CN104203277A - 梯牧草变应原和用于调节免疫反应的方法和用途 - Google Patents

梯牧草变应原和用于调节免疫反应的方法和用途 Download PDF

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Publication number
CN104203277A
CN104203277A CN201380008385.XA CN201380008385A CN104203277A CN 104203277 A CN104203277 A CN 104203277A CN 201380008385 A CN201380008385 A CN 201380008385A CN 104203277 A CN104203277 A CN 104203277A
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CN
China
Prior art keywords
peptide
protein
allergy
experimenter
allergen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380008385.XA
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English (en)
Chinese (zh)
Inventor
A·塞特
V·舒尔滕
H·格雷
B·彼得斯
J·格林鲍姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
La Jolla Institute for Allergy and Immunology
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La Jolla Institute for Allergy and Immunology
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Publication date
Application filed by La Jolla Institute for Allergy and Immunology filed Critical La Jolla Institute for Allergy and Immunology
Publication of CN104203277A publication Critical patent/CN104203277A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201380008385.XA 2012-02-07 2013-02-07 梯牧草变应原和用于调节免疫反应的方法和用途 Pending CN104203277A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261596156P 2012-02-07 2012-02-07
US61/596,156 2012-02-07
US201261734886P 2012-12-07 2012-12-07
US61/734,886 2012-12-07
PCT/US2013/025213 WO2013119863A1 (en) 2012-02-07 2013-02-07 Timothy grass allergens and methods and uses for immune response modulation

Publications (1)

Publication Number Publication Date
CN104203277A true CN104203277A (zh) 2014-12-10

Family

ID=48948025

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380008385.XA Pending CN104203277A (zh) 2012-02-07 2013-02-07 梯牧草变应原和用于调节免疫反应的方法和用途

Country Status (13)

Country Link
US (1) US10428124B2 (https=)
EP (1) EP2812026A4 (https=)
JP (1) JP2015513527A (https=)
KR (1) KR20140129124A (https=)
CN (1) CN104203277A (https=)
AU (1) AU2013216993C1 (https=)
BR (1) BR112014019504A2 (https=)
CA (1) CA2864084A1 (https=)
EA (1) EA201491481A1 (https=)
HK (1) HK1204929A1 (https=)
IN (1) IN2014MN01513A (https=)
MX (1) MX2014009285A (https=)
WO (1) WO2013119863A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US12201652B2 (en) * 2016-05-03 2025-01-21 Stemcell Technologies Canada Inc. Intracellular delivery of biomolecules to induce tolerance

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WO2015054217A2 (en) 2013-10-07 2015-04-16 La Jolla Institute For Allergy And Immunology Methods and uses for reducing an allergic response in a subject
WO2015054231A1 (en) 2013-10-07 2015-04-16 La Jolla Institute For Allergy And Immunology Methods and uses for identifying responders to allergy therapy
WO2015077442A2 (en) 2013-11-20 2015-05-28 La Jolla Institute For Allergy And Immunology Grass pollen immunogens and methods and uses for immune response modulation
AU2014352986A1 (en) 2013-11-20 2016-06-16 Alk-Abello A/S Pan pollen immunogens and methods and uses thereof for immune response modulation
BR112016011930A2 (pt) 2013-12-23 2017-09-26 Alk Abello As combinações de peptídeos e seus usos em tratamento de alergia de ácaro de poeira
WO2015131053A1 (en) 2014-02-28 2015-09-03 Alk-Abelló A/S Polypeptides derived from phl p and methods and uses thereof for immune response modulation
EP3925968A3 (en) 2014-10-07 2022-03-02 Cytlimic Inc. Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell
CN113388021A (zh) 2015-03-09 2021-09-14 Cytlimic公司 源于gpc3的肽、使用其的医药组合物、免疫诱导剂、及抗原呈递细胞的制造方法
RU2709015C2 (ru) 2015-04-07 2019-12-13 Ситлимик Инк. Лекарственное средство
US11291718B2 (en) 2016-10-11 2022-04-05 Cytlimic Inc. Method for treating cancer by administering a toll-like receptor agonist and LAG-3 IgG fusion protein
CN119086940A (zh) * 2017-04-28 2024-12-06 朋友股份有限公司 变态反应的抗原及其表位
JP7770314B2 (ja) * 2019-11-25 2025-11-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 診断及び処置のための抗原ニューロン特異的エノラーゼペプチド
CN120349374B (zh) * 2025-03-25 2025-10-10 长沙理工大学 一种米渣短肽及其在降尿酸中的应用

Citations (4)

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CN1665835A (zh) * 2002-06-25 2005-09-07 默克专利股份公司 草花粉过敏原Phl p4 的 DNA 序列和用重组方法进行的制备
CN1675240A (zh) * 2002-08-19 2005-09-28 默克专利股份公司 来自梯牧草的主要过敏原Phl p1的变异体
US20090070897A1 (en) * 2006-01-12 2009-03-12 Goldman Barry S Genes and uses for plant improvement
US20110217325A1 (en) * 2001-09-18 2011-09-08 Circassia Limited T cell epitopes of the cyn d 1 allergen from bermuda grass pollen

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US7214786B2 (en) * 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
WO2004047793A1 (en) * 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
AU2006204997B2 (en) 2005-01-12 2011-09-01 Monsanto Technology, Llc Genes and uses for plant improvement
PL2244734T3 (pl) * 2008-02-01 2017-01-31 Murdoch Childrens Research Institute Sposób indukcji tolerancji na alergen
EP2388268A1 (en) * 2010-05-18 2011-11-23 Stallergenes S.A. Recombinant Der p 2 expressed in Pichia pastoris as a "natural-like" allergen for immunotherapy and diagnostic purposes
US20120100163A1 (en) 2010-10-15 2012-04-26 Alk-Abello A/S Suppression of a type 1 hypersensitivity immune response with an unrelated antigen
US20120100164A1 (en) 2010-10-15 2012-04-26 Alk-Abello A/S Suppression of a hypersensitivity immune response with unrelated antigen derived from allergen source material
US9700071B2 (en) * 2012-03-26 2017-07-11 Axcella Health Inc. Nutritive fragments, proteins and methods
JP2015514126A (ja) 2012-04-16 2015-05-18 アルク−アベッロ エイ／エスＡｌｋ−Ａｂｅｌｌｏ Ａ／Ｓ 非特異的アレルギー免疫療法において使用するための植物プロフィリンポリペプチド

Patent Citations (4)

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US20110217325A1 (en) * 2001-09-18 2011-09-08 Circassia Limited T cell epitopes of the cyn d 1 allergen from bermuda grass pollen
CN1665835A (zh) * 2002-06-25 2005-09-07 默克专利股份公司 草花粉过敏原Phl p4 的 DNA 序列和用重组方法进行的制备
CN1675240A (zh) * 2002-08-19 2005-09-28 默克专利股份公司 来自梯牧草的主要过敏原Phl p1的变异体
US20090070897A1 (en) * 2006-01-12 2009-03-12 Goldman Barry S Genes and uses for plant improvement

Non-Patent Citations (6)

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Title
KAO S ET AL.: "Q7XAS6_CYNDA，Proteomics and immunological analyses of novel allergen, Cyn d 22 from Bermuda grass pollen", 《HTTP://WWW.UNIPROT.ORG/UNIPROT/Q7XAS6.TXT?VERSION=44》 *
OSEROFF C ET AL.: "Molecular determinants of T cell epitope recognition to the common timothy grass allergen", 《THE JOURNAL OF IMMUNOLOGY》 *
TILL S ET AL.: "IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis", 《CLIN EXP IMMUNOL》 *
VALERIA C ET AL.: "Identification of grass pollen allergens by two-dimensional gel electrophoresis and serological screening", 《PROTEOMICS》 *
VRTALA S ET AL.: "Molecular, immunological, and structural characterization of PhI p 6, amajor allergen and P-partical-associated protein from Timothy grass (Phleum pretense) pollen", 《J IMMUNOL》 *
WURTZEN PA ET AL.: "Identification of isoform-specific T-cell epitopes in the major timothy grass pollen allergen,Phl p5", 《CLIN EXP ALLERGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12201652B2 (en) * 2016-05-03 2025-01-21 Stemcell Technologies Canada Inc. Intracellular delivery of biomolecules to induce tolerance

Also Published As

Publication number Publication date
EA201491481A1 (ru) 2014-11-28
BR112014019504A2 (pt) 2017-06-27
IN2014MN01513A (https=) 2015-09-11
US10428124B2 (en) 2019-10-01
JP2015513527A (ja) 2015-05-14
US20150023992A1 (en) 2015-01-22
HK1204929A1 (en) 2015-12-11
EP2812026A4 (en) 2016-04-27
CA2864084A1 (en) 2013-08-15
EP2812026A1 (en) 2014-12-17
MX2014009285A (es) 2015-02-04
AU2013216993B2 (en) 2016-09-15
KR20140129124A (ko) 2014-11-06
AU2013216993C1 (en) 2017-01-19
WO2013119863A1 (en) 2013-08-15
AU2013216993A1 (en) 2014-08-21

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