CN104189785A

CN104189785A - Medicine for treating cardiovascular and cerebrovascular diseases

Info

Publication number: CN104189785A
Application number: CN201410501472.5A
Authority: CN
Inventors: 田丽华; 耿建芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-27
Filing date: 2014-09-27
Publication date: 2014-12-10

Abstract

The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases. The medicine is prepared from the following active ingredients in parts by weight: 12 parts of salvia miltiorrhiza, 15 parts of Chinese date, 9 parts of radix paeoniae rubra and 6 parts of curcuma zedoary. Clinical experiments prove that the medicine can be applied to treating the cardiovascular and cerebrovascular diseases safely and effectively.

Description

A kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease.

Background technology

Cardiovascular and cerebrovascular disease is the common disease of middle-aged and elderly people. at present, along with the risk factor of China's cerebrovascular disease is controlled preferably, the sickness rate of cerebral hemorrhage class cerebrovascular disease declines just year by year, but still thering is higher disability rate and mortality rate. cardiovascular and cerebrovascular disease clinical onset mostly is falls forward suddenly dusk, syncope, hemiplegia, the symptoms such as facial hemiparalysis and aphasia or hemiplegia.Application Western medicine is the key for the treatment of life for rescue patient in time; as antiplatelet aggregation, neuroprotective, thromboembolism treatment, reduction intracranial pressure and prevent and treat complication etc.; but using Chinese medicine eleminating phlegm and freeing channels and blood circulation promoting and blood stasis dispelling, is also the important feasible measure that promotes patient's functional rehabilitation.But still lacking at present, primary disease generally acknowledges effective treatment by Chinese herbs medicine.

Medical material present Research involved in the present invention is as follows:

Radix Salviae Miltiorrhizae [another name] Arisaema balansae Engl., Radix Campylotropis Hirtella (Herba Myrsines Africanae), Herba Wedeliae Wallichii root, blood mountain root, RADIX SALVIAE MILTIORRHIZAE, Radix Salviae Miltiorrhizae.[source] this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Spring, Qiu Erji excavate, and remove silt, dry.[nature and flavor] hardship, is slightly cold.[return through] GUIXIN, Liver Channel.[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.[usage and dosage] 9～15g.[attention] should not be with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.[storage] puts dry place.[extracts] < < whole nation Chinese herbal medicine compilation > >

Fructus Jujubae [source] this product is the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Gather during fruit maturation autumn, dries.Its root, bark are also used as medicine, and can adopt at any time.[process of preparing Chinese medicine] removes impurity, cleans, and dries.Used time breaks or enucleation.[nature and flavor] are sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] be (Fructus Jujubae) really: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.[usage and dosage] 6～15g.[extracts] < < Chinese Pharmacopoeia > >.

Radix Paeoniae Rubra [source] this product is the root of Paeoniaceae plant peony, CHUANSHAO medicine, Paeonia obovata Maxim., hair leaf Paeonia obovata Maxim., Paeonia mairei Lévl., Paeonia anomala and tuber Radix Paeoniae.The 8-9 month excavates, and removes aerial parts and earth, when dry in the sun is extremely half-dried, is bundled into wisp, shines to foot dry.[nature and flavor] hardship, is slightly cold.[return through] returns liver, spleen channel.[function cures mainly] clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis, discharging fresh blood stool; Conjunctival congestion and swelling pain, carbuncle skin infection; Amenorrhea, dysmenorrhea, metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood, hernia abdominal mass is gathered; Injury from falling down.[usage and dosage] 4 ~ 10g.[attention] blood deficiency is without disease and the routed careful clothes of person of carbuncle of the stasis of blood.

Rhizoma Curcumae [source] this product is the rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary and RADIX CURCUMAE.In 12 months, the last ten-days period, when aerial parts is withered, excavate root, remove the earth on rhizome, clean, put and in pot, steam or boil about 15min, dry or dry, hit fibrous root.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, spleen channel.[function cures mainly] circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Main vim and vigour are pained, eating accumulation, abdominal distention, amenorrhea due to stagnation of blood, dysmenorrhea, lump in the abdomen tumor mass in the abdomen, traumatic injury.[usage and dosage] 3 ~ 10g.

Summary of the invention

The present invention aims to provide a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease, by selecting suitable medical material and proportioning thereof, reaches the safe and effective object that is applied to cardiovascular and cerebrovascular diseases.

In order to achieve the above object, the present invention is by the following technical solutions:

A medicine that is used for the treatment of cardiovascular and cerebrovascular disease, is characterized in that, it is that raw medicinal material by following weight proportion is prepared from: 12 parts of Radix Salviae Miltiorrhizaes, 15 parts, Fructus Jujubae, 9 parts of Radix Paeoniae Rubra, 6 parts of Rhizoma Curcumae.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

1, data and method

1.1 physical data

Inventor choose at random in January, 2011 to 2013 year December accept Patients with Cardiovascular/Cerebrovascular Diseases 80 examples of being in hospital for medical treatment, be divided at random each 40 examples of matched group and treatment group.All patients all meet the basic feature of all kinds of cerebrovascular disease, and without tract complication such as other hearts, liver, kidneys.

Male 26 examples in matched group, female's 14 examples, age 46～69(average 57.5) and year, disease time 3～15 h.

Male 23 examples in treatment group, female's 17 examples, age 46～72(average 58.1) year, disease time is 2～16h.

The physical data methods by statistics such as two groups of patients' age, sex, the course of disease are processed rear not statistically significant (P>0.05), have comparability.

1.2 Therapeutic Method

Matched group patient adopts conventional western medical treatment, comprise blood pressure, intracranial pressure and the cerebral edema of taking the circumstances into consideration to improve the treatment measures such as cerebral circulation, encephaledema, brain protection and control patient, remove nourishing brain cell simultaneously, maintain electrolyte, water balance, memory complication prevention etc.;

Treatment group is applied the decoct that the present invention makes according to specific embodiment 1 on the basis of matched group, and every bu morning, noon and afternoon take for three times.

All take 15 days as a course for the treatment of, treat altogether two courses for the treatment of for two groups.

1.3 criterion of therapeutical effect

Patient all before treatment, treatment carries out corresponding neurological deficits score and corresponding efficacy evaluation after 2 courses for the treatment of.

Be almost recovered: neurological deficits score reduces 91%～100%, and disability degree is 0 grade;

Marked improvement: neurological deficits score reduces 46%～90%, and disability degree is 1～3 grade;

Progressive: neurological deficits score reduces 18%～45%;

Unchanged: neurological deficits score is unchanged;

Worsen: neurological deficits score increases on the contrary.

1.4 statistical procedures

The data obtained is processed with SPSS18.0 software, and rate for enumeration data (%) represents.

2, result

The comparison treatment group effective percentage of 2.1 liang of group clinical efficacies is obviously better than matched group, compares for two groups, and difference has statistical significance, in Table 1.

Two groups of curative effect comparisons of table l

Group	n	Be almost recovered	Marked improvement	Progressive	Invalid	Worsen	Total effective rate
								Treatment group	40	19	6	11	4	0	90%*
Matched group	40	12	11	9	6	2	80%

* P<0.05 compares matched group.

Before the relatively treatment of 2.2 neurological deficits score, treatment 2 courses for the treatment of after, two groups of patients' neurological deficits score comparison, has statistical significance (P<0.05, in Table 2).

The comparison of neurological deficits score before and after table 2 liang group patient treatment

Group	n	Before treatment	After treatment
				Treatment group	40	19.3±6.8	14.2±5.9*
Matched group	40	19.2±6.7	11.8±5.5*

* P<0.05 compares before treatment.

Visible, the medicine that the present invention makes can safe and effective treatment cardiovascular and cerebrovascular disease, has good promotional value.

The specific embodiment

In order to understand better and to implement the present invention, below in conjunction with specific embodiment, further illustrate the present invention.

Specific embodiment 1

Take: 12 grams of Radix Salviae Miltiorrhizaes, 15 grams, Fructus Jujubae, 9 grams of Radix Paeoniae Rubra, 6 grams of Rhizoma Curcumae; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of one day consumption of normal adult.

Be used for the treatment of cardiovascular and cerebrovascular disease.Oral, every bu morning, noon and afternoon take for three times.

Specific embodiment 2

Take: 12 grams of Radix Salviae Miltiorrhizaes, 15 grams, Fructus Jujubae, 9 grams of Radix Paeoniae Rubra, 6 grams of Rhizoma Curcumae; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, pack, must meet the powder of one day consumption of normal adult.

Be used for the treatment of cardiovascular and cerebrovascular disease.Oral, take once every day.

Specific embodiment 3

Take: 12 grams of Radix Salviae Miltiorrhizaes, 15 grams, Fructus Jujubae, 9 grams of Radix Paeoniae Rubra, 6 grams of Rhizoma Curcumae; Add 6 times of water gagings, decoct 3 times, decoct 1 hour at every turn, merge decoction liquor, concentrated, dry, incapsulate shell, must meet the capsule of one day consumption of normal adult.

Be used for the treatment of cardiovascular and cerebrovascular disease.Oral, every bu is taken for twice sooner or later.

Claims

1. a medicine that is used for the treatment of cardiovascular and cerebrovascular disease, is characterized in that, it is that raw medicinal material by following weight proportion is prepared from: 12 parts of Radix Salviae Miltiorrhizaes, 15 parts, Fructus Jujubae, 9 parts of Radix Paeoniae Rubra, 6 parts of Rhizoma Curcumae.