CN104189125A - 一种治疗痛风的外用瑶药组合物及其制备方法 - Google Patents
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Abstract
本发明属民族医药领域，公开了一种治疗痛风的外用瑶药组合物及其制备方法：其原料以重量份计，包括猫爪草3-30份、爬墙风3-30份、黑九牛3-30份、林寨亮3-30份、能秃咪3-30份、挨背咪3-30份。其剂型为散剂。其制备过程包括：原料药材粉碎、烘烤、消毒杀菌后制成散剂。使用方法为外敷或熏洗。临床试验表明，本发明药组合物具有解毒消肿、疏经活络、散瘀止痛之效。促进肿胀消退、缓解关节疼痛，达到治疗痛风的目的。该瑶药组合物疗效迅速、稳定，无毒副作用，是一种对痛风具有防治作用的保健药。
Description
技术领域
本发明属于民族医药领域，具体涉及一种治疗痛风的外用瑶药组合物及其制备方法。
背景技术
痛风是一组嘌呤代谢紊乱所致的疾病，嘌呤代谢中有关酶活性的先天性或后天性缺陷导致尿酸生成过多，尿酸排出过少，或二者兼有之，使血浆尿酸盐浓度超过饱和限度。通常以大于420umol/L(7mg/dl)定为高尿酸血症(hyperuricemia)。其临床表现可有无症状高尿酸血症，急性痛风关节炎，间歇性发作或慢性痛风石性关节炎，甚至出现痛风性肾病(急性尿酸性肾病，尿酸盐性间质性肾炎和肾结石)。
瑶医认为本病为风闷(瑶文：muerng mun)，包括松节闷(瑶文：Mung baengc)或松节病(瑶文：guan jieh baengc)等。瑶医认为痛风的病机主要为外邪痹阻于肢体、经络，使气血运行失畅所致。风寒湿热之邪壅于关节经络，气血郁滞不通，临床表现为关节疼痛、关节屈伸痛增等症状。本病病位在肌表经络，久则深及筋骨，穷必及肾，痰浊血瘀凝聚经隧，内及脏腑，浊湿蕴热，煎熬尿液，可见尿血、石淋。浊毒久稽，损伤肝肾，寒热错杂，壅塞三焦以至“关格”，尿闭险恶之象环生。瑶医根据盈亏平衡理论将此病分为三期，分别为盈亏不显期、盈盛而亏不著期、盈更盛而亏更著期。盈亏不显期治法为健脾利湿，益气通络；盈盛而亏不著期治法为泄毒化瘀，清热利湿；亏盛而盈不著期治法为温经散寒，除湿通络。瑶医多运用猫爪草、爬墙风、黑九牛、林寨亮、、能秃咪、挨背咪等瑶药外用治疗，拟达到解毒消肿、疏经活络、散瘀止痛的功效。
发明内容
本发明提供了一种治疗痛风的外用瑶药组合物。该药物组合物采用具有解毒消肿、疏经活络、散瘀止痛等功效的瑶药成分，能够在较短时间内促进肿胀消退、缓解疼痛的作用。
1.本发明通过以下技术方案实现：
其原料以重量份计，包括猫爪草3-30份、爬墙风3-30份、黑九牛3-30份、林寨亮3-30份、能秃咪3-30份、挨背咪3-30份。
本发明瑶药组合物所包括原料的作用：
猫爪草：味甘、辛，性温；属打药。解毒、化痰散结。主治瘰疬；结核；咽炎；疔疮；蛇咬伤；疟疾；偏头痛；牙痛。
爬墙风(夹竹桃科植物络石藤Trachelosperumum jasminoides(Lindl.)Lam.)，瑶语bahzingh buerng。味苦，性平。属打药。祛风除湿，调经活络，散瘀止痛。治风湿痹痛、风湿性关节炎、坐骨神经痛、小便不利、肺结核、跌打损伤、外伤肌腱挛缩。
黑九牛(毛莨科植物威灵仙Clematis chinensis Osbeck)，瑶语giev juov nqungh。根，味辛、微苦，性温。叶，味苦，性平。属打药。根，祛风除湿，通经活络，止痛，利尿消肿。叶，清热解毒。治风湿痹痛、筋骨疼痛、关节不利、四肢麻木、腰肌劳损、小便不利、浮肿、跌打损伤、骨鲠喉。
林寨亮(冬青科植物铁冬青Iiex rotunda Thunb.的树皮、枝、叶)，瑶名linh zaixndiangx。味苦，性凉。属打药。清热解毒，消肿止痛，止血生肌。治感冒发热、咽喉肿瘤、扁桃体炎、急性胃肠炎、痢疾、胃十二指肠溃疡、肾炎水肿、盆腔炎、附件炎、急慢性肝炎、风湿关节痛、湿疹、皮炎、烧烫伤、毒蛇咬伤。
能秃咪(车前草科植物大车前Plantago major L.)，瑶语hnangh zeih miev。味甘，性寒。属打药。清热解毒，利尿通淋，化痰止咳，止血，接筋。治感冒发烧咳嗽、慢性气管炎、黄疸型肝炎、胆囊炎、尿路感染、血尿、尿潴留、脚气浮肿、肾炎水肿、尿路结石、小儿发热惊风、小儿咳嗽、白浊、白带、外伤出血、筋断。
挨背咪(菊科植物白子菜Gynura divaricata(L.)DC.的全草)，瑶名ngoih bei miev。味甘、淡，性凉。属打药。清热解毒，散瘀消肿，止痛，凉血止血，舒筋，接骨。治肺结核、支气管炎、胃脘痛、急性关节炎、蛔虫病、小儿疳积、目赤肿痛、乳腺炎、跌打损伤、骨折、外伤出血、痈疮肿毒、烧烫伤。
全方均为打药，瑶医认为风闷(瑶文：muerng mun)的主要病机为外邪痹阻于肢体、经络，风寒湿热之邪壅于关节经络，痰浊血瘀凝聚经隧，内及脏腑，损伤肝肾，本病过盈，非打不足以祛邪，故全方运用猫爪草、爬墙风、黑九、林寨亮、能秃咪、挨背咪共同组成解毒消肿、疏经活络、散瘀止痛之剂。全方充分体现了瑶医风打盈亏的思想，对于盈症，打盈是关键。
2.本发明瑶药组合物的制备方法，其包括如下步骤：
按重量份分别称取上述原料药材，将其进行粉碎过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封包装，制成散剂。
3.本发明瑶药组合物的剂型，其特征为：散剂。
4.本发明瑶药组合物的使用方法为：外敷或熏洗。
5.本发明具有以下功效：
具有明确的解毒消肿、疏经活络、散瘀止痛之效；本发明瑶药组合物疗效确切、迅速、稳定，无毒副作用，是一种治疗痛风的保健药。
具体实施方式
下面通过实施例对本发明作进一步说明，但是不作为对本发明保护范围的任何限制。
1.实施例1-6的成分及重量组分见表1。
2.实施例1-6的试验设计为：
选择在广西中医药大学仁爱分院、广西民族医院、广西壮医院、广西崇左市人民医院就诊的痛风病例60例，每个实施例10例，进行临床观察。
3.实施例1-6瑶药组合物制备方法：
取实施例1-3的瑶药组合物相应量，混合，粗粉碎，过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封包装成散剂。取实施例4-6的瑶药组合物相应量，混合，粗粉碎，过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封分装成每袋20g的散剂。
4.实施例1-6的治疗方法为：
实施例1-3每次用120克净重，水煎熏洗患处，一天二次。实施例4-6每次用20克散剂酒调敷患处，一天二次。每疗程3天。停药后观察临床症状及实验室指标。观察期间禁止使用任何其他治疗药物，也不采用其他非药物治疗方法。
5.本发明实施例1-6的实施结果见表2。
表1：本发明瑶药组合物成分及重量组分
表2：本发明对痛风疗效对比
| 处理 | 有效率 | 不良反应 |
| 实施例1 | 90.00％(9/10) | 无 |
| 实施例2 | 80.00％(8/10) | 无 |
| 实施例3 | 70.00％(7/10) | 无 |
| 实施例4 | 90.00％(9/10) | 无 |
| 实施例5 | 70.00％(7/10) | 无 |
| 实施例6 | 80.00％(8/10) | 无 |
| 合计 | 80.00％(48/60) | 无 |
Claims (5)
1.一种治疗痛风的外用瑶药组合物及其制备方法，其特征在于：其原料以重量份计，包括猫爪草3-30份、爬墙风3-30份、黑九牛3-30份、林寨亮3-30份、能秃咪3-30份、挨背咪3-30份。
2.一种如权利要求1所述的治疗痛风的外用瑶药组合物的剂型，其特征在于：其剂型为散剂。
3.一种如权利要求1所述的治疗痛风的瑶药组合物的制备方法，其特征在于：将瑶药组合物的原料药材进行粗粉碎，过80目筛，搅拌至混合均匀，进行烤干、消毒和杀菌处理；对上述处理后的混合物进行防潮的密封包装成散剂。
4.一种如权利要求1所述的治疗痛风的外用瑶药组合物的使用方法，其特征在于：使用方法为外敷或外洗。
5.一种如权利要求1所述的治疗痛风的外用瑶药组合物，其特征在于：具有解毒消肿、疏经活络、散瘀止痛之效，可促进肿胀消退、缓解关节疼痛，达到治疗痛风的目的。
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| CN104644782A (zh) * | 2015-01-25 | 2015-05-27 | 汪甬伟 | 猫爪草组合物外用治疗痛风 |
| CN111388632A (zh) * | 2020-04-30 | 2020-07-10 | 陈柯汝 | 一种外用通经活络瑶药经络贴及其制备方法 |
| CN114470088A (zh) * | 2022-03-02 | 2022-05-13 | 广西瑶震医药技术开发有限公司 | 一种瑶医解毒利湿茶组合物及其制备方法 |
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| CN104644782A (zh) * | 2015-01-25 | 2015-05-27 | 汪甬伟 | 猫爪草组合物外用治疗痛风 |
| CN111388632A (zh) * | 2020-04-30 | 2020-07-10 | 陈柯汝 | 一种外用通经活络瑶药经络贴及其制备方法 |
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