CN104224840B - A kind of compound drug for treating the ulcer of lower limb - Google Patents
A kind of compound drug for treating the ulcer of lower limb Download PDFInfo
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- CN104224840B CN104224840B CN201410462483.7A CN201410462483A CN104224840B CN 104224840 B CN104224840 B CN 104224840B CN 201410462483 A CN201410462483 A CN 201410462483A CN 104224840 B CN104224840 B CN 104224840B
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Abstract
The present invention discloses a kind of compound drug for treating the ulcer of lower limb, and its technical scheme is：Comprising pig nail powder and ROX, the proportioning (weight ratio) of pig nail powder and ROX is 4~6: 0.8~1.2.The processing technology of pig nail powder is to take fresh pig nail, removes after debris and to be cleaned with clear water, is then bakeed with the fiery low baking temperature of carbon to sallow, then with mortar grinder, crosses 60~100 mesh soil sieves, then pours out ROX pulvis, is sufficiently mixed therewith uniform.When treating the ulcer of lower limb, the surface of a wound is first removed into the muscle that rots with 3.5%~4.1% hydrogenperoxide steam generator cleaning and sterilizing, the surface of a wound is set to expose the granulation of oozing of blood, apply after compound drug and to be wrapped up with antiseptic gauze, a medicine was changed every 2~3 days after first treatment, until Wound healing.Its of the invention raw material sources are wide, cheap, pollution-free, technique is simple, easy to use, to patient's short treating period, good effect, have no side effect.
Description
Technical field
Ulcer of lower limb compound drug is treated the present invention relates to one kind, is particularly suitable for use in cureless not clear with western medicine
The compound drug of the ulcer of lower limb treatment of reason, is also applied for because lower extremity surgery wound controls the treatment for the patient that can not be healed long.
Background technology
The ulcer of lower limb is surgical common disease, frequently-occurring disease, and chronic ulcer of lower limb more belongs to difficult and complicated illness, and this ulcer is for a long time
Still recurrent exerbation after can not healing or healing, has a strong impact on people normally life and work.Ulcer of lower limb induced factor has many
Kind, venous hypertension and venous return are not freely its main causes.According to pertinent literature, ulcer caused by venous hypertension is accounted for
70%, arterial hypertension, which causes, accounts for 10%, and other account for 20%.At other in 20%, it is considered as due to artery and vein to have 15%
High pressure, which is combined, to be caused, and oedema is then the key pathological factor to form the ulcer of lower limb.On the treatment of the ulcer of lower limb, traditional west
Hospital's method is typically used：Surgical debridement, skin grafting, local skin flap's musculocutaneous flap Transfer, closed negative pressure attract, external application growth because
The measure such as son and dressing, to radical cure ulcer, preferably will also be performed the operation after ulcer wound surface healing, be tied with a great saphenous vein high position
Based on pricking and stripping off.So, the technical scheme of the western medical treatment ulcer of lower limb, which exists, cures slow speed, course for the treatment of length, weak curative effect, operation
Wound is big, the shortcoming more than complication, high medical expense, also beyond the ability to bear of general family of wage-earners.In
In terms of medical treatment, Chinese invention patent CN101648007A, CN1843375A, CN102018909A, CN101648002A etc.
The medicament of some professional treatment ulcers of lower limb is disclosed, there is certain curative effect, but there is also course for the treatment of length, curative effect be low, the surface of a wound is cured
Sum velocity is slow, dosage component source is not wide, difficult, medicament of drawing materials processes the shortcomings of easily being recurred after complicated, wound healing.
The content of the invention
To overcome the deficiencies in the prior art, the present invention provides a kind of compound drug for treating the ulcer of lower limb, its technical scheme
It is：Comprising pig nail powder and ROX, the proportioning (weight ratio) of pig nail powder and ROX is 4~6: 0.8~1.2.Pig
The processing technology of hoof nail powder is：Cleaned, then bakeed with the fiery low baking temperature of carbon to Jiao with clear water after taking fresh pig nail, removing debris
Huang, then with mortar grinder, cross 60~100 mesh soil sieves.Make and filled in proportion with pouring out ROX pulvis after pig nail powder
Divide well mixed, it is now with the current.When treating the ulcer of lower limb, first the surface of a wound is cleaned with 3.5%~4.1% hydrogenperoxide steam generator
Sterilization, removes the muscle that rots, the surface of a wound is exposed the granulation of oozing of blood, applies after compound drug and to be wrapped up with antiseptic gauze, through controlling for the first time
A medicine was changed after treatment every 2~3 days, until Wound healing.
The evaluation criterion of the clinical efficacy of the present invention, reference《Important Clinical Researches of New Drugs guideline》Improve slightly, its
In, cure：The clinical symptom disappearances such as itch, exanthemv, skin color recovers normal；It is effective：Symptom is obtained substantially after treatment
Improve, skin color recovers normal, and wound healing area is more than 2/3；Effectively：Clinical symptoms take a turn for the better before relatively treating, skin color
Improve, wound healing is more than 1/2, less than 2/3；It is invalid：These parameters are not met.
Clinical test results of the present invention are using " card square (X2) test " relevant experimental data is handled.
The compound drug treatment that Clinical observation group of the present invention is provided using inventor, i.e., when treating the ulcer of lower limb,
First the surface of a wound is removed the muscle that rots, the surface of a wound is exposed the meat of oozing of blood with 3.5%~4.1% hydrogenperoxide steam generator cleaning and sterilizing
Bud, applies after compound drug and to be wrapped up with antiseptic gauze, a medicine is changed every 2~3 days after first treatment, until Wound healing.
Control group is using the traditional treatment method treatment of doctor trained in Western medicine, i.e., when treating the ulcer of lower limb, first with 3.5%~4.1% hydrogen peroxide
Clean the surface of a wound, rear spray " bFGF bovine basic fibroblast growth factor externally used solution " (trade name bFGF-ESSEX), then with sterilizing yarn
Cloth is wrapped up, and drip-feed antibiotic anti-inflammatory changes a medicine in every 2 days.
The model case of the present invention of table 1 treats single dose check experiment result
Find out from the observations of table 1, alone ROX external application, 40 days surface of a wound have no the sign taking a favorable turn, instruction sheet is used
Antibiotic processing is of no curative effect substantially；Alone pig nail powder processing, although can heal, but the time is long, and speed is slow；Use trotter
First powder and the mixed processing of ROX 5: 1, although the state of an illness of patient Zhang is more serious than control patient Mr. Wang when experiment starts, wound
Mouth healing time is more notable than alone pig nail powder processing Mr. Wang to be shortened, and Wound healing speed is also fast.Clinical observation patient Zhang adopts
After the compound drug processing wound of the present invention, hence it is evident that find out that the surface of a wound receives water, proposes purulence, knot eggplant, healing, the state of an illness is good day by day
Turn, it is safely and effectively to illustrate medicament of the present invention.
The clinical test statistical result of the present invention of table 2
Note：Clinical test project implementation place is in Yancheng City Tinghu District township hospital, and " * " is to exist with control group difference
In 0.05 level significantly, " * * " be with control group difference in 0.01 level it is extremely notable.Statistical analysis technique is card square test.
The table of table 3 note is same with this table.
The result of the test recorded from table 2 finds out using the cure rate of compound drug test group of the present invention, obvious effective rate, always have
Efficiency is all remarkably higher than traditional western medicine treatment control group.Have no one occur have to medicament allergy hair should, its treat into
This also treats control group far below western medicine.Absolutely prove that the compound drug of the present invention is cheap, safe and effective.
The present invention of table 3 compares in epithelial growth speed and wound healing time
In terms of the statistics that table 3 is recorded, the epithelial growth speed pole of pharmacy test group of the present invention is significantly faster than traditional west
Hospital's method control group, wound healing time pole further illustrates the treatment of the present invention considerably less than traditional western medicine control group
The compound drug of the ulcer of lower limb is safely and effectively.
In summary, the preparation of " a kind of compound drug for treating the ulcer of lower limb " of the invention is simple, raw material sources are wide, price
It is cheap, pollution-free, easy to use, to patient's short treating period, good effect, healing speed is fast, patient is had no side effect.Tens of examples
Patients clinical is treated, and achieves satisfied effect.It is the preferred treatment technical side of the ulcer of lower limb patient of general wage-earners
Case.
Embodiment
Further illustrate the present invention below by way of specific embodiment, but following examples be merely to illustrate the present invention and to this
Invention is not limited.
Embodiment one
Take fresh pig nail, remove after debris and to be cleaned with clear water, then bakeed with the fiery low baking temperature of carbon to sallow, then ground with mortar
Mill, crosses 60 mesh soil sieves.The ratio after pig nail powder in 6: 1 is made with pouring out the pulvis in roxithromycin capsules, it is fully mixed
Close uniform, it is now with the current.When treating the ulcer of lower limb, first the surface of a wound is removed rotten with 3.5% hydrogenperoxide steam generator cleaning and sterilizing
Rotten muscle, makes the surface of a wound expose the granulation of oozing of blood, is wrapped up after uniformly applying 0.3 millimeters thick compound drug with antiseptic gauze, later every
A medicine was changed every 2.5 days, until Wound healing.
Embodiment two
Take fresh pig nail, remove after debris and to be cleaned with clear water, then bakeed with the fiery low baking temperature of carbon to sallow, then ground with mortar
Mill, crosses 80 mesh soil sieves.The ratio after pig nail powder in 5: 1 is made with pouring out the pulvis in roxithromycin capsules, it is fully mixed
Close uniform, it is now with the current.When treating the ulcer of lower limb, first the surface of a wound is removed rotten with 3.8% hydrogenperoxide steam generator cleaning and sterilizing
Rotten muscle, makes the surface of a wound expose the granulation of oozing of blood, is wrapped up after uniformly applying 0.25 millimeters thick compound drug with antiseptic gauze, later every
A medicine was changed every 2 days, until Wound healing.
Embodiment three
Take fresh pig nail, remove after debris and to be cleaned with clear water, then bakeed with the fiery low baking temperature of carbon to sallow, then ground with mortar
Mill, crosses 100 mesh soil sieves.The ratio after pig nail powder in 4: 1 is made with pouring out the pulvis in roxithromycin capsules, it is fully mixed
Close uniform, it is now with the current.When treating the ulcer of lower limb, first the surface of a wound is removed rotten with 4.1% hydrogenperoxide steam generator cleaning and sterilizing
Rotten muscle, makes the surface of a wound expose the granulation of oozing of blood, is wrapped up after uniformly applying 0.2 millimeters thick compound drug with antiseptic gauze, later every
A medicine was changed every 2 days, until Wound healing.
Claims (5)
1. a kind of compound drug for treating the ulcer of lower limb, is characterized in include pig nail powder and ROX, pig nail powder and Luo Hong
The proportioning (weight ratio) of mycin is 4~6: 0.8~1.2.
2. a kind of compound drug for treating the ulcer of lower limb, is characterised by the manufacture craft of pig nail powder according to claim 1
It is to take fresh pig nail to remove after debris with clear water to clean, is then bakeed with the fiery low baking temperature of carbon to sallow, then with mortar grinder, mistake
60~100 mesh soil sieves.
3. a kind of compound drug for treating the ulcer of lower limb, is characterized in pig nail powder and ROX glue according to claim 1
Pulvis in capsule need to be mixed in proportion, now with the current.
4. a kind of compound drug for treating the ulcer of lower limb, is characterized in, when treating the ulcer of lower limb, first will according to claim 1
The surface of a wound is removed the muscle that rots, the surface of a wound is exposed the granulation of oozing of blood with 3.5%~4.1% hydrogenperoxide steam generator cleaning and sterilizing, is applied
Wrapped up after upper compound drug with antiseptic gauze.
5. a kind of compound drug for treating the ulcer of lower limb, is characterized in every 2~3 after first treatment according to claim 1
It changes a medicine, until Wound healing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410462483.7A CN104224840B (en) | 2014-09-03 | 2014-09-03 | A kind of compound drug for treating the ulcer of lower limb |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410462483.7A CN104224840B (en) | 2014-09-03 | 2014-09-03 | A kind of compound drug for treating the ulcer of lower limb |
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| Publication Number | Publication Date |
|---|---|
| CN104224840A CN104224840A (en) | 2014-12-24 |
| CN104224840B true CN104224840B (en) | 2017-07-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410462483.7A Active CN104224840B (en) | 2014-09-03 | 2014-09-03 | A kind of compound drug for treating the ulcer of lower limb |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648007A (en) * | 2008-08-13 | 2010-02-17 | 代龙 | Pharmaceutical composition for treating ulcus cruris and preparation method thereof |
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2014
- 2014-09-03 CN CN201410462483.7A patent/CN104224840B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648007A (en) * | 2008-08-13 | 2010-02-17 | 代龙 | Pharmaceutical composition for treating ulcus cruris and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 下肢溃疡的病因及治疗进展;赵东红;《实用医药杂志》;20100228;第27卷(第2期);第172页，左栏第2段第4-6行 * |
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| CN104224840A (en) | 2014-12-24 |
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Effective date of registration: 20211116 Address after: 276800 workshop A4 and A6, electronic information industrial park, Gaoxin seventh Road, Donggang District, Rizhao City, Shandong Province Patentee after: Rizhao Ruiji e-commerce industry Co., Ltd Address before: 224002 room 504, building 1, No. 33, Wengang North Road, Yancheng City, Jiangsu Province Patentee before: Cai Guoxiang |