Central Catheter) phlebitis and preparation method thereof | |
| CN105106527B (en) | A kind of Chinese medicine composition and preparation method thereof and pharmacy application | |
| CN103110764A (en) | Drug for treating acute toxic heat flaming herpes zoster | |
| CN103735682A (en) | Drug for treating allergic dermatitis and preparation method thereof | |
| CN101095742A (en) | Medicinal composition for treating verruca vulgaris | |
| CN1907371B (en) | Chinese patent medicine for treating anus cryptitis and hemorrhoid | |
| CN106110177A (en) | One treats psoriasic external medicinal liquid | |
| CN106177075A (en) | The cold compress bag for the treatment of allergic skin and preparation method thereof | |
| CN105412625A (en) | Traditional Chinese medicine composition for treating internal injury headache | |
| CN104721279A (en) | Traditional Chinese medicine ointment for treating psoriasis and preparation method thereof | |
| CN104906531A (en) | Bee venom liniment for treating prostatitis and preparation method therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141224 |
|
| RJ01 | Rejection of invention patent application after publication |