Background technology
Facial paralysis, formal name used at school facial paralysis, also claims facial neuritis, bell's palsy, hunter syndrome, is commonly called as " wapperijaw bar ", " wapperijaw ", " facial paralysis ", " hanging skew wind ", " wapperijaw wind " etc.Facial paralysis is because human body vim and vigour are not enough, facial, ear is attacked by wind and cold; make local meridian stasis stagnant; caused by the mistake of muscle arteries and veins is supported; namely the facial nerve tissue ischemia that a variety of causes causes makes nervus facialis occur degeneration; virus or inflammatory factor are invaded nervus facialis and occur edema; demyelination, even axonal degeneration are downright bad, thus cause nerve can not arrange the normal activity of facial muscle and occur facial paralysis.
Facial paralysis is differentiated: 1) most patient often in early morning wash one's face, gargle time catch sight of that side buccal action is ineffective, face is crooked.2) the complete paralytic of sick side surface part histrionic muscles, forehead line disappears, palpebral fissure expands, nasolabial fold is smooth, ptosis of labial angle, and time grinningly, bicker is askew to strong lateral deviation.3) sick side can not make wrinkle volume, the action such as frown, close order, air-blowing and be in a pout.The drum cheek, with when whistling, leaks gas because Ipsilateral lip can not close.4), during feed, food debris is often stranded in the tooth buccal space of disease side, and often has saliva to drop down from this side.5) because lacrimal point is with lower eyelid ectropion, make tear can not be excessive by normal drainage.
Doctor trained in Western medicine thinks that facial paralysis caused because face nerve lacks nutrition, VB1 and VB12 that Chang great Liang uses, and the medicine of trophic nerve carrys out injection for curing.
The traditional Chinese medical science is thought, " gathering of heresy, its gas must be empty ".Primary disease is many by physical weakness, overworks, and venation is hollow, and wind and cold is attacked, so that stagnant through vapour lock, disharmony between QI and blood, the stagnant passages through which vital energy circulates of the stasis of blood, and it is foster to cause meridians to lose in moistening, and muscle vertical delaying does not receive, and facial paralysis occurs.The method of Chinese traditional treatment facial paralysis has a variety of, common are the tens of kinds for the treatment of ways such as acupuncture, physical therapy, massage, plaster, acusector.
The patent of invention of disclosed facial paralysis has a lot at present, such as: Chinese invention patent application number: 200810015849.0, disclose plaster of a kind of facial paralysis and preparation method thereof, the raw material of the weight proportion that it adopts is: Moschus 2-6MG, Radix Angelicae Sinensis 3-10G, Olibanum 3-10G, Myrrha 3-10G, double hook 3-10G, Concha 10-20G, Crinis Carbonisatus 3-6G, Semen Ricini 15-30G, Plumbum preparatium 150-250G and Oleum sesami 100-200G.Moschus, Radix Angelicae Sinensis, Olibanum, Myrrha and double hook raw material of Chinese medicine are pulverized by described weight proportion by its manufacture method, powder raw material is obtained for subsequent use after being mixed homogeneously in the lump with the raw material of pulverizing by Crinis Carbonisatus, again co-grinding raw material is put into Oleum sesami to simmer in water minimum 4 hours, in medicinal liquid, put into Plumbum preparatium after crossing filtering residue, insert on gauze after stirring, cooling and make plaster.Chinese invention patent application number: 200810068992.6 plaster disclosing a kind of facial paralysis, its component and quality formula as follows: Semen Ricini 20 ~ 50 grams, Semen Sinapis Albae 25 ~ 60 grams, Semen Strychni (processed) 2 ~ 4 grams, Rhizoma Arisaematis 2 ~ 4 grams, Radix Aconiti Kusnezoffii 2 ~ 4 grams, 45.5 grams, vaseline, 4.5 grams, benzoic acid.Chinese invention patent application number: 201310149857.5 disclose plaster of a kind of facial paralysis and preparation method thereof, step is: 1. by Flos Carthami 9-11g, Radix daturae 10-15g, Herba Asari 9-11g, Rhizoma Gastrodiae 12-17g, Scorpio 9-11g, Herba Rabdosiae Ternifoliae 7-10g join in the medicinal Oleum sesami of 480-520g and soak, and filter to obtain immersion oil; 2. by Rhizoma Typhonii 12-17g, Dens Bovis seu Bubali 10-15g, Aconitum carmichjaelii Debx. 12-17g, Scolopendra 9-11g, Radix Litseae 8-12g, Folium Styracis Suberifoliae 8-12g, Fructus cinnamomi camphorae 9-11g, Radix Solani Melongenae 7-10g pulverize; 3. by immersion oil and the mixing of 240-260g Plumbum preparatium, be brewed into cream, then add the powder be ground into and mix well, cooling, makes plaster.
But the Chinese medicine preparation of existing facial paralysis is mostly unguentum, bring inconvenience to the use of modern society fast pace patient.
Summary of the invention
The object of the invention is to overcome the weak point in existing technology, the Chinese medicine of the facial paralysis of a kind of taking convenience, instant effect, short treating period is provided.
The object of the invention is to be achieved through the following technical solutions:
A Chinese medicine for facial paralysis, makes primarily of Rhizoma Chuanxiong, Rhizoma Zingiberis, Fructus Piperis, Flos Caryophylli, Cortex Magnoliae Officinalis, Ramulus Mori, Caulis Sargentodoxae, Hirudo, Bombyx Batryticatus and Scorpio, and as preferably, their weight proportion is as follows:
Rhizoma Chuanxiong 18-27 Rhizoma Zingiberis 12-24 Flos Caryophylli 12-24 Cortex Magnoliae Officinalis 6-18 Ramulus Mori 6-18
Caulis Sargentodoxae 6-18 Fructus Piperis 1-6 Hirudo 3-9 Bombyx Batryticatus 3-9 Scorpio 3-9
As one of further preferred technical scheme, the Chinese medicine of facial paralysis of the present invention, it is the medicament be prepared from by the raw material of following weight proportioning:
Rhizoma Chuanxiong 24 Rhizoma Zingiberis 18 Flos Caryophylli 15 Cortex Magnoliae Officinalis 12 Ramulus Mori 12
Caulis Sargentodoxae 12 Fructus Piperis 3 Hirudo 6 Bombyx Batryticatus 9 Scorpio 6
As further preferred technical scheme two, the Chinese medicine of facial paralysis of the present invention, it is the medicament be prepared from by the raw material of following weight proportioning:
Rhizoma Chuanxiong 24 Rhizoma Zingiberis 24 Flos Caryophylli 18 Cortex Magnoliae Officinalis 12 Ramulus Mori 12
Caulis Sargentodoxae 12 Fructus Piperis 3 Hirudo 6 Bombyx Batryticatus 9 Scorpio 9
As further preferred technical scheme three, the Chinese medicine of facial paralysis of the present invention, it is the medicament be prepared from by the raw material of following weight proportioning:
Rhizoma Chuanxiong 18 Rhizoma Zingiberis 15 Flos Caryophylli 18 Cortex Magnoliae Officinalis 18 Ramulus Mori 18
Caulis Sargentodoxae 12 Fructus Piperis 1 Hirudo 3 Bombyx Batryticatus 6 Scorpio 6
Present invention also offers a kind of preparation method of Chinese medicine of facial paralysis, comprise the following steps:
(1) respectively Rhizoma Chuanxiong, Rhizoma Zingiberis, Fructus Piperis, Flos Caryophylli, Cortex Magnoliae Officinalis, Ramulus Mori and Caulis Sargentodoxae powder are broken into coarse powder;
(2) getting and take Fructus Piperis and Flos Caryophylli, is the alcohol reflux 1-2 hour of 95% by 5-10 times amount volume ratio, filters, and reclaims ethanol, is concentrated into the thick paste that relative density is 1.15-1.30, for subsequent use;
(3) medicinal residues of above-mentioned Fructus Piperis and Flos Caryophylli and Rhizoma Chuanxiong, Rhizoma Zingiberis, Cortex Magnoliae Officinalis, Ramulus Mori, Caulis Sargentodoxae are merged, after being fully uniformly mixed, with 5-10 times amount water soaking 2-4 hour, decoct 2-4 hour, filter, filtering residue adds 3-5 times of water gaging again, decoct 1-2 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.05-1.15;
(4) by the thick paste mix homogeneously that above-mentioned steps (2) and step (3) are made, drying under reduced pressure, crosses 80-200 mesh sieve after pulverizing, obtains uniform fine powder;
(5) take Hirudo, Bombyx Batryticatus and Scorpio, dry, mix homogeneously, pulverizes, and crosses 80-200 mesh sieve, obtains uniform fine powder;
(6) fine powder mixing step (4) and step (5) obtained incapsulates shell and makes capsule, or adds corresponding adjuvant and make granule, micropill or tablet.
The Chinese medicine of facial paralysis of the present invention, wherein Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.Fructus Piperis warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards, expectorant.For gastrofrigid vomiting, stomachache is had loose bowels, inappetence, epilepsy abundant expectoration.Flos Caryophylli warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.The expectorant of Cortex Magnoliae Officinalis dampness, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.Ramulus Mori wind-damp dispelling, sharp joint.For takeing on arm, joint aches is numb.Caulis Sargentodoxae heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.Hirudo removing blood stasis, removing blood stasis, stimulates the menstrual flow.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.Bombyx Batryticatus expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes is scorching, facial paralysis.Scorpio endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Chinese medicine of the present invention, can combined effect, mutual gain; Can dispelling cold by warming the meridian, increase tissue metabolism; Dispelling wind and removing obstruction in the collateral, makes blood vessels smooth; Strengthening vital QI to eliminate pathogenic factors; Benefiting QI for activating blood circulation; Facial paralysis spontaneous recovery.
Compared to the prior art the present invention, has following technique effect:
1, the Chinese medicine of facial paralysis of the present invention, cure rate is high, short treating period, soon effective.
2, the Chinese medicine of facial paralysis of the present invention, can be prepared into oral formulations, such as capsule, pill, granule or other dosage form, avoids the inconvenience using unguentum to bring.
3, the Chinese medicine of facial paralysis of the present invention, medication is simplified, and dosage is few, and medical material is all listed by Chinese Pharmacopoeia, and source is wide, cost is low.
4, the Chinese medicine preparation of facial paralysis of the present invention, preparation is simple, is applicable to suitability for industrialized production.
Detailed description of the invention:
Below by way of the description of detailed description of the invention, the invention will be further described.
The preparation of embodiment 1 capsule
Preparation method is as follows: Rhizoma Chuanxiong, Rhizoma Zingiberis, Fructus Piperis, Flos Caryophylli, Cortex Magnoliae Officinalis, Ramulus Mori and Caulis Sargentodoxae powder are broken into coarse powder by (1) respectively; (2) get and take Fructus Piperis 3kg and Flos Caryophylli 15kg, be the alcohol reflux 2 hours of 95% by 6 times amount volume ratios, filter, reclaim ethanol, be concentrated into the thick paste that relative density is 1.15-1.30, for subsequent use; (3) medicinal residues of above-mentioned Fructus Piperis and Flos Caryophylli and 24kg Rhizoma Chuanxiong, 18kg Rhizoma Zingiberis, 12kg Cortex Magnoliae Officinalis, 12kg Ramulus Mori, 12kg Caulis Sargentodoxae are merged, after being fully uniformly mixed, with 6 times amount water soaking 4 hours, decoct 2 hours, filter, filtering residue adds 3 times of water gagings again, decoct 1 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.05-1.10; (4) by the thick paste mix homogeneously that above-mentioned steps (2) and step (3) are made, drying under reduced pressure, crosses 100 mesh sieves after pulverizing, obtains uniform fine powder; (5) take Hirudo 6kg, Bombyx Batryticatus 9kg and Scorpio 6kg, dry, mix homogeneously, pulverizes, and crosses 100 mesh sieves, obtains uniform fine powder; (6) fine powder mixing step (4) and step (5) obtained incapsulates shell and makes capsule.
The preparation of embodiment 2 capsule
Preparation method is as follows: Rhizoma Chuanxiong, Rhizoma Zingiberis, Fructus Piperis, Flos Caryophylli, Cortex Magnoliae Officinalis, Ramulus Mori and Caulis Sargentodoxae powder are broken into coarse powder by (1) respectively; (2) get and take Fructus Piperis 3kg and Flos Caryophylli 18kg, be the alcohol reflux 2 hours of 95% by 10 times amount volume ratios, filter, reclaim ethanol, be concentrated into the thick paste that relative density is 1.15-1.30, for subsequent use; (3) medicinal residues of above-mentioned Fructus Piperis and Flos Caryophylli and 24kg Rhizoma Chuanxiong, 24kg Rhizoma Zingiberis, 12kg Cortex Magnoliae Officinalis, 12kg Ramulus Mori, 12kg Caulis Sargentodoxae are merged, after being fully uniformly mixed, with 10 times amount water soaking 2 hours, decoct 2 hours, filter, filtering residue adds 4 times of water gagings again, decoct 1 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.05-1.15; (4) by the thick paste mix homogeneously that above-mentioned steps (2) and step (3) are made, drying under reduced pressure, crosses 200 mesh sieves after pulverizing, obtains uniform fine powder; (5) take Hirudo 6kg, Bombyx Batryticatus 9kg and Scorpio 9kg, dry, mix homogeneously, pulverizes, and crosses 200 mesh sieves, obtains uniform fine powder; (6) fine powder mixing step (4) and step (5) obtained incapsulates shell and makes capsule.
The preparation of embodiment 3 capsule
Rhizoma Chuanxiong 18 Rhizoma Zingiberis 15 Flos Caryophylli 18 Cortex Magnoliae Officinalis 18 Ramulus Mori 18
Caulis Sargentodoxae 12 Fructus Piperis 1 Hirudo 3 Bombyx Batryticatus 6 Scorpio 6
Preparation method is as follows: Rhizoma Chuanxiong, Rhizoma Zingiberis, Fructus Piperis, Flos Caryophylli, Cortex Magnoliae Officinalis, Ramulus Mori and Caulis Sargentodoxae powder are broken into coarse powder by (1) respectively; (2) get and take Fructus Piperis 1kg and Flos Caryophylli 18kg, be the alcohol reflux 2 hours of 95% by 6 times amount volume ratios, filter, reclaim ethanol, be concentrated into the thick paste that relative density is 1.15-1.30, for subsequent use; (3) medicinal residues of above-mentioned Fructus Piperis and Flos Caryophylli and 18kg Rhizoma Chuanxiong, 15kg Rhizoma Zingiberis, 18kg Cortex Magnoliae Officinalis, 18kg Ramulus Mori, 12kg Caulis Sargentodoxae are merged, after being fully uniformly mixed, with 8 times amount water soaking 2 hours, decoct 2 hours, filter, filtering residue adds 5 times of water gagings again, decoct 2 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.05-1.15; (4) by the thick paste mix homogeneously that above-mentioned steps (2) and step (3) are made, drying under reduced pressure, crosses 80 mesh sieves after pulverizing, obtains uniform fine powder; (5) take Hirudo 3kg, Bombyx Batryticatus 6kg and Scorpio 6kg, dry, mix homogeneously, pulverizes, and crosses 80 mesh sieves, obtains uniform fine powder; (6) fine powder mixing step (4) and step (5) obtained incapsulates shell and makes capsule.
The preparation of embodiment 4 granule
Preparation method is as follows: Rhizoma Chuanxiong, Rhizoma Zingiberis, Fructus Piperis, Flos Caryophylli, Cortex Magnoliae Officinalis, Ramulus Mori and Caulis Sargentodoxae powder are broken into coarse powder by (1) respectively; (2) get and take Fructus Piperis 6kg and Flos Caryophylli 21kg, be the alcohol reflux 2 hours of 95% by 8 times amount volume ratios, filter, reclaim ethanol, be concentrated into the thick paste that relative density is 1.15-1.30, for subsequent use; (3) medicinal residues of above-mentioned Fructus Piperis and Flos Caryophylli and 27kg Rhizoma Chuanxiong, 24kg Rhizoma Zingiberis, 18kg Cortex Magnoliae Officinalis, 12kg Ramulus Mori, 12kg Caulis Sargentodoxae are merged, after being fully uniformly mixed, with 6 times amount water soaking 4 hours, decoct 2 hours, filter, filtering residue adds 3 times of water gagings again, decoct 1 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.05-1.10; (4) by the thick paste mix homogeneously that above-mentioned steps (2) and step (3) are made, drying under reduced pressure, crosses 100 mesh sieves after pulverizing, obtains uniform fine powder; (5) take Hirudo 9kg, Bombyx Batryticatus 9kg and Scorpio 9kg, dry, mix homogeneously, pulverizes, and crosses 100 mesh sieves, obtains uniform fine powder; (6) fine powder mixing step (4) and step (5) obtained, adds dextrin, sucrose, 95% appropriate amount of ethanol, granulates, obtain granule of the present invention.
Clinical data
One, the clinical observation for the treatment of by Chinese herbs facial paralysis of the present invention:
1.1 physical data
Since 2012, inventor has carried out clinical comparison medication to our hospital 296 routine Peripheral Facial Paralysis Patients and has observed, wherein man 172 example, and female 124 example, the course of disease is the shortest 3 days, the longest 2 years.Age reckling 5 years old, the maximum 70 years old.All patients are divided into three groups at random, wherein treatment by Chinese herbs group 116 example of the present invention, acupuncture and moxibustion therapy group 90 example, western medicine group 90 example.
1.2 Therapeutic Method
Treatment by Chinese herbs group: give the capsule prepared with the embodiment of the present invention 1, every day three times, each 2, one after each meal.7 days courses for the treatment of, serve on 3 courses for the treatment of.
Acupuncture and moxibustion therapy group: adopt traditional acupuncture method, treats 21 days.
Western medicine group: acute stage oral prednisone, continuous 7 days, decrement gradually in later 7 days.If any clear and definite viral infection evidence, antiviral agents can be used simultaneously; Treatment whole process adds vitamin B1, B12.Treat 21 days.
1.3 efficacy assessment standard
Recovery from illness: facial all regions are normal.Comprise bilateral volume stricture of vagina, nasolabial fold recovers symmetry, frown and close one's eyes normal, during the drum cheek, bicker is air tight, and be not detained food debris between tooth cheek during feed, without distortion of commissure when talking and laugh, facial expression is normal.
Effective: to examine and can find out slight miopragia, slight synkinesia may be had; Symmetrical when face is static, tension force is normal, and upper jaw motion is medium, and eyes firmly can be completely closed, and degree fond of food that is not salty is asymmetric.
Effective: to have obvious miopragia, the harmless property of single bilateral is asymmetric, can be observed and not serious synkinesia, contracture and (or) half side facial spasm; When face is static, tension force is normal, and upper jaw motion is faint, can be completely closed when eye is exerted oneself, and mouth is obviously asymmetric.
Invalid: after treating 3 courses for the treatment of, facial static time asymmetric, the upper jaw is without motion, and eye can not be completely closed, and mouth only has light exercise.
1.4 statistical method
Data acquisition SPSS19.0 software carries out statistical analysis, measurement data with
represent, before and after treatment, Indexes Comparison adopts t inspection; Enumeration data adopts X
2inspection.P < 0.05 represents that difference has statistical significance.
1.5 therapeutic outcomes, see table 1
The efficacy data of table 1 three kinds of Therapeutic Method facial paralysis
Group |
Number of cases |
Cure (%) |
Effective (%) |
Effectively (%) |
Invalid (%) |
Total effective rate (%) |
Treatment group |
116 |
79(68.1)*
& |
23(19.8)*
& |
10(8.6)*
& |
4(3.4) |
97(96.6)*
& |
Acupuncture group |
90 |
19(21.1) |
31(34.5) |
28(31.1) |
12(13.3) |
78(86.7) |
Western medicine group |
90 |
15(16.7) |
27(30.0) |
31(34.4) |
17(18.9) |
73(81.1) |
Note: treatment group and acupuncture group P < 0.05.Treatment group compares P < 0.05 with Western medicine group.
As can be seen from Table 1, after the treatment of 3 courses for the treatment of, treatment by Chinese herbs group of the present invention, cure rate up to 68.1%, far above other treatment group.Total effective rate is 96.6%, also higher than other treatment group.It is high that the Chinese medicine of visible facial paralysis of the present invention compared with prior art has cure rate, the advantages such as short treating period.
Two, model case:
1, Wang, man, 34 years old, patient caused facial paralysis by cool breeze invasion and attack before 7 days, and right side face muscle rigidity, facial hemiparalysis, saliva is more than, on inspection, is diagnosed as face paralysis.Take Chinese medicine 1 of the present invention course for the treatment of, facial muscle symptom takes a turn for the better, and takes for 3 courses for the treatment of, and all diseases disappear, recovery from illness.
2, grandson, man, 54 years old, builder, because night work is tired, invasion and attack of having a cold, trouble facial paralysis 3 months, distortion of commissure, can not rouse the cheek, white and thin fur, floating pulse.Take Chinese medicine 1 of the present invention course for the treatment of, facial muscle symptom takes a turn for the better, and takes for 3 courses for the treatment of, and all diseases disappear, recovery from illness.
3, Lee, female, 20 years old, student, went out to camp, suffers from cold, and next day, facial hemiparalysis, dizzy weak, and close order incomplete, the drum cheek is all asymmetric, thin fur, thready pulse; Take Chinese medicine 1 of the present invention course for the treatment of, facial muscle symptom takes a turn for the better, and takes for 3 courses for the treatment of, and all diseases disappear, recovery from illness.
4, Lee, man, 60 years old, retired worker, patient's private prosecution, before January, played rear face numbness morning, leaks when distortion of commissure, drinking-water, diagnosis facial paralysis, and take Chinese medicine 1 of the present invention course for the treatment of, facial muscle symptom takes a turn for the better, and takes for 3 courses for the treatment of, and all diseases disappear, recovery from illness.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.