CN104208337A - Traditional Chinese medicine lozenge for treating pertussis and preparation method - Google Patents

Abstract

The invention discloses traditional Chinese medicine lozenge for treating pertussis and a preparation method and belongs to the field of traditional Chinese medicine. Active ingredients of the traditional Chinese medicine lozenge comprise smoked plum, paniculate spotflower herb, sea hibiscus, chrysanthemum bean, bitter almond, polygonum cuspidatum, piper sarmentosum, pericarpium areca, celery, himalayan foamflower herb, babysbreath, water-chestnut root, platycodon grandiflorum, roughhaired holly root and chestnut leaf. The traditional Chinese medicine lozenge is proper in medicine compatibility, conforms to the traditional Chinese medicine and pharmacy, and modern medicine and pharmacology theories, and plays roles of clearing heat, removing toxicity, moistening lung to arrest cough, relieving swelling and pain, inhibiting and killing bordetella pertussis, and relieving cough and asthma; the traditional Chinese medicine lozenge is convenient to take, accurate in curative effect, safe and worthy of broad clinic popularization; the traditional Chinese medicine lozenge does not have side effect; the pertussis does not relapse after being cured.

Description

A kind of pertussal Traditional Chinese medicine lozenge and preparation method for the treatment of

Affiliated technical field

The present invention relates to the field of Chinese medicines, relate in particular to a kind of pertussal Traditional Chinese medicine lozenge and preparation method for the treatment of.

Background technology

Pertussis is the common Acute respiratory infectious disease of children's, and bordetella pertussis is the pathogenic bacterium of primary disease.It is characterized by paroxysmal spasmodic cough, cough end is with special air-breathing roar, and the course of disease is longer, can reach several weeks even about 3 months, therefore there is the title of pertussis.

During paroxysmal spasmodic cough, superior vena cava pressure increases, and returns painstaking effort stream and is obstructed and has blood stasis phenomenon, and common face and the puffiness of the eyes, when apasm of coughing is violent, can occur nose Nv, spitting of blood and eye subconjunctival hemorrhage etc., and intracranial hemorrhage even occurs.The every impact of the frequent person of paroxysmal spasmodic cough sleep, cause infant tired, do not like activity, loss of appetite, add vomiting, secondary infection, can cause malnutrition.As without secondary infection, the general body temperature of infant is normal, and pulmonary is without positive sign or have unfixed rale.

Teenager and adult's pertussis have the trend of increasing in recent years, can account for 10.2% of total case when popular.One group of adult's pertussis confirming through antibacterial culturing, the mean age is 35 years old, vomits after having classical symptom and paroxysmal spasmodic cough, but also can only have dry cough several weeks, rare complication.Great majority still can be adhered to work, though I,, without much miseries, can be used as the source of infection, especially threaten children's, should pay attention to.

At present, treat pertussal medicine a lot, but curative effect is general, side effect is larger, the good not object that does not reach rapid healing of some effects.

Summary of the invention

The invention provides a kind of pertussal Traditional Chinese medicine lozenge and preparation method for the treatment of; The selected medical material compatibility of Traditional Chinese medicine lozenge of the present invention is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is the effect of heat-clearing and toxic substances removing, nourishing the lung to arrest cough, reducing swelling and alleviating pain, bordetella pertussis is played to inhibition killing action, antitussive and antiasthmatic, taking convenience, determined curative effect, non-relapse after healing, safety has no side effect, wide popularization and application on clinic.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Treat a pertussal Traditional Chinese medicine lozenge, raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:

33～57 parts of 36～60 parts of Apiosdelavayi Franch. of 38～62 parts of Cortex seu flos hibisci tiliacei of 39～63 parts of Herba Spilanthis Acmellae of Fructus Mume

28～52 parts of 30～54 parts of Pericarpium Arecae of 31～55 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 30～54 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

23～47 parts of 25～49 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 27～51 parts of Caulis et folium pavettae hongkongensiss of 27～51 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

15～39 parts of 18～42 parts of Folium Castaneae of 22～46 portions of Radix Ilicis Asprellaes of 23～47 parts of Herba Sonchi Oleracei of Radix Platycodonis.

Raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:

37～53 parts of 40～56 parts of Apiosdelavayi Franch. of 42～58 parts of Cortex seu flos hibisci tiliacei of 43～59 parts of Herba Spilanthis Acmellae of Fructus Mume

32～48 parts of 34～50 parts of Pericarpium Arecae of 35～51 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 34～50 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

27～43 parts of 29～45 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 31～47 parts of Caulis et folium pavettae hongkongensiss of 31～47 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

19～35 parts of 22～38 parts of Folium Castaneae of 26～42 portions of Radix Ilicis Asprellaes of 27～43 parts of Herba Sonchi Oleracei of Radix Platycodonis.

Raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:

41～49 parts of 44～52 parts of Apiosdelavayi Franch. of 46～54 parts of Cortex seu flos hibisci tiliacei of 47～55 parts of Herba Spilanthis Acmellae of Fructus Mume

36～44 parts of 38～46 parts of Pericarpium Arecae of 39～47 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 38～46 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

31～39 parts of 33～41 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 35～43 parts of Caulis et folium pavettae hongkongensiss of 35～43 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

23～31 parts of 26～34 parts of Folium Castaneae of 30～38 portions of Radix Ilicis Asprellaes of 31～39 parts of Herba Sonchi Oleracei of Radix Platycodonis.

Raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:

45 parts of 48 parts of Apiosdelavayi Franch. of 50 parts of Cortex seu flos hibisci tiliacei of 51 parts of Herba Spilanthis Acmellae of Fructus Mume

40 parts of 42 parts of Pericarpium Arecae of 43 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 42 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

35 parts of 37 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 39 parts of Caulis et folium pavettae hongkongensiss of 39 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

27 parts of 30 parts of Folium Castaneae of 34 portions of Radix Ilicis Asprellaes of 35 parts of Herba Sonchi Oleracei of Radix Platycodonis.

Treat a preparation method for pertussal Traditional Chinese medicine lozenge, comprise following processing step:

(1) Fructus Mume, Cortex seu flos hibisci tiliacei and Herba Sonchi Oleracei are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice standby;

(2) Herba Spilanthis Acmellae, Rhizoma Polygoni Cuspidati and Angiopteris magna Ching (Angiopteris majuscula Ching) are put into container, carry out pulverization process, grind into powder, cross 160 order fine powders, standby;

(3) Apiosdelavayi Franch., Semen Armeniacae Amarum, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Pericarpium Arecae, Herba Apii graveolentis, Caulis et folium pavettae hongkongensis, Radix Platycodonis, Radix Ilicis Asprellae and Folium Castaneae are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.13, standby;

(4) Herba tiarellae polyphyllae is cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 ℃ of simmer down tos, relative density is 1.12～1.16 is standby;

(5) above-mentioned steps (1)～(4) prepared juice, fine powder and thick paste are mixed, make tablet, obtain the pertussal Traditional Chinese medicine lozenge for the treatment of of the present invention.

The property of medicine of the present invention's Chinese medicine used is as follows:

Fructus Mume: sour in the mouth, property is flat; Enter liver, spleen, lung, kidney, stomach, large intestine channel.Astringing lung-QI and relieving cough, relieving diarrhea with astringents, hemostasis is promoted the production of body fluid, relieving colic caused by ascaris.Cure mainly chronic cough, deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis.< < detailed outline > > carries: " astringing intestine to stop diarrhea of astringing the lung, controls chronic cough, dysentery, and regurgitation is dysphagic, ascariasis of biliary tract vomiting and diarrhea, detumescence, gushes expectorant, and parasite killing is separated ichthyotoxin, horse mump, sulfur poison." modern medicine study confirmation; Fructus Mume has obvious antibacterial action; dysentery bacterium, bacillus pyocyaneus, Bacillus typhi, escherichia coli, tubercule bacillus, Bacillus proteus, staphylococcus aureus, messy vibrio and various fungus are all had to inhibitory action; and can stimulate the hormonal secretion of the parotid gland; and clearization blood, strengthens metabolic function.

Herba Spilanthis Acmellae: acrid in the mouth, warm in nature.Detoxification and promoting urination, relieving cough and relieving asthma, reducing swelling and alleviating pain.For malaria, toothache, enteritis, dysentery, cough, asthma, pertussis, pulmonary tuberculosis.Venom is controlled in external, dog bite, carbuncle furuncle and phyma poison.The conventional Chinese herbal medicine handbook > > of the < < of Guangzhou army carries: " relieving cough and relieving asthma, reducing swelling and alleviating pain.The cough that cures cold, chronic bronchitis, asthma, pertussis, pulmonary tuberculosis, venom, sore swollen toxin, toothache.”

Cortex seu flos hibisci tiliacei: sweet in the mouth, light, cold nature; Return lung meridian.Clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat, furuncle swells and ache, manihot poisoning.< < Xinhua book on Chinese herbal medicine outline > > carries: " effect have bring down a fever, emesis, cough-relieving function.Cough bronchitis is used for having a fever; External application toxic swelling.”

Apiosdelavayi Franch.: mildly bitter flavor, cool in nature; Return lung meridian.Heat clearing away, removing toxic substances, cough-relieving.Cure mainly laryngopharynx swelling and pain, cold cough, pertussis, scrofula, carbuncle, impetigo.

Semen Armeniacae Amarum: bitter in the mouth, slightly warm in nature, slightly poisonous; Return lung, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature; Return liver, gallbladder, lung meridian.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis is not Xiaed ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Modern medicine study confirmation, Huzhang has obvious anastalsis to traumatic hemorrhage, and for oral administration also have anastalsis to upper gastrointestinal hemorrhage, and Rhizoma Polygoni Cuspidati extract has antipyretic effect, and scald wound is had convergence, protected from infection and antiinflammation.

Radix Piperis sarmentosi (Herba Piperis Sarmentosi): bitter in the mouth, warm in nature; GUIXIN, lung, spleen, large intestine channel.Expelling wind and cold, promoting the circulation of QI to relieve pain, active, detumescence.The main air cough with asthma of trembling with fear, rheumatic arthralgia, distension and fullness in the abdomen, dysentery, puerperal swelling of the feet, traumatic injury.The < < SHENGCAO property of medicine is standby wants > > to carry: " control toothache, wash rotten foot.”

Pericarpium Arecae: acrid in the mouth, slightly warm in nature is nontoxic; Return spleen, lung, stomach warp.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, row water.Control gastral cavity abdomen painful abdominal mass swollen, beriberi, edema.< < Japan hanako materia medica > > carries: " lower all gas, only cholera, leads to intestine and small intestine, and spleen benefiting and stimulating the appetite, in tune.”

Herba Apii graveolentis: taste is cool, sweet, property is pungent; Enter liver, gallbladder, pericardium channel.Clearing away heat-damp and promoting diuresis, suppressing the hyperactive liver stomach invigorating, removing heat from the liver, nourishes blood.< < health communication > > carries: " heat is washed in clearing stomach, promoting blood circulation, and tasty and refreshing tooth wets one's whistle, improving eyesight stuffy nose relieving, refreshment stomach invigorating, nourishing the lung to arrest cough." modern medicine study confirmation, it is also many that Herba Apii graveolentis contains the content of mineral substances such as abundant vitamin A, vitamin B1, vitamin B2, vitamin C and Citrin, calcium, ferrum, phosphorus, also has in addition the compositions such as protein, mannitol and dietary fiber; In addition, Herba Apii graveolentis also have that clearing away stomach-heat, promoting blood circulation, strong tooth wet one's whistle, the effect of improving eyesight refreshment, nourishing the lung to arrest cough.

Herba tiarellae polyphyllae: bitter in the mouth, cold in nature, nontoxic; Return lung meridian.Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Main furuncle, nameless gall, cough, asthma, hepatitis, traumatic injury.< < Sichuan WuLong's medicine is planted figure will > > and is carried: " control deafness, asthma.”

Caulis et folium pavettae hongkongensis: property is flat, bitter in the mouth.Clearing away heat and promoting diuresis, preventing phlegm from forming and stopping coughing.For acute icterohepatitis, acute nephritis, pertussis, lithangiuria, tinea pedis,, banded Blisters rash, conjunctivitis, erysipelas.< < does not record > > and carries: " expectorant knot on the breast that disappears, saliva is as shellac varnish, and the heart is coerced expectorant water, bladder prolonged fluid-retention; pathogenic wind arthralgia chiefly caused by damp pathogen, carrion between skin, in order, gum is slightd; sharp large intestine, promoting blood circulation, beneficial color and luster.”

Angiopteris magna Ching (Angiopteris majuscula Ching): bitter in the mouth, puckery, cold in nature; GUIXIN, lung, large intestine channel.Heat-clearing and toxic substances removing, hemostasis, damp eliminating diuresis.Cure mainly enteritis, dysentery, dyspepsia abdominal distention.Oedema due to nephritis, pulmonary tuberculosis, hemoptysis, metrorrhagia, traumatic injury, rheumatism, gastric and duodenal ulcers.

Radix Platycodonis: bitter in the mouth, pungent, property is flat; Return lung meridian.Lung qi dispersing sore-throat relieving, the evacuation of pus of eliminating the phlegm.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.< < Li Gao > > carries: " sharp chest and diaphragm, (controlling) throat gas is stopped up and pain, broken stagnant gas and long-pending piece, (removing) pulmonary wind heat, the clear sharp head, sharp key.”

Herba Sonchi Oleracei: bitter in the mouth, cold in nature; Enter the heart, spleen, stomach three warps.Heat-clearing and toxic substances removing, removing blood stasis with potent drugs is invigorated blood circulation, evacuation of pus.For appendicitis, peritoneal abscess, enteritis, dysentery, acute and chronic pelvic inflammatory disease, cough due to lung-heat, pulmonary tuberculosis, spits blood, epistaxis; Traumatic injury is controlled in external, and furuncle swells and ache, impetigo, eczema scrotum.

Radix Ilicis Asprellae: bitter in the mouth, sweet, cold in nature; Return lung, liver, large intestine channel.Clearing away heat and promoting production of body fluid, dissipating blood stasis removing toxic substances.Main flu, headache, dizzy, calentura excessive thirst, eruptive disease, diarrhea of heat type, lung abscess, pertussis, laryngopharynx swelling and pain, hemorrhoidal bleeding, gonorrhea, furuncle swelling toxin, traumatic injury.The medicine will > > of < < Nanning City carries: " heat-clearing and toxic substances removing, lung moistening is quenched the thirst.Soothe sore throat thirsty, hemoptysis, eruptive disease.”

Folium Castaneae: taste is micro-sweet, property is flat.Clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling.Main pertussis, pulmonary tuberculosis, swelling throat is sick, toxic swelling, dermatitis rhus.The modern Practical Chinese medicinal > of < < > carries: " be astringent.External is coated with dermatitis rhus.”

The present invention compared with prior art, has following beneficial effect:

The selected medical material compatibility of Traditional Chinese medicine lozenge of the present invention is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is the effect of heat-clearing and toxic substances removing, nourishing the lung to arrest cough, reducing swelling and alleviating pain, bordetella pertussis is played to inhibition killing action, antitussive and antiasthmatic, taking convenience, determined curative effect, non-relapse after healing, safety has no side effect, wide popularization and application on clinic.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of Traditional Chinese medicine lozenge effective ingredient of the present invention forms and weight is:

Fructus Mume 59g Herba Spilanthis Acmellae 58g Cortex seu flos hibisci tiliacei 56g Apiosdelavayi Franch. 53g

Semen Armeniacae Amarum 51g Rhizoma Polygoni Cuspidati 50g Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 50g Pericarpium Arecae 48g

Herba Apii graveolentis 47g Herba tiarellae polyphyllae 47g Caulis et folium pavettae hongkongensis 45g Angiopteris magna Ching (Angiopteris majuscula Ching) 43g

Radix Platycodonis 43g Herba Sonchi Oleracei 42g Radix Ilicis Asprellae 38g Folium Castaneae 35g.

Treat a preparation method for pertussal Traditional Chinese medicine lozenge, comprise following processing step:

(1) Fructus Mume, Cortex seu flos hibisci tiliacei and Herba Sonchi Oleracei are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice standby;

(2) Herba Spilanthis Acmellae, Rhizoma Polygoni Cuspidati and Angiopteris magna Ching (Angiopteris majuscula Ching) are put into container, carry out pulverization process, grind into powder, cross 160 order fine powders, standby;

(3) Apiosdelavayi Franch., Semen Armeniacae Amarum, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Pericarpium Arecae, Herba Apii graveolentis, Caulis et folium pavettae hongkongensis, Radix Platycodonis, Radix Ilicis Asprellae and Folium Castaneae are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.13, standby;

(4) Herba tiarellae polyphyllae is cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 ℃ of simmer down tos, relative density is 1.12～1.16 is standby;

(5) above-mentioned steps (1)～(4) prepared juice, fine powder and thick paste are mixed, make tablet, obtain the pertussal Traditional Chinese medicine lozenge for the treatment of of the present invention.

Usage and dosage: buccal or oral, every day 2 times, morning, noon and afternoon each 1 time, each 2, buccal or after meal warm water delivery service; Within 6 days, be 1 course for the treatment of, can fully recover 2～3 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.

Embodiment 2

The raw material of Traditional Chinese medicine lozenge effective ingredient of the present invention forms and weight is:

Fructus Mume 55g Herba Spilanthis Acmellae 54g Cortex seu flos hibisci tiliacei 52g Apiosdelavayi Franch. 49g

Semen Armeniacae Amarum 47g Rhizoma Polygoni Cuspidati 46g Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 46g Pericarpium Arecae 44g

Herba Apii graveolentis 43g Herba tiarellae polyphyllae 43g Caulis et folium pavettae hongkongensis 41g Angiopteris magna Ching (Angiopteris majuscula Ching) 39g

Radix Platycodonis 39g Herba Sonchi Oleracei 38g Radix Ilicis Asprellae 34g Folium Castaneae 31g.

Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 3

The raw material of Traditional Chinese medicine lozenge effective ingredient of the present invention forms and weight is:

Fructus Mume 51g Herba Spilanthis Acmellae 50g Cortex seu flos hibisci tiliacei 48g Apiosdelavayi Franch. 45g

Semen Armeniacae Amarum 43g Rhizoma Polygoni Cuspidati 42g Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 42g Pericarpium Arecae 40g

Herba Apii graveolentis 39g Herba tiarellae polyphyllae 39g Caulis et folium pavettae hongkongensis 37g Angiopteris magna Ching (Angiopteris majuscula Ching) 35g

Radix Platycodonis 35g Herba Sonchi Oleracei 34g Radix Ilicis Asprellae 30g Folium Castaneae 27g.

Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 4

The raw material of Traditional Chinese medicine lozenge effective ingredient of the present invention forms and weight is:

Fructus Mume 47g Herba Spilanthis Acmellae 46g Cortex seu flos hibisci tiliacei 44g Apiosdelavayi Franch. 41g

Semen Armeniacae Amarum 39g Rhizoma Polygoni Cuspidati 38g Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 38g Pericarpium Arecae 36g

Herba Apii graveolentis 35g Herba tiarellae polyphyllae 35g Caulis et folium pavettae hongkongensis 33g Angiopteris magna Ching (Angiopteris majuscula Ching) 31g

Radix Platycodonis 31g Herba Sonchi Oleracei 30g Radix Ilicis Asprellae 26g Folium Castaneae 23g.

Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 5

The raw material of Traditional Chinese medicine lozenge effective ingredient of the present invention forms and weight is:

Fructus Mume 43g Herba Spilanthis Acmellae 42g Cortex seu flos hibisci tiliacei 40g Apiosdelavayi Franch. 37g

Semen Armeniacae Amarum 35g Rhizoma Polygoni Cuspidati 34g Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 34g Pericarpium Arecae 32g

Herba Apii graveolentis 31g Herba tiarellae polyphyllae 31g Caulis et folium pavettae hongkongensis 29g Angiopteris magna Ching (Angiopteris majuscula Ching) 27g

Radix Platycodonis 27g Herba Sonchi Oleracei 26g Radix Ilicis Asprellae 22g Folium Castaneae 19g.

Traditional Chinese medicine lozenge preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Clinical data:

1, case selection:

As the pertussal Traditional Chinese medicine lozenge for the treatment of, select the routine clinical observation of pertussis patient 120 make a definite diagnosis, patient to be divided at random two groups for the treatment of group and matched groups, treatment group 60 examples, male's 31 examples wherein, women's 29 examples, 1～20 years old age, 10.5 years old mean age, the course of disease 2 months; Matched group 60 examples, male's 29 examples wherein, women's 31 examples, 2～19 years old age, 10.5 years old mean age, the course of disease 1 month.

The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.

2, medicament selection:

Treatment group is taken Traditional Chinese medicine lozenge of the present invention, buccal or oral, every day 2 times, morning, noon and afternoon each 1 time, each 2, buccal or after meal warm water delivery service; Within 6 days, be 1 course for the treatment of, take continuously 2～3 courses for the treatment of, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.

Matched group is taken pentoxyverine citrate sheet, oral, a 25mg, and 3～4 times on the one, within 5 years old, with last 6.25～12.5mg, 2～3 times on the one, the course for the treatment of is depending on the state of an illness.

3, efficacy determination:

(1) cure: cough symptom all disappears, it is normal that throat pain is recovered.

(2) effective: cough symptom is clearly better, and throat pain alleviates to some extent.

(3) effective: cough symptom takes a turn for the better to some extent, and throat pain obviously alleviates.

(4) invalid: by treating rear cough symptom without taking a turn for the better or increasing the weight of.

4, result:

Select in the treatment group of medicine of the present invention, cure 35 examples, effective 13 examples, effective 10 examples, invalid 2 examples, cure rate 58.3%, total effective rate 96.7%.

In matched group, cure 10 examples, effective 18 examples, effective 13 examples, invalid 19 examples, cure rate 16.7%, total effective rate 68.3%.

Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is given an example:

1, Yao, female, 2 years old, Jinan, Shandong Province people.Patient's flu, slightly heating, dry cough.Take Traditional Chinese medicine lozenge treatment of the present invention, take after 2 courses for the treatment of, paroxysmal paroxysmal spasmodic cough alleviates, and number of times reduces, and crow sample air-suction-noise disappears, and patient's spirit appetite recovers normal gradually.

2, Zou, man, 7 years old, Zhenjiang, Jiangsu people.Patient's flu, cough, can have watery nasal discharge, sneeze, takes Traditional Chinese medicine lozenge treatment of the present invention, takes after 1 course for the treatment of, and above symptom is clearly better, takes after 2 courses for the treatment of, transference cure, spirit is recovered normally gradually, follows up a case by regular visits to so far not recurrence.

3, Cui, female, 10 years old, people from Hefei ,Anhui.Patient started cough before two days, during once played two pin antibiotic, but when cough is heavy, rear to our hospital when light, takes Traditional Chinese medicine lozenge treatment of the present invention, takes after 1 course for the treatment of, cough symptom disappears substantially, continues to take after 2 courses for the treatment of, cough symptom disappears completely.

4, hole, man, 5 years old, Zhejiang Jiaxing people.Patient flows clear nasal mucus, and dry cough was used several drugs treatment, and poor effect is rear to our hospital, takes Traditional Chinese medicine lozenge of the present invention, takes after 1 course for the treatment of, and symptom disappears substantially, fully recovers after taking the 2nd course for the treatment of.

5, Peng, female, 15 years old, people from Jieyang, Guangdong.Patient is drowsiness, and rhinorrhea can be followed heating sometimes, and body temperature is no more than 38 ℃; Spirit is poor, and inappetence is rear to our hospital, takes Traditional Chinese medicine lozenge of the present invention, takes after 1 course for the treatment of, and without rhinorrhea symptom, body temperature is normal, fully recovers after taking the 2nd course for the treatment of.

6, Jiang, man, 8 years old, people from Changchun, Jilin.Patient's cough, expectorant Huang is sticky, xerostomia pharyngalgia, red tongue with yellow fur.Take Traditional Chinese medicine lozenge of the present invention after 1 course for the treatment of, xerostomia pharyngalgia symptom alleviates, and amount of expectoration reduces, and takes Traditional Chinese medicine lozenge of the present invention and fully recovers after 2 courses for the treatment of.

Claims (5)

1. treat a pertussal Traditional Chinese medicine lozenge, it is characterized in that: raw material composition and the parts by weight of making described Traditional Chinese medicine lozenge effective ingredient are:

33～57 parts of 36～60 parts of Apiosdelavayi Franch. of 38～62 parts of Cortex seu flos hibisci tiliacei of 39～63 parts of Herba Spilanthis Acmellae of Fructus Mume

28～52 parts of 30～54 parts of Pericarpium Arecae of 31～55 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 30～54 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

23～47 parts of 25～49 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 27～51 parts of Caulis et folium pavettae hongkongensiss of 27～51 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

15～39 parts of 18～42 parts of Folium Castaneae of 22～46 portions of Radix Ilicis Asprellaes of 23～47 parts of Herba Sonchi Oleracei of Radix Platycodonis.

2. a kind of pertussal Traditional Chinese medicine lozenge for the treatment of according to claim 1, is characterized in that: the raw material of making described Traditional Chinese medicine lozenge effective ingredient forms and parts by weight are:

37～53 parts of 40～56 parts of Apiosdelavayi Franch. of 42～58 parts of Cortex seu flos hibisci tiliacei of 43～59 parts of Herba Spilanthis Acmellae of Fructus Mume

32～48 parts of 34～50 parts of Pericarpium Arecae of 35～51 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 34～50 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

27～43 parts of 29～45 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 31～47 parts of Caulis et folium pavettae hongkongensiss of 31～47 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

19～35 parts of 22～38 parts of Folium Castaneae of 26～42 portions of Radix Ilicis Asprellaes of 27～43 parts of Herba Sonchi Oleracei of Radix Platycodonis.

3. a kind of pertussal Traditional Chinese medicine lozenge for the treatment of according to claim 1, is characterized in that: the raw material of making described Traditional Chinese medicine lozenge effective ingredient forms and parts by weight are:

41～49 parts of 44～52 parts of Apiosdelavayi Franch. of 46～54 parts of Cortex seu flos hibisci tiliacei of 47～55 parts of Herba Spilanthis Acmellae of Fructus Mume

36～44 parts of 38～46 parts of Pericarpium Arecae of 39～47 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 38～46 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

31～39 parts of 33～41 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 35～43 parts of Caulis et folium pavettae hongkongensiss of 35～43 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

23～31 parts of 26～34 parts of Folium Castaneae of 30～38 portions of Radix Ilicis Asprellaes of 31～39 parts of Herba Sonchi Oleracei of Radix Platycodonis.

4. a kind of pertussal Traditional Chinese medicine lozenge for the treatment of according to claim 1, is characterized in that: the raw material of making described Traditional Chinese medicine lozenge effective ingredient forms and parts by weight are:

45 parts of 48 parts of Apiosdelavayi Franch. of 50 parts of Cortex seu flos hibisci tiliacei of 51 parts of Herba Spilanthis Acmellae of Fructus Mume

40 parts of 42 parts of Pericarpium Arecae of 43 parts of Rhizoma Polygoni Cuspidati of Semen Armeniacae Amarum, 42 Fen Radix Piperis sarmentosi (Herba Piperis Sarmentosi)

35 parts of 37 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s of 39 parts of Caulis et folium pavettae hongkongensiss of 39 parts of Herba tiarellae polyphyllaes of Herba Apii graveolentis

27 parts of 30 parts of Folium Castaneae of 34 portions of Radix Ilicis Asprellaes of 35 parts of Herba Sonchi Oleracei of Radix Platycodonis.

5. as described in claim 1～4 any one, treat a preparation method for pertussal Traditional Chinese medicine lozenge, it is characterized in that: comprise following processing step:

(1) Fructus Mume, Cortex seu flos hibisci tiliacei and Herba Sonchi Oleracei are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice standby;

(2) Herba Spilanthis Acmellae, Rhizoma Polygoni Cuspidati and Angiopteris magna Ching (Angiopteris majuscula Ching) are put into container, carry out pulverization process, grind into powder, cross 160 order fine powders, standby;

(3) Apiosdelavayi Franch., Semen Armeniacae Amarum, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Pericarpium Arecae, Herba Apii graveolentis, Caulis et folium pavettae hongkongensis, Radix Platycodonis, Radix Ilicis Asprellae and Folium Castaneae are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.13, standby;

(4) Herba tiarellae polyphyllae is cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 ℃ of simmer down tos, relative density is 1.12～1.16 is standby;

(5) above-mentioned steps (1)～(4) prepared juice, fine powder and thick paste are mixed, make tablet, obtain the described pertussal Traditional Chinese medicine lozenge for the treatment of.