CN104189736A - Japanese beauty-berry enema for treating hemorrhage of lower digestive tract and preparation method thereof - Google Patents
Japanese beauty-berry enema for treating hemorrhage of lower digestive tract and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Japanese beauty-berry enema for treating hemorrhage of lower digestive tract. Every 100ml of the Japanese beauty-berry enema comprises the following main ingredients by weight: 6-12g of Japanese beauty-berry extract, 6-15g of fructus psoraleae aqueous extract, 5-10g of curcuma aqueous extract, 4-9g of subprostrate sophora, 3-9g of fresh garlic extract and 5-12g of lalang grass rhizome aqueous extract. The Japanese beauty-berry enema for treating the hemorrhage of lower digestive tract has obvious treatment effect on the hemorrhage of the lower digestive tract, has the effects of benefiting qi, nourishing blood, astringing to stop bleeding, promoting blood circulation to remove blood stasis, tonifying qi for strengthening spleen, clearing heat and promoting diuresis, can stop bleeding quickly for the hemorrhage, such as hematemesis, hematochezia and blood stasis, of the lower digestive tract and has good curative effect on the hemorrhage of the lower digestive tract.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage and preparation method thereof.
Background technology
Digestive tract below Qu Shi ligament (comprising sky, ileum, colon and rectum) claims lower digestive tract.The hemorrhage blood of finding a great convenience that the pathological changes at above-mentioned position causes, lower digestive tract hemorrhage, shows as blood and is discharged by anus, or blood and feces together discharges, and it is scarlet or dark red that color is more.If pathological changes is at empty, ileum or right hemicolon, hemorrhage amount is less in addition, and hemorrhage speed is slower, can discharge melena (tarry stools), and this kind of situation easily obscured mutually with hemorrhage due to Lesions in Upper Gastrointestinal Tract.In addition, when Lesions in Upper Gastrointestinal Tract is hemorrhage, as amount of bleeding is large, speed is fast, blood the enteric cavity time of staying in short-term, also can show as anus and discharge dark red, cerise hemafecia even, this kind of situation also easily obscured with lower digestive tract Lesion Hemorrhage mutually.Lower digestive tract is on a small quantity when hemorrhage (being less than 500ml), can be very soon compensatory by body and do not cause manifest symptom; When amount of bleeding is above over 800-1000ml, especially loss person more in a short time, all can have the performances such as giddy, weak, cardiopalmus, pulse quickening, blood pressure drops, palor, can there is the performance of shock in severe patient more, all prompts for massive hemorrhage while having above-mentioned performance.Massive hemorrhage patient, when transference cures such as its giddy, cold sweat, cardiopalmus, palors, pulse and blood pressure maintain normal level and point out and hemorrhagely stop.Lower digestive tract hemorrhage great majority are due to digestive tract disease itself, and minority case may be the local hemorrhage phenomenon of systemic disease, therefore disease history inquire and physical examination are still necessary diagnosis algorithm.In general, bleeding part is higher, and the color of having blood in stool is darker; Bleeding part is lower, and the color of having blood in stool is scarlet, or shows as blood.This also depends on hemorrhage speed and quantity certainly, and as fast in hemorrhage speed and hemorrhage quantity is large, and the time that blood stops in digestive tract is short, even if bleeding part is higher, has blood in stool and also may be cerise.Carefully collect medical history and positive sign, helpful to judging hemorrhage reason, as blood drips after defecation, and mutually mix person with feces and be more common in internal hemorrhoid, anal fissure or rectal polyp; Moderate is had blood in stool above and is more common in mesentery and portal thrombosis, acute hemorrhagic necrotic enteritis, ileum colonic diverticula and ischemic colitis, and even Lesions in Upper Gastrointestinal Tract is hemorrhage also can show as in a large number and have blood in stool, and when diagnosis, is distinguished.Blood mixes mutually with feces, with mucus person, should consider colon cancer, polyp of colon, chronic ulcerative colitis; Feces is sanguinopurulent or hemafecia with mucus and pus, should consider bacillary dysentery, colonic blood trematodiasis, chronic colitis, tuberculosis of colon etc.; Have blood in stool with tormina, even occur shock phenomenon, should consider mesenteric embolism, hemorrhagic necrosis enteritis, ischemic colitis, intussusception etc.; Have blood in stool with abdominal mass person, should consider colon cancer, intussusception etc.Have blood in stool with skin or other organ hemorrhage signs person, note the situations such as disease in the blood system, acute infectious diseases, severe liver diseases, uremia, vitamin C deficiency.
Foreign data demonstration, the patient of lower digestive tract hemorrhage accounts for 0.02% of average annual total number of hospitalized, and case fatality rate is about 3.6%.Lower digestive tract hemorrhage is more common in gerontal patient, the more than 200 times of the incidence rate Shi20Sui adolescence of 80 years old old man's lower digestive tract hemorrhage.Cause the common cause of lower digestive tract hemorrhage to have: the diverticulitis of lower digestive tract intestinal accounts for 20%-55%; Angiodysplasia accounts for 3%-40%; Tumor accounts for 8%-26%; Inflammation accounts for 6%-22%; Optimum anorectal disease accounts for 9%-10%.Character, position, blood loss and the speed of hemorrhage pathological changes is depended in the clinical manifestation of digestive tract hemorrhage, also has relation with systemic conditions such as age of patient, cardiorenal functions.The acute majority of bleeding profusely shows as hematemesis; Chronic small amount bleeding is with the positive performance of feces occult blood; Bleeding part is when jejunum Qu Shi ligament is above, and clinical manifestation is hematemesis, as more of a specified duration in the gastric retention time in hemorrhage rear blood, because become acidemia Lactoferrin through gastric acid effect, is coffee-like.As hemorrhage speed is fast, amount of bleeding is many.The color of hematemesis is cerise.Melena or stool tarry just represent that bleeding part is in upper gastrointestinal.In hemorrhage peripheral circulatory failure evolution, can there is clinically giddy, cardiopalmus, nauseating, thirsty, blindness or faint; Skin is greyish white, clammy because vasoconstriction and hemoperfusion are not enough; Press and present after nail matrix palely, and prolongedly lose recovery.Venous engorgement is poor, and body surface vein is often sunken.Patient feels fatigue and weak, further can occur lethargy, dysphoria, even bradykinesia, confusion.Old people's organ reserve function is low, and it is sick that old people often has the old basis such as cerebral arteriosclerosis, hypertension, coronary heart disease, chronic bronchial in addition, though amount of bleeding is little, also causes multiple organ dysfunction syndrome, increased death risk factor.
Very common although have blood in stool, but can not ignore.Except taking measures active prevention, we it is also understood that to have blood in stool to indicate which disease, so that after occurring having blood in stool, we can carry out tentative diagnosis.Hemorrhoid: having blood in stool occurs in defecation process or after an action of the bowels, color is scarlet, blood and feces are mixed, and amount of bleeding is changeable.Anal fissure: having blood in stool of causing is also more common clinically, and color is scarlet, oozes or toilet paper is wiped blood, has after an action of the bowels the violent pain of anus.Rectum cancerates: having blood in stool that this type of disease causes is comparatively similar to hemorrhoid, has blood in stool and is cerise, becomes to drip shape and invests stool surface.Become thin late period with anal orifice and rectal intestine tenesmus and whole body, and times of defecation increases, and constipation alternately occurs with diarrhoea.Rectum, polyp of colon: what cause has blood in stool, color is scarlet, painless, blood does not mix with stool, and some patients are at the surface band groove of stool.Ulcerative colitis: ulcerative colitis causes has blood in stool, is mostly mixed with mucus or is bloody purulent stool, and with lower abdominal pain, heating, just frequently and the disease such as tenesmus.Digestive tract disease: if in general stool is pitch shape or is dark red, bleeding part is upper digestive tract more; If color is red, is mostly that disease of lower digestive tract is hemorrhage.
At present, the medicine for the treatment of digestive tract hemorrhage has a lot, but be all the medicine for the treatment of upper gastrointestinal hemorrhage substantially, for the problems referred to above, the Chinese patent literature of publication number 102258690A (application number 201010188517.X) discloses the Chinese medicine composition that is used for the treatment of duodenal hemorrhage, digestive tract hemorrhage, the medicament of being made by the Chinese medicine of following weight proportion scope: Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Radix Astragali 10-35 part, Radix Angelicae Sinensis 10-20 part, Endoconcha Sepiae 10-30 part, Concha Ostreae (forging) 5-20 part, Pulvis Fumi Carbonisatus 3-10 part.The Chinese patent literature of publication number 101401856 (application number 200810218995.3) discloses a kind of Chinese patent medicine for the treatment of digestive tract hemorrhage and preparation method thereof, and this Chinese patent medicine is the Fructus Mume powder and edible white vinegar and the ball becoming by charred medicinal herb with its property retained.Publication number 103432463A(application number 201310403696.8) Chinese patent discloses a kind of Chinese medicine preparation for the treatment of upper gastrointestinal hemorrhage, and this Chinese medicine preparation is made by the Chinese medicine of following weight portion: Folium Linderae strychnifoliae 3-10 part, Herba Pyrolae 25-50 part, Folium Ilicis Cornutae 15-25 part, Herba Moslae Chinensis 10-20 part, Ganoderma lucidum seu Japonicum 5-10 part, Flos Cycadis Revolute 25-50 part, Lindernia angustifolia (Benth.) Wettst. 25-50 part, Herba Salviae Cavaleriei 15-25 part, Radix Salviae plebeiae 15-35 part, Radix Artemisiae ordosicae 5-10 part, Flos Imperatae 15-25 part, Herba Stylophori Lasiocapi 5-10 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Aconiti Lateralis Preparata 5-15 part.Can find out, aspect treatment lower digestive tract hemorrhage, be also short of very much, the medicine of this respect is also considerably less, and the curative effect of only several treatment digestive tract hemorrhage medicines is also undesirable.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide the Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage, adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.There is therapeutic effect good, have no side effect, the advantage that treatment cost is low.Another object of the present invention is just to provide the preparation method of above-mentioned Folium Callicarpae Formosanae enema.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage, the main component of every 100ml Folium Callicarpae Formosanae enema: Folium Callicarpae Formosanae water extract 6-12g, Fructus Psoraleae water extract 6-15g, Radix Curcumae water extract 5-10g, Radix Sophorae Tonkinensis water extract 4-9g, fresh garlic extract 3-9g, 5-12g(is preferred for Rhizoma Imperatae water extract, Rhizoma Imperatae water extract 7-10g; Be more preferably Rhizoma Imperatae water extract 8g).
The Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage, preferably scheme is, the main component of every 100ml Folium Callicarpae Formosanae enema: Folium Callicarpae Formosanae water extract 8-10g, Fructus Psoraleae water extract 9-12g, Radix Curcumae water extract 6-9g, Radix Sophorae Tonkinensis water extract 5-8g, fresh garlic extract 5-7g, Rhizoma Imperatae water extract 7-10g.
The Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage, the scheme being more preferably is, the main component of every 100ml Folium Callicarpae Formosanae enema: Folium Callicarpae Formosanae water extract 9g, Fructus Psoraleae water extract 11g, Radix Curcumae water extract 8g, Radix Sophorae Tonkinensis water extract 7g, fresh garlic extract 6g, Rhizoma Imperatae water extract 8g.
The preparation method of above-mentioned Folium Callicarpae Formosanae enema, step is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked to 1-2 days, be placed in marmite, decoct with water twice, boil 1-2 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 1-2 hour, boil for the second time 0.5-1 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(5) step (1)-step (4) gains are placed in to glass container, adding distil water, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
According to preparation method recited above: step (1) water consumption is the 1.5-2.5 doubly (preferably, water consumption is 2.0 times of Bulbus Allii weight) of Bulbus Allii weight.
According to preparation method recited above: step (1) is soaked (preferably, soaking at 55 ℃) at 50 ℃-60 ℃.
According to preparation method recited above: step (1) is carried out vapor distillation (preferably, the quantity of steam with 120kg/h carries out vapor distillation) with the quantity of steam of 100kg/h-140kg/h.
According to preparation method recited above: step (3) is concentrated into the thick paste that relative density is 1.2-1.4 (preferably, be concentrated into relative density and be 1.3 thick paste).
According to preparation method recited above: step (4) adds the ethanol (ethanol that preferably, adds 4-6 times of Folium Callicarpae Formosanae coarse powder quality) of 4-6 times of Folium Callicarpae Formosanae coarse powder quality.
According to preparation method recited above: the preferred Callicarpa nudiflora of Folium Callicarpae Formosanae, Callicarpa lobo-apiculata Metc. or the Folium Callicarpae Macrophyllae described in step (4).
Using method: the emptying defecation of trying one's best before coloclysis, anal canal is inserted to 15cm-20cm and carry out retention enema.Every 6 hours coloclysis 1 time, each 100ml, keeps the constant temperature of 38-41 ℃ of medicinal liquid, and injection speed slows down, and with 10min, is advisable.Coloclysis finishes rapidly anal canal to be extracted gently afterwards, and buttocks muscles is clutched to anus place, keeps medicinal liquid to be detained in vivo more than 1 hour as far as possible, within 5 days, is a course for the treatment of.
This Folium Callicarpae Formosanae enema is remarkable to treatment lower digestive tract hemorrhage effect, this product contains abundant plant biological active component, the mutual compatibility of component, can strengthen autoimmunity, has the effect of reducing swelling and alleviating pain, promoting regeneration of the tissue and arresting bleeding, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, cooling blood for hemostasis, clearing away heat-damp and promoting diuresis.
The pharmacological effect of each crude drug is respectively:
Folium Callicarpae Formosanae: call as big blade, catch up with wind purple, false great Ai.Acrid in the mouth, hardship, property is flat.Return liver, spleen, stomach warp.There is dissipating blood stasis hemostasis, the effect of reducing swelling and alleviating pain.Leaves contains a kind of hemostatic compositions that is referred to as flavonoid condensed tannin, has the effect of hemostasis, dissipating blood stasis, antiinflammatory.With the formulated injection of Folium Callicarpae Formosanae extract, the hemorrhage and postoperative hemorrhage of otch while can be used for treating gastrointestinal hemorrhage, surgical operation.Leaf is mainly used in spitting blood, spitting of blood, and epistaxis, has blood in stool; External curing traumatic hemorrhage.Root is mainly used in treating swelling and pain by traumatic injury, rheumatic ostalgia.Can astringing to arrest bleeding, again can cooling blood for hemostasis, be applicable to various interior traumatic hemorrhage.
Fructus Psoraleae: acrid in the mouth, hardship, warm in nature.Dry mature fruit for legumes psoraleae.Return kidney, spleen channel.There is warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, the effect of antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea.External curing vitiligo, alopecia areata.
Radix Curcumae: acrid in the mouth, hardship, cold in nature.Dried root for zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Return liver, the heart, lung meridian.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, the effect of promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature.Attach to the lung and stomach meridians.Dry root and rhizome for leguminous plant Sophora tonkinensis Gagnep..There is heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain.For fire-toxin, pent up laryngopharynx swelling and pain, gingivitis, throat gingival swelling and pain, cough due to lung-heat's excessive thirst, jaundice, constipation with heat retention.
Fresh garlic: acrid in the mouth is peppery, warm in nature.Enter spleen, stomach, lung, warming the spleen and stomach, eliminating mass is long-pending, the effect of removing toxic substances, parasite killing.Mainly contain Oleum Bulbus Allii, garlicin, sulfuration sulfinic acid lipid, S-alkane (alkene)-Cys derivant.γ-Pidolidone polypeptide, glycoside, polysaccharide, lipid and plurality of enzymes etc.Bulbus Allii extract is exactly garlicin, and main component is allyl sulfide.Garlicin can suppress dysentery bacterium, Bacillus typhi breeding, and staphylococcus, streptococcus pneumoniae etc. is had to obvious inhibition kill activity.Oral garlicin can be treated animal enteritis, dysentery, inappetence etc. clinically.
Rhizoma Imperatae: sweet in the mouth, cold in nature.Return lung, stomach, urinary bladder channel.Dry rhizome for grass Herba Imperatae, Arundoin, Coixol, fernenol, simiarenol, Isoarborinol, Anemonin, also containing sterols: stigmasterol, cupreol, campesterol, saccharide, volume sucrose, glucose and a small amount of fructose, xylose, simple acids: citric acid, oxalic acid and malic acid.There is cooling blood for hemostasis, the effect of heat-clearing and toxic substances removing.For heat in blood, spit blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, acute nephritis edema, dysuria, the gastric heat sound of vomiting of vomitting, coughs.
The present invention is from traditional medicine theory, through constantly clinical research for many years, some medicines prescription that screening is therefrom chosen, carried out pharmacology, the research such as pharmacodynamics and clinical practice, pioneering developing by Folium Callicarpae Formosanae, Fructus Psoraleae water, Radix Curcumae, Radix Sophorae Tonkinensis, fresh garlic and Rhizoma Imperatae forms, and has benefiting QI and nourishing blood, the effect of astringing to arrest bleeding, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, cooling blood for hemostasis, clearing away heat-damp and promoting diuresis.Be used for the treatment of and have blood in stool, stool is purple dim, and very black is as pitch shape, dull pain in the epigastrium, lustreless complexion, or deficiency of QI with disinclination to talk, pale tongue, thready and rapid pulse.To spitting blood, have blood in stool, the lower digestive tract hemorrhage such as heavy blood can quick-acting haemostatic powder, and lower digestive tract hemorrhage is had to good curative effect.
technical advantage of the present invention is also embodied in:
1, selected materials is all Chinese medicine material, has no side effect;
2, raw material of Chinese medicine of the present invention is through dialectical compatibility, coordinates using paving mutually, thereby effectively brings into play its effect, and treatment lower digestive tract hemorrhage is had to significant curative effect.
3, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Accompanying drawing explanation
Fig. 1 is used the remission number of having blood in stool after the Folium Callicarpae Formosanae enema of embodiment 5 gained treatment lower digestive tract hemorrhage.
Fig. 2 is used melena remission number after the Folium Callicarpae Formosanae enema of embodiment 5 gained treatment lower digestive tract hemorrhage.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1the preparation process of the Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked 1 day, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 1 hour, boil for the second time 0.5 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add 4 times of amount ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(5) step (1)-step (4) gains are placed in to glass container, adding distil water, the main component of the every 100ml of Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of control gained: Folium Callicarpae Formosanae water extract 6g, Fructus Psoraleae water extract 6g, Radix Curcumae water extract 5g, Radix Sophorae Tonkinensis water extract 4g, fresh garlic extract 3g, Rhizoma Imperatae water extract 5g, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
Instructions of taking: the emptying defecation of trying one's best before coloclysis, anal canal is inserted to 15cm-20cm and carry out retention enema.Every 6 hours coloclysis 1 time, each 100ml, keeps the constant temperature of 38-41 ℃ of medicinal liquid, and injection speed slows down, and with 10min, is advisable.Coloclysis finishes rapidly anal canal to be extracted gently afterwards, and buttocks muscles is clutched to anus place, keeps medicinal liquid to be detained in vivo more than 1 hour as far as possible, within 5 days, is a course for the treatment of.
model case one:king XX, female, 55 years old, people from Jingmen City, Hubei Province.Because of melena repeatedly 10 years, then fall ill and be admitted to hospital for more than 20 day.Patient has hypertension history 5 years, duodenal ulcer disease history more than ten years.Be not admitted to hospital health check-up except anemia looks, borborygmus 6-7 beat/min, not and other are abnormal.Outer court's gastroscopy: chronic superficial atrophic gastritis, rotten to the corn companion is hemorrhage for descendant duodenum.Routine blood test: leukocyte 5.14 * 109/L. neutrophilic granulocyte 0.54, hemoglobin 50 g/L.Electrocardiogram, hepatic and renal function etc. are showed no obvious abnormalities.AD: lower digestive tract hemorrhage, the hemorrhage possibility of duodenal ulcer companion.Monosaccate small intestinal endoscopy: see the erosion of mucosa many places and ecchymosis apart from front tooth 95 cm jejunum epimeres, and see place's 1.0 cm * 0.8 cm mucosa protuberances, air spots, is shown in activeness cerise oozing of blood, gets 2 of biopsies, gives metal hemostatic clamp forceps pinching blood after biopsy.And local injection sodium morrhuate hemostasis.Small intestinal pathologic finding: small intestinal mucosa chronic inflammation is accompanied erosion, oozed out, several amyloids depositions are seen on surface, congo red staining is positive.After enteroscope lower hemostasia and transfusion symptomatic treatment, patient's melena and hematemesis stop.
Using the Folium Callicarpae Formosanae enema of embodiment 1 gained treatment lower digestive tract hemorrhage after 2 courses for the treatment of, the symptom of melena is eased, see this effect, Mrs Wang determines to continue to use the Folium Callicarpae Formosanae enema of this embodiment 1 gained treatment lower digestive tract hemorrhage, use again after 2 courses for the treatment of, the phenomenon of melena has not had substantially, occurs seldom that the phenomenon of having blood in stool, Mrs Wang adhere to again consolidating 2 courses for the treatment of with the Folium Callicarpae Formosanae enema of embodiment 1 gained treatment lower digestive tract hemorrhage yet again.Follow up a case by regular visits to so far and do not have blood in stool again, fecal occult blood testing is negative.
embodiment 2the preparation process of the Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 2 hours, boil for the second time 1 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add 6 times of amount ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(5) step (1)-step (4) gains are placed in to glass container, adding distil water, the main component of the every 100ml of Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of control gained: Folium Callicarpae Formosanae water extract 12g, Fructus Psoraleae water extract 15g, Radix Curcumae water extract 10g, Radix Sophorae Tonkinensis water extract 9g, fresh garlic extract 9g, Rhizoma Imperatae water extract 12g, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
Instructions of taking: the emptying defecation of trying one's best before coloclysis, anal canal is inserted to 15cm-20cm and carry out retention enema.Every 6 hours coloclysis 1 time, each 100ml, keeps the constant temperature of 38-41 ℃ of medicinal liquid, and injection speed slows down, and with 10min, is advisable.Coloclysis finishes rapidly anal canal to be extracted gently afterwards, and buttocks muscles is clutched to anus place, keeps medicinal liquid to be detained in vivo more than 1 hour as far as possible, within 5 days, is a course for the treatment of.
model case two:xue XX, man, 62 years old, people from Ganzhou.Cause is the weak 3 Ge Yue people institutes of melena repeatedly.Be not admitted to hospital health check-up under anemia looks, xiphoid-process light tenderness, 7-9 time/min of borborygmus, not and other are abnormal.Routine blood test shows hemoglobin 87g/L.The total protein 51.3g/L that has a blood test after being admitted to hospital, albumin 32.0g/L. immunoglobulin level compared with normal value obviously declines, IgG4.400g/L, IgA0.351g/L, IgM0.098g/L.Stool routine is shown and is occulted blood.Blood thyroid function and Tumor invasion show no obvious abnormalities.Small intestinal CT shows that transverse colon intestinal wall thickens, edema, the multiple lymphadenectasis of mesentery and posterior peritoneum, the calcification of sigmoid colon wall, multiple liver cysts.Ascending colon many places fester is shown in colonoscopy, apart from anus 55 to 60cm with apart from anus 48 to 50cm place's colonic mucosa, is the change of paving stone sample, the visible sludged blood of central authorities and oozing of blood.Local stenosis of bowel.Pathologic finding shows the reaction of intestinal mucosa chronic inflammatory, sees lamellar congo red staining positive material in interstitial.
Using the Folium Callicarpae Formosanae enema of embodiment 2 gained treatment lower digestive tract hemorrhage after 2 courses for the treatment of, it is normal that stool is tending towards, and bleeding is also eased.Use again the Folium Callicarpae Formosanae enema of embodiment 2 gained treatment lower digestive tract hemorrhage after 2 courses for the treatment of, seldom see bleeding, so go to hospital to be ECT, check, show that enteric hemorrhage phenomenon is well controlled, Mr. Xue is very delight.Consider and think thoroughly to cure disease, adhere to again consolidating 2 courses for the treatment of with the Folium Callicarpae Formosanae enema of embodiment 2 gained treatment lower digestive tract hemorrhage.In the following up a case by regular visits to of later stage, do not recur again.
embodiment 3the preparation process of the Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked 1 day, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 1.2 hours, boil for the second time 0.6 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add 4 times of amount ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(5) step (1)-step (4) gains are placed in to glass container, adding distil water, the main component of the every 100ml of Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of control gained: Folium Callicarpae Formosanae water extract 8g, Fructus Psoraleae water extract 9g, Radix Curcumae water extract 6g, Radix Sophorae Tonkinensis water extract 5g, fresh garlic extract 5g, Rhizoma Imperatae water extract 7g, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
Instructions of taking: the emptying defecation of trying one's best before coloclysis, anal canal is inserted to 15cm-20cm and carry out retention enema.Every 6 hours coloclysis 1 time, each 100ml, keeps the constant temperature of 38-41 ℃ of medicinal liquid, and injection speed slows down, and with 10min, is advisable.Coloclysis finishes rapidly anal canal to be extracted gently afterwards, and buttocks muscles is clutched to anus place, keeps medicinal liquid to be detained in vivo more than 1 hour as far as possible, within 5 days, is a course for the treatment of.
embodiment 4the preparation process of the Folium Callicarpae Formosanae oral liquid of inhibition gastrointestinal hemorrhage is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 1.8 hours, boil for the second time 0.8 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add 6 times of amount ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(5) step (1)-step (4) gains are placed in to glass container, adding distil water, the main component of the every 100ml of Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of control gained: Folium Callicarpae Formosanae water extract 10g, Fructus Psoraleae water extract 12g, Radix Curcumae water extract 9g, Radix Sophorae Tonkinensis water extract 8g, fresh garlic extract 7g, Rhizoma Imperatae water extract 10g, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
Instructions of taking: the emptying defecation of trying one's best before coloclysis, anal canal is inserted to 15cm-20cm and carry out retention enema.Every 6 hours coloclysis 1 time, each 100ml, keeps the constant temperature of 38-41 ℃ of medicinal liquid, and injection speed slows down, and with 10min, is advisable.Coloclysis finishes rapidly anal canal to be extracted gently afterwards, and buttocks muscles is clutched to anus place, keeps medicinal liquid to be detained in vivo more than 1 hour as far as possible, within 5 days, is a course for the treatment of.
model case three:high XX, man, 58 years old, the Guangyuan City people of Sichuan Province.Health was good in the past, at certain afternoon, had eaten a decocting in water egg, about 1 as a child started afterwards stomachache, just go to toilet afterwards pull out be stool.Think and eat bad belly, drunk one bowl the period of the day from 11 a.m. to 1 p.m tea, have better.What ate that night is gruel, goes to clinic to open some medicines at 7 in evening, and after having eaten, what 10 left and right started to pull out has been all blood, not stool.Before 6 of the next mornings, went altogether 4 times.Go local hospital emergency treatment to check blood count in 7 of mornings, result is all good, forwarded anorectal section to, doctor checks and is not Internal hemorrhoid hemorrhage, is likely enterorrhagia, need to do enteroscopy, after three days, do intestinal mirror on an empty stomach, it is enterorrhagia that result shows, so be in hospital undergoing treatment, symptom is eased, but in the ensuing time, intermittently occurs having blood in stool always.
In April, 2011, is not intended to pleasant to the ear friend and has introduced the Folium Callicarpae Formosanae enema that the present invention treats lower digestive tract hemorrhage, and Mr. Gao also liked to try and sees at that time.Unexpectedly, using the Folium Callicarpae Formosanae enema of embodiment 4 gained treatment lower digestive tract hemorrhage after 1 course for the treatment of, the symptom of having blood in stool is just clearly better.2 courses for the treatment of of Folium Callicarpae Formosanae enema of continuing again to use embodiment 4 gained treatment lower digestive tract hemorrhage, the symptom of having blood in stool obviously disappears, and it is more ruddy that complexion also becomes.Continue to treat with embodiment 4 gained the Folium Callicarpae Formosanae enema of lower digestive tract hemorrhage and consolidate the state of an illness 1 course for the treatment of.In the following up a case by regular visits to of later stage, learn Mr.'s Gao not recurrence in the time more than 3 years so far.
embodiment 5the preparation process of the Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 1.5 hours, boil for the second time 0.7 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add 5 times of amount ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(5) step (1)-step (4) gains are placed in to glass container, adding distil water, the main component of the every 100ml of Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of control gained: Folium Callicarpae Formosanae water extract 9g, Fructus Psoraleae water extract 11g, Radix Curcumae water extract 8g, Radix Sophorae Tonkinensis water extract 7g, fresh garlic extract 6g, Rhizoma Imperatae water extract 8g, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
Instructions of taking: the emptying defecation of trying one's best before coloclysis, anal canal is inserted to 15cm-20cm and carry out retention enema.Every 6 hours coloclysis 1 time, each 100ml, keeps the constant temperature of 38-41 ℃ of medicinal liquid, and injection speed slows down, and with 10min, is advisable.Coloclysis finishes rapidly anal canal to be extracted gently afterwards, and buttocks muscles is clutched to anus place, keeps medicinal liquid to be detained in vivo more than 1 hour as far as possible, within 5 days, is a course for the treatment of.
test example:in order to verify the Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of embodiment 5 gained, we have carried out contrast test.Patient 200 people are selected in experiment, are divided into randomly matched group and test group, and every group number is identical, is respectively 100 people.Test 1 week before, carries out Continuous Observation to this crowd, records symptom and variation.Our every days same equal time, medication under square one, and observe simultaneously, record every patient's of group health.Matched group: adopt other treatment scheme, such as oral Mesalazine table etc.; Experimental group: the Folium Callicarpae Formosanae enema of practical embodiment 5 gained carries out retention enema, every 6 hours coloclysis once, each 100 ml, the constant temperature that maintenance medicinal liquid is 38-41 ℃, 5 days is a course for the treatment of.Curative effect situation criterion: cure: have blood in stool and the symptom such as melena disappears completely.Effective: to have blood in stool and the symptom such as melena alleviates or part disappears.Invalid: to have blood in stool and the symptom such as melena is unchanged and symptomatic recurrence, wherein effectively comprise and curing and effective.
Observation period is limited to 4 courses for the treatment of, and observed content is as follows:
1, every 2 days, observe once, record the number that hematochezia disease is obviously alleviated, add up each course for the treatment of and have blood in stool the number of remission, result is as accompanying drawing 1:
Analyze: from accompanying drawing 1, can find out, the Folium Callicarpae Formosanae enema of embodiment 5 gained treatment lower digestive tract hemorrhage, has good mitigation to alleviating the symptom of having blood in stool, more than the good effect that adopts other treatment scheme.
2, every 2 days, observe once, record the number that melena disease is obviously alleviated, the number of adding up each the melena remission course for the treatment of, result is as accompanying drawing 2:
Analyze: from accompanying drawing 2, can find out, the Folium Callicarpae Formosanae enema of embodiment 5 gained treatment lower digestive tract hemorrhage, has good mitigation to alleviating the symptom of having blood in stool, more than the good effect that adopts other treatment scheme.
3, the Comparison of therapeutic of the experimental group of the Folium Callicarpae Formosanae enema of the treatment lower digestive tract hemorrhage of the matched group of employing other treatment scheme and use embodiment 5 gained, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, use embodiment 5 gained treatment lower digestive tract hemorrhage Folium Callicarpae Formosanae enema only have 2 people invalid, and employing other treatment scheme has 13 people invalid, and the cure rate of the Folium Callicarpae Formosanae enema of use embodiment 5 gained treatment lower digestive tract hemorrhage is up to 81%, total effective rate has reached 98%, and adopts the cure rate of other treatment scheme only to reach 38%.Experiment shows to use the Folium Callicarpae Formosanae enema of embodiment 5 gained treatment lower digestive tract hemorrhage to compare with adopting other treatment scheme, and its curative effect increases substantially, and cure rate significantly promotes, and inefficiency is low.
From accompanying drawing 1-2, can obviously find out, the alleviation number of each symptom of the experimental group of the Folium Callicarpae Formosanae enema of embodiment 5 gained treatment lower digestive tract hemorrhage is far more than the matched group that adopts other treatment scheme.The Folium Callicarpae Formosanae enema of taking embodiment 5 gained treatment lower digestive tract hemorrhage has each symptom of patient up to 56% to be eased after 2 courses for the treatment of, when taking 4 courses for the treatment of, 92% a patient symptom is well alleviated.To sum up, can find out, the Folium Callicarpae Formosanae enema of gained treatment lower digestive tract hemorrhage of the present invention has good curative effect to treatment lower digestive tract hemorrhage, adopt Chinese medicinal material simple and easy to get as raw material, instant effect, and without any side effects, there is benefiting QI and nourishing blood, the effect of astringing to arrest bleeding, blood circulation promoting and blood stasis dispelling, replenishing QI to invigorate the spleen, cooling blood for hemostasis, clearing away heat-damp and promoting diuresis., to spitting blood, have blood in stool, the lower digestive tract hemorrhage such as heavy blood can quick-acting haemostatic powder, and lower digestive tract hemorrhage is had to good curative effect, can reach the object of rapid alleviation patient misery.
Finally it should be noted that, embodiment is the specific embodiment of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the Folium Callicarpae Formosanae enema for the treatment of lower digestive tract hemorrhage, is characterized in that the main component of every 100ml Folium Callicarpae Formosanae enema: Folium Callicarpae Formosanae water extract 6-12g, Fructus Psoraleae water extract 6-15g, Radix Curcumae water extract 5-10g, Radix Sophorae Tonkinensis water extract 4-9g, fresh garlic extract 3-9g, Rhizoma Imperatae water extract 5-12g.
2. Folium Callicarpae Formosanae enema according to claim 1, is characterized in that, the main component of every 100ml Folium Callicarpae Formosanae enema: Folium Callicarpae Formosanae water extract 8-10g, Fructus Psoraleae water extract 9-12g, Radix Curcumae water extract 6-9g, Radix Sophorae Tonkinensis water extract 5-8g, fresh garlic extract 5-7g, Rhizoma Imperatae water extract 7-10g.
3. Folium Callicarpae Formosanae enema according to claim 1, is characterized in that, the main component of every 100ml Folium Callicarpae Formosanae enema: Folium Callicarpae Formosanae water extract 9g, Fructus Psoraleae water extract 11g, Radix Curcumae water extract 8g, Radix Sophorae Tonkinensis water extract 7g, fresh garlic extract 6g, Rhizoma Imperatae water extract 8g.
4. according to the preparation method of the arbitrary described Folium Callicarpae Formosanae enema of claim 1-3, it is characterized in that, step is as follows:
(1) garlic clove is pulverized, be placed in storagetank, soak, the Bulbus Allii slurry after immersion is squeezed in boiler and is carried out vapor distillation, and distillate is separated through oil water separator, obtains Bulbus Allii extract;
(2) respectively Radix Curcumae, Radix Sophorae Tonkinensis and Rhizoma Imperatae are soaked to 1-2 days, be placed in marmite, decoct with water twice, boil 1-2 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Curcumae water extract, Radix Sophorae Tonkinensis water extract, Rhizoma Imperatae water extract;
(3) Fructus Psoraleae is placed in to marmite, decocts with water twice, boil for the first time 1-2 hour, boil for the second time 0.5-1 hour, twice filtrate merges, and is concentrated into thick paste shape, dries, and obtains Fructus Psoraleae water extract;
(4) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel separated, discard ethanol mother solution, precipitation, 60 ℃ of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(5) step (1)-(4) gains are placed in to glass container, adding distil water, mix homogeneously, sterilization, subpackage makes Folium Callicarpae Formosanae enema.
5. the preparation method of Folium Callicarpae Formosanae enema according to claim 4, is characterized in that, step (1) water consumption is 1.5-2.5 times (preferably, water consumption is 2.0 times of Bulbus Allii weight) of Bulbus Allii weight.
6. the preparation method of Folium Callicarpae Formosanae enema according to claim 4, is characterized in that, step (1) is soaked (preferably, at 55 ℃, soaking) at 50 ℃-60 ℃.
7. the preparation method of Folium Callicarpae Formosanae enema according to claim 4, is characterized in that: step (1) is carried out vapor distillation (preferably, the quantity of steam with 120kg/h carries out vapor distillation) with the quantity of steam of 100kg/h-140kg/h.
8. the preparation method of Folium Callicarpae Formosanae enema according to claim 4, is characterized in that: step (3) is concentrated into the thick paste that relative density is 1.2-1.4 (preferably, be concentrated into relative density and be 1.3 thick paste).
9. the preparation method of Folium Callicarpae Formosanae enema according to claim 4, is characterized in that: step (4) adds the ethanol (ethanol that preferably, adds 4-6 times of Folium Callicarpae Formosanae coarse powder quality) of 4-6 times of Folium Callicarpae Formosanae coarse powder quality.
10. the preparation method of Folium Callicarpae Formosanae enema according to claim 4, is characterized in that: the preferred Callicarpa nudiflora of Folium Callicarpae Formosanae, Callicarpa lobo-apiculata Metc. or the Folium Callicarpae Macrophyllae described in step (4).
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| JP2011157293A (en) * | 2010-01-29 | 2011-08-18 | Tokyo Univ Of Agriculture & Technology | Antioxidant |
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