CN104208594A

CN104208594A - Pharmaceutical composition for treating vascular tumor

Info

Publication number: CN104208594A
Application number: CN201410489554.2A
Authority: CN
Inventors: 李绍礼
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-23
Filing date: 2014-09-23
Publication date: 2014-12-17

Abstract

The invention discloses a pharmaceutical composition for treating a vascular tumor. The pharmaceutical composition comprises the following raw materials of, by weight, 12-24 parts of red-rooted salvia roots, 12-24 parts of safflowers, 12-24 parts of dragon's bloods, 12-24 parts of common clubmoss herb, 12-24 parts of garden balsam stems, 12-24 parts of gambir plant, 9-21 parts of dittany barks, 9-21 parts of rhizoma sparganii, 9-21 parts of rhizoma curcumae, 9-21 parts of rhizoma arisaematis, 9-21 parts of leech, 9-21 parts of natural indigo, 9-21 parts of calomel, and 9-21 parts of borneol. According to the pharmaceutical composition for treating the vascular tumor, the raw materials are active components, and the pharmaceutical composition is good in vascular tumor treatment effect.

Description

A kind of pharmaceutical composition for the treatment of vascular tumor

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of vascular tumor.

Background technology

Vascular tumor is hemangioma and lymphangiomatous being collectively referred to as, vascular system comprises blood vessel and lymphatic vessel, vascular anomalies (vascular anomalies) is a proper noun, refer in particular to the large class disease damage of hemangioma (hemangioma) and vascular malformation (vascular malformations) two, the latter comprises vascular malformation and lymphatic malformation.According to the literature, the sickness rate of hemangioma when neonatal sickness rate is 1.1%, 1 years old is up to 10%, and wherein, 35% occurs in incidence.Early stage documents and materials are referred to as vascular tumor by vascular disease both at home and abroad, after in recognizing vascular anomalies, be not greatly neoplastic disease but after developmental disorder, derived from again this noun of vascular malformation, but this appellation of vascular tumor (hemangioma) is retained, specially refer to tumor or paraneoplastic disease in vascular anomalies.

In foreign literature, use vascular tumors (Garzon etc., 2000) censure blood vessel (hemangiomas), to show and the corresponding of vascular malformation and difference, the malignant tumor that vascular tumor (hemangioma) should comprise vascular system is as pernicious hemangiopericytoma etc.Clinically, vascular anomalies majority is vascular malformation, that is to say, the ratio of the real shared vascular anomalies of hemangioma is also little, the vascular anomalies of being especially grown up, and the overwhelming majority is vascular malformation.Therefore because hemangioma has spontaneous regression trend in the Childhood. to growing up period, vascular anomalies has not almost had real hemangioma (except hemangioma traces).The vascular anomalies of Childhood had been likely both hemangioma, was likely also vascular malformation, as for both constituent ratios, and who many who widow, the survey data of this respect is also imperfect at present.It is generally acknowledged, the vascular anomalies of Childhood is more common with hemangioma.

Vascular tumor is oral cavity, jaw face common disease, and traditional Therapeutic Method has operation, freezing, laser etc., and curative effect is all not too satisfied.What employing was more at present is to treat as sclerosing agent local injection with Bleomycin A5, and effect is better.Bleomycin A5 is produced by Pingyang streptomycete, and Main Ingredients and Appearance is bleomycin A5, through suppressing DNA to synthesize, affects cellular metabolism function, and untoward reaction is few, and side effect is mainly heating, pneumonia sample symptom and pulmonary fibrosis and changes.Therefore, utilize clinically this side effect principle treatment hemangioma, Bleomycin A5 injects after tumor body, in local accumulation, high concentration medicine destroys rapidly blood sinus endotheliocyte and causes thrombosis, makes its degeneration, atrophy, degeneration form fibrosis, thereby makes the healing of disappearing of tumor body.

For avoiding western medical treatment defect, release with the scheme that treats of herbal composite treatment vascular tumor very necessary.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of good pharmaceutical composition of vascular tumor effect for the treatment of.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, by the raw material of following weight parts, is made:

Preferably, it is to be made by weight by following raw materials according:

More preferably, it is to be made by weight by following raw materials according:

The medically acceptable dosage forms such as the dosage form preferred particulates agent of pharmaceutical composition of the present invention, capsule, tablet, powder, their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in preparation treatment vascular tumor medicine.

In pharmaceutical composition prescription of the present invention:

Radix Salviae Miltiorrhizae--its removing heat from blood, invigorate blood circulation, the dredging collateral effect of having one's ideas straightened out;

Flos Carthami--get its promoting blood circulation to remove obstruction in the collateral, Eradicates stasis of blood analgesic effect;

Sanguis Draxonis--get its stasis-dispelling and pain-killing, hemostasia and promoting granulation sore, anticancer swollen effect;

Herba Lycopodii--get its expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral effect;

Herba speranskiae tuberculatae--get its expelling wind and removing dampness, promoting blood circulation and detumescence analgesic effect;

Ramulus Uncariae Cum Uncis--get its heat clearing away, the effect of endogenous wind stopping relieving convulsion;

Qi Cheongju transconversion into heat of Cortex Dictamni--Qu effect of wetting, dispel the wind;

Rhizoma Sparganii--get its removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, control malignant tumor effect;

Rhizoma Curcumae--get its circulation of qi promoting removing blood stasis, removing food stagnancy analgesic effect;

Rhizoma Arisaematis--get its drying dampness to eliminate phlegm, dispel the wind and separate warp, dispersing swelling and dissipating binds, antitumaous effect;

Hirudo--get its removing blood stasis, removing blood stasis, stimulate the menstrual flow, control venous thrombosis effect;

Celadon black pigment used by women in ancient times to paint their eyebrows--get its removing heat from blood, remove swollen toxin expelling, antitumaous effect;

Calomelas--get its removing the necrotic tissue and promoting granulation, toxin expelling sterilization, repair anti-cell effect, anticancer swollen effect;

Borneolum Syntheticum--get its clearing away heat to alleviate pain, have one's ideas straightened out, bacteriostasis.

Pharmaceutical composition of the present invention, has blood vessel dilating perforation, blood circulation, anti-blood resistance bolt, vessel softening function, repairs blood vessel, inwall granulation promoting, changes tumor skin ulcer evacuation of pus, anticancer sterilization, the removing heat from blood and promoting blood circulation, Cheongju stasis of blood function of drying that disappears, and can improve blood premunition.

The specific embodiment

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.

Embodiment 1

Above-mentioned raw materials is smashed, crossed 80 mesh sieves, add making pellets by mixing medical powder with honey, obtain pill.

Embodiment 2

By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 ℃ time survey), add the magnesium stearate adjuvant of conventional amount used, make capsule, 0.5g/ grain.

Embodiment 3

By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 ℃ time survey), the magnesium stearate adjuvant that adds conventional amount used, technique is made tablet routinely, 0.5 part/sheet of specification.

Embodiment 4

Above-mentioned raw materials is mixed, pulverized 80 mesh sieves, obtain powder.

Embodiment 5

By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 ℃ time survey), add appropriate cane sugar powder, technique granulation agent routinely, 10g/ bag.

Experimental example: clinical effectiveness

For many years, medicine composite for curing vascular tumor of the present invention clinical observation, all obtains promising result, is now reported as follows:

1, physical data

77 routine patients all hitch institute and out-patient, and the oldest 18 years old, smaller part year; The course of disease is the longest 4 years, the shortest half a year.

2, diagnostic criteria

According to the general inspection method of vascular tumor.

Take the granule that the embodiment of the present invention 5 obtains, every day 2 times, each 1 bag, infant consumption successively decreases, and 30 days courses for the treatment of, takes 3 courses for the treatment of.

3, criterion of therapeutical effect

Effective: visible tumor disappears and more than lasting January;

Effective: two maximum orthogonal diameter products of tumor dwindle more than 50% and more than lasting January; Or two maximum orthogonal diameter products of tumor dwindle less than 50%, increase and be no more than 25% and lasting more than one month;

Invalid: two maximum orthogonal diameter products increases of tumor are no more than 25%.

4, therapeutic outcome

Claims

1. a pharmaceutical composition for the treatment of vascular tumor, is characterized in that: this pharmaceutical composition is to be made by the raw material of following weight parts:

2. the pharmaceutical composition for the treatment of vascular tumor according to claim 1, is characterized in that: this pharmaceutical composition is to be made by the raw material of following weight parts:

3. the pharmaceutical composition for the treatment of vascular tumor according to claim 1, is characterized in that: this pharmaceutical composition is to be made by the raw material of following weight parts:

4. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment vascular tumor in claim 1-3.