CN104187710A - 炎性肠病全营养配方食品 - Google Patents
炎性肠病全营养配方食品 Download PDFInfo
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- CN104187710A CN104187710A CN201410361921.0A CN201410361921A CN104187710A CN 104187710 A CN104187710 A CN 104187710A CN 201410361921 A CN201410361921 A CN 201410361921A CN 104187710 A CN104187710 A CN 104187710A
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- lactobacillus
- vitamin
- bifidobacterium
- peptide
- food
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Abstract
本发明提供了供炎性肠病患者食用的全营养配方食品、特定全营养配方食品或非全营养配方食品。该配方根据《特殊医学用途配方食品通则》的要求,结合炎性肠病患者的体质特征,综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果,依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则)研制而成。该产品采用10种以上药食两用的中药提取物精华、多种益生菌、益生元为主要原料,以短肽、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质辅料,不仅可作为单一营养来源满足炎性肠病患者的营养需求,还有起到益胃生津、消积化滞、养阴清热、行气消食及防治炎性肠病的功效。
Description
技术领域
本发明属于药食同源类配方与食品技术领域,具体是将 “药食同源之中药”的传统中医精髓理论和“多重益生菌”有机结合起来,添加以短肽、益生元、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质为辅料制成的防治炎性肠病的全营养配方食品、特定全营养配方食品或非全营养配方食品。
背景技术
炎性肠病,简称IBD,是一种特殊的慢性肠道炎症性疾病,主要包括克罗恩病(CD)和溃疡性结肠炎(UC),近30年来,我国IBD发病率有不断攀升的趋势,根据国内文献报道,近5年的病例数是上世纪90年代同期的8倍,IBD已逐渐成为我国消化科的常见病,很多老百姓口中的“慢性肠炎”很可能就是IBD,IBD患者肠道不能正常吸收进食的碳水化合物、蛋白质、脂肪、维生素及多种微量元素,加上肠道炎症或服用的药物可能造成食欲不佳,因此IBD常伴随着不同程度的营养不良,甚至影响小孩正常的生长发育,营养支持对IBD症状缓解及促进愈合有重要的作用,因此保持自身良好的营养状态是治疗IBD一个重要的部分,IBD并没有存在专门的特殊饮食,不同人能耐受的食物有异,因此IBD总的饮食原则是保证自己膳食平衡同时避免一些使疾病恶化的食物,很多专家都认为,炎性肠病并不可怕,只要养成健康的生活方式,保证进食、休息、用药规律,定期随访监测病情,炎性肠病是可以控制的的碳水化合物、蛋白质、脂肪、维生素及多种微量元素,IBD 的病因和发病机制尚未完全明确,已知肠道粘膜免疫系统异常反应所导致的炎症反应在IBD发病中起重要作用,认为这是由多因素相互作用所致,主要包括环境、遗传、感染和免疫因素,一、环境因素近几十年来,IBD(UC和CD)的发病率持续增高,这一现象首先出现在社会经济高度发达的北美、北欧,继而是西欧、南欧,最近才是日本、南美,这一现象反映了环境因素微妙但却重要的变化,如饮食、吸烟或暴露于其他尚不明确的因素,二、遗传因素,IBD发病的另一个重要现象是IBD患者一级亲属发病率显著高于普通人群,而患者的配偶发病率不增加,瑞典一项大规模的研究发现,CD发病率单卵双胞显著高于双卵双胞,已有大量关于IBD相关基因的报道,早期研究主要集中在HLA等位基因以及细胞因子基因多态性上,但报道的结果不一,主要可能与不同种族、人群遗传背景有关,近年对基因组进行定位克隆,在IBD家族的大样本研究发现,IBD的易感点位于第3、7、12、16号染色体上,有关研究尚在深入进行中,认为,IBD不仅是多基因病,而且也是遗传异质性疾病(不同人由不同基因引起),患者在一定的环境因素作用下由于遗传易感而发病,三、感染因素微生物在IBD发病中的作用一直受到重视,但至今尚未找到某一特异微生物病原与IBD有恒定关系,有研究认为副结核分枝杆菌及麻疹病毒与CD有关,但证据尚缺乏说服力。近年关于微生物致病性的另一种观点正日益受到重视,这一观点认为IBD(特别是CD)是针对自身正常肠道菌丛的异常免疫反应引起的,有两方面的证据支持这一观点,一方面来自IBD的动物模型,用转基因或敲除基因方法造成免疫缺陷的IBD动物模型,在肠道无菌环境下不会发生肠道炎症,但如重新恢复肠道正常菌丛状态,则出现肠道炎症,
“药食同源”是中华原创医学之中对人类最有价值的贡献之一;中医历来强调“药疗不如食疗”,食疗成为现代人追求返璞归真、健康饮食的最佳选择;让人们在享受美食的过程中祛除病痛,避免了打针、吃药,甚至手术之苦。
对于特殊营养食品,在美国、欧盟等发达国家都有相应的规定和开发应用;而我国GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中全营养食品明确规定:2.1.1全营养配方食品:可作为单一营养来源满足目标人群营养需求的特殊医学用途配方食品;2.1.2特定全营养配方食品:可作为单一营养来源满足目标人群在特定疾病或医学状况下营养需求的特殊医学用途配方食品。
中医传统医学认为:“脾(即消化系统)为后天之本”,肠胃健康是健康之本,人体营养的99%需要靠肠道吸收,肠内疾病也是万病之源;但随着年龄越大,肠道中有益菌群(益生菌)比例逐渐减少;如双岐杆菌在婴幼儿时期占98%,到中年时降至10%,65岁以后仅占5%;人越老,益生菌越少,肠道功能也随之逐渐下降,越来越多的研究显示,正常菌群在人体消化、免疫和抗病等方面有诸多不可替代的作用;肠道菌群组成的改变与多种疾病,特别是肠道疾病的发生发展密切相关,而从已有临床研究发现:益生菌能起到调节肠道菌群,控制肠道炎症作用,是一种安全有效的干预调节方法。
肠道微生态系统与炎性肠病的联系:在人类炎症性肠病中,定植的菌落是引起炎症的主要因素之一,克罗恩氏病患者,其小肠T淋巴细胞对细菌抗原高度敏感,这种病人的局部耐受机制消失,另外,克罗恩病和溃疡性结肠炎患者肠道分泌的IgG抗体量增加,用以对抗广谱的共生细菌,由IgG介导的炎症免疫应答对肠道粘膜有损伤作用,这主要是由于他们激活了补体反应和一系列炎症介质的级联反应,而且,在肠道发炎的病人中,粘附于上皮表面的细菌数量比健康人的多。菌落成份对肠道免疫系统的无限制激活,在炎症性肠道疾病的病理生理学上可能起着至关重要的作用。一些克罗恩病患者(17%-25%)调节宿主对细菌免疫应答的NOD2/CARD15基因有突变;由此可见,炎性肠病与肠道微生态失衡有着密切的联系。
直接口服益生菌虽有一定效果,但是由于益生菌一在肠道内无法定植,且停留、占位很少,易流失,停服后有害菌易复发,相关患者需要长期服用,治疗周期长,往往使用后复发率非常高;为缩短相关患者的治疗周期,减少停药后复发率,本团队通过近叁年来对益生菌在肠道内定植机理的关健技术研究,努力寻求改进益生菌在肠道内定植的“药食同源之中药”复方,考虑到益生菌在肠道内定植的几个关键要素:益生元的存在能起到定植作用、肠道pH环境的降低和提高益生菌细胞的肠道粘附能力等,基于上述要素,本课题组从数十种“药食同源之中药”中筛选合适的食材,首次发现了添加山药、薏仁、鸡内金、芡实和菊芋等药食同源之中药成分的提取物及水苏糖,酵母、L-谷氨酰胺等后,对外源益生菌有很强的定植作用,为肠道微生态制剂中益生菌的组方选择提供实验依据。
目前市场上有利用以食源性短肽为主要原料,添加药食两用的石斛、山楂、鸡内金、沙棘、木瓜、莱菔子等的提取物、复合维生素和矿物质,组成复合配方,还有利用益生菌为主要原料的产品,但还没有发现结合炎性肠病患者的体质特征,依据传统中医的精髓理论,因人而异,黄金配伍以十种以上药食两用的中药提取物精华、多种益生菌、益生元为主要原料,以短肽、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质辅料制成的全营养配方食品、特定全营养配方食品或类似产品。
发明目的
本发明的目的是在继承中医精髓理论治病方法上,开创性将多种抗糖尿病益生菌与“药食同源之中药”复方的提取物有机结合起来, 添加以短肽、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质为辅料,不仅能够补充炎性肠病患者所必需营养素,改善机体营养状况,还能并利用药食两用中草药中的功能因子调节机体功能,益生菌能起到调节肠道菌群,毒副作用小、安全有效,且人们容易接受的适合炎性肠病患者食用的全营养配方食品、特定全营养配方食品或非全营养配方食品。
发明内容:
本研发团队根据《特殊医学用途配方食品通则》的要求,结合炎性肠病患者的体质特征,综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果,依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则),采用10种以上药食两用的中药提取物精华、多种益生菌、短肽、益生元为主要原料,以氨基酸、水溶性膳食纤维、复合维生素、复合矿物质辅料,不仅可作为单一营养来源满足炎性肠病患者的营养需求,还有益胃生津、消积化滞、养阴清热、行气消食、及防治炎性肠病的全营养配方食品、特定全营养配方食品或非全营养配方食品(组合成的复合配方)。
本发明配方的主要成分为:
1. 中药提取物是根据糖尿病患者的体质特征从中医理论中的肝、脾、肾三脏同调为主原则,利用药食两用中草药中的功能因子调节机体功能防治炎性肠病,并选取以下几大类药物进行配伍;其中:
石斛味甘,性微寒,能养阴清热,益胃生津,山楂所含的解脂酶能促进脂肪类食物的消化和促进胃液分泌和增加胃内酶素等功能,山楂具有消积化滞、收敛止痢、活血化淤等功效,主治饮食积滞、胸膈脾满、疝气血淤闭经等症,山楂中含有山萜类及黄酮类等药物成分,具有显著的扩张血管及降压作用,有增强心肌、抗心律不齐、调节血脂及胆固醇含量的功能,鸡内金性甘平、微寒、无毒,归脾、胃、肾、膀胱经,可消食健胃,涩精止遗,主治消积滞,健脾胃。治食积胀满,呕吐反胃,沙棘中含有的黄酮类化合物具有很高的药用价值,可降低胆固醇,缓解心绞痛发作,还有抗炎症的作用,木瓜中含有一种酵素,能消化蛋白质,有利于人体对食物进行消化和吸收有健脾消食的功效,含大量丰富的胡萝卜素、蛋白质、钙盐、蛋白酶、柠檬酶等,可以防治炎症,莱菔子消食除胀,降气化痰。用于饮食停滞、脘腹胀痛、大便秘结、积滞泻痢、痰壅喘咳,木香味辛、苦,性温;归脾、胃、肺经,行气止痛;调中导滞。主胞胁胀满足 ;脘腹胀痛;哎吐泄泻;痢疾后重,青皮具有疏肝破气,散结消痰的作用,能够治胸胁胃脘疼痛,疝气,食积,白术可以补脾,益胃,燥湿,和中,安胎,用于治脾胃气弱,不思饮食,猴头菇可以行气消食,健脾开胃,安神益智,用于食积不消,脘腹胀痛,脾虚食少,失眠多梦,
本发明所述的药食两用中药提取物是指石斛、山楂、鸡内金、沙棘、木瓜、莱菔子、木香、青皮、白术、冬虫夏草、蛹虫草、生姜、猴头菇、砂仁、益智仁、肉豆蔻、钝顶螺旋藻、松花粉、枸杞、麦芽、栀子、陈皮、茯苓、丁香、杏仁、佛手、甘草、乌梅、杏仁、葡萄干、胚芽米、纳豆、葛根、山药、其中的10种以上采用生物酶解或预水解SBE提取并微胶囊化,经喷雾干燥及冷冻干燥的提取物全部混合。
2. 多种益生菌: 使益生菌能大部分通过胃的强酸环境到达肠道,以促进益生菌的增殖,调节肠内微生态平衡,促进对微量元素的吸收,增强脾胃运动功能,加速药效的吸收,改善黏膜表面的微生物群或酶的平衡,或刺激机体特异性或非特异性免疫机制,提高机体定植抗力或免疫力;Xing等用双歧杆菌和乳酸杆菌预处理肝缺血再灌注大鼠,可以明显降低肠源性内毒素血症的水平并预防肝损伤的发生;选择性肠道脱污染也是调整肠道微生态的重要措施,有研究应用肠道不吸收抗生素利福昔明(rifaximin),通过抑制肠道中产尿素酶及产氨细菌的生长,来防治炎性肠病的发生;
本发明所述的多种益生菌是指微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)、嗜热链球菌其中的四种以上或全部混合。
3. 短肽:即为低聚肽,是指利用生物酶工程技术从动物或植物蛋白中分离提取的一类小分子蛋白质,其平均分子量在1000Dalton以下,易溶于水,对酸、热稳定,可以不需经过消化而直接吸收,生物利用率高,在吸收和利用上优于游离的氨基酸和完整的蛋白质,可应用于蛋白质补充食品中,尤其对于消化吸收能力低下的人群,短肽是极佳的氮源,除营养功能外,短肽还具有一系列的生理活性功能:提高小肠的消化吸收功能, 增强机体免疫力,抗氧化, 辅助调节血糖,辅助调节血脂,辅助降血压,抗辐射, 促进矿物质吸收, 增强药食两用中草药中功能因子的作用效果;
本发明所述的短肽是指海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽其中一种、几种或全部混合。
4. 益生元: 以促益生菌肠道定植、肠道收敛、降低肠道pH环境,也不被大多数的肠道腐败菌利用,但可以促进人体内有益细菌——乳杆菌、双歧 杆菌的生长繁殖,从而可以抑制腐败菌生长,有助于改善和维持肠道正常功能;长期食用可以延缓衰老、通便、提高免疫力、减轻肝脏负担、提高营养素的吸收率,特别是能够改善机体对钙、铁、锌等金属离子 的吸收;可选择性地促进有益菌(双歧、乳酸)的生长繁殖外,还可代谢为酸性产物如乳酸等有机酸,使结肠内pH值降低,抑制肠道有害细菌的生长;使小肠内水电解质滞留在肠腔,产生高渗效果,刺激肠蠕动引起缓泻,从而促进肠道内毒素及其他毒性物质的排出,乳果糖还可直接灭活肠道中内毒素、降低肠道pH值,已广范应用于炎性肠病的治疗;
本发明所述的益生元本是指低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖其中的一种、几种或全部混合。
5. 氨基酸:分为必需氨基酸与非必需氨基酸,是构成蛋白质的基本单位,赋予蛋白质特定的分子结构形态,使其具有生化活性;摄取适量的蛋氨酸有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用;亮氨酸能够修复肌肉,控制血糖,并给身体组织提供能量,必需氨基酸苯丙氨酸可以抑制癌瘤生长,又可以降低药物的毒副作用,赖氨酸可提高食物蛋白质的吸收和利用,达到均衡营养,促进生长发育;精氨酸有助于将血液中的氨转变为尿素而排泄出去;对于高氨血症,肝脏机能障碍等均有功效;组氨酸降低胃液酸度,缓和胃肠手术的疼痛,减轻妊娠期呕吐及胃部灼热感,抑制由植物神经紧张而引起的消化道溃烂,对过敏性疾病,如哮喘等也有功效;色氨酸可以预防糙皮病、抑郁症,改善睡眠和调节情绪;
本发明所述的氨基酸是指蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸其中的一种、几种或全部混合。
6.维生素和矿物质:
维生素和矿物质是人体必需的营养素,本发明中添加的维生素为维生素和矿物质是人体必需的营养素;
本发明中添加的维生素为维生素A、维生素D、维生素E、维生素K、维生素K1、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、维生素Be、维生素Bu、烟酸、叶酸、泛酸、胆碱、生物素其中的 一种、几种或全部混合;
本发明中添加的矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬、钼其中的一种、几种或全部混合,本发明所述的矿物质添加为该矿物质的有机或无机化合物;
本发明中维生素矿物质的添加量参照GB14880《食品营养强化剂使用卫生标准》、GB2760《食品添加剂使用标准》执行。
7.本发明以微胶囊、生物酶解、预水解SBE、喷雾干燥及冷冻干燥集成创新,构成的产业化生产的关键技术;微囊化保护技术,有效解决了口服过程中高温以及强酸胃液对益生菌的灭活;采用三层蛋白质深埋微胶囊技术,再与经生物酶解或预水解SBE技术提取并微囊化处理后的中药提取物混合均匀,以解决“多重益生菌”与“药食同源之中药”组分的共存问题,具有一定的抗高温和强酸特性,有利于益生菌通过口服顺利通过胃液到达肠道内停留定植,使产品防治炎性肠病功效与市场同类产品相比大幅提高;
8.采用上述集成创新工艺将各种配料混合均匀制成粉状的固体饮料、颗粒剂,并分装成10g/包,用约150ml温开水(45度)溶解后,直接饮用或经鼻饲摄入;也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用,若做成饮料则省去经喷雾干燥,少添加黑芝麻粉等,分装成10-65ml/瓶,每日早、中、晚饭后0.5小时各饮1瓶,所有操作均在洁净干燥环境内进行;
本配方全营养配方食品的特性及其对机体的作用主要表现在以下几个方面:
1.本发明是根据《特殊医学用途配方食品通则》的要求,结合炎性肠病患者的体质特征,综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果研制的,因人而异,黄金配伍;
2.本发明依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则),采用10种以上药食两用的中药提取物精华、多种益生菌、益生元为主要原料,以短肽、氨基酸、复合维生素、复合矿物质辅料,各种配料的有机组合,将各种功能进行融合,并通过有效成分之间的协同作用,增强作用效果;
3. 具有高效吸收性,利用本发明配方,各种组分采用适宜的比例搭配制备的食品,经一定量水溶解后呈等渗状态,能快速 通过胃到达小肠,吸收快速、完全,可以迅速补充炎性肠病患者所需营养,不增加肝肾负担;
4. 本发明配方中采用各种药食两用中草药的提取物,含有多种功能活性成分,不仅提高了功能因子的浓度,减少各种杂质的摄入,有助于减轻肝肾负担,具有增强人体抵抗力的作用,还有益胃生津、消积化滞、养阴清热、行气消食及防治炎性肠病的功效;
5.本发明配方中所含的益生菌,多种益生菌能够维护肠道正常细菌菌群平衡,抑制病原菌的生长,防止胃肠障碍等,在肠道内合成维生素、氨基酸和提高机体对钙离子的吸收,增强人体免疫机能,预防抗生素的副作用,提高宿主对放射线的耐受性,乳杆菌显著增加肠粘膜免疫球蛋白A(SIgA)含量,对机体肠粘膜局部免疫具有调节作用,调节胃、肠微生态,能提高钙、磷、铁的利用率,促进铁和维生素D的吸收,产生维生素K及维生素B,还可以减少胆固醇的吸收;
6. 本发明配方食品以多种来源的食源性生物活性短肽为氮源,因为短肽不需消化即可吸收,更有利于机体的利用,可以有效改善炎性肠病患者负氮平衡,而且食源性短肽能够改善肠粘膜上皮细胞的结构和功能,提高肠粘膜的吸收能力;
7.本组方采用了本团队通过近叁年来对益生菌在肠道内定植机理的关健技术研究的成果, 改进益生菌在肠道内定植的“药食同源之中药”复方,结合了益生元的存在能起到定植作用、肠道pH环境的降低和提高益生菌细胞的肠道粘附能力等要素,因此该食品配方的组成大大增强了对外源益生菌的定植作用;
8.本发明配方中所含的益生元,通过促进肠内益生菌的生长繁殖,抑制腐败菌的生长,同时在肠粘膜表面形成一道保护屏障,可以抵御肠道腐败菌对肠粘 膜的损伤,减少肠内有害物质的吸收,还可以促进肠道蠕动,加速肠内残留物质的排出,可以防止便秘,而且通过促进肠道益生菌的生长繁殖也可以增强机体免疫力,短肽 与活性多糖等生物活性物质具有协同作用;
9、本发明配方中所含的氨基酸,是构成蛋白质的基本单位,赋予蛋白质特定的分子结构形态,使其具有生化活性,有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用,能够修复肌肉,控制血糖,并给身体组织提供能量,还可提高食物蛋白质的吸收和利用,达到均衡营养,促进生长发育;
10、本发明配方食品含多种维生素和矿物质,可迅速补充炎性肠病患者所需的微量营养素,短肽通过与钙、铁、锌等的螯合后,更增加了矿物质元素的吸收率;
11、本发明配方中不含脂肪和胆固醇,能够在补充蛋白质、微量营养素的同时,不会增加脂肪、胆固醇的摄入,避免了肉、蛋等髙蛋白食物的不利影响。
具体实施方式
下面通过以下实施例对本发明作进一步说明,它将有助于理解本发明。
实施例一
实施案例一 实现本发明目的炎性肠病全营养配方食品其包括以重量计的下列组分: 药食两用的提取物: 石斛12g、山楂12g、鸡内金11g、沙棘11g、木瓜10g、莱菔子10g、木香8g、青皮8g、白术8g、冬虫夏草7g、蛹虫草7g、生姜6g、猴头菇6g、砂仁6g、益智仁6g、肉豆蔻5g、钝顶螺旋藻5g、松花粉5g、枸杞5g、麦芽5g、栀子4g、陈皮4g、茯苓4g、丁香4g、杏仁4g、佛手3g、甘草3g、乌梅3g、杏仁3g、葡萄干3g、胚芽米3g、纳豆3g、葛根3g、山药3g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g; 制作时先将以是石斛、山楂、鸡内金、沙棘、木瓜、莱菔子、木香、青皮、白术、冬虫夏草、蛹虫草、生姜、猴头菇、砂仁、益智仁、肉豆蔻、枸杞、麦芽、栀子、陈皮、茯苓、丁香、杏仁、佛手、甘草、乌梅、杏仁、葡萄干、葛根、山药浸泡后加入β-环状糊精,用预水解SBE技术提取后,经喷雾干燥而制备的粉状物质,再添加生物酶解提取的短肽、益生元、氨基酸、冬虫夏草、蛹虫草、水溶性膳食纤维、葛根粉、黑芝麻粉、黑豆粉、莲子粉、扁豆粉、多种维生素及矿物质混合后进行巴氏灭菌1小时,然后添加微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)、嗜热链球菌并混合的各种配料混合均匀制成粉状的固体饮料、颗粒剂,并分装成10g/包,用约150ml温开水(45度)溶解后,直接饮用或经鼻饲摄入;也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用,若做成饮料则省去经喷雾干燥,少添加黑芝麻粉等,分装成10-65ml/瓶,每日早、中、晚饭后0.5小时各饮1瓶,所有操作均在洁净干燥环境内进行。
实施例二
上述炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 石斛12g、山楂12g、鸡内金10g、沙棘10g、木瓜10g、莱菔子10g、蛹虫草9g、冬虫夏草9g、生姜9g、猴头菇8g、砂仁8g、益智仁8g、肉豆蔻8g、钝顶螺旋藻7g、松花粉7g、枸杞7g、麦芽7g、栀子6g、陈皮6g、茯苓6g、杏仁6g、佛手4g、甘草4g、乌梅4g、杏仁4g、葡萄干3g、葛根3g、山药3g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
实施例三
上述炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 山楂14g、鸡内金12g、沙棘12g、木瓜12g、莱菔子10g、蛹虫草10g、生姜10g、猴头菇9g、砂仁9g、益智仁8g、肉豆蔻8g、钝顶螺旋藻8g、松花粉8g、枸杞7g、麦芽7g、栀子7g、陈皮7g、茯苓7g、杏仁6g、佛手6g、甘草5g、乌梅4g、杏仁4g、葡萄干4g、葛根3g、山药3g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
实施例四
上述炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 山楂14g、鸡内金12g、沙棘12g、木瓜12g、莱菔子12g、蛹虫草12g、猴头菇12g、砂仁10g、益智仁10g、肉豆蔻10g、松花粉10g、枸杞8g、麦芽8g、栀子8g、陈皮8g、茯苓8g、杏仁6g、佛手6g、甘草6g、乌梅4g、杏仁4g、葛根4g、山药4g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)250g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A 0.01g、维生素D 0.000015 g、维生素E 0.12g、维生素K 0.0075 g、维生素K10.00001 g、维生素C1 0.625g、维生素B1 0.016g、维生素B2 0.016g、维生素B6 0.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素 0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15 g、锌6.2g、硒 0.00012 g、铜 0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
实施例五
上述炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 山楂15g、鸡内金15g、沙棘14g、木瓜13g、莱菔子13g、蛹虫草12g、猴头菇12g、砂仁12g、益智仁11g、肉豆蔻11g、松花粉10g、枸杞10g、麦芽9g、栀子9g、陈皮8g、茯苓7g、佛手7g、乌梅6g、山药6g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)250g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A 0.01g、维生素D 0.000015 g、维生素E 0.12g、维生素K 0.0075 g、维生素C1 0.625g、维生素B1 0.016g、维生素B2 0.016g、维生素B6 0.015g、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15 g、锌6.2g、硒 0.00012 g、铜 0.007g、锰0.018g。
本发明以微胶囊、生物酶解、预水解SBE、喷雾干燥及冷冻干燥集成创新,构成的产业化生产的关键技术;微囊化保护技术,有效解决了口服过程中高温以及强酸胃液对益生菌的灭活;采用三层蛋白质深埋微胶囊技术,再与经生物酶解或预水解SBE技术提取并微囊化处理后的中药提取物混合均匀,以解决“多重益生菌”与“药食同源之中药”组分的共存问题,具有一定的抗高温和强酸特性,有利于益生菌通过口服顺利通过胃液到达肠道内停留定植,使产品防治炎性肠病的功效与市场同类产品相比大幅提高。
Claims (6)
1.炎性肠病全营养配方食品,其特征在于其原料成分含量包括以重量计的下列组分:药食两用的提取物: 石斛12g、山楂12g、鸡内金11g、沙棘11g、木瓜10g、莱菔子10g、木香8g、青皮8g、白术8g、冬虫夏草7g、蛹虫草7g、生姜6g、猴头菇6g、砂仁6g、益智仁6g、肉豆蔻5g、钝顶螺旋藻5g、松花粉5g、枸杞5g、麦芽5g、栀子4g、陈皮4g、茯苓4g、丁香4g、杏仁4g、佛手3g、甘草3g、乌梅3g、杏仁3g、葡萄干3g、胚芽米3g、纳豆3g、葛根3g、山药3g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g; 制作时先将以是石斛、山楂、鸡内金、沙棘、木瓜、莱菔子、木香、青皮、白术、冬虫夏草、蛹虫草、生姜、猴头菇、砂仁、益智仁、肉豆蔻、枸杞、麦芽、栀子、陈皮、茯苓、丁香、杏仁、佛手、甘草、乌梅、杏仁、葡萄干、葛根、山药浸泡后加入β-环状糊精,用预水解SBE技术提取后,经喷雾干燥而制备的粉状物质,再添加生物酶解提取的短肽、益生元、氨基酸、冬虫夏草、蛹虫草、水溶性膳食纤维、葛根粉、黑芝麻粉、黑豆粉、莲子粉、扁豆粉、多种维生素及矿物质混合后进行巴氏灭菌1小时,然后添加微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)、嗜热链球菌并混合的各种配料混合均匀制成粉状的固体饮料、颗粒剂,并分装成10g/包,用约150ml温开水(45度)溶解后,直接饮用或经鼻饲摄入;也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用,若做成饮料则省去经喷雾干燥,少添加黑芝麻粉等,分装成10-65ml/瓶,每日早、中、晚饭后0.5小时各饮1瓶,所有操作均在洁净干燥环境内进行。
2.根据权利要求1所述的炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 石斛12g、山楂12g、鸡内金10g、沙棘10g、木瓜10g、莱菔子10g、蛹虫草9g、冬虫夏草9g、生姜9g、猴头菇8g、砂仁8g、益智仁8g、肉豆蔻8g、钝顶螺旋藻7g、松花粉7g、枸杞7g、麦芽7g、栀子6g、陈皮6g、茯苓6g、杏仁6g、佛手4g、甘草4g、乌梅4g、杏仁4g、葡萄干3g、葛根3g、山药3g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
3.根据权利要求1所述的炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 山楂14g、鸡内金12g、沙棘12g、木瓜12g、莱菔子10g、蛹虫草10g、生姜10g、猴头菇9g、砂仁9g、益智仁8g、肉豆蔻8g、钝顶螺旋藻8g、松花粉8g、枸杞7g、麦芽7g、栀子7g、陈皮7g、茯苓7g、杏仁6g、佛手6g、甘草5g、乌梅4g、杏仁4g、葡萄干4g、葛根3g、山药3g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
4.根据权利要求1所述的炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 山楂14g、鸡内金12g、沙棘12g、木瓜12g、莱菔子12g、蛹虫草12g、猴头菇12g、砂仁10g、益智仁10g、肉豆蔻10g、松花粉10g、枸杞8g、麦芽8g、栀子8g、陈皮8g、茯苓8g、杏仁6g、佛手6g、甘草6g、乌梅4g、杏仁4g、葛根4g、山药4g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)250g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A 0.01g、维生素D 0.000015 g、维生素E 0.12g、维生素K 0.0075 g、维生素K10.00001 g、维生素C1 0.625g、维生素B1 0.016g、维生素B2 0.016g、维生素B6 0.015g、维生素B0.0023g、维生素Be 、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素 0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15 g、锌6.2g、硒 0.00012 g、铜 0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
5.根据权利要求1所述的炎性肠病全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 山楂15g、鸡内金15g、沙棘14g、木瓜13g、莱菔子13g、蛹虫草12g、猴头菇12g、砂仁12g、益智仁11g、肉豆蔻11g、松花粉10g、枸杞10g、麦芽9g、栀子9g、陈皮8g、茯苓7g、佛手7g、乌梅6g、山药6g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)125g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)125g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)250g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)200g、复合氨基酸(L-谷氨酰胺、(蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、维生素A 0.01g、维生素D 0.000015 g、维生素E 0.12g、维生素K 0.0075 g、维生素C1 0.625g、维生素B1 0.016g、维生素B2 0.016g、维生素B6 0.015g、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15 g、锌6.2g、硒 0.00012 g、铜 0.007g、锰0.018g。
6.本发明以微胶囊、生物酶解、预水解SBE、喷雾干燥及冷冻干燥集成创新,构成的产业化生产的关键技术;微囊化保护技术,有效解决了口服过程中高温以及强酸胃液对益生菌的灭活;采用三层蛋白质深埋微胶囊技术,再与经生物酶解或预水解SBE技术提取并微囊化处理后的中药提取物混合均匀,以解决“多重益生菌”与“药食同源之中药”组分的共存问题,具有一定的抗高温和强酸特性,有利于益生菌通过口服顺利通过胃液到达肠道内停留定植,使产品防治炎性肠病功效与市场同类产品相比大幅提高。
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CN109380734A (zh) * | 2017-08-04 | 2019-02-26 | 江苏美中医疗科技有限公司 | 一种克罗恩氏病患者专用特膳食品 |
CN112236155A (zh) * | 2018-05-31 | 2021-01-15 | 深圳华大生命科学研究院 | 一种组合物及其应用 |
CN112236155B (zh) * | 2018-05-31 | 2024-10-18 | 深圳华大生命科学研究院 | 一种组合物及其应用 |
CN110432482A (zh) * | 2019-07-05 | 2019-11-12 | 上海奥医高科技实业有限公司 | 一种小儿过敏性皮炎专用型临床营养配方及其制备方法 |
CN110638043A (zh) * | 2019-11-04 | 2020-01-03 | 光明乳业股份有限公司 | 一种富含益生菌的全营养配方食品及其制备方法与应用 |
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CN114794485A (zh) * | 2022-03-28 | 2022-07-29 | 上海启立生物科技有限公司 | 一种用于整体调理肠道与免疫健康的营养品 |
CN116555126A (zh) * | 2023-06-27 | 2023-08-08 | 深圳市波尔顿科技有限公司 | 具有肠炎治疗作用的含益生菌的组合物及其应用 |
CN116555126B (zh) * | 2023-06-27 | 2023-09-15 | 深圳市波尔顿科技有限公司 | 具有肠炎治疗作用的含益生菌的组合物及其应用 |
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