CN104189125B - 一种治疗痛风的外用瑶药组合物及其制备方法 - Google Patents
一种治疗痛风的外用瑶药组合物及其制备方法 Download PDFInfo
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Abstract
本发明属民族医药领域，公开了一种治疗痛风的外用瑶药组合物及其制备方法：其原料以重量份计，包括猫爪草3‑30份、爬墙风3‑30份、黑九牛3‑30份、林寨亮3‑30份、能秃咪3‑30份、挨背咪3‑30份。其剂型为散剂。其制备过程包括：原料药材粉碎、烘烤、消毒杀菌后制成散剂。使用方法为外敷或熏洗。临床试验表明，本发明药组合物具有解毒消肿、疏经活络、散瘀止痛之效。促进肿胀消退、缓解关节疼痛，达到治疗痛风的目的。该瑶药组合物疗效迅速、稳定，无毒副作用，是一种对痛风具有防治作用的保健药。
Description
技术领域
本发明属于民族医药领域，具体涉及一种治疗痛风的外用瑶药组合物及其制备方法。
背景技术
痛风是一组嘌呤代谢紊乱所致的疾病，嘌呤代谢中有关酶活性的先天性或后天性缺陷导致尿酸生成过多，尿酸排出过少，或二者兼有之，使血浆尿酸盐浓度超过饱和限度。通常以大于420umol/L(7mg/dl)定为高尿酸血症(hyperuricemia)。其临床表现可有无症状高尿酸血症，急性痛风关节炎，间歇性发作或慢性痛风石性关节炎，甚至出现痛风性肾病(急性尿酸性肾病，尿酸盐性间质性肾炎和肾结石)。
瑶医认为本病为风闷(瑶文：muerng mun)，包括松节闷(瑶文：Mung baengc)或松节病(瑶文：guan jieh baengc)等。瑶医认为痛风的病机主要为外邪痹阻于肢体、经络，使气血运行失畅所致。风寒湿热之邪壅于关节经络，气血郁滞不通，临床表现为关节疼痛、关节屈伸痛增等症状。本病病位在肌表经络，久则深及筋骨，穷必及肾，痰浊血瘀凝聚经隧，内及脏腑，浊湿蕴热，煎熬尿液，可见尿血、石淋。浊毒久稽，损伤肝肾，寒热错杂，壅塞三焦以至“关格”，尿闭险恶之象环生。瑶医根据盈亏平衡理论将此病分为三期，分别为盈亏不显期、盈盛而亏不著期、盈更盛而亏更著期。盈亏不显期治法为健脾利湿，益气通络；盈盛而亏不著期治法为泄毒化瘀，清热利湿；亏盛而盈不著期治法为温经散寒，除湿通络。瑶医多运用猫爪草、爬墙风、黑九牛、林寨亮、、能秃咪、挨背咪等瑶药外用治疗，拟达到解毒消肿、疏经活络、散瘀止痛的功效。
发明内容
本发明提供了一种治疗痛风的外用瑶药组合物。该药物组合物采用具有解毒消肿、疏经活络、散瘀止痛等功效的瑶药成分，能够在较短时间内促进肿胀消退、缓解疼痛的作用。
1.本发明通过以下技术方案实现：
其原料以重量份计，包括猫爪草3-30份、爬墙风3-30份、黑九牛3-30份、林寨亮3-30份、能秃咪3-30份、挨背咪3-30份。
本发明瑶药组合物所包括原料的作用：
猫爪草：味甘、辛，性温；属打药。解毒、化痰散结。主治瘰疬；结核；咽炎；疔疮；蛇咬伤；疟疾；偏头痛；牙痛。
爬墙风(夹竹桃科植物络石藤Trachelosperumum jasminoides(Lindl.)Lam.)，瑶语bah zingh buerng。味苦，性平。属打药。祛风除湿，调经活络，散瘀止痛。治风湿痹痛、风湿性关节炎、坐骨神经痛、小便不利、肺结核、跌打损伤、外伤肌腱挛缩。
黑九牛(毛莨科植物威灵仙Clematis chinensis Osbeck)，瑶语giev juovnqungh。根，味辛、微苦，性温。叶，味苦，性平。属打药。根，祛风除湿，通经活络，止痛，利尿消肿。叶，清热解毒。治风湿痹痛、筋骨疼痛、关节不利、四肢麻木、腰肌劳损、小便不利、浮肿、跌打损伤、骨鲠喉。
林寨亮(冬青科植物铁冬青Iiex rotunda Thunb.的树皮、枝、叶)，瑶名linh zaixndiangx。味苦，性凉。属打药。清热解毒，消肿止痛，止血生肌。治感冒发热、咽喉肿瘤、扁桃体炎、急性胃肠炎、痢疾、胃十二指肠溃疡、肾炎水肿、盆腔炎、附件炎、急慢性肝炎、风湿关节痛、湿疹、皮炎、烧烫伤、毒蛇咬伤。
能秃咪(车前草科植物大车前Plantago major L.)，瑶语hnangh zeih miev。味甘，性寒。属打药。清热解毒，利尿通淋，化痰止咳，止血，接筋。治感冒发烧咳嗽、慢性气管炎、黄疸型肝炎、胆囊炎、尿路感染、血尿、尿潴留、脚气浮肿、肾炎水肿、尿路结石、小儿发热惊风、小儿咳嗽、白浊、白带、外伤出血、筋断。
挨背咪(菊科植物白子菜Gynura divaricata(L.)DC.的全草)，瑶名ngoih beimiev。味甘、淡，性凉。属打药。清热解毒，散瘀消肿，止痛，凉血止血，舒筋，接骨。治肺结核、支气管炎、胃脘痛、急性关节炎、蛔虫病、小儿疳积、目赤肿痛、乳腺炎、跌打损伤、骨折、外伤出血、痈疮肿毒、烧烫伤。
全方均为打药，瑶医认为风闷(瑶文：muerng mun)的主要病机为外邪痹阻于肢体、经络，风寒湿热之邪壅于关节经络，痰浊血瘀凝聚经隧，内及脏腑，损伤肝肾，本病过盈，非打不足以祛邪，故全方运用猫爪草、爬墙风、黑九、林寨亮、能秃咪、挨背咪共同组成解毒消肿、疏经活络、散瘀止痛之剂。全方充分体现了瑶医风打盈亏的思想，对于盈症，打盈是关键。
2.本发明瑶药组合物的制备方法，其包括如下步骤：
按重量份分别称取上述原料药材，将其进行粉碎过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封包装，制成散剂。
3.本发明瑶药组合物的剂型，其特征为：散剂。
4.本发明瑶药组合物的使用方法为：外敷或熏洗。
5.本发明具有以下功效：
具有明确的解毒消肿、疏经活络、散瘀止痛之效；本发明瑶药组合物疗效确切、迅速、稳定，无毒副作用，是一种治疗痛风的保健药。
具体实施方式
下面通过实施例对本发明作进一步说明，但是不作为对本发明保护范围的任何限制。
1.实施例1-6的成分及重量组分见表1。
2.实施例1-6的试验设计为：
选择在广西中医药大学仁爱分院、广西民族医院、广西壮医院、广西崇左市人民医院就诊的痛风病例60例，每个实施例10例，进行临床观察。
3.实施例1-6瑶药组合物制备方法：
取实施例1-3的瑶药组合物相应量，混合，粗粉碎，过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封包装成散剂。取实施例4-6的瑶药组合物相应量，混合，粗粉碎，过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封分装成每袋20g的散剂。
4.实施例1-6的治疗方法为：
实施例1-3每次用120克净重，水煎熏洗患处，一天二次。实施例4-6每次用20克散剂酒调敷患处，一天二次。每疗程3天。停药后观察临床症状及实验室指标。观察期间禁止使用任何其他治疗药物，也不采用其他非药物治疗方法。
5.本发明实施例1-6的实施结果见表2。
表1：本发明瑶药组合物成分及重量组分
表2：本发明对痛风疗效对比
| 处理 | 有效率 | 不良反应 |
| 实施例1 | 90.00％(9/10) | 无 |
| 实施例2 | 80.00％(8/10) | 无 |
| 实施例3 | 70.00％(7/10) | 无 |
| 实施例4 | 90.00％(9/10) | 无 |
| 实施例5 | 70.00％(7/10) | 无 |
| 实施例6 | 80.00％(8/10) | 无 |
| 合计 | 80.00％(48/60) | 无 |
Claims (4)
1.一种治疗痛风的外用瑶药组合物，其特征在于：由以下重量份的原料组成：猫爪草3-30份、爬墙风3-30份、黑九牛3-30份、林寨亮3-30份、能秃咪3-30份、挨背咪3-30份。
2.根据权利要求1所述的治疗痛风的外用瑶药组合物，其特征在于：所述组合物的剂型为散剂。
3.一种如权利要求1所述的治疗痛风的瑶药组合物的制备方法，其特征在于：将瑶药组合物的原料药材进行粗粉碎，过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封包装成散剂。
4.一种如权利要求1所述的治疗痛风的外用瑶药组合物在制备预防或治疗痛风的药物中的应用，其特征在于：所述组合物具有解毒消肿、疏经活络、散瘀止痛之效，能促进肿胀消退、缓解关节疼痛，达到治疗痛风的目的。
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