CN104193668A - 大孔树脂自发酵液中提取l-色氨酸的方法 - Google Patents
大孔树脂自发酵液中提取l-色氨酸的方法 Download PDFInfo
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- CN104193668A CN104193668A CN201410455120.0A CN201410455120A CN104193668A CN 104193668 A CN104193668 A CN 104193668A CN 201410455120 A CN201410455120 A CN 201410455120A CN 104193668 A CN104193668 A CN 104193668A
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- Prior art keywords
- trp
- resin
- concentrated
- liquid
- dry
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- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims abstract description 63
- 239000011347 resin Substances 0.000 title claims abstract description 47
- 229920005989 resin Polymers 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000000855 fermentation Methods 0.000 title claims abstract description 13
- 230000004151 fermentation Effects 0.000 title claims abstract description 13
- 229960004799 tryptophan Drugs 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 claims abstract description 14
- 230000008025 crystallization Effects 0.000 claims abstract description 14
- 238000000926 separation method Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000012452 mother liquor Substances 0.000 claims description 21
- 238000010521 absorption reaction Methods 0.000 claims description 15
- 239000013078 crystal Substances 0.000 claims description 14
- 239000008213 purified water Substances 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 14
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 11
- 238000005374 membrane filtration Methods 0.000 claims description 10
- 230000008929 regeneration Effects 0.000 claims description 10
- 238000011069 regeneration method Methods 0.000 claims description 10
- 238000011084 recovery Methods 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 6
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 230000009849 deactivation Effects 0.000 claims description 4
- 239000010408 film Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 230000000392 somatic effect Effects 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 239000010409 thin film Substances 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 239000003463 adsorbent Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000011068 loading method Methods 0.000 claims description 2
- 230000001172 regenerating effect Effects 0.000 claims description 2
- 238000010583 slow cooling Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 230000003245 working effect Effects 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410455120.0A CN104193668B (zh) | 2014-09-10 | 2014-09-10 | 大孔树脂自发酵液中提取l-色氨酸的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410455120.0A CN104193668B (zh) | 2014-09-10 | 2014-09-10 | 大孔树脂自发酵液中提取l-色氨酸的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104193668A true CN104193668A (zh) | 2014-12-10 |
CN104193668B CN104193668B (zh) | 2016-02-03 |
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Family Applications (1)
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CN201410455120.0A Active CN104193668B (zh) | 2014-09-10 | 2014-09-10 | 大孔树脂自发酵液中提取l-色氨酸的方法 |
Country Status (1)
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CN (1) | CN104193668B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110031583A (zh) * | 2018-12-29 | 2019-07-19 | 浙江工业大学 | 分离测定n-琥珀酰色氨酸对映异构体的液相色谱方法 |
CN110759849A (zh) * | 2019-11-18 | 2020-02-07 | 河南巨龙生物工程股份有限公司 | 一种色氨酸二次母液回收工艺 |
CN112970944A (zh) * | 2021-03-12 | 2021-06-18 | 廊坊梅花生物技术开发有限公司 | 利用氨基酸发酵副产物生产饲料添加剂方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101376646A (zh) * | 2007-08-29 | 2009-03-04 | 天津科技大学 | 从发酵液中提取l-色氨酸的新方法 |
CN101691349A (zh) * | 2009-10-20 | 2010-04-07 | 山东恩贝生物工程有限公司 | 一种从发酵液中提取色氨酸的工艺 |
CN101864466A (zh) * | 2010-05-26 | 2010-10-20 | 成都圣凯生物科技有限公司 | 利用工程菌株bl21-de3发酵获取5-羟基色氨酸的方法 |
CN102344403A (zh) * | 2011-08-10 | 2012-02-08 | 山东鲁抗生物制造有限公司 | 离子交换树脂直接提取发酵液中色氨酸的方法 |
-
2014
- 2014-09-10 CN CN201410455120.0A patent/CN104193668B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101376646A (zh) * | 2007-08-29 | 2009-03-04 | 天津科技大学 | 从发酵液中提取l-色氨酸的新方法 |
CN101691349A (zh) * | 2009-10-20 | 2010-04-07 | 山东恩贝生物工程有限公司 | 一种从发酵液中提取色氨酸的工艺 |
CN101864466A (zh) * | 2010-05-26 | 2010-10-20 | 成都圣凯生物科技有限公司 | 利用工程菌株bl21-de3发酵获取5-羟基色氨酸的方法 |
CN102344403A (zh) * | 2011-08-10 | 2012-02-08 | 山东鲁抗生物制造有限公司 | 离子交换树脂直接提取发酵液中色氨酸的方法 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110031583A (zh) * | 2018-12-29 | 2019-07-19 | 浙江工业大学 | 分离测定n-琥珀酰色氨酸对映异构体的液相色谱方法 |
CN110759849A (zh) * | 2019-11-18 | 2020-02-07 | 河南巨龙生物工程股份有限公司 | 一种色氨酸二次母液回收工艺 |
CN112970944A (zh) * | 2021-03-12 | 2021-06-18 | 廊坊梅花生物技术开发有限公司 | 利用氨基酸发酵副产物生产饲料添加剂方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104193668B (zh) | 2016-02-03 |
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Effective date of registration: 20190115 Address after: 832000 Tianshan Road, No. 94 District, Shihezi Development Zone, Urumqi City, Xinjiang Uygur Autonomous Region Co-patentee after: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY CO.,LTD. Patentee after: XINJIANG TIANFU YANGGUANG BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Address before: 83-2014 Tianfu Science and Technology Park, No. 95 District, Shihezi Development Zone, Xinjiang Uygur Autonomous Region Co-patentee before: JIANGSU SEL BIOCHEMISTRY Co.,Ltd. Patentee before: XINJIANG TIANFU YANGGUANG BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. |
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CP03 | Change of name, title or address |
Address after: 832000 No.3 Tianshan Road, No.94 community, Shihezi Development Zone, Urumqi, Xinjiang Uygur Autonomous Region Co-patentee after: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY CO.,LTD. Patentee after: Xinjiang Zheda sunshine Biotechnology Co.,Ltd. Address before: 832000 Tianshan Road, No. 94 District, Shihezi Development Zone, Urumqi City, Xinjiang Uygur Autonomous Region Co-patentee before: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY CO.,LTD. Patentee before: XINJIANG TIANFU YANGGUANG BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. |
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CP03 | Change of name, title or address | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Urumqi City, Xinjiang Uygur Autonomous Region Patentee after: Xinjiang Shangni Biotechnology Co.,Ltd. Patentee after: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY Co.,Ltd. Address before: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Urumqi City, Xinjiang Uygur Autonomous Region Patentee before: Xinjiang Zheda sunshine Biotechnology Co.,Ltd. Patentee before: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20210902 Address after: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Xinjiang Uygur Autonomous Region Patentee after: Xinjiang Shangni Biotechnology Co.,Ltd. Patentee after: Hangzhou Shangni Biotechnology Co.,Ltd. Address before: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Urumqi City, Xinjiang Uygur Autonomous Region Patentee before: Xinjiang Shangni Biotechnology Co.,Ltd. Patentee before: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20211117 Address after: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Xinjiang Uygur Autonomous Region Patentee after: Xinjiang Shangni Biotechnology Co.,Ltd. Patentee after: JIANGSU SEL BIOCHEMISTRY Co.,Ltd. Address before: 832000 No. 3, Tianshan Road, community 94, Shihezi Development Zone, Xinjiang Uygur Autonomous Region Patentee before: Xinjiang Shangni Biotechnology Co.,Ltd. Patentee before: Hangzhou Shangni Biotechnology Co.,Ltd. |
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TR01 | Transfer of patent right | ||
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Effective date of registration: 20230105 Address after: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Xinjiang Uygur Autonomous Region Patentee after: Xinjiang Shangni Biotechnology Co.,Ltd. Address before: 832000 No.3, Tianshan Road, No.94 community, Shihezi Development Zone, Xinjiang Uygur Autonomous Region Patentee before: Xinjiang Shangni Biotechnology Co.,Ltd. Patentee before: JIANGSU SEL BIOCHEMISTRY Co.,Ltd. |